The Best Hotels Closest to Mayo Clinic Scottsdale in Phoenix for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Mayo Clinic Scottsdale hotels

A cluster of modern, multi-story buildings with a river in the foreground.

A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.

A dining area with a glass table, wooden chairs, and potted plants.

An outdoor patio with a stone wall, wooden pergola, and a cactus.

1. Inn at Eagle Mountain

3.1 km from Mayo Clinic Scottsdale

Stephanie

NT$4,285

NT$4,892 total

includes taxes & fees

Oct 25 - Oct 26

An outdoor dining table set with chairs, string lights, and a sunset view.

A modern kitchen area with a dining table and chairs, a stone accent wall, and various kitchen appliances and storage cabinets.

A multi-story hotel with a prominent entrance, large windows, and a well-lit facade.

A modern living room with a sectional sofa, orange ottomans, a dining area, and a kitchen with a stone accent wall.

2. Home2 Suites by Hilton Mesa Longbow, AZ

14.8 km from Mayo Clinic Scottsdale

Damon

NT$5,012

NT$5,728 total

includes taxes & fees

Nov 1 - Nov 2

A swimming pool with lounge chairs and a covered seating area, surrounded by palm trees and a building with multiple windows.

A hotel room with two beds, a TV, a desk, a chair, and a view of palm trees.

A modern hotel with a covered entrance, multiple floors, and a parking lot.

A modern lobby with a brick wall, seating area, and a flat-screen TV.

3. Hyatt Place Phoenix/Mesa

17.8 km from Mayo Clinic Scottsdale

greg

NT$4,374

NT$4,998 total

includes taxes & fees

Oct 25 - Oct 26

A hotel lobby with a reception desk, seating area, and a large wall mural.

A hotel lobby with multiple seating areas, a reception desk, and a kitchen in the background.

A hotel room with a sofa, a TV, a desk, and a chair. There are framed pictures on the wall.

A hotel room with a sofa, a desk, a chair, a bed, and a door leading to another room.

4. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale, 8.9 km from Mayo Clinic Scottsdale

Wilson

NT$2,727

NT$3,108 total

includes taxes & fees

Oct 25 - Oct 26

A wooden door with a glass panel, a doormat, and a small window above it.

A modern kitchen with white cabinets, a built-in oven, and a large window.

A bedroom with a desk, a bed, a ceiling fan, and a window with blinds.

5. Close to Hiking! Family-friendly Mesa Retreat

13.6 km from Mayo Clinic Scottsdale

NT$5,832

NT$25,370 total

includes taxes & fees

Oct 29 - Oct 30

A spacious lobby with a high ceiling, multiple seating areas, a reception desk, and a television screen.

A spacious hotel lobby with a reception desk, seating areas, and a view of the dining and kitchen areas.

A bar area with multiple seating options, a bar counter, and a television screen displaying sports.

A multi-story hotel with a flat roof and balconies, surrounded by well-maintained grass and trees.

6. Embassy Suites by Hilton Phoenix Scottsdale

17.8 km from Mayo Clinic Scottsdale

Matthew

NT$5,049

NT$5,709 total

includes taxes & fees

Nov 1 - Nov 2

A modern infinity pool with a view of mountains and a sunset.

An outdoor seating area with fire pits and lounge chairs, surrounded by trees and a building with illuminated windows in the background.

A poolside lounge with a view of a hotel building, a TV, and a bar area with a bottle of champagne.

A restaurant with high tables and booths, floral wall decorations, and a view of the mountains.

7. Talking Stick Resort

8.8 km from Mayo Clinic Scottsdale

Jessica

NT$6,881

NT$8,770 total

includes taxes & fees

Nov 15 - Nov 16

An outdoor lounge area with white sofas, a fire pit, and a pool in the background.

A spacious hotel lobby with modern furniture, large windows, and a flat-screen TV.

A modern outdoor lounge area with white furniture, a pool, and large umbrellas.

A modern kitchen with a bar area, bar stools, and a dining table with chairs.

8. AC Hotel by Marriott Scottsdale North

Paradise Valley Village, 13.4 km from Mayo Clinic Scottsdale

Kristen

NT$4,893

NT$5,532 total

includes taxes & fees

Oct 31 - Nov 1

A circular fire feature with a stone border, surrounded by a landscaped garden with cacti and shrubs, under a sunset sky.

A modern lobby with a central water feature, seating area, and a stone pillar.

A modern bar area with seating, a digital menu display, and a beverage refrigerator.

A pool area with lounge chairs and umbrellas, surrounded by buildings with balconies and outdoor seating.

9. Courtyard Scottsdale Salt River

12.2 km from Mayo Clinic Scottsdale

Karl

NT$5,023

NT$5,725 total

includes taxes & fees

Oct 25 - Oct 26

A modern hotel with a brick facade, large windows, and a covered entrance area.

A modern lobby with a sectional sofa, a round coffee table, and a mural on the wall.

An outdoor patio area with round tables and chairs, a fire pit, and a large umbrella.

A hotel room with a desk, two beds, a TV, and a large window.

