Lake Nona Medical City 4 Stars Hotels

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Our top choices for Lake Nona Medical City 4-star hotels

DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando
4.0 star property
Florida Center
8.4 out of 10, Very Good, (6913)
"Great hotel great food"
United States
Malika
The price is NT$2,816
NT$3,168 total
includes taxes & fees
Jan 15 - 2026/1/16
DoubleTree by Hilton at the Entrance to Universal Orlando

Hyatt Regency Orlando International Airport

Hyatt Regency Orlando International Airport
4.0 star property
Orlando
9.4 out of 10, Exceptional, (3843)
"Great stay"
United States
Dan
The price is NT$6,270
NT$7,054 total
includes taxes & fees
Jan 6 - 2026/1/7
Hyatt Regency Orlando International Airport

Hyatt Regency Orlando

Hyatt Regency Orlando
4.5 star property
International Drive District
9.2 out of 10, Wonderful, (1881)
"Clean and beautifully maintained hotel . "
United States
Puneet
The price is NT$4,230
NT$6,508 total
includes taxes & fees
Dec 28 - Dec 29
Hyatt Regency Orlando

Walt Disney World Dolphin

Walt Disney World Dolphin
4.0 star property
Bay Lake
8.8 out of 10, Excellent, (4000)
"Great place to stay"
United States
Steven
The price is NT$6,380
NT$8,753 total
includes taxes & fees
Jan 3 - 2026/1/4
Walt Disney World Dolphin

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
4.0 star property
Orlando
9.4 out of 10, Exceptional, (4166)
"Great stay"
United States
Shawna
The price is NT$3,504
NT$3,942 total
includes taxes & fees
Jan 14 - 2026/1/15
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Hilton Orlando Lake Buena Vista - Disney Springs® Area

Hilton Orlando Lake Buena Vista - Disney Springs® Area
4.0 star property
Lake Buena Vista
8.6 out of 10, Excellent, (1453)
"Perfect hotel to stay."
United States
Dennis
The price is NT$4,764
NT$6,813 total
includes taxes & fees
Jan 8 - 2026/1/9
Hilton Orlando Lake Buena Vista - Disney Springs® Area

DoubleTree by Hilton Hotel Orlando at SeaWorld

DoubleTree by Hilton Hotel Orlando at SeaWorld
4.0 star property
International Drive District
7.6 out of 10, Good, (6298)
"Clean room, the breakfast buffet was great, and the pool area was beautiful "
United States
Brandon
The price is NT$2,186
NT$3,345 total
includes taxes & fees
Jan 4 - 2026/1/5
DoubleTree by Hilton Hotel Orlando at SeaWorld

Sheraton Vistana Villages Resort Villas, I-Drive/Orlando

Sheraton Vistana Villages Resort Villas, I-Drive/Orlando
4.0 star property
International Drive District
9.2 out of 10, Wonderful, (2800)
"Great stay! "
United States
JULIA D
The price is NT$4,159
NT$4,679 total
includes taxes & fees
Jan 14 - 2026/1/15
Sheraton Vistana Villages Resort Villas, I-Drive/Orlando

Courtyard by Marriott Lake Buena Vista at Vista Centre

Courtyard by Marriott Lake Buena Vista at Vista Centre
4.0 star property
Orlando
8.2 out of 10, Very Good, (1424)
"Friendly staff, clean and comfortable room."
United States
Laura
The price is NT$2,741
NT$3,438 total
includes taxes & fees
Jan 4 - 2026/1/5
Courtyard by Marriott Lake Buena Vista at Vista Centre

Rosen Shingle Creek

Rosen Shingle Creek
4.5 star property
Orlando
9.4 out of 10, Exceptional, (4373)
"Great resort will revisit one day "
United States
Jewel
The price is NT$3,760
NT$4,230 total
includes taxes & fees
Jan 23 - 2026/1/24
Rosen Shingle Creek

Hilton Vacation Club Mystic Dunes Orlando

Hilton Vacation Club Mystic Dunes Orlando
4.0 star property
Kissimmee
9.0 out of 10, Wonderful, (4512)
"Clean rooms, great location and value."
United States
Jennifer
The price is NT$3,160
NT$4,660 total
includes taxes & fees
Jan 5 - 2026/1/6
Hilton Vacation Club Mystic Dunes Orlando

