The Best Hotels Closest to Mayo Clinic Scottsdale in Phoenix for 2026

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Our top choices for Mayo Clinic Scottsdale hotels

A cluster of modern, multi-story buildings with a river in the foreground.

A dining area with a glass table, wooden chairs, and potted plants.

A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.

An outdoor patio with a stone wall, wooden pergola, and a cactus.

1. Inn at Eagle Mountain

3.1 km from Mayo Clinic Scottsdale

Shelby

NT$4,202

NT$4,797 total

includes taxes & fees

Oct 25 - Oct 26

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

A breakfast buffet area with various pastries and a sign indicating the price of a cheese danish.

A hotel courtyard with a paved walkway, palm trees, and a building with multiple balconies and a glass facade.

2. Sonesta Select Scottsdale at Mayo Clinic Campus

0.3 km from Mayo Clinic Scottsdale

Michael

NT$3,400

NT$3,875 total

includes taxes & fees

Oct 11 - Oct 12

A hotel lobby with a reception desk, seating area, and a large wall mural.

A hotel lobby with multiple seating areas, a reception desk, and a kitchen in the background.

A hotel room with a sofa, a desk, a chair, a bed, and a door leading to another room.

A hotel room with two beds, a desk, a lamp, and a window with curtains.

3. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale, 8.9 km from Mayo Clinic Scottsdale

Paul

NT$2,674

NT$3,047 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with two beds, a desk with a chair, a TV, and a lamp.

A modern hotel lobby with a fireplace, seating area, kitchen, and a large TV.

A modern hotel lobby with a central bar area, seating arrangements, and a clean, contemporary design.

4. Comfort Suites Scottsdale Talking Stick Entertainment District

9.6 km from Mayo Clinic Scottsdale

William

NT$3,460

NT$3,945 total

includes taxes & fees

Oct 25 - Oct 26

A modern outdoor lounge area with sofas, chairs, and a glass-top coffee table with a fire feature.

A multi-story hotel with a central courtyard, parking, and a mountainous backdrop.

A spacious living area with a sofa, chairs, a coffee table, and a TV mounted on the wall.

A bar area with a long counter, multiple stools, and overhead pendant lighting.

5. Hyatt House North Scottsdale

14.1 km from Mayo Clinic Scottsdale

Slyqavious

NT$4,289

NT$4,889 total

includes taxes & fees

Oct 25 - Oct 26

A spacious living area with a kitchen, modern furniture, and a fireplace.

A hotel room with a large bed, a dresser with drawers, a wardrobe, and a wall-mounted TV displaying a pool view.

A modern lobby with a pool view, orange seating, and a wooden accent wall.

A modern kitchen with blue cabinets, a stainless steel refrigerator, and a white countertop.

6. Fountain Park Hotel, BW Signature Collection

7.3 km from Mayo Clinic Scottsdale

Guadalupe

NT$3,119

NT$3,561 total

includes taxes & fees

Oct 8 - Oct 9

A hotel room with two beds, a TV, a desk, and a window with a view.

A hotel room with two beds, a desk, a TV, and a balcony with a view.

A pool area with a clear blue pool, lounge chairs, and a multi-story building with balconies.

A modern hotel room with a large window, a desk with a lamp, a microwave, and a chair.

7. Spark by Hilton Fountain Hills Scottsdale

7.6 km from Mayo Clinic Scottsdale

Herlyn

NT$2,710

NT$3,094 total

includes taxes & fees

Oct 15 - Oct 16

A modern infinity pool with a view of mountains and a sunset.

An outdoor seating area with fire pits and lounge chairs, surrounded by trees and a building with illuminated windows in the background.

A modern bar area with a unique ceiling design, a bar counter with multiple screens, and a patterned carpet.

A poolside lounge with a view of a hotel building, a TV, and a bar area with a bottle of champagne.

