Find Family Hotels in Lake Nona Medical City, FL

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Lake Nona Medical City Family Hotels

Our top choices for Lake Nona Medical City family-friendly hotels

Outdoor banquet area
Rosen Shingle Creek

Rosen Shingle Creek

Rosen Shingle Creek
4.5 star property
Orlando
9.4 out of 10, Exceptional, (4361)
"Great resort "
United States
Camille
The price is NT$3,469
NT$3,902 total
includes taxes & fees
Dec 18 - Dec 19
Rosen Shingle Creek
Free daily continental breakfast
La Quinta Inn & Suites by Wyndham Orlando Airport North

La Quinta Inn & Suites by Wyndham Orlando Airport North

La Quinta Inn & Suites by Wyndham Orlando Airport North
3.0 star property
Airport North
7.4 out of 10, Good, (847)
"nice and clean staff was great also"
United States
sumatran
The price is NT$2,471
NT$2,779 total
includes taxes & fees
Dec 17 - Dec 18
La Quinta Inn & Suites by Wyndham Orlando Airport North
Pillowtop beds, in-room safe, desk, blackout drapes
Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport
3.0 star property
Airport North
8.8 out of 10, Excellent, (3751)
"Beautiful property, excellent staff and love the shuttle service to the airport!"
United States
Robert
The price is NT$2,442
NT$2,748 total
includes taxes & fees
Dec 16 - Dec 17
Wingate by Wyndham - Orlando International Airport
Lobby
Hyatt House Orlando Airport

Hyatt House Orlando Airport

Hyatt House Orlando Airport
3.5 star property
Airport North
9.6 out of 10, Exceptional, (2789)
"Great stay close to airport and plenty of dining available "
United States
Lonnie
The price is NT$3,556
NT$4,001 total
includes taxes & fees
Dec 21 - Dec 22
Hyatt House Orlando Airport
Lobby lounge
Aloft Orlando Lake Buena Vista

Aloft Orlando Lake Buena Vista

Aloft Orlando Lake Buena Vista
3.0 star property
Orlando
8.8 out of 10, Excellent, (1908)
"Great stay"
United States
Gerard
The price is NT$2,433
NT$2,737 total
includes taxes & fees
Dec 18 - Dec 19
Aloft Orlando Lake Buena Vista
Business center
Spark by Hilton Orlando near Universal

Spark by Hilton Orlando near Universal

Spark by Hilton Orlando near Universal
2.5 star property
Florida Center
9.0 out of 10, Wonderful, (430)
"The rooms and breakfast were lovely"
United States
MacKenzie Rose
The price is NT$2,741
NT$3,083 total
includes taxes & fees
Jan 13 - 2026/1/14
Spark by Hilton Orlando near Universal
Outdoor pool, pool umbrellas, sun loungers
Cambria Hotel Orlando Airport

Cambria Hotel Orlando Airport

Cambria Hotel Orlando Airport
3.0 star property
Orlando
8.8 out of 10, Excellent, (1937)
"The room was clean and the staff was welcoming and friendly!"
United States
Otthoniel
The price is NT$3,023
NT$3,401 total
includes taxes & fees
Dec 21 - Dec 22
Cambria Hotel Orlando Airport
Room, 2 Queen Beds | Laptop workspace, blackout drapes, iron/ironing board, cribs/infant beds
Sonesta Essential Orlando Airport

Sonesta Essential Orlando Airport

Sonesta Essential Orlando Airport
3.0 star property
Orlando
8.0 out of 10, Very Good, (245)
"The hotel was very clean and the customer.service was great. "
United States
Heather
The price is NT$2,776
NT$3,123 total
includes taxes & fees
Dec 15 - Dec 16
Sonesta Essential Orlando Airport
Courtyard
Nobile Hotel Parkway at Celebration Orlando

Nobile Hotel Parkway at Celebration Orlando

Nobile Hotel Parkway at Celebration Orlando
2.5 star property
Kissimmee
8.0 out of 10, Very Good, (1008)
"The staff were so nice and very friendly, they made my stay here very welcoming. "
United States
Giselle
The price is NT$1,168
NT$2,282 total
includes taxes & fees
Dec 15 - Dec 16
Nobile Hotel Parkway at Celebration Orlando
Children's activities
DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando
4.0 star property
Florida Center
8.4 out of 10, Very Good, (6891)
"Wonderful stay. Great location!"
United States
Charmaine
The price is NT$3,060
NT$3,443 total
includes taxes & fees
Dec 17 - Dec 18
DoubleTree by Hilton at the Entrance to Universal Orlando
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Lake Nona Medical City Hotel Reviews

DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando

10/10 Excellent
"Was there for a pre-cruise night/day for EPIC Universe. It was perfect!"
Tonya 1-night trip
Posted 19 hours ago
DoubleTree by Hilton at the Entrance to Universal Orlando

Explore a world of travel with Expedia

Frequently asked questions

What's Lake Nona Medical City like for family-friendly vacations?
The relaxing destination of Lake Nona Medical City is a good choice if you've been thinking about a trip with your kids. The entertainment, lake views, and coffee shops are just some of the things that make this an attractive family vacation spot. Take to the air and fly into Orlando Intl. Airport (MCO), which is the closest airport, or Kissimmee, FL (ISM-Kissimmee Gateway), which is located 11.1 mi (17.8 km) from the center of Lake Nona Medical City.
What's there to see and do with your family in Lake Nona Medical City?
While you and your family are visiting Lake Nona Medical City, you might want to check out some kid-friendly attractions such as Universal Orlando Resort and Universal Studios Florida. Make sure you have plenty of time to take in activities in the area like Disney Springs™, Epcot®, and Walt Disney World® Resort.