The Best Hotels Closest to Mayo Clinic Scottsdale in Phoenix for 2026

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Our top choices for Mayo Clinic Scottsdale hotels

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

A modern living room with a fireplace, a large flat-screen TV, and comfortable seating.

A breakfast buffet area with various pastries and a sign indicating the price of a cheese danish.

1. Sonesta Select Scottsdale at Mayo Clinic Campus

0.3 km from Mayo Clinic Scottsdale

Chad

NT$2,141

NT$2,440 total

includes taxes & fees

Aug 22 - Aug 23

A cluster of modern, multi-story buildings with a river in the foreground.

A golf course with a pond, a clubhouse, and a hilly backdrop.

A dining area with a glass table, wooden chairs, and potted plants.

An outdoor patio with a stone wall, wooden pergola, and a cactus.

2. Inn at Eagle Mountain

3.1 km from Mayo Clinic Scottsdale

Lucia

NT$2,826

NT$3,226 total

includes taxes & fees

Aug 25 - Aug 26

An outdoor seating area with sofas, tables, and umbrellas, featuring a fire feature in the center.

A hotel room with two beds, a desk, a sofa, and a TV.

A spacious living area with a sofa, armchairs, and a coffee table. There is a TV mounted on the wall and a balcony with outdoor seating.

A multi-story hotel with a parking lot and a road leading to a roundabout.

3. Hyatt Place North Scottsdale

14.1 km from Mayo Clinic Scottsdale

Derrick

NT$2,198

NT$2,506 total

includes taxes & fees

Sep 7 - Sep 8

A spacious dining area with multiple tables and chairs, large windows, and a television mounted on the wall.

A reception area with a stone wall, a wooden reception desk, and a modern elevator.

A hotel room with two beds, a desk with a chair, a TV, and a lamp.

A modern hotel lobby with a fireplace, seating area, kitchen, and a large TV.

4. Comfort Suites Scottsdale Talking Stick Entertainment District

9.6 km from Mayo Clinic Scottsdale

Cecilia

NT$2,358

NT$2,689 total

includes taxes & fees

Aug 30 - Aug 31

A hotel room with two beds, a TV, a desk, and a window with a view.

A pool area with a clear blue pool, lounge chairs, and a multi-story building with balconies.

A hotel room with two beds, a desk, a TV, and a balcony with a view.

A modern hotel room with a large window, a desk with a lamp, a microwave, and a chair.

5. Spark by Hilton Fountain Hills Scottsdale

7.6 km from Mayo Clinic Scottsdale

Jim

NT$1,939

NT$2,214 total

includes taxes & fees

Aug 26 - Aug 27

A spacious living area with a kitchen, modern furniture, and a fireplace.

A hotel room with a large bed, a dresser with drawers, a wardrobe, and a wall-mounted TV displaying a pool view.

A spacious lobby with a high ceiling, modern chandeliers, a fire feature, and a large TV screen.

A modern lobby with a pool view, orange seating, and a wooden accent wall.

6. Fountain Park Hotel, BW Signature Collection

7.3 km from Mayo Clinic Scottsdale

David

NT$2,684

NT$3,064 total

includes taxes & fees

Aug 23 - Aug 24

A modern breakfast area with a counter displaying various food items and a sign reading "TOP IT BREAKFAST".

A modern hotel lobby with a curved reception desk, seating area with sofas and chairs, and a large wall with a 'HOME2' sign.

An outdoor patio with round tables and white wicker chairs, red umbrellas, and a brick building in the background.

A hotel room with two beds, a desk, a chair, a window with a view, and a storage sign.

7. Tru By Hilton Scottsdale Salt River

8.9 km from Mayo Clinic Scottsdale

Andrea

NT$2,463

NT$2,808 total

includes taxes & fees

Sep 6 - Sep 7

A circular fire feature with a stone border, surrounded by a landscaped garden with cacti and shrubs, under a sunset sky.

A Courtyard by Marriott hotel with a modern design, featuring a covered entrance and stone pillars.

A pool area with lounge chairs and umbrellas, surrounded by buildings with balconies and outdoor seating.

A modern bar area with seating, a digital menu display, and a beverage refrigerator.

8. Courtyard Scottsdale Salt River

12.2 km from Mayo Clinic Scottsdale

Karl

NT$2,588

NT$2,950 total

includes taxes & fees

Aug 27 - Aug 28

An outdoor patio area with stone pillars, a fire pit, and seating arrangements.