Marriott's Grande Vista

Marriott's Grande Vista
4.0 star property
Orlando
9.0 out of 10, Wonderful, (3719)
"Very good place"
United States
Makenlove
The price is NT$4,008
NT$4,509 total
includes taxes & fees
Jan 14 - 2026/1/15
Marriott's Grande Vista

DoubleTree by Hilton Orlando Airport

DoubleTree by Hilton Orlando Airport
4.0 star property
Airport North
8.8 out of 10, Excellent, (2201)
"Fantastic stay"
United States
Victor
The price is NT$4,625
NT$5,203 total
includes taxes & fees
Jan 4 - 2026/1/5
DoubleTree by Hilton Orlando Airport

Margaritaville Resort Orlando

Margaritaville Resort Orlando
4.0 star property
Kissimmee
8.8 out of 10, Excellent, (3623)
"We love staying at this hotel. "
United States
Sonnia
The price is NT$4,276
NT$6,570 total
includes taxes & fees
Jan 5 - 2026/1/6
Margaritaville Resort Orlando

Rosen Plaza on International Drive

Rosen Plaza on International Drive
4.0 star property
International Drive District
9.2 out of 10, Wonderful, (1794)
"Great place to stay"
United States
Joshua
The price is NT$3,756
NT$4,329 total
includes taxes & fees
Jan 4 - 2026/1/5
Rosen Plaza on International Drive

Avanti International Resort

Avanti International Resort
4.0 star property
International Drive District
7.8 out of 10, Good, (4341)
"Enjoyed our stay "
United States
Sheltra
The price is NT$2,384
NT$3,319 total
includes taxes & fees
Jan 4 - 2026/1/5
Avanti International Resort

DoubleTree by Hilton Hotel Orlando Downtown

DoubleTree by Hilton Hotel Orlando Downtown
4.0 star property
Ivanhoe Village
8.2 out of 10, Very Good, (2913)
"Excellent hotel "
United States
Maite
The price is NT$3,333
NT$3,749 total
includes taxes & fees
Dec 25 - Dec 26
DoubleTree by Hilton Hotel Orlando Downtown

Caribe Royale Orlando

Caribe Royale Orlando
4.5 star property
Orlando
9.2 out of 10, Wonderful, (4527)
"excellent place to stay. "
United States
Arshad
The price is NT$5,482
NT$7,514 total
includes taxes & fees
Dec 25 - Dec 26
Caribe Royale Orlando

Rosen Centre Hotel

Rosen Centre Hotel
4.0 star property
International Drive District
9.0 out of 10, Wonderful, (4150)
"The hotel was great!"
United States
Robin
The price is NT$3,380
NT$3,841 total
includes taxes & fees
Jan 4 - 2026/1/5
Rosen Centre Hotel

Universal’s Loews Portofino Bay Hotel

Universal’s Loews Portofino Bay Hotel
4.0 star property
Florida Center
9.0 out of 10, Wonderful, (1001)
"Excellent staff restaurants and rooms! "
United States
Catherine
The price is NT$18,306
NT$20,594 total
includes taxes & fees
Jan 11 - 2026/1/12
Universal’s Loews Portofino Bay Hotel
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Frequently asked questions

How much does it cost to stay in a 4-star hotel in Lake Nona Medical City?
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What's the difference between 5-star and 4-star hotels in Lake Nona Medical City?
Treat yourself to luxury living during your Lake Nona Medical City getaway by staying at a 4-star hotel. As well as featuring upscale surroundings, these properties are usually filled with amenities like large beds, bathrobes and plenty more. A 5-star hotel will go the extra mile to make your trip an even more indulgent and memorable one. Round-the-clock concierge assistance, luxurious spas and gourmet dining are just the start of the superior services and conveniences you'll likely have access to.
Does Lake Nona Medical City have any 4-star all-inclusive resorts?
Enjoy a carefree vacation experience where almost everything is included in the one upfront rate by using our "All inclusive" filter. Staying within budget is a breeze when your room, meals and many activities are already taken care of. After more options? Browse the great offers on our standard 4-star options in and around Lake Nona Medical City too.

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