10. Springhill Suites Phoenix Scottsdale Marriott

18.2 km from Mayo Clinic Scottsdale

Lucinda

NT$4,442

NT$5,062 total

includes taxes & fees

Oct 25 - Oct 26

An outdoor patio area with stone pillars, a fire pit, and seating arrangements.

A golf course with a mountain backdrop, surrounded by desert vegetation.

A lounge area with a grand piano, blue seating, and a stone wall.

A historic building with arched entrances and a bell tower, surrounded by cacti and desert landscaping.

11. Wekopa Casino Resort

10.3 km from Mayo Clinic Scottsdale

jennifer

NT$2,738

NT$4,091 total

includes taxes & fees

Nov 17 - Nov 18

A spacious lobby with a large seating area, a reception desk, and artwork on the walls.

A buffet counter with various food items, a refrigerator, and a wall-mounted clock.

A spacious lobby with leather armchairs, a patterned rug, and a large metal coffee table.

12. Best Western Plus Scottsdale Thunderbird Suites

Thunderbird Industrial Airpark, 12.1 km from Mayo Clinic Scottsdale

Susan

NT$3,513

NT$4,004 total

includes taxes & fees

Oct 22 - Oct 23

A hotel room with two beds, a desk with a chair, a TV, and a lamp.

A reception area with a stone wall, a wooden reception desk, and a modern elevator.

A modern hotel lobby with a central bar area, seating arrangements, and a clean, contemporary design.

13. Comfort Suites Scottsdale Talking Stick Entertainment District

9.6 km from Mayo Clinic Scottsdale

LAURA

NT$3,528

NT$4,023 total

includes taxes & fees

Nov 1 - Nov 2

A modern breakfast area with a counter displaying various food items and a sign reading "TOP IT BREAKFAST".

An outdoor patio with round tables and white wicker chairs, red umbrellas, and a brick building in the background.

A hotel pool area with multiple lounge chairs, a small pool, and a building with a sign.

A modern hotel lobby with a curved reception desk, seating area with sofas and chairs, and a large wall with a 'HOME2' sign.

14. Tru By Hilton Scottsdale Salt River

8.9 km from Mayo Clinic Scottsdale

Colleen

NT$3,966

NT$4,522 total

includes taxes & fees

Nov 8 - Nov 9

A hotel room with a bed, desk, chair, television, fireplace, and a dining area.

A breakfast buffet with various food items and a coffee machine.

A reception area with a counter, two armchairs, and a round table.

An outdoor patio with a grill, table, and chairs.

15. Sonesta ES Suites Scottsdale Paradise Valley

14 km from Mayo Clinic Scottsdale

Denine

NT$3,856

NT$4,395 total

includes taxes & fees

Oct 25 - Oct 26

A spacious lobby with stone walls, comfortable seating, and a large window offering a mountain view.

A spacious restaurant with wooden flooring, high tables, and chairs, featuring a bar area and large windows overlooking a scenic view.

A spacious lobby with a central table set for a small gathering, flanked by seating and a modern ceiling design.

A spacious outdoor lounge area with a fire feature, comfortable seating, a bar with a view, and a stone wall.

16. Hilton North Scottsdale At Cavasson

13.4 km from Mayo Clinic Scottsdale

Marcos

NT$8,347

NT$9,513 total

includes taxes & fees

Oct 31 - Nov 1

A resort with multiple buildings, a large pool area, and surrounding mountains.

An outdoor wedding reception with round tables set with white chairs, floral centerpieces, and a view of the city in the background.

A dining area with a table and chairs, a view of a cityscape, and decorative wall panels.

A dining area with a table set for six, overlooking a scenic landscape.

17. ADERO Scottsdale Resort, Autograph Collection

3.6 km from Mayo Clinic Scottsdale

Garrett

NT$5,921

NT$8,055 total

includes taxes & fees

Oct 18 - Oct 19

An outdoor dining area with wicker furniture and candles, overlooking a well-maintained garden and buildings.

A kitchen with a large island, granite countertops, and a mural of a desert landscape.

A hotel with a modern design, featuring a prominent entrance, a landscaped garden with a fountain, and palm trees.

A spacious lobby with a fireplace, seating area, and a dining setup.

18. Sonesta Suites Scottsdale Gainey Ranch

12.3 km from Mayo Clinic Scottsdale

Eric

NT$4,828

NT$6,611 total

includes taxes & fees

Oct 25 - Oct 26

A courtyard with outdoor seating and a fire pit, surrounded by a building with multiple windows and doors.

A modern hotel lobby with a reception desk, marble counter, and a seating area with tables and chairs.

A bar area with a bar counter, multiple chairs, and a sofa.

A swimming pool with a tiled edge, lounge chairs, and a fitness area with treadmills and exercise equipment.

19. Aiden by Best Western Scottsdale North

8.7 km from Mayo Clinic Scottsdale

PATRICK

NT$3,315

NT$3,779 total

includes taxes & fees

Oct 26 - Oct 27

A hotel dining area with a table and chairs, patterned curtains, and a view through large windows.

A hotel room with a large window, a desk, a bed, a TV, and a chair.

A building entrance with a stone facade, large glass doors, and potted plants.