A lounge area with a grand piano, blue seating, and a stone wall.

A historic building with arched entrances and a bell tower, surrounded by cacti and desert landscaping.

A dining area with a large table set for six, surrounded by chairs, with a view of cacti and a stone wall outside.

9. Wekopa Casino Resort

10.3 km from Mayo Clinic Scottsdale

Kim

NT$3,507

NT$5,881 total

includes taxes & fees

Aug 24 - Aug 25

An outdoor dining table set with chairs, string lights, and a sunset view.

A modern lobby with a seating area, a kitchen, and a reception desk.

A modern kitchen area with a dining table and chairs, a stone accent wall, and various kitchen appliances and storage cabinets.

A multi-story hotel with a prominent entrance, large windows, and a well-lit facade.

10. Home2 Suites by Hilton Mesa Longbow, AZ

14.8 km from Mayo Clinic Scottsdale

Marie

NT$3,048

NT$3,482 total

includes taxes & fees

Aug 29 - Aug 30

A modern outdoor lounge area with sofas, chairs, and a glass-top coffee table with a fire feature.

A bar area with a long counter, multiple stools, and overhead pendant lighting.

A spacious living area with a sofa, chairs, a coffee table, and a TV mounted on the wall.

A multi-story hotel with a central courtyard, parking, and a mountainous backdrop.

11. Hyatt House North Scottsdale

14.1 km from Mayo Clinic Scottsdale

Christopher

NT$2,684

NT$3,059 total

includes taxes & fees

Aug 23 - Aug 24

A well-maintained courtyard with a gazebo, palm trees, and a pathway leading to a building with a grey facade.

A hotel room with two beds, a desk, a lamp, and a window with curtains.

A hotel lobby with a reception desk, seating area, and a large wall mural.

A hotel room with a sofa, a TV, a desk, and a chair. There are framed pictures on the wall.

12. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale, 8.9 km from Mayo Clinic Scottsdale

Caroline

NT$2,128

NT$2,425 total

includes taxes & fees

Sep 1 - Sep 2

A modern infinity pool with a view of mountains and a sunset.

An outdoor seating area with fire pits and lounge chairs, surrounded by trees and a building with illuminated windows in the background.

A modern bar area with a unique ceiling design, a bar counter with multiple screens, and a patterned carpet.

A poolside lounge with a view of a hotel building, a TV, and a bar area with a bottle of champagne.

13. Talking Stick Resort

8.8 km from Mayo Clinic Scottsdale

Daryl

NT$3,809

NT$5,254 total

includes taxes & fees

Sep 7 - Sep 8

A courtyard with outdoor seating and a fire pit, surrounded by a building with multiple windows and doors.

A swimming pool with a tiled edge, lounge chairs, and a fitness area with treadmills and exercise equipment.

A bar area with a bar counter, multiple chairs, and a sofa.

A modern hotel lobby with a bar area, seating, a coffee machine, and a TV.

14. Aiden by Best Western Scottsdale North

8.7 km from Mayo Clinic Scottsdale

Todd

NT$2,234

NT$2,546 total

includes taxes & fees

Aug 21 - Aug 22

A pool area with a covered seating area, a staircase, and a building with large windows.

A Holiday Inn & Suites building with a curved facade, multiple balconies, and a well-lit entrance.

A modern bar area with a long counter, multiple seating options, and a television screen displaying a news program.

A breakfast bar with a variety of baked goods and a sign indicating fresh baked items.

15. Holiday Inn Hotel & Suites Scottsdale North - Airpark by IHG

9.7 km from Mayo Clinic Scottsdale

Christiaan Leonard

NT$2,556

NT$2,913 total

includes taxes & fees

Aug 30 - Aug 31

A resort with multiple buildings, a large pool area, and surrounding mountains.

A dining area with a table set for six, overlooking a scenic landscape.

Three people in a swimming pool with rocks and a red umbrella in the background.

An outdoor wedding reception with round tables set with white chairs, floral centerpieces, and a view of the city in the background.

16. ADERO Scottsdale Resort, Autograph Collection

3.6 km from Mayo Clinic Scottsdale

Kristen

NT$3,547

NT$5,326 total

includes taxes & fees

Aug 27 - Aug 28

An outdoor patio area with a central fire feature, seating arrangements, and a covered walkway.

