Find Resorts & Hotels with Spas in Lake Nona Medical City, FL

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Check availability on Lake Nona Medical City Resorts & Hotels with Spas

Our top choices for Lake Nona Medical City hotels with a spa

Couples treatment rooms, sauna, hot tub, steam room, body treatments
Rosen Shingle Creek

Rosen Shingle Creek

Rosen Shingle Creek
4.5 star property
Orlando
9.4 out of 10, Exceptional, (4360)
"Great resort "
United States
Camille
The price is NT$3,469
NT$3,902 total
includes taxes & fees
Dec 18 - Dec 19
Rosen Shingle Creek
Outdoor pool, pool umbrellas, sun loungers
Kompose Boutique Resort at Theme Parks

Kompose Boutique Resort at Theme Parks

Kompose Boutique Resort at Theme Parks
3.0 star property
Kissimmee
9.4 out of 10, Exceptional, (1978)
"Beautiful resort with very friendly staff. "
United States
kristie
The price is NT$1,905
NT$3,400 total
includes taxes & fees
Dec 17 - Dec 18
Kompose Boutique Resort at Theme Parks
Couples treatment rooms, hot tub, steam room, body treatments
Hyatt Regency Orlando

Hyatt Regency Orlando

Hyatt Regency Orlando
4.5 star property
International Drive District
9.2 out of 10, Wonderful, (1868)
"Clean and beautifully maintained hotel . "
United States
Puneet
The price is NT$3,486
NT$5,645 total
includes taxes & fees
Dec 21 - Dec 22
Hyatt Regency Orlando
Couples treatment rooms, body treatments, aromatherapy
Caribe Royale Orlando

Caribe Royale Orlando

Caribe Royale Orlando
4.5 star property
Orlando
9.2 out of 10, Wonderful, (4502)
"Beautiful room great ammenities, the staff was great"
United States
Jennifer
The price is NT$4,960
NT$6,914 total
includes taxes & fees
Dec 17 - Dec 18
Caribe Royale Orlando
Property amenity
Wyndham Grand Orlando Resort Bonnet Creek

Wyndham Grand Orlando Resort Bonnet Creek

Wyndham Grand Orlando Resort Bonnet Creek
4.0 star property
Orlando
8.8 out of 10, Excellent, (2825)
"It’s a good property that is close to all of Disney world parks and shops. "
United States
Keith
The price is NT$4,741
NT$6,808 total
includes taxes & fees
Jan 1 - 2026/1/2
Wyndham Grand Orlando Resort Bonnet Creek
Body wraps, body scrubs, facials, massage/treatment rooms
Marriott's Grande Vista

Marriott's Grande Vista

Marriott's Grande Vista
4.0 star property
Orlando
9.0 out of 10, Wonderful, (3683)
"Great stay "
United States
Monica
The price is NT$3,400
NT$3,825 total
includes taxes & fees
Dec 15 - Dec 16
Marriott's Grande Vista
Couples treatment rooms, sauna, hot tub, steam room, body treatments
Margaritaville Resort Orlando

Margaritaville Resort Orlando

Margaritaville Resort Orlando
4.0 star property
Kissimmee
8.8 out of 10, Excellent, (3650)
"Beautiful resort with great amenities and hospitality abounds!!"
United States
Audrey
The price is NT$3,625
NT$5,814 total
includes taxes & fees
Dec 15 - Dec 16
Margaritaville Resort Orlando
Outdoor pool, open 7:00 AM to 11:00 PM, cabanas (surcharge)
Meliá Orlando Celebration

Meliá Orlando Celebration

Meliá Orlando Celebration
4.0 star property
Celebration
8.6 out of 10, Excellent, (1569)
"was a very nice stay"
United States
Taylor Elaine
The price is NT$2,901
NT$4,426 total
includes taxes & fees
Dec 21 - Dec 22
Meliá Orlando Celebration
Hot stone massages, deep-tissue massages, body wraps, body scrubs
Renaissance Orlando Resort – Disney Springs® Area

Renaissance Orlando Resort – Disney Springs® Area

Renaissance Orlando Resort – Disney Springs® Area
4.0 star property
Lake Buena Vista
8.6 out of 10, Excellent, (632)
"Excellent hotel !"
United States
AMADO ALEXANDER GARCIA
The price is NT$3,057
NT$4,808 total
includes taxes & fees
Jan 4 - 2026/1/5
Renaissance Orlando Resort – Disney Springs® Area
Couples treatment rooms, body treatments, aromatherapy, body wraps
Sheraton Orlando Lake Buena Vista Resort

Sheraton Orlando Lake Buena Vista Resort

Sheraton Orlando Lake Buena Vista Resort
4.0 star property
Orlando
7.8 out of 10, Good, (1413)
"We had a great experience! Very clean , quiet , next bar .. the pool side is beautiful "
United States
Kyesha
The price is NT$2,340
NT$3,473 total
includes taxes & fees
Dec 17 - Dec 18
Sheraton Orlando Lake Buena Vista Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Lake Nona Medical City Hotel Reviews

DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando

10/10 Excellent
"Was there for a pre-cruise night/day for EPIC Universe. It was perfect!"
Tonya 1-night trip
Posted 16 hours ago
DoubleTree by Hilton at the Entrance to Universal Orlando

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Frequently asked questions

Looking for a spa hotel in Lake Nona Medical City?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the entertainment choices and shopping in Lake Nona Medical City—your day trip starts here. Discover the lakeside setting and many popular restaurants during your stay. Hotels with spas are the perfect way to take a break from your daily routine and add a layer of luxury to your weekend away.
What's there to see and do in Lake Nona Medical City?
Enjoy all that Lake Nona Medical City has to offer when you visit Universal Orlando Resort, Universal Studios Florida, and Disney Springs™. If you have extra time while you're in the area, you might want to see Epcot® and Walt Disney World® Resort.
What is a Lake Nona Medical City spa hotel?
Spa hotels in Lake Nona Medical City provide lodging and have a full on-site spa offering services including facials as well as body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.