The Best Hotels Closest to Mayo Clinic Scottsdale in Phoenix for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Mayo Clinic Scottsdale hotels

A modern hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

A hotel courtyard with a paved walkway, palm trees, and a building with multiple balconies and a glass facade.

A modern living room with a fireplace, a large flat-screen TV, and comfortable seating.

1. Sonesta Select Scottsdale at Mayo Clinic Campus

0.3 km from Mayo Clinic Scottsdale

louis

NT$3,467

NT$3,951 total

includes taxes & fees

Oct 27 - Oct 28

A cluster of modern, multi-story buildings with a river in the foreground.

A golf course with a pond, a clubhouse, and a hilly backdrop.

An outdoor patio with a stone wall, wooden pergola, and a cactus.

A dining area with a glass table, wooden chairs, and potted plants.

2. Inn at Eagle Mountain

3.1 km from Mayo Clinic Scottsdale

Stephanie

NT$4,171

NT$4,762 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with two beds, a desk with a chair, a TV, and a lamp.

A modern hotel lobby with a central bar area, seating arrangements, and a clean, contemporary design.

A modern hotel lobby with a fireplace, seating area, kitchen, and a large TV.

A reception area with a stone wall, a wooden reception desk, and a modern elevator.

3. Comfort Suites Scottsdale Talking Stick Entertainment District

9.6 km from Mayo Clinic Scottsdale

LAURA

NT$3,528

NT$4,023 total

includes taxes & fees

Nov 1 - Nov 2

A hotel lobby with a reception desk, seating area, and a large wall mural.

A hotel lobby with multiple seating areas, a reception desk, and a kitchen in the background.

A hotel room with two beds, a desk, a lamp, and a window with curtains.

A hotel room with a sofa, a TV, a desk, and a chair. There are framed pictures on the wall.

4. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale, 8.9 km from Mayo Clinic Scottsdale

Wilson

NT$2,727

NT$3,108 total

includes taxes & fees

Oct 25 - Oct 26

An outdoor dining table set with chairs, string lights, and a sunset view.

A modern living room with a sectional sofa, orange ottomans, a dining area, and a kitchen with a stone accent wall.

A modern kitchen area with a dining table and chairs, a stone accent wall, and various kitchen appliances and storage cabinets.

A modern lobby with a seating area, a kitchen, and a reception desk.

5. Home2 Suites by Hilton Mesa Longbow, AZ

14.8 km from Mayo Clinic Scottsdale

Damon

NT$5,150

NT$5,885 total

includes taxes & fees

Oct 25 - Oct 26

A spacious living area with a kitchen, modern furniture, and a fireplace.

A spacious lobby with a high ceiling, modern chandeliers, a fire feature, and a large TV screen.

A hotel room with a large bed, a dresser with drawers, a wardrobe, and a wall-mounted TV displaying a pool view.

A modern kitchen with blue cabinets, a stainless steel refrigerator, and a white countertop.

6. Fountain Park Hotel, BW Signature Collection

7.3 km from Mayo Clinic Scottsdale

Guadalupe

NT$3,532

NT$4,032 total

includes taxes & fees

Oct 21 - Oct 22

A modern office space with multiple desks, chairs, and a meeting area.

A hotel with a clear sky, a sign for 'Spark by Hilton', and a well-maintained lawn.

A hotel room with a large bed, a desk with a phone, a chair, a desk lamp, a painting, and a view of the outdoors.

A hotel room with two beds, a desk, a TV, and a balcony with a view.

7. Spark by Hilton Fountain Hills Scottsdale

7.6 km from Mayo Clinic Scottsdale

Herlyn

NT$2,763

NT$3,155 total

includes taxes & fees

Oct 27 - Oct 28

An outdoor patio area with stone pillars, a fire pit, and seating arrangements.

A dining area with a large table set for six, surrounded by chairs, with a view of cacti and a stone wall outside.

A lounge area with a grand piano, blue seating, and a stone wall.

A historic building with arched entrances and a bell tower, surrounded by cacti and desert landscaping.

