The Best Hotels Closest to Mayo Clinic Scottsdale in Phoenix for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Mayo Clinic Scottsdale hotels

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

1. Sonesta Select Scottsdale at Mayo Clinic Campus

0.3 km from Mayo Clinic Scottsdale

louis

NT$3,895 total

includes taxes & fees

Dec 14 - Dec 15

A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.

2. Inn at Eagle Mountain

3.1 km from Mayo Clinic Scottsdale

A Candy

NT$5,838 total

includes taxes & fees

Nov 18 - Nov 19

A modern infinity pool with a view of mountains and a sunset.

3. Talking Stick Resort

8.8 km from Mayo Clinic Scottsdale

Nabeel

NT$4,915 total

includes taxes & fees

Dec 14 - Dec 15

A swimming pool with lounge chairs and a covered seating area, surrounded by palm trees and a building with multiple windows.

4. Hyatt Place Phoenix/Mesa

17.8 km from Mayo Clinic Scottsdale

Laura

NT$3,802 total

includes taxes & fees

Nov 22 - Nov 23

An outdoor dining table set with chairs, string lights, and a sunset view.

5. Home2 Suites by Hilton Mesa Longbow, AZ

14.8 km from Mayo Clinic Scottsdale

Jillian Louise

NT$5,107 total

includes taxes & fees

Nov 28 - Nov 29

A modern dining area with multiple tables and chairs, a fireplace, and a television mounted on the wall.

6. Comfort Suites Scottsdale Talking Stick Entertainment District

9.6 km from Mayo Clinic Scottsdale

LAURA

NT$3,922 total

includes taxes & fees

Nov 29 - Nov 30

A hotel room with a bed, desk, chair, television, fireplace, and a dining area.

7. Sonesta ES Suites Scottsdale Paradise Valley

14 km from Mayo Clinic Scottsdale

James

NT$3,858 total

includes taxes & fees

Nov 23 - Nov 24

A restaurant setting with round tables, chairs, and empty wine glasses.

8. Aiden by Best Western Scottsdale North

8.7 km from Mayo Clinic Scottsdale

Ryan

NT$3,225 total

includes taxes & fees

Dec 14 - Dec 15

A circular fire feature with a stone border, surrounded by a landscaped garden with cacti and shrubs, under a sunset sky.

9. Courtyard Scottsdale Salt River

12.2 km from Mayo Clinic Scottsdale

Karl

NT$4,694 total

includes taxes & fees

Nov 27 - Nov 28

A modern hotel with a brick facade, large windows, and a covered entrance area.

10. Springhill Suites Phoenix Scottsdale Marriott

18.2 km from Mayo Clinic Scottsdale

Anna

NT$4,111 total

includes taxes & fees

Nov 22 - Nov 23

A modern living room with a dining area, large windows, and decorative hanging lights.

11. Element by Marriott Scottsdale at SkySong

18.4 km from Mayo Clinic Scottsdale

Darryl

NT$3,792 total

includes taxes & fees

Nov 22 - Nov 23

A hotel room with two beds, a television, a desk with a lamp, and artwork on the wall.

12. Spark by Hilton Fountain Hills Scottsdale

7.6 km from Mayo Clinic Scottsdale

Herbert M Beatty

NT$3,054 total

includes taxes & fees

Nov 22 - Nov 23

A hotel lobby with a reception desk, seating area, and a large wall mural.

13. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale, 8.9 km from Mayo Clinic Scottsdale

Saad

NT$3,708 total

includes taxes & fees

Dec 14 - Dec 15

An outdoor seating area with sofas, tables, and umbrellas, featuring a fire feature in the center.

14. Hyatt Place Scottsdale - North

14.1 km from Mayo Clinic Scottsdale

Ted

NT$4,685 total

includes taxes & fees

Dec 14 - Dec 15

A golf course with sand bunkers, a flagstick, and mountains in the background.

