What is Santo Domingo like?

Travelers to Mexico City's Santo Domingo neighborhood will be sure to enjoy a stay in this neighborhood.

How many hotels should I expect to find in the Santo Domingo area?

Book one of Expedia's 5 hotels and other accommodations in Santo Domingo and start exploring everything Mexico City has to offer.

If I need to cancel my hotel reservation in Santo Domingo, will I receive a refund?

Yes, most room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals in Santo Domingo.

Where can I learn more about changing or cancelling my trip to Santo Domingo?

For additional details about updating your trip to Santo Domingo or cancelling it, click here .

What are the top things to see and do in Santo Domingo?

Centro Cultural y Social Veracruzano, Parroquia de San Juan Bautista, and Casa del Teatro are just a few of the places to visit in and around Santo Domingo. While you're out sightseeing, Museo Diego Rivera Anahuacalli and Centro Cultural Elena Garro are a couple of additional sights to visit in Mexico City.

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Dates

March 2026

April 2026

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Our top choices for Santo Domingo hotels

NH Collection Mexico City Airport T2

Venustiano Carranza, 13.8 km from Santo Domingo

Derrick

NT$6,596 total

includes taxes & fees

Mar 6 - Mar 7

Camino Real Aeropuerto Mexico

Venustiano Carranza, 14.5 km from Santo Domingo

JOSE LUIS

NT$4,649 total

includes taxes & fees

Mar 6 - Mar 7

Breakfast, lunch, dinner served; Mexican cuisine

Zocalo Central & Rooftop Mexico City

Historic Center, 12.1 km from Santo Domingo

Guadalupe

NT$6,914 total

includes taxes & fees

Mar 17 - Mar 18

Fiesta Inn Ciudad de Mexico Aeropuerto

Venustiano Carranza, 14.3 km from Santo Domingo

Arturo

NT$4,724 total

includes taxes & fees

Mar 7 - Mar 8

Courtyard Mexico City Airport

Venustiano Carranza, 14.8 km from Santo Domingo

Mauricio

NT$6,429 total

includes taxes & fees

Mar 7 - Mar 8

Grand Prix-WeEnjoyHotels-Aeropuerto

Granjas México, 10.8 km from Santo Domingo

oscar

NT$2,882 total

includes taxes & fees

Feb 23 - Feb 24

Standard Room | In-room safe, soundproofing, free WiFi, wheelchair access

Hotel Amala

7.6 km from Santo Domingo

Salvador

Holiday Inn Express Mexico Aeropuerto by IHG

Granjas México, 10.6 km from Santo Domingo

Lina

NT$3,387 total

includes taxes & fees

Mar 18 - Mar 19

Hotel Ancona - Adults Only

13.8 km from Santo Domingo

Samuel

Rooftop bar, alfresco dining, open daily

Fiesta Americana Viaducto Aeropuerto

Granjas México, 10.3 km from Santo Domingo

Ruben

NT$5,291 total

includes taxes & fees

Feb 28 - Mar 1

Business Suite with living area and street view | In-room safe, individually decorated, laptop workspace, blackout drapes

We Hotel Aeropuerto

Venustiano Carranza, 14.1 km from Santo Domingo

Laura

Historico Central Hotel

Historic Center, 12 km from Santo Domingo

Clarence

NT$4,245 total

includes taxes & fees

Mar 3 - Mar 4

Krystal Urban Aeropuerto Cd de Mexico

11.2 km from Santo Domingo

rosa

NT$2,840 total

includes taxes & fees

Mar 1 - Mar 2

Fiesta Inn Plaza Central Aeropuerto

9.2 km from Santo Domingo

Talmadge

NT$3,401 total

includes taxes & fees

Mar 1 - Mar 2

Hotel Escala Siglo XXI

Cuauhtémoc, 9.4 km from Santo Domingo

Jhoan Arturo

NT$898 total

includes taxes & fees

Mar 22 - Mar 23

5 restaurants, breakfast, lunch, dinner served; French cuisine

InterContinental Presidente Mexico City by IHG

Polanco, 11.4 km from Santo Domingo

Tamara

NT$11,157 total

includes taxes & fees

Mar 1 - Mar 2

Camino Real Polanco Mexico

11.1 km from Santo Domingo

Alan

NT$6,939 total

includes taxes & fees

Mar 15 - Mar 16

Holiday Inn Express Mexico Basilica by IHG

14.7 km from Santo Domingo

Mary Jane

NT$2,672 total

includes taxes & fees

Mar 22 - Mar 23

Hotel Brasilia

16.6 km from Santo Domingo

guillermo guerrero

NT$2,944 total

includes taxes & fees

Feb 26 - Feb 27

Marquis Reforma Hotel Spa

Colonia Cuauhtémoc, 10.7 km from Santo Domingo

Jennifer

NT$9,039 total

includes taxes & fees

Feb 28 - Mar 1

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Where to stay in Santo Domingo

Find the best Santo Domingo areas and neighborhoods for the activities you enjoy most.

The Cibeles fountain in Mexico City is an exact replica of the Cibeles fountain that is located in the Plaza de Cibeles in Madrid, Spain

Roma Norte

Known for its fascinating museums and popular shops, there's plenty to explore in Roma Norte. Check out top attractions like Avenida Insurgentes and MUCA Roma, and jump on the metro at Insurgentes Station or Sevilla Station to see more of the city.

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Polanco

Luxury shopping along Presidente Masaryk Avenue and upscale restaurants await, while nearby Chapultepec Park houses the National Museum of Anthropology and other cultural institutions. Enjoy a stroll in Parque Lincoln or explore Polanquito's vibrant dining scene.

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La Condesa

Fashionable and popular with young professionals, Condesa boasts international restaurants, bars, and nightclubs. Stroll along tree-lined avenues, admire Art Deco architecture, and visit landmarks like Edificio San Martín and Basurto Building.

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Palacio de Bellas Artes featuring heritage architecture, a square or plaza and theater scenes

Historic Center

Historic center with 1,550 significant buildings, the neighborhood offers museums like MUNAL and Palacio de Bellas Artes. Enjoy upscale eateries, fashionable stores, and pedestrianized streets for easy exploration.

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Reforma

Consider a visit to Angel of Independence Monument and take some time to enjoy the important monuments during your time in Reforma. If you want to see more of the city, jump on the metro at Insurgentes Station or Cuauhtemoc Station.

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Top Santo Domingo Hotel Reviews

Grand Prix-WeEnjoyHotels-Aeropuerto

10/10 Excellent

"Unexpectedly nice hotel near the Mexico City airport with a free and frequent airport shuttle. Very modern hotel with large rooms, huge TVs (70 inch), comfortable beds, great showers, electric window blinds, lots of power outlets and...cool configurable mood lighting. It was the perfect place to stay overnight near the airport to get a good shower, great sleep and a stress-free ride to the airport. A great value for the price. Will definitely stay here again."