8. Wekopa Casino Resort

10.3 km from Mayo Clinic Scottsdale

jennifer

NT$3,782

NT$5,284 total

includes taxes & fees

Oct 21 - Oct 22

A modern outdoor lounge area with sofas, chairs, and a glass-top coffee table with a fire feature.

A spacious living area with a sofa, chairs, a coffee table, and a TV mounted on the wall.

A bar area with a long counter, multiple stools, and overhead pendant lighting.

A reception area with marble reception desks, a wooden ceiling, and a wall-mounted refrigerator.

9. Hyatt House North Scottsdale

14.1 km from Mayo Clinic Scottsdale

Cassie

NT$4,374

NT$4,985 total

includes taxes & fees

Nov 1 - Nov 2

A landscaped garden with a fountain, palm trees, and a building with a red roof.

A pool area with a rock formation, palm trees, and lounge chairs.

A courtyard with palm trees, a fountain, and a bench.

A modern kitchen with a glass dining table, bar stools, and a built-in island with a microwave and oven.

10. Westgate Painted Mountain Golf Resort

17.4 km from Mayo Clinic Scottsdale

Tammie

NT$3,258

NT$3,723 total

includes taxes & fees

Nov 2 - Nov 3

A courtyard with outdoor seating and a fire pit, surrounded by a building with multiple windows and doors.

A bar area with a bar counter, multiple chairs, and a sofa.

A modern hotel lobby with a bar area, seating, a coffee machine, and a TV.

A swimming pool with a tiled edge, lounge chairs, and a fitness area with treadmills and exercise equipment.

11. Aiden by Best Western Scottsdale North

8.7 km from Mayo Clinic Scottsdale

Marie

NT$3,315

NT$3,778 total

includes taxes & fees

Oct 26 - Oct 27

A swimming pool with lounge chairs and a covered seating area, surrounded by palm trees and a building with multiple windows.

A restaurant with multiple round tables and bar stools, a self-service beverage dispenser, and a television mounted on the wall.

A modern hotel with a covered entrance, multiple floors, and a parking lot.

A modern lobby with a brick wall, seating area, and a flat-screen TV.

12. Hyatt Place Phoenix/Mesa

17.8 km from Mayo Clinic Scottsdale

Firas

NT$4,374

NT$4,998 total

includes taxes & fees

Oct 26 - Oct 27

A modern outdoor seating area with sofas and a central fire feature.

A hotel lobby with a tiled floor, a large chandelier, and a sign for the Arizona Ballroom.

A hotel courtyard with a swimming pool, palm trees, and a covered seating area.

A modern hotel lobby with a white sofa, armchairs, a coffee table, and a dining area with chairs and a table. Large windows provide a view of the outdoors.

13. Delta Hotels by Marriott Phoenix Mesa

18.7 km from Mayo Clinic Scottsdale

Samantha

NT$3,467

NT$3,962 total

includes taxes & fees

Oct 26 - Oct 27

A modern breakfast area with a counter displaying various food items and a sign reading "TOP IT BREAKFAST".

An outdoor patio with round tables and white wicker chairs, red umbrellas, and a brick building in the background.

A hotel room with two beds, a desk, a chair, a window with a view, and a storage sign.

A hotel pool area with multiple lounge chairs, a small pool, and a building with a sign.

14. Tru By Hilton Scottsdale Salt River

8.9 km from Mayo Clinic Scottsdale

Colleen

NT$3,718

NT$4,239 total

includes taxes & fees

Nov 8 - Nov 9

A spacious lobby with a high ceiling, multiple seating areas, a reception desk, and a television screen.

A multi-story hotel with a flat roof and balconies, surrounded by well-maintained grass and trees.

A spacious hotel lobby with a reception desk, seating areas, and a view of the dining and kitchen areas.

An outdoor seating area with a fire feature, surrounded by a fence and palm trees, under a sunset sky.