15. Hampton Inn & Suites Scottsdale at Talking Stick

9.1 km from Mayo Clinic Scottsdale

Kevin Boland- Martin

NT$4,438 total

includes taxes & fees

Nov 22 - Nov 23

A modern outdoor lounge area with sofas, chairs, and a glass-top coffee table with a fire feature.

16. Hyatt House North Scottsdale

14.1 km from Mayo Clinic Scottsdale

Katherine

NT$5,707 total

includes taxes & fees

Nov 22 - Nov 23

A modern outdoor seating area with sofas and a central fire feature.

17. Delta Hotels by Marriott Phoenix Mesa

18.7 km from Mayo Clinic Scottsdale

Joshua

NT$4,018 total

includes taxes & fees

Dec 13 - Dec 14

A group of people dining at an outdoor table with a view of a pool and palm trees.

18. Mountain Shadows Resort Scottsdale

17 km from Mayo Clinic Scottsdale

karen

NT$9,060 total

includes taxes & fees

Nov 23 - Nov 24

A spacious lobby with a large seating area, a reception desk, and artwork on the walls.

19. Best Western Plus Scottsdale Thunderbird Suites

Thunderbird Industrial Airpark, 12.1 km from Mayo Clinic Scottsdale

Irene

NT$3,798 total

includes taxes & fees

Dec 14 - Dec 15

A modern breakfast area with a counter displaying various food items and a sign reading "TOP IT BREAKFAST".

20. Tru By Hilton Scottsdale Salt River

8.9 km from Mayo Clinic Scottsdale

Colleen

NT$3,959 total

includes taxes & fees

Dec 14 - Dec 15

View all properties

Compare popular hotels close to Mayo Clinic Scottsdale

Property	Property class	Guest rating
Sonesta Select Scottsdale at Mayo Clinic Campus	3.0 star property	8.4 Very good 1,087 reviews	View
Inn at Eagle Mountain	3.5 star property	9.0 Wonderful 1,041 reviews	View
Talking Stick Resort	4.0 star property	9.4 Exceptional 5,198 reviews	View
Hyatt Place Phoenix/Mesa	3.0 star property	9.2 Wonderful 2,003 reviews	View
Home2 Suites by Hilton Mesa Longbow, AZ	4.0 star property	9.6 Exceptional 932 reviews	View

Top Mayo Clinic Scottsdale Hotel Reviews

A living room with a sofa, a coffee table, and a kitchen area with a refrigerator and microwave.

Starlite Motel

Central Mesa

10/10 Excellent

Virginia

Mountain Shadows Resort Scottsdale

Paradise Valley

10/10 Excellent

Rachael

Home2 Suites by Hilton Mesa Longbow, AZ

Falcon Field Area

10/10 Excellent

Alvin

Hyatt House North Scottsdale

Scottsdale

10/10 Excellent

Alexander

Comfort Suites Scottsdale Talking Stick Entertainment District

Scottsdale

10/10 Excellent

Darla

Canopy by Hilton Scottsdale Old Town

Old Town

10/10 Excellent

Shahar

Courtyard Scottsdale Salt River

Scottsdale

10/10 Excellent

Monica

A modern lounge area with a sectional sofa, armchairs, and a coffee table.

The 233 Suites Unscripted by Hyatt

Downtown

10/10 Excellent

Jade

A modern lounge area with seating, a bar, and a fireplace.

Hotel Valley Ho

Old Town

10/10 Excellent

Andrew T

An outdoor patio area with a central fire feature, seating arrangements, and a covered walkway.

Residence Inn Scottsdale Salt River

Scottsdale

10/10 Excellent

Maria Robelle

Inn at Eagle Mountain

Eagle Mountain

10/10 Excellent

carla

A pool area with multiple swimming pools, lounge chairs, and potted plants.

Fairfield Inn & Suites by Marriott Tempe

Tempe

10/10 Excellent

I planned a weekend staycation and just wanted a quiet weekend. The price was shockingly great for the location and quality, the reviews and photos sold me and it didn't disappoint. The pool is beautiful. The restaurant in the hotel is pretty good as well, we ordered the Cowboy Burger and the Surf n Turf Burger and both were very good. The hotel was clean, the location is convenient being by Tempe Marketplace so there's plenty to eat and do, and it was overall a great option. I'd absolutely stay...

