Find Boutique Hotels in Clayton, MO

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Our top choices for Clayton boutique hotels

Moonrise Hotel

Moonrise Hotel
4.0 star property
Delmar Loop
9.0 out of 10, Wonderful, (1923)
"Great place"
United States
Edward
The price is NT$3,911
NT$4,651 total
includes taxes & fees
Jan 12 - 2026/1/13
Moonrise Hotel

The Cheshire

The Cheshire
4.0 star property
Richmond Heights
8.6 out of 10, Excellent, (1001)
"Very friendly staff. Clean, comfortable, and a GREAT breakfast!"
United States
Christine
The price is NT$3,706
NT$4,400 total
includes taxes & fees
Jan 18 - 2026/1/19
The Cheshire

Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Seven Gables, St. Louis West, a Tribute Portfolio Hotel
3.5 star property
Clayton
8.4 out of 10, Very Good, (577)
"Love this place."
United States
Robert
The price is NT$4,114
NT$5,102 total
includes taxes & fees
Jan 2 - 2026/1/3
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Clayton Hotel Reviews

Frequently asked questions

What's the best boutique accommodation in Clayton?
Seven Gables, St. Louis West, a Tribute Portfolio Hotel is a favorite hotel with our travelers looking for a stylish accommodation, and features 32 guestrooms, a garden, and free WiFi.
What's there to see and do in Clayton?
The shopping, restaurants, and sporting events are just some of the things to enjoy while you're in the area. Activities and attractions to experience around Clayton include St. Louis Union Station, Busch Stadium, and Chapel of St. Timothy And St. Titus, Concordia Seminary. You might also want to consider exploring Saint Louis Galleria Mall, St. Louis Art Museum, and St. Louis Zoo while you're here.
What's the best way to get to my boutique hotel in Clayton?
You have a few options for traveling to and around Clayton. The closest major airport is St. Louis Lambert Intl. Airport (STL), which is located 7.3 mi (11.7 km) away, but St. Louis, MO (SUS-Spirit of St. Louis) may also be an option. Make your way to Clayton Station to catch metro.

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