8. Talking Stick Resort

8.8 km from Mayo Clinic Scottsdale

Meghan Rebbecca

NT$6,475

NT$8,289 total

includes taxes & fees

Oct 21 - Oct 22

A courtyard with outdoor seating and a fire pit, surrounded by a building with multiple windows and doors.

A modern hotel lobby with a bar area, seating, a coffee machine, and a TV.

A bar area with a bar counter, multiple chairs, and a sofa.

A modern hotel lobby with a reception desk, marble counter, and a seating area with tables and chairs.

9. Aiden by Best Western Scottsdale North

8.7 km from Mayo Clinic Scottsdale

Ioana G

NT$3,251

NT$3,705 total

includes taxes & fees

Oct 11 - Oct 12

An outdoor dining table set with chairs, string lights, and a sunset view.

A modern living room with a sectional sofa, orange ottomans, a dining area, and a kitchen with a stone accent wall.

A multi-story hotel with a prominent entrance, large windows, and a well-lit facade.

A modern lobby with a seating area, a kitchen, and a reception desk.

10. Home2 Suites by Hilton Mesa Longbow, AZ

14.8 km from Mayo Clinic Scottsdale

Damon

NT$4,918

NT$5,620 total

includes taxes & fees

Nov 1 - Nov 2

An outdoor patio area with stone pillars, a fire pit, and seating arrangements.

A golf course with a mountain backdrop, surrounded by desert vegetation.

A lounge area with a grand piano, blue seating, and a stone wall.

A dining area with a large table set for six, surrounded by chairs, with a view of cacti and a stone wall outside.

11. Wekopa Casino Resort

10.3 km from Mayo Clinic Scottsdale

jennifer

NT$3,697

NT$6,086 total

includes taxes & fees

Oct 8 - Oct 9

A hotel room with a bed, desk, chair, television, fireplace, and a dining area.

A hotel room with a bed, a desk with a TV, a sofa, and a coffee table.

An outdoor patio with a grill, table, and chairs.

A reception area with a counter, two armchairs, and a round table.

12. Sonesta ES Suites Scottsdale Paradise Valley

14 km from Mayo Clinic Scottsdale

Michael

NT$3,781

NT$4,309 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a large bed, a dining table with chairs, a sofa, a television, and a kitchenette.

A hotel breakfast area with a self-serve station, seating, and a trash bin.

A hotel room with a desk, chair, television, lamp, and a framed artwork on the wall.

A swimming pool with lounge chairs and umbrellas, surrounded by a fence and palm trees.

13. Holiday Inn Express Scottsdale North by IHG

Central Scottsdale, 12 km from Mayo Clinic Scottsdale

Melanie

NT$3,050

NT$3,476 total

includes taxes & fees

Oct 26 - Oct 27

An outdoor patio area with round tables and chairs, a pool in the background, and a covered seating area.

A hotel room with a desk, a bed, a TV, a sofa, a small table, and a view of the outdoors.

A hotel reception area with a large bridge mural, a reception desk, and a snack bar.

A hotel room with a bed, a desk, a chair, a sofa, a small table, and a TV.

14. Staybridge Suites Scottsdale - Talking Stick by IHG

9.7 km from Mayo Clinic Scottsdale

Gentry

NT$5,243

NT$5,978 total

includes taxes & fees

Oct 26 - Oct 27

A hotel dining area with a table and chairs, patterned curtains, and a view through large windows.

A hotel room with a large window, a desk, a bed, a TV, and a chair.

A hotel lobby with a bar area, seating, and a reception desk.

A golf course with sand bunkers, a flagstick, and mountains in the background.

15. Hampton Inn & Suites Scottsdale at Talking Stick

9.1 km from Mayo Clinic Scottsdale

Mark

NT$3,643

NT$4,154 total

includes taxes & fees

Nov 1 - Nov 2

A modern breakfast area with a counter displaying various food items and a sign reading "TOP IT BREAKFAST".

An outdoor patio with round tables and white wicker chairs, red umbrellas, and a brick building in the background.

A hotel pool area with multiple lounge chairs, a small pool, and a building with a sign.

