A city skyline at dusk with a prominent bridge arching over a body of water.

Find hotels in Southhampton, St. Louis

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Southhampton hotels

A lobby with a reception desk, seating area, and a bicycle in the background.

1. Drury Inn & Suites St. Louis Forest Park

Drury Inn & Suites St. Louis Forest Park
3.0 star property
3.3 km from Southhampton
9.4 out of 10, Exceptional, (1,020 reviews)
"Great place to stay"
United States
Robert
The price is NT$4,735
NT$5,536 total
includes taxes & fees
Oct 4 - Oct 5
Drury Inn & Suites St. Louis Forest Park
A modern hotel lobby with a reception desk, seating area, and a refreshment bar.

2. SpringHill Suites St. Louis Brentwood

SpringHill Suites St. Louis Brentwood
3.0 star property
5.9 km from Southhampton
9.0 out of 10, Wonderful, (1,004 reviews)
"It was very clean and the breakfast was good and the staff was great. I would definitely recommend this Hotel to my Family and Friends thank you."
United States
Cheryl
The price is NT$3,667
NT$4,326 total
includes taxes & fees
Oct 18 - Oct 19
SpringHill Suites St. Louis Brentwood
An indoor swimming pool with lounge chairs and a pool table, surrounded by large windows.

3. Hampton Inn & Suites St. Louis at Forest Park

Hampton Inn & Suites St. Louis at Forest Park
3.5 star property
Dogtown, 4.7 km from Southhampton
9.4 out of 10, Exceptional, (1,006 reviews)
"This was an excellent location and the front desk staff made great recommendations for places to eat and things to do."
United States
Jennifer
The price is NT$4,401
NT$5,190 total
includes taxes & fees
Oct 5 - Oct 6
Hampton Inn & Suites St. Louis at Forest Park
An outdoor seating area with a fire pit, cushioned benches, and a covered patio with string lights.

4. Home2 Suites by Hilton St. Louis/Forest Park

Home2 Suites by Hilton St. Louis/Forest Park
3.0 star property
The Grove, 5.3 km from Southhampton
8.6 out of 10, Excellent, (1,001 reviews)
"Staff was nice and helpful food was great and room was amazing!!! "
United States
paullita jeanne
The price is NT$4,941
NT$5,778 total
includes taxes & fees
Oct 4 - Oct 5
Home2 Suites by Hilton St. Louis/Forest Park
An outdoor patio with a fire pit, seating, and a building in the background.

5. Courtyard by Marriott St. Louis Brentwood

Courtyard by Marriott St. Louis Brentwood
3.0 star property
6.3 km from Southhampton
9.4 out of 10, Exceptional, (904 reviews)
"Clean comfortable room and mattress."
United States
Aaron
The price is NT$3,755
NT$4,580 total
includes taxes & fees
Oct 11 - Oct 12
Courtyard by Marriott St. Louis Brentwood
A modern bar area with a wooden bar counter, black bar stools, and a large wall with city names.

6. Fairfield Inn & Suites by Marriott St. Louis Downtown

Fairfield Inn & Suites by Marriott St. Louis Downtown
3.0 star property
Downtown West, 7.9 km from Southhampton
9.2 out of 10, Wonderful, (1,002 reviews)
"Nice hotel, great staff. Directly across the street from Energizer/City Park. Parking is $25/night and well worth it."
United States
James
The price is NT$3,973
NT$4,732 total
includes taxes & fees
Oct 5 - Oct 6
Fairfield Inn & Suites by Marriott St. Louis Downtown
A long bar with multiple tables and chairs, wooden floors, and ornate chandeliers.

7. River City Casino & Hotel

River City Casino & Hotel
4.0 star property
6.7 km from Southhampton
9.0 out of 10, Wonderful, (1,807 reviews)
"Would definitely stay here again!"
United States
Ashley
The price is NT$3,087
NT$4,056 total
includes taxes & fees
Oct 15 - Oct 16
River City Casino & Hotel
A courtyard with outdoor seating, a central fountain, and a view of a tower.

8. The Knight Center at Washington University

The Knight Center at Washington University
2.5 star property
7.4 km from Southhampton
9.4 out of 10, Exceptional, (692 reviews)
"Great stay"
United States
Kenney
The price is NT$5,376
NT$6,181 total
includes taxes & fees
Oct 4 - Oct 5
The Knight Center at Washington University
A cozy lounge area with leather sofas, a fireplace, and a bar counter.

9. The Cheshire

The Cheshire
4.0 star property
5.5 km from Southhampton
8.8 out of 10, Excellent, (1,011 reviews)
"Fantastic hotel, clean and nice rooms, great breakfast and location"
United States
Matthew
The price is NT$4,716
NT$5,600 total
includes taxes & fees
Oct 18 - Oct 19
The Cheshire
The Clayton Plaza Hotel sign with a stone wall and plants in front.

10. Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
3.5 star property
8.2 km from Southhampton
9.0 out of 10, Wonderful, (3,455 reviews)
"Great place to stay."
United States
Sivakumar
The price is NT$2,939
NT$3,431 total
includes taxes & fees
Oct 11 - Oct 12
Clayton Plaza Hotel & Extended Stay
A restaurant with round tables and chairs, a bar area, and a patterned ceiling.

11. Drury Plaza Hotel St. Louis Brentwood

Drury Plaza Hotel St. Louis Brentwood
4.0 star property
6.9 km from Southhampton
9.6 out of 10, Exceptional, (1,018 reviews)
"Excellent place to stay. Beautiful hotel, amazing friendly and attentive staff. Would highly recommend!!"
United States
Janell
The price is NT$4,322
NT$5,131 total
includes taxes & fees
Oct 4 - Oct 5
Drury Plaza Hotel St. Louis Brentwood
A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.

