
Find hotels in Southhampton, St. Louis
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Southhampton hotels

Hyatt Select St. Louis Airport
Hyatt Select St. Louis Airport
Pear Tree Inn St. Louis Airport
Pear Tree Inn St. Louis Airport
Wingate by Wyndham St. Louis Airport
Wingate by Wyndham St. Louis Airport
River City Casino & Hotel
River City Casino & Hotel
Drury Inn & Suites St. Louis Airport
Drury Inn & Suites St. Louis Airport
Motel 6 Hazelwood, MO
Motel 6 Hazelwood, MO
Drury Plaza Hotel St. Louis at the Arch
Drury Plaza Hotel St. Louis at the Arch
Best Western St. Louis Inn
Best Western St. Louis Inn
The Principal Hotel
The Principal Hotel
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Hampton Inn & Suites St. Louis at Forest Park
Hampton Inn & Suites St. Louis at Forest Park
Pear Tree Inn St. Louis Arnold
Pear Tree Inn St. Louis Arnold
Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66
Drury Inn & Suites Southwest St. Louis
Drury Inn & Suites Southwest St. Louis
Hilton St. Louis Airport
Hilton St. Louis Airport
Hilton Garden Inn St. Louis Airport
Hilton Garden Inn St. Louis Airport
Drury Plaza Hotel St. Louis Chesterfield
Drury Plaza Hotel St. Louis Chesterfield
The Wildwood Hotel
The Wildwood Hotel
Holiday Inn Express & Suites St. Louis South - I-55 by IHG
Holiday Inn Express & Suites St. Louis South - I-55 by IHG
Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. LouisWhere to stay in Southhampton

Downtown St. Louis
Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Busch Stadium or Gateway Arch National Park might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

Clayton
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Berkeley
Visitors highly recommend Berkeley for its abundant dining options, and you can make a stop by James S. McDonnell Prologue Room while you're in town.

Downtown West
If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
Top Southhampton Hotel Reviews

Clayton Plaza Hotel & Extended Stay
Frequently asked questions
Explore a world of travel with Expedia
- 5 Star Hotels in Richmond Heights
- Downtown St. Louis Hotels
- Hotels near St. Louis Union Station Mini Golf
- Business Hotels in St. Louis
- Hotels with a Pool in The Hill
- Hotel Wedding Venues Hotels in St. Louis
- St. Louis Hotels
- Hotels near Mildred Lane Kemper Art Museum
- Hotels near Anheuser-Busch Brewery
- Hotels near St. Louis Science Center
- Hotels near The Muny Theater
- Casino Hotels in Downtown St. Louis
- Guest Houses in Sunnen Station
- Hotels with an Indoor Pool in St. Louis
- Extended Stay America Hotels in Lemay
- Mehlville Hotels
- Historic Hotels in Central West End
- Pet-Friendly Hotels in St. Louis
- Hotels near Gateway Arch National Park
- Business Hotels in Clayton
- Hotels with Free Parking in Downtown St. Louis
- Beach Hotels in Kirkwood
- Hotels near Busch Stadium
- Resorts & Hotels with Spas in St. Louis
- B&B in Webster Groves
- Webster Groves Hotels
- Hotels near Gateway Arch
- Houseboats in St Louis City County
- Apartments in St Louis City County
- Hotels with Bars in St. Louis
- Hotels near Powell Symphony Hall
- Cheap Hotels in Downtown St. Louis
- Hotels near City Museum
- Adults Only Resorts & in St. Louis
- Luxury Hotels in Downtown St. Louis
- Business Hotels in Brentwood
- Hotels with Bars in Central West End
- Hotels near Federal Reserve Bank of St. Louis
- Hotels near Washington Avenue Historic District
- Hotels near St. Louis Aquarium at Union Station
- Hotels near St. Louis Zoo
- Hotels near Dome at America’s Center
- Hotels with a Pool in Richmond Heights
- Hotels with Hot Tubs in Clayton
- Romantic Hotels in Clayton
- Brentwood Hotels
- Hotels near River City Casino
- Boutique Hotels in Clayton
- Hotels near St. Alphonsus Liguori Catholic Church
- Romantic Hotels in Richmond Heights
- Gay friendly Hotels in Downtown St. Louis
- Resorts & Hotels with Spas in Central West End
- Hotels near St. Louis University
- Hotels near Washington University in St. Louis
- Red Roof Inn Hotels in St. Louis
- Hotels near Grant's Farm
- Soulard Hotels
- Hotels near Barnes Jewish Hospital
- Hotels near Messiah Lutheran Church
- Hotels near Central West End Station
- Shaw Hotels
- Hotel Wedding Venues Hotels in Clayton
- Grant's Farm
- Visit Lindenwood Park
- Old Courthouse
- Pulitzer Foundation for the Arts
- Sheldon Concert Hall
- Visit Central West End
- Enterprise Center
- St. Louis Science Center
- Missouri History Museum
- Affton Vacations
- Eugene Field House & St. Louis Toy Museum
- Barnes Jewish Hospital
- Visit St. Louis
- Visit Compton Heights
- Campbell House Museum
- The Muny Theater
- St. Louis Vacations
- Missouri Botanical Gardens and Arboretum
- St. Louis Zoo
- Chatillon-Demenil House
- Cathedral Basilica of St. Louis
- Saint Louis Galleria Mall
- Griot Museum of Black History
- Forest Park
- Rent A Wreck Rental Cars in St. Louis
- Car rentals near St. Louis
- Easirent.com Rental Cars in St. Louis
- Car rental Webster Groves
- Car rental Crestwood
- Car rentals near Anheuser-Busch Brewery
- Car rentals near Clayton
- Car rental Richmond Heights
- Car rentals near Compton Hill Reservoir Park
- Car rentals near Dome at America’s Center
- Dollar Rent A Car Rental Cars in Webster Groves


















































































