Find Boutique Hotels in Clayton, MO

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Our top choices for Clayton boutique hotels

Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Seven Gables, St. Louis West, a Tribute Portfolio Hotel
3.5 star property
Clayton
8.4 out of 10, Very Good, (577)
"Love this place."
United States
Robert
The price is NT$4,118
NT$5,106 total
includes taxes & fees
Dec 29 - Dec 30
Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Moonrise Hotel

Moonrise Hotel
4.0 star property
Delmar Loop
9.0 out of 10, Wonderful, (1914)
"The staff was very friendly and courteous. The hotel itself is quirky and fun"
United States
Deborah
The price is NT$3,541
NT$4,212 total
includes taxes & fees
Dec 28 - Dec 29
Moonrise Hotel

The Cheshire

The Cheshire
4.0 star property
Richmond Heights
8.6 out of 10, Excellent, (1000)
"Excellent place to stay. "
United States
Todd
The price is NT$3,709
NT$4,404 total
includes taxes & fees
Jan 18 - 2026/1/19
The Cheshire
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Clayton Hotel Reviews

Frequently asked questions

What's the best boutique accommodation in Clayton?
Seven Gables, St. Louis West, a Tribute Portfolio Hotel is a favorite hotel with our travelers looking for a stylish accommodation, and features 32 guestrooms, a garden, and free WiFi.
What's there to see and do in Clayton?
The shopping, restaurants, and sporting events are just some of the things to enjoy while you're in the area. Activities and attractions to experience around Clayton include St. Louis Union Station, Busch Stadium, and Chapel of St. Timothy And St. Titus, Concordia Seminary. You might also want to consider exploring Saint Louis Galleria Mall, St. Louis Art Museum, and St. Louis Zoo while you're here.
What's the best way to get to my boutique hotel in Clayton?
You have a few options for traveling to and around Clayton. The closest major airport is St. Louis Lambert Intl. Airport (STL), which is located 7.3 mi (11.7 km) away, but St. Louis, MO (SUS-Spirit of St. Louis) may also be an option. Make your way to Clayton Station to catch metro.

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