Krimsun

Hyatt Place Scottsdale - North

Scottsdale

10/10 Excellent

Yoana

A hotel pool area with sun loungers, a children's play area, and a building with a sign.

Home2 Suites by Hilton Scottsdale Salt River

Scottsdale

10/10 Excellent

Tracy

A swimming pool with people on inflatable floats, lounge chairs, and umbrellas in the background.

Wekopa Casino Resort

Fort McDowell

10/10 Excellent

Helen

A resort with multiple buildings, a large pool area, and surrounding mountains.

ADERO Scottsdale Resort, Autograph Collection

Scottsdale

10/10 Excellent

LaKoya

Frequently Asked Questions

What's the area like around Mayo Clinic Scottsdale?

Mayo Clinic Scottsdale is located in a welcoming area of Scottsdale known for its array of dining options and sporting events. If you're looking for a convenient place to stay, check out the 22 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Mayo Clinic Scottsdale?

Adjacent to Mayo Clinic Scottsdale, Sonesta Select Scottsdale at Mayo Clinic Campus is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices within 5 miles include ADERO Scottsdale Resort, Autograph Collection and Inn at Eagle Mountain.

How many hotels will I be able to find close to Mayo Clinic Scottsdale?

Expedia has 22 hotels and other accommodations within a mile from Mayo Clinic Scottsdale.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Scottsdale, will I receive a refund?

Yes! The majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to view top deals close to Mayo Clinic Scottsdale.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Scottsdale?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Scottsdale, go to https://www.expedia.com/service/.

What can I see and do near Mayo Clinic Scottsdale?

You might spend a leisurely day outdoors at Scottsdale Ranch Park and Fountain Hills Botanical Garden. Explore nature at Desert Sonoran Botanical Garden Trailhead and Golden Eagle Trailhead. Eagle Mountain Golf Course, Golf Club at Eagle Mountain, or SunRidge Canyon Golf Club are some local sights worth checking out.

Find hotels near Mayo Clinic Scottsdale, Phoenix from NT$2,829

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Mayo Clinic Scottsdale hotels

1. Sonesta Select Scottsdale at Mayo Clinic Campus

2. Inn at Eagle Mountain

3. Talking Stick Resort

4. Hyatt Place Phoenix/Mesa

5. Home2 Suites by Hilton Mesa Longbow, AZ

6. Comfort Suites Scottsdale Talking Stick Entertainment District

7. Sonesta ES Suites Scottsdale Paradise Valley

8. Aiden by Best Western Scottsdale North

9. Courtyard Scottsdale Salt River

10. Springhill Suites Phoenix Scottsdale Marriott

11. Element by Marriott Scottsdale at SkySong

12. Spark by Hilton Fountain Hills Scottsdale

13. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

14. Hyatt Place Scottsdale - North

15. Hampton Inn & Suites Scottsdale at Talking Stick

16. Hyatt House North Scottsdale

17. Delta Hotels by Marriott Phoenix Mesa

18. Mountain Shadows Resort Scottsdale

19. Best Western Plus Scottsdale Thunderbird Suites

20. Tru By Hilton Scottsdale Salt River

Compare popular hotels close to Mayo Clinic Scottsdale

Top Mayo Clinic Scottsdale Hotel Reviews

Starlite Motel

10/10 Excellent

Frequently Asked Questions

What's the area like around Mayo Clinic Scottsdale?

What's the best place to stay near Mayo Clinic Scottsdale?

How many hotels will I be able to find close to Mayo Clinic Scottsdale?

If I need to cancel the hotel reservation for my stay near Mayo Clinic Scottsdale, will I receive a refund?

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Scottsdale?

What can I see and do near Mayo Clinic Scottsdale?

Explore a world of travel with Expedia