12. The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis
4.5 star property
Central West End, 6.5 km from Southhampton
9.2 out of 10, Wonderful, (1,014 reviews)
"Loved the location and everything about this place. Will definitely stay again"
United States
Tosha
The price is NT$5,049
NT$6,890 total
includes taxes & fees
Oct 5 - Oct 6
The Royal Sonesta Chase Park Plaza St. Louis
A hotel room with two beds, a chair, a desk, and a large window.

13. Forest Park Hotel by MDR

Forest Park Hotel by MDR
3.0 star property
The Hill, 3.4 km from Southhampton
7.4 out of 10, Good, (1,650 reviews)
"Comfortable bed and room. Friendly staff. Convenient location."
United States
Janice
The price is NT$2,454
NT$3,018 total
includes taxes & fees
Oct 28 - Oct 29
Forest Park Hotel by MDR
A modern hotel room with a large bed, a desk with a chair, a blue armchair, a sofa, a TV, and a large window offering a city view.

14. DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park
4.0 star property
Central West End, 6 km from Southhampton
8.4 out of 10, Very good, (1,000 reviews)
"Always a good place to stay when we have a trip to the doctor at Barnes Jewish or WashU"
United States
Kevin
The price is NT$4,827
NT$5,692 total
includes taxes & fees
Oct 12 - Oct 13
DoubleTree by Hilton St. Louis Forest Park
An indoor swimming pool with clear glass ceilings, large windows, and a sunlit area with umbrellas.

15. Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
3.5 star property
Downtown St. Louis, 9.8 km from Southhampton
8.8 out of 10, Excellent, (1,424 reviews)
"Staff was very friendly and room was awesome."
United States
Andy
The price is NT$3,362
NT$3,931 total
includes taxes & fees
Oct 26 - Oct 27
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.

16. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West, 8.7 km from Southhampton
9.0 out of 10, Wonderful, (2,126 reviews)
"Great place to stay!"
United States
Zane
The price is NT$4,562
NT$5,493 total
includes taxes & fees
Oct 22 - Oct 23
21C Museum Hotel St Louis
A multi-story hotel with a prominent corner location, large windows, and a well-lit facade.

17. Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
4.0 star property
Downtown St. Louis, 9.5 km from Southhampton
9.0 out of 10, Wonderful, (1,355 reviews)
"Beautiful place to stay"
United States
Karen
The price is NT$3,622
NT$4,308 total
includes taxes & fees
Oct 11 - Oct 12
Embassy Suites by Hilton St. Louis Downtown
An outdoor dining area with a table and chairs, a neon sign, and a glass railing overlooking a cityscape.

18. Aloft by Marriott St Louis Central West End

Aloft by Marriott St Louis Central West End
3.0 star property
Central West End, 6.1 km from Southhampton
8.6 out of 10, Excellent, (1,010 reviews)
"Lovely location and amazing room"
United States
Jacob
The price is NT$3,617
NT$4,229 total
includes taxes & fees
Oct 5 - Oct 6
Aloft by Marriott St Louis Central West End
A rooftop terrace with wicker furniture, offering a city view.

19. Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch
3.0 star property
Downtown St. Louis, 9.3 km from Southhampton
9.6 out of 10, Exceptional, (3,786 reviews)
"Excellent stay"
United States
Salvatore
The price is NT$4,287
NT$5,012 total
includes taxes & fees
Oct 5 - Oct 6
Drury Plaza Hotel St. Louis at the Arch
A rooftop restaurant with round tables, chairs, and a view of the city.

20. Moonrise Hotel

Moonrise Hotel
4.0 star property
7.7 km from Southhampton
9.0 out of 10, Wonderful, (2,030 reviews)
"Great location, clean rooms, and friendly staff. We will definitely stay again."
United States
Nicole
The price is NT$4,195
NT$4,989 total
includes taxes & fees
Oct 4 - Oct 5
Moonrise Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Southhampton

Find the best Southhampton areas and neighborhoods for the activities you enjoy most.
The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Old Courthouse or Gateway Arch National Park might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

A fountain in front of a red brick building with green roofs and white trim.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Top Southhampton Hotel Reviews

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

10/10 Excellent
"We have stayed at this Hampton multiple times in the past couple years. It is about a 15-20 minute walk to Busch Stadium. The staff is always super friendly and helpful. Our room is clean. The breakfast is good especially the orange juice. The breakfast staff is always there to help. We highly recommend this property."
Mr Bill 1-night trip
Posted less than an hour ago
Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Frequently asked questions

What is Southhampton like?
Travelers to the Southhampton neighborhood in St. Louis will be sure to enjoy their stay.
How many hotels will I find in the Southhampton area?
When you want to kick up your feet after a day of exploring the sights in St. Louis, you can choose from 18 Expedia hotels and other accommodations in Southhampton.
If I need to cancel my hotel reservation in Southhampton, will I receive a refund?
Yes! The majority of hotel room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of check in. If you booked a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then filter by "fully refundable" to view the best deals in Southhampton.
Where can I learn more about changing or cancelling my trip to Southhampton?
To find more details about rescheduling or cancelling your trip to Southhampton, click here.
What can I see and do in this St. Louis neighborhood?
A few places to visit in the area around Southhampton include The Heavy Anchor, Das Bevo, and Miniature Museum of Greater St. Louis. When you're sightseeing in St. Louis, Lindenwood Park and River des Peres Greenway Trailhead are also worth a stop.

Explore a world of travel with Expedia