A modern lounge area with dark blue upholstered chairs, round tables, and a leather sofa.

A multi-story residential building with balconies, a landscaped courtyard with seating, and a fire pit.

A swimming pool with lounge chairs and umbrellas, surrounded by buildings with balconies and outdoor seating areas.

17. Residence Inn Scottsdale Salt River

12 km from Mayo Clinic Scottsdale

Michael

NT$3,547

NT$4,044 total

includes taxes & fees

Aug 27 - Aug 28

A hotel room with a bed, desk, television, fireplace, and seating area.

A breakfast buffet with various food items and a coffee machine.

A reception area with a counter, two armchairs, and a round table.

An outdoor patio with a grill, table, and chairs.

18. Sonesta ES Suites Scottsdale Paradise Valley

14 km from Mayo Clinic Scottsdale

Jonathan

NT$2,269

NT$2,586 total

includes taxes & fees

Sep 7 - Sep 8

A hotel dining area with a table and chairs, patterned curtains, and a view through large windows.

A hotel lobby with a bar area, seating, and a reception desk.

A golf course with sand bunkers, a flagstick, and mountains in the background.

A building entrance with a stone facade, large glass doors, and potted plants.

19. Hampton Inn & Suites Scottsdale at Talking Stick

9.1 km from Mayo Clinic Scottsdale

Jesse

NT$2,568

NT$2,928 total

includes taxes & fees

Aug 28 - Aug 29

An outdoor seating area with fire pit, red Adirondack chairs, and a covered patio with string lights.

A modern hotel room with a dining area, a bed, a desk, and a view of the city.

A modern lounge area with vibrant seating, a central table, and a kitchen area in the background.

A modern hotel lobby with a variety of seating options, including tables and chairs, a sofa area, and a reception desk.

20. Home2 Suites by Hilton Scottsdale North

15 km from Mayo Clinic Scottsdale

Domnika

NT$2,594

NT$2,956 total

includes taxes & fees

Aug 28 - Aug 29

View all properties

Compare popular hotels close to Mayo Clinic Scottsdale

Property	Property class	Guest rating
Sonesta Select Scottsdale at Mayo Clinic Campus	8.4 Very Good 1,110 reviews	View
Inn at Eagle Mountain	9.0 Wonderful 1,003 reviews	View
Hyatt Place North Scottsdale	9.2 Wonderful 1,216 reviews	View
Comfort Suites Scottsdale Talking Stick Entertainment District	9.2 Wonderful 1,984 reviews	View
Spark by Hilton Fountain Hills Scottsdale	8.8 Excellent 304 reviews	View

Top Mayo Clinic Scottsdale Hotel Reviews

Comfort Suites Scottsdale Talking Stick Entertainment District

8/10 Good

"Not a bad hotel for short stay. In a great area with tons of restaurants and stores and a mini golf basically on the property. Rooms are huge. Only issue is you can hear every conversation in the room beside or above you. Not a fan of that. Breakfast is decent. Need more colour in the hotel! Great for one night stay."

Great Wolf Lodge Arizona

10/10 Excellent

"Un excelente servicio"

Fountain Park Hotel, BW Signature Collection

8/10 Good

"Easy in and out, decent gym and a cute coffee shop across the street. Quiet and a good experience."

Inn at Eagle Mountain

8/10 Good

"Need a better system for food....no convenient restaurants except the italian one in house...pricey. should have breakfast available."

Aiden by Best Western Scottsdale North

10/10 Excellent

"Well maintained property. I forgot my ball cap in the lobby and the front desk personnel Daniel saved it until I got back at the end of the day. The room is very clean. Also walking distance to restaurants."

Staybridge Suites Scottsdale - Talking Stick by IHG

10/10 Excellent

"First the welcoming as soon as we checked in was above and beyond. The young man who checked us in was so respectful,kind , and courteous to my fiancé and I. Like every time we have stayed at Staybridge the property, inside and out is very clean. The dining area, food, coffee, drinks, was very good. Rooms are very clean, beds are very comfortable."

Frequently asked questions

What's the area like around Mayo Clinic Scottsdale?

Mayo Clinic Scottsdale is located in a welcoming area of Scottsdale known for its array of dining options and sporting events. If you're looking for a convenient place to stay, check out the 23 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Mayo Clinic Scottsdale?

