Find hotels in Midtown, St. Louis from NT$1,688
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Discover 1,764 Midtown hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Element St. Louis Midtown
Element St. Louis Midtown

Residence Inn by Marriott St Louis Downtown
Residence Inn by Marriott St Louis Downtown

Best Western Troy Hotel
Best Western Troy Hotel

Red Roof Inn St Louis - Troy, IL
Red Roof Inn St Louis - Troy, IL

Holiday Inn Express Troy by IHG
Holiday Inn Express Troy by IHG

Motel 6 Troy, IL
Motel 6 Troy, IL
Where to stay in Midtown

Downtown St. Louis
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Clayton
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
Creve Coeur
Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

Downtown West
If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.
Top Midtown Hotel Reviews

Pear Tree Inn St. Louis Airport
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top St. Louis neighborhoods
- Hotels in Downtown St. Louis
- Hotels in Clayton
- Hotels in Central West End
- Hotels in Creve Coeur
- Hotels in Downtown West
- Hotels in Soulard
- Hotels in St. Charles Historic District
- Hotels in The Hill
- Hotels in Ladue
- Hotels in University City
- Hotels in Midtown
- Hotels in Dogtown
- Hotels in The Grove
- Hotels in Tower Grove South
- Hotels in Shaw
- Hotels in Lafayette Square
- Hotels in The Gate
- Hotels in Benton Park
- Hotels in Southwest Garden
- Hotels in Tower Grove East
Hotels near popular St. Louis Attractions
- Hotels near St. Louis University
- Hotels near Chaifetz Arena
- Hotels near Scott Joplin House State Historic Site
- Hotels near Museum of Contemporary Religious Art
- Hotels near Samuel Cupples House
- Hotels near Busch Stadium
- Hotels near St. Louis Union Station
- Hotels near Gateway Arch
- Hotels near Washington University in St. Louis
- Hotels near St. Louis Zoo
Hotels Close to Nearby Airports
Midtown Hotels by Star Rating
Explore more hotels
- Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
- Pear Tree Inn St. Louis Airport
- Pear Tree Inn St. Louis Near Union Station
- Marriott St. Louis Grand
- Best Western St. Louis-Kirkwood Route 66
- AC Hotel St. Louis Clayton
- 21C Museum Hotel St Louis
- Drury Inn & Suites St. Louis Union Station
- Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
- Home2 Suites by Hilton St. Louis Downtown
- La Quinta Inn & Suites by Wyndham St. Louis Westport
- River City Casino & Hotel
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