Find Business Hotels in Lake Nona Medical City, FL

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Our top choices for Lake Nona Medical City business-friendly hotels

Aloft Orlando Lake Nona

Aloft Orlando Lake Nona
3.0 star property
Lake Nona
9.8 out of 10, Exceptional, (273)
"Great staff and nice amenities. "
United States
David
The price is NT$4,379
NT$4,927 total
includes taxes & fees
Dec 25 - Dec 26
Aloft Orlando Lake Nona

Courtyard Orlando Lake Nona

Courtyard Orlando Lake Nona
3.0 star property
Lake Nona
9.6 out of 10, Exceptional, (594)
"Mya, at the front desk, was exceptional and was a great start to our experience!"
United States
James
The price is NT$4,789
NT$5,442 total
includes taxes & fees
Jan 4 - 2026/1/5
Courtyard Orlando Lake Nona

Residence Inn Orlando Lake Nona

Residence Inn Orlando Lake Nona
3.0 star property
Lake Nona
9.6 out of 10, Exceptional, (326)
"Very clean hotel and spacious room with comfortable seating and kitchen area. The location was great for me as I was there visiting someone in an area hospital. There are also restaurants and coffee shops right outside the entrance. "
United States
Sharon
The price is NT$5,010
NT$5,692 total
includes taxes & fees
Dec 25 - Dec 26
Residence Inn Orlando Lake Nona

Rosen Shingle Creek

Rosen Shingle Creek
4.5 star property
Orlando
9.4 out of 10, Exceptional, (4369)
"Great resort will revisit one day "
United States
Jewel
The price is NT$3,760
NT$4,230 total
includes taxes & fees
Jan 23 - 2026/1/24
Rosen Shingle Creek

Seasons Florida Resort

Seasons Florida Resort
2.0 star property
Kissimmee
8.8 out of 10, Excellent, (3305)
"Excellent location and value, very clean and friendly check in"
United States
Jason
The price is NT$1,985
NT$2,253 total
includes taxes & fees
Jan 4 - 2026/1/5
Seasons Florida Resort

DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel

DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel
3.0 star property
International Drive District
8.6 out of 10, Excellent, (734)
"What a wonderful stay! "
United States
Lucia
The price is NT$2,651
NT$2,983 total
includes taxes & fees
Jan 14 - 2026/1/15
DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel

Country Inn & Suites by Radisson, Orlando Airport, FL

Country Inn & Suites by Radisson, Orlando Airport, FL
3.0 star property
Airport North
7.8 out of 10, Good, (4338)
"Always enjoy my stay here. "
United States
David
The price is NT$2,697
NT$3,034 total
includes taxes & fees
Jan 7 - 2026/1/8
Country Inn & Suites by Radisson, Orlando Airport, FL

DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando
4.0 star property
Florida Center
8.4 out of 10, Very Good, (6908)
"Great hotel great food"
United States
Malika
The price is NT$3,078
NT$3,463 total
includes taxes & fees
Jan 15 - 2026/1/16
DoubleTree by Hilton at the Entrance to Universal Orlando

La Quinta Inn & Suites by Wyndham Orlando Airport North

La Quinta Inn & Suites by Wyndham Orlando Airport North
3.0 star property
Airport North
7.4 out of 10, Good, (901)
"Staff was very friendly, quick and easy check in. "
United States
Lisa
The price is NT$2,999
NT$3,374 total
includes taxes & fees
Jan 5 - 2026/1/6
La Quinta Inn & Suites by Wyndham Orlando Airport North

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
4.0 star property
Orlando
9.4 out of 10, Exceptional, (4166)
"Great stay"
United States
Shawna
The price is NT$3,504
NT$3,942 total
includes taxes & fees
Jan 14 - 2026/1/15
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Lake Nona Medical City Hotel Reviews

Frequently asked questions

Why book your business-friendly hotel in Lake Nona Medical City with Expedia?
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How can I find cheap business-friendly hotels in Lake Nona Medical City?
When work takes you on the road in Lake Nona Medical City, our "business friendly" filter will help you find the right hotel. From free WiFi to concierge services and conference spaces, they have the amenities you need for a comfortable and productive stay. Another useful tip? Refine your search by your budget and preferred star rating to view the most affordable accommodations.

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