A hotel lobby with a bar area, seating, and a reception desk.

20. Hampton Inn & Suites Scottsdale at Talking Stick

9.1 km from Mayo Clinic Scottsdale

Mark

NT$3,773

NT$4,302 total

includes taxes & fees

Nov 1 - Nov 2

View all properties

Top Mayo Clinic Scottsdale Hotel Reviews

Holiday Inn & Suites Scottsdale North - Airpark by IHG

10/10 Excellent

"Super happy with the attentive staff there!! The restaurant has delicious food and breakfast as well! Servers where always so nice and made dinner enjoyable! One of the best hotels I’ve stayed at! Definitely will be coming back!!"

Comfort Suites Scottsdale Talking Stick Entertainment District

10/10 Excellent

"Property was really relaxing, close to restaurants and shopping centers. Pop stroke being in the parking lot was fun. We'll definitely be going back!"

Sonesta Select Scottsdale at Mayo Clinic Campus

8/10 Good

"Comfortable and clean property"

Sonesta Simply Suites Phoenix Scottsdale

10/10 Excellent

"W"

Talking Stick Resort

10/10 Excellent

"Amazing place, well maintained and clean. Only issue is that it's a drive to Old Town Scottsdale and and centers. But their Bellhop team and SUV's are available to run you anywhere in a 5 mile radius and are all amazingly friendly. And I believe the gym needs to be bigger with more equipment."

Inn at Eagle Mountain

8/10 Good

"Clean room"

Aiden by Best Western Scottsdale North

10/10 Excellent

"We were so pleased with our stay at this property. The property, amenities, and room exceeded our expectations. We would not hesitate to stay at this property again in the future."

Tru By Hilton Scottsdale Salt River

10/10 Excellent

"Very clean rooms and the staff very polite and friendly,"

Fountain Park Hotel, BW Signature Collection

8/10 Good

"Hotel was conveniently located to the shops at Fountain Hills. Busy street. Room had a slightly musty smell but was clean. Breakfast was offered (coffee, pastries), but was not extensive. Overall, excellent value for the price paid."

Frequently asked questions

What's the area like around Mayo Clinic Scottsdale?

Mayo Clinic Scottsdale is located in a welcoming area of Scottsdale known for its array of dining options and sporting events. If you're looking for a convenient place to stay, check out the 22 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Mayo Clinic Scottsdale?

Adjacent to Mayo Clinic Scottsdale, Sonesta Select Scottsdale at Mayo Clinic Campus is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices within 5 miles include ADERO Scottsdale Resort, Autograph Collection and Inn at Eagle Mountain.

How many hotels will I be able to find close to Mayo Clinic Scottsdale?

Expedia has 22 hotels and other accommodations within a mile from Mayo Clinic Scottsdale.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Scottsdale, will I receive a refund?

Yes! The majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to view top deals close to Mayo Clinic Scottsdale.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Scottsdale?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Scottsdale, go to https://www.expedia.com/service/.

What can I see and do near Mayo Clinic Scottsdale?

You might spend a leisurely day outdoors at Scottsdale Ranch Park and Fountain Hills Botanical Garden. Explore nature at Desert Sonoran Botanical Garden Trailhead and Golden Eagle Trailhead. Eagle Mountain Golf Course, Golf Club at Eagle Mountain, or SunRidge Canyon Golf Club are some local sights worth checking out.

Find hotels near Mayo Clinic Scottsdale, Phoenix from NT$3,108

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mayo Clinic Scottsdale hotels

1. Inn at Eagle Mountain

2. Home2 Suites by Hilton Mesa Longbow, AZ

3. Hyatt Place Phoenix/Mesa

4. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

5. Close to Hiking! Family-friendly Mesa Retreat

6. Embassy Suites by Hilton Phoenix Scottsdale

7. Talking Stick Resort

8. AC Hotel by Marriott Scottsdale North

9. Courtyard Scottsdale Salt River

10. Springhill Suites Phoenix Scottsdale Marriott

11. Wekopa Casino Resort

12. Best Western Plus Scottsdale Thunderbird Suites

13. Comfort Suites Scottsdale Talking Stick Entertainment District

14. Tru By Hilton Scottsdale Salt River

15. Sonesta ES Suites Scottsdale Paradise Valley

16. Hilton North Scottsdale At Cavasson

17. ADERO Scottsdale Resort, Autograph Collection

18. Sonesta Suites Scottsdale Gainey Ranch

19. Aiden by Best Western Scottsdale North

20. Hampton Inn & Suites Scottsdale at Talking Stick

Top Mayo Clinic Scottsdale Hotel Reviews

Holiday Inn & Suites Scottsdale North - Airpark by IHG

Comfort Suites Scottsdale Talking Stick Entertainment District

Sonesta Select Scottsdale at Mayo Clinic Campus

Sonesta Simply Suites Phoenix Scottsdale

Talking Stick Resort

Inn at Eagle Mountain

Aiden by Best Western Scottsdale North

Tru By Hilton Scottsdale Salt River

Fountain Park Hotel, BW Signature Collection

Frequently asked questions

Explore a world of travel with Expedia