A hotel room with two beds, a desk, a chair, a window with a view, and a storage sign.

16. Tru By Hilton Scottsdale Salt River

8.9 km from Mayo Clinic Scottsdale

Colleen

NT$3,756

NT$4,283 total

includes taxes & fees

Nov 1 - Nov 2

A spacious lobby with a large seating area, a reception desk, and artwork on the walls.

A buffet counter with various food items, a refrigerator, and a wall-mounted clock.

17. Best Western Plus Scottsdale Thunderbird Suites

Thunderbird Industrial Airpark, 12.1 km from Mayo Clinic Scottsdale

Susan

NT$4,238

NT$4,830 total

includes taxes & fees

Oct 27 - Oct 28

A resort with multiple buildings, a large pool area, and surrounding mountains.

A dining area with a table and chairs, a view of a cityscape, and decorative wall panels.

Three people in a swimming pool with rocks and a red umbrella in the background.

A dining area with a table set for six, overlooking a scenic landscape.

18. ADERO Scottsdale Resort, Autograph Collection

3.6 km from Mayo Clinic Scottsdale

Garrett

NT$7,308

NT$9,613 total

includes taxes & fees

Oct 11 - Oct 12

A spacious lobby with a modern staircase, a comfortable seating area, and a large window providing natural light.

A hotel room with two beds, a nightstand, a lamp, and framed pictures on the wall.

A hotel pool area with two hot tubs and lounge chairs.

A hotel reception area with a reception desk, a large mirror, framed pictures on the wall, a potted plant, and a welcome mat.

19. Sleep Inn North Scottsdale near Mayo Clinic

Paradise Valley Village, 13.5 km from Mayo Clinic Scottsdale

Andrew

NT$4,024

NT$4,550 total

includes taxes & fees

Oct 25 - Oct 26

A hotel pool area with sun loungers, a children's play area, and a building with a sign.

An outdoor patio area with round tables and white wicker chairs, red umbrellas, and potted plants.

A hotel room with a bed, a green sofa, a TV, a desk, and a green carpet.

A modern kitchen with a central island, bar stools, and a sign that reads "inspired table".

20. Home2 Suites by Hilton Scottsdale Salt River

9.6 km from Mayo Clinic Scottsdale

Felipe

NT$4,145

NT$4,726 total

includes taxes & fees

Nov 1 - Nov 2

View all properties

Compare popular hotels close to Mayo Clinic Scottsdale

Property	Property class	Guest rating
Inn at Eagle Mountain	9.0 Wonderful 1,023 reviews	View
Sonesta Select Scottsdale at Mayo Clinic Campus	8.4 Very good 1,087 reviews	View
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale	8.8 Excellent 1,857 reviews	View
Comfort Suites Scottsdale Talking Stick Entertainment District	9.2 Wonderful 2,035 reviews	View
Hyatt House North Scottsdale	9.4 Exceptional 1,009 reviews	View

Top Mayo Clinic Scottsdale Hotel Reviews

Talking Stick Resort

10/10 Excellent

"Pools and restaurants were excellent and reasonably priced. Rooms were spacious and housekeeping was best I’ve seen in any other hotel since Covid. We enjoyed our stay."

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

8/10 Good

"Clean room"

Sonesta Simply Suites Phoenix Scottsdale

8/10 Good

"The staff are very friendly and helpful. The rooms are big and spacious. They provide a good alternative when you’re away from home and traveling."

Wekopa Casino Resort

10/10 Excellent

"I enjoyed the property every one is very welcoming. I felt safe. I enjoyed the pool.the food was affordable and very flavorful. I would love for the buffet to be open during the week. But having more than one option is great and staying open until one is also amazing."

Fountain Park Hotel, BW Signature Collection

10/10 Excellent

"Breakfast…..was the Exact Opposite of everything else about this great hotel. If u ever wanted to experience what breakfast would be like if u were in prison…this was it. The guy stood in one spot & pointed whenever asked a question….it was weird indeed !!"