Adjacent to Mayo Clinic Scottsdale, Sonesta Select Scottsdale at Mayo Clinic Campus is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices within 5 miles include ADERO Scottsdale Resort, Autograph Collection and Inn at Eagle Mountain.

How many hotels will I be able to find close to Mayo Clinic Scottsdale?

Expedia has 23 hotels and other accommodations within a mile from Mayo Clinic Scottsdale.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Scottsdale, will I receive a refund?

Yes! The majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to view top deals close to Mayo Clinic Scottsdale.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Scottsdale?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Scottsdale, go to https://www.expedia.com/service/.

What can I see and do near Mayo Clinic Scottsdale?

You might spend a leisurely day outdoors at Scottsdale Ranch Park and Fountain Hills Botanical Garden. Explore nature at Desert Sonoran Botanical Garden Trailhead and Golden Eagle Trailhead. Eagle Mountain Golf Course, McDowell Mountain Golf Club, or Golf Club at Eagle Mountain are some local sights worth checking out.

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Our top choices for Mayo Clinic Scottsdale hotels

1. Sonesta Select Scottsdale at Mayo Clinic Campus

2. Inn at Eagle Mountain

3. Hyatt Place North Scottsdale

4. Comfort Suites Scottsdale Talking Stick Entertainment District

5. Spark by Hilton Fountain Hills Scottsdale

6. Fountain Park Hotel, BW Signature Collection

7. Tru By Hilton Scottsdale Salt River

8. Courtyard Scottsdale Salt River

9. Wekopa Casino Resort

10. Home2 Suites by Hilton Mesa Longbow, AZ

11. Hyatt House North Scottsdale

12. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

13. Talking Stick Resort

14. Aiden by Best Western Scottsdale North

15. Holiday Inn Hotel & Suites Scottsdale North - Airpark by IHG

16. ADERO Scottsdale Resort, Autograph Collection

17. Residence Inn Scottsdale Salt River

18. Sonesta ES Suites Scottsdale Paradise Valley

19. Hampton Inn & Suites Scottsdale at Talking Stick

20. Home2 Suites by Hilton Scottsdale North

Compare popular hotels close to Mayo Clinic Scottsdale

Top Mayo Clinic Scottsdale Hotel Reviews

Comfort Suites Scottsdale Talking Stick Entertainment District

Great Wolf Lodge Arizona

Fountain Park Hotel, BW Signature Collection

Inn at Eagle Mountain

Aiden by Best Western Scottsdale North

Staybridge Suites Scottsdale - Talking Stick by IHG

Frequently asked questions

Explore a world of travel with Expedia

Find hotels near Mayo Clinic Scottsdale, Phoenix from NT$2,214

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mayo Clinic Scottsdale hotels

1. Sonesta Select Scottsdale at Mayo Clinic Campus

2. Inn at Eagle Mountain

3. Hyatt Place North Scottsdale

4. Comfort Suites Scottsdale Talking Stick Entertainment District

5. Spark by Hilton Fountain Hills Scottsdale

6. Fountain Park Hotel, BW Signature Collection

7. Tru By Hilton Scottsdale Salt River

8. Courtyard Scottsdale Salt River

9. Wekopa Casino Resort

10. Home2 Suites by Hilton Mesa Longbow, AZ

11. Hyatt House North Scottsdale

12. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

13. Talking Stick Resort

14. Aiden by Best Western Scottsdale North

15. Holiday Inn Hotel & Suites Scottsdale North - Airpark by IHG

16. ADERO Scottsdale Resort, Autograph Collection

17. Residence Inn Scottsdale Salt River

18. Sonesta ES Suites Scottsdale Paradise Valley

19. Hampton Inn & Suites Scottsdale at Talking Stick

20. Home2 Suites by Hilton Scottsdale North

Compare popular hotels close to Mayo Clinic Scottsdale

Top Mayo Clinic Scottsdale Hotel Reviews

Comfort Suites Scottsdale Talking Stick Entertainment District

Great Wolf Lodge Arizona

Fountain Park Hotel, BW Signature Collection

Inn at Eagle Mountain

Aiden by Best Western Scottsdale North

Staybridge Suites Scottsdale - Talking Stick by IHG

Frequently asked questions

Explore a world of travel with Expedia