15. Embassy Suites by Hilton Phoenix Scottsdale

17.8 km from Mayo Clinic Scottsdale

Matthew

NT$5,022

NT$5,678 total

includes taxes & fees

Nov 1 - Nov 2

A resort with multiple buildings, a large pool area, and surrounding mountains.

A dining area with a table set for six, overlooking a scenic landscape.

Three people in a swimming pool with rocks and a red umbrella in the background.

A dining area with a table and chairs, a view of a cityscape, and decorative wall panels.

16. ADERO Scottsdale Resort, Autograph Collection

3.6 km from Mayo Clinic Scottsdale

Garrett

NT$6,992

NT$9,282 total

includes taxes & fees

Oct 21 - Oct 22

A hotel room with a bed, desk, chair, television, fireplace, and a dining area.

A hotel room with a bed, a desk with a TV, a sofa, and a coffee table.

A reception area with a counter, two armchairs, and a round table.

A breakfast buffet with various food items and a coffee machine.

17. Sonesta ES Suites Scottsdale Paradise Valley

14 km from Mayo Clinic Scottsdale

Denine

NT$3,953

NT$4,505 total

includes taxes & fees

Nov 1 - Nov 2

A spacious lobby with a large seating area, a reception desk, and artwork on the walls.

A spacious lobby with leather armchairs, a patterned rug, and a large metal coffee table.

A buffet counter with various food items, a refrigerator, and a wall-mounted clock.

18. Best Western Plus Scottsdale Thunderbird Suites

Thunderbird Industrial Airpark, 12.1 km from Mayo Clinic Scottsdale

Susan

NT$3,639

NT$4,148 total

includes taxes & fees

Oct 27 - Oct 28

A hotel room with a large bed, a dining table with chairs, a sofa, a television, and a kitchenette.

A hotel gym with dumbbells on racks, a bench, and a mirror.

A hotel breakfast area with a self-serve station, seating, and a trash bin.

A swimming pool with lounge chairs and umbrellas, surrounded by a fence and palm trees.

19. Holiday Inn Express Scottsdale North by IHG

Central Scottsdale, 12 km from Mayo Clinic Scottsdale

Melanie

NT$3,402

NT$3,877 total

includes taxes & fees

Oct 26 - Oct 27

An outdoor patio area with round tables and chairs, a pool in the background, and a covered seating area.

A hotel reception area with a large bridge mural, a reception desk, and a snack bar.

A hotel room with a bed, a desk, a chair, a sofa, a small table, and a TV.

A multi-story hotel with illuminated signage reading "Talking Stick" and "Resort".

20. Staybridge Suites Scottsdale - Talking Stick by IHG

9.7 km from Mayo Clinic Scottsdale

Steve

NT$5,346

NT$6,096 total

includes taxes & fees

Oct 26 - Oct 27

View all properties

Compare popular hotels close to Mayo Clinic Scottsdale

Property	Property class	Guest rating
Sonesta Select Scottsdale at Mayo Clinic Campus	8.4 Very good 1,088 reviews	View
Inn at Eagle Mountain	9.0 Wonderful 1,035 reviews	View
Comfort Suites Scottsdale Talking Stick Entertainment District	9.2 Wonderful 2,058 reviews	View
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale	8.8 Excellent 1,879 reviews	View
Home2 Suites by Hilton Mesa Longbow, AZ	9.6 Exceptional 918 reviews	View

Top Mayo Clinic Scottsdale Hotel Reviews

Hampton Inn & Suites Scottsdale at Talking Stick

10/10 Excellent

"Rooms were large, staff was friends. Elevator was centrally located and the location is in close proximity to many fun places."

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

10/10 Excellent

"The staff was exceptionally helpful and kind."

Wekopa Casino Resort

8/10 Good

"The sports bar was amazing and food was very reasonably priced."

Comfort Suites Scottsdale Talking Stick Entertainment District

10/10 Excellent

"Clean room air cond works foot staff very helpful"

Sonesta Select Scottsdale at Mayo Clinic Campus

10/10 Excellent

"all good happy place to stay"

Aiden by Best Western Scottsdale North

10/10 Excellent

"We really enjoyed the suite on the lower floor with access to the pool area/patio very comfortable bed, sheets and towels were excellent. I would definitely stay again if we are in the area."