Sonesta Select Scottsdale at Mayo Clinic Campus

8/10 Good

"Rooms were clean and comfortable. The "restaurant" was not really what I considered a restaurant, but a walk up counter to order with limited choices. The hours were also limited and did not work due to testing times at Mayo Clinic. There were no close restaurants in the area without driving."

Home2 Suites by Hilton Scottsdale Salt River

8/10 Good

"Love the lay out of the room. Very clean also. Food was good except for the milk inside the fridge, i think it was all expired. The guy informed the staff about it. The dining area was very warm, or the AC was off?? Staff was very friendly."

Spark by Hilton Fountain Hills Scottsdale

10/10 Excellent

"It was a comfortable stay."

Staybridge Suites Scottsdale - Talking Stick by IHG

10/10 Excellent

"Best free breakfast I have experienced. Rooms were clean."

Frequently asked questions

What's the area like around Mayo Clinic Scottsdale?

Mayo Clinic Scottsdale is located in a welcoming area of Scottsdale known for its array of dining options and sporting events. If you're looking for a convenient place to stay, check out the 22 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Mayo Clinic Scottsdale?

Adjacent to Mayo Clinic Scottsdale, Sonesta Select Scottsdale at Mayo Clinic Campus is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices within 5 miles include ADERO Scottsdale Resort, Autograph Collection and Inn at Eagle Mountain.

How many hotels will I be able to find close to Mayo Clinic Scottsdale?

Expedia has 22 hotels and other accommodations within a mile from Mayo Clinic Scottsdale.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Scottsdale, will I receive a refund?

Yes! The majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to view top deals close to Mayo Clinic Scottsdale.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Scottsdale?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Scottsdale, go to https://www.expedia.com/service/.

What can I see and do near Mayo Clinic Scottsdale?

You might spend a leisurely day outdoors at Scottsdale Ranch Park and Fountain Hills Botanical Garden. Explore nature at Desert Sonoran Botanical Garden Trailhead and Golden Eagle Trailhead. Eagle Mountain Golf Course, Golf Club at Eagle Mountain, or SunRidge Canyon Golf Club are some local sights worth checking out.

Find hotels near Mayo Clinic Scottsdale, Phoenix from NT$3,047

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Mayo Clinic Scottsdale hotels

1. Inn at Eagle Mountain

2. Sonesta Select Scottsdale at Mayo Clinic Campus

3. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

4. Comfort Suites Scottsdale Talking Stick Entertainment District

5. Hyatt House North Scottsdale

6. Fountain Park Hotel, BW Signature Collection

7. Spark by Hilton Fountain Hills Scottsdale

8. Talking Stick Resort

9. Aiden by Best Western Scottsdale North

10. Home2 Suites by Hilton Mesa Longbow, AZ

11. Wekopa Casino Resort

12. Sonesta ES Suites Scottsdale Paradise Valley

13. Holiday Inn Express Scottsdale North by IHG

14. Staybridge Suites Scottsdale - Talking Stick by IHG

15. Hampton Inn & Suites Scottsdale at Talking Stick

16. Tru By Hilton Scottsdale Salt River

17. Best Western Plus Scottsdale Thunderbird Suites

18. ADERO Scottsdale Resort, Autograph Collection

19. Sleep Inn North Scottsdale near Mayo Clinic

20. Home2 Suites by Hilton Scottsdale Salt River

Compare popular hotels close to Mayo Clinic Scottsdale

Top Mayo Clinic Scottsdale Hotel Reviews

Talking Stick Resort

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Sonesta Simply Suites Phoenix Scottsdale

Wekopa Casino Resort

Fountain Park Hotel, BW Signature Collection

Sonesta Select Scottsdale at Mayo Clinic Campus

Home2 Suites by Hilton Scottsdale Salt River

Spark by Hilton Fountain Hills Scottsdale

Staybridge Suites Scottsdale - Talking Stick by IHG

Frequently asked questions

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