Spark by Hilton Fountain Hills Scottsdale

8/10 Good

"Clean rooms although a slightly weird smell in our room when we arrived. Nothing gross just odd but it went away. Very nice and attentive staff. The continental breakfast could be a little bit nicer, but I definitely think for the size and quality of the hotel, It was expected."

Inn at Eagle Mountain

10/10 Excellent

"A very nice and peaceful place, the surroundings and people were warm and down to earth,I will definitely be coming back."

Holiday Inn & Suites Scottsdale North - Airpark by IHG

10/10 Excellent

"Wonderful personnel, clean environment and easy access to restaurants etc. The only down was the towels were very scratchy. The free Lyft was so convenient and easy to use. I really enjoyed my week."

Frequently asked questions

What's the area like around Mayo Clinic Scottsdale?

Mayo Clinic Scottsdale is located in a welcoming area of Scottsdale known for its array of dining options and sporting events. If you're looking for a convenient place to stay, check out the 22 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Mayo Clinic Scottsdale?

Adjacent to Mayo Clinic Scottsdale, Sonesta Select Scottsdale at Mayo Clinic Campus is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices within 5 miles include ADERO Scottsdale Resort, Autograph Collection and Inn at Eagle Mountain.

How many hotels will I be able to find close to Mayo Clinic Scottsdale?

Expedia has 22 hotels and other accommodations within a mile from Mayo Clinic Scottsdale.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Scottsdale, will I receive a refund?

Yes! The majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to view top deals close to Mayo Clinic Scottsdale.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Scottsdale?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Scottsdale, go to https://www.expedia.com/service/.

What can I see and do near Mayo Clinic Scottsdale?

You might spend a leisurely day outdoors at Scottsdale Ranch Park and Fountain Hills Botanical Garden. Explore nature at Desert Sonoran Botanical Garden Trailhead and Golden Eagle Trailhead. Eagle Mountain Golf Course, Golf Club at Eagle Mountain, or SunRidge Canyon Golf Club are some local sights worth checking out.

Find hotels near Mayo Clinic Scottsdale, Phoenix from NT$3,108

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mayo Clinic Scottsdale hotels

1. Sonesta Select Scottsdale at Mayo Clinic Campus

2. Inn at Eagle Mountain

3. Comfort Suites Scottsdale Talking Stick Entertainment District

4. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

5. Home2 Suites by Hilton Mesa Longbow, AZ

6. Fountain Park Hotel, BW Signature Collection

7. Spark by Hilton Fountain Hills Scottsdale

8. Wekopa Casino Resort

9. Hyatt House North Scottsdale

10. Westgate Painted Mountain Golf Resort

11. Aiden by Best Western Scottsdale North

12. Hyatt Place Phoenix/Mesa

13. Delta Hotels by Marriott Phoenix Mesa

14. Tru By Hilton Scottsdale Salt River

15. Embassy Suites by Hilton Phoenix Scottsdale

16. ADERO Scottsdale Resort, Autograph Collection

17. Sonesta ES Suites Scottsdale Paradise Valley

18. Best Western Plus Scottsdale Thunderbird Suites

19. Holiday Inn Express Scottsdale North by IHG

20. Staybridge Suites Scottsdale - Talking Stick by IHG

Compare popular hotels close to Mayo Clinic Scottsdale

Top Mayo Clinic Scottsdale Hotel Reviews

Hampton Inn & Suites Scottsdale at Talking Stick

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Wekopa Casino Resort

Comfort Suites Scottsdale Talking Stick Entertainment District

Sonesta Select Scottsdale at Mayo Clinic Campus

Aiden by Best Western Scottsdale North

Spark by Hilton Fountain Hills Scottsdale

Inn at Eagle Mountain

Holiday Inn & Suites Scottsdale North - Airpark by IHG

Frequently asked questions

Explore a world of travel with Expedia