The Best Hotels Closest to Mayo Clinic Scottsdale in Phoenix for 2026

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Our top choices for Mayo Clinic Scottsdale hotels

A cluster of modern, multi-story buildings with a river in the foreground.

A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.

A golf course with a pond, a clubhouse, and a hilly backdrop.

A dining area with a glass table, wooden chairs, and potted plants.

1. Inn at Eagle Mountain

3.1 km from Mayo Clinic Scottsdale

Andrei

NT$5,046

NT$5,761 total

includes taxes & fees

Oct 5 - Oct 6

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

A breakfast buffet area with various pastries and a sign indicating the price of a cheese danish.

A hotel courtyard with a paved walkway, palm trees, and a building with multiple balconies and a glass facade.

A modern living room with a fireplace, a large flat-screen TV, and comfortable seating.

2. Sonesta Select Scottsdale at Mayo Clinic Campus

0.3 km from Mayo Clinic Scottsdale

Michael

NT$3,409

NT$3,885 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with two beds, a desk with a chair, a TV, and a lamp.

A modern hotel lobby with a central bar area, seating arrangements, and a clean, contemporary design.

A reception area with a stone wall, a wooden reception desk, and a modern elevator.

3. Comfort Suites Scottsdale Talking Stick Entertainment District

9.6 km from Mayo Clinic Scottsdale

William

NT$3,297

NT$3,759 total

includes taxes & fees

Oct 11 - Oct 12

A hotel lobby with a reception desk, seating area, and a large wall mural.

A hotel room with two beds, a desk, a lamp, and a window with curtains.

A hotel lobby with multiple seating areas, a reception desk, and a kitchen in the background.

A hotel room with a sofa, a TV, a desk, and a chair. There are framed pictures on the wall.

4. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale, 8.9 km from Mayo Clinic Scottsdale

Cathleen

NT$2,681

NT$3,055 total

includes taxes & fees

Oct 4 - Oct 5

An outdoor dining table set with chairs, string lights, and a sunset view.

A modern kitchen area with a dining table and chairs, a stone accent wall, and various kitchen appliances and storage cabinets.

A modern lobby with a seating area, a kitchen, and a reception desk.

A modern living room with a sectional sofa, orange ottomans, a dining area, and a kitchen with a stone accent wall.

5. Home2 Suites by Hilton Mesa Longbow, AZ

14.8 km from Mayo Clinic Scottsdale

Damon

NT$4,415

NT$5,045 total

includes taxes & fees

Oct 4 - Oct 5

A spacious living area with a kitchen, modern furniture, and a fireplace.

A spacious lobby with a high ceiling, modern chandeliers, a fire feature, and a large TV screen.

A modern lobby with a pool view, orange seating, and a wooden accent wall.

A modern kitchen with blue cabinets, a stainless steel refrigerator, and a white countertop.

6. Fountain Park Hotel, BW Signature Collection

7.3 km from Mayo Clinic Scottsdale

Guadalupe

NT$3,472

NT$3,964 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with two beds, a TV, a desk, and a window with a view.

A modern office space with multiple desks, chairs, and a meeting area.

A hotel room with two beds, a desk, a TV, and a balcony with a view.

A modern hotel room with a large window, a desk with a lamp, a microwave, and a chair.

7. Spark by Hilton Fountain Hills Scottsdale

7.6 km from Mayo Clinic Scottsdale

Peyton

NT$2,455

NT$2,803 total

includes taxes & fees

Oct 11 - Oct 12

An outdoor patio area with stone pillars, a fire pit, and seating arrangements.

A historic building with arched entrances and a bell tower, surrounded by cacti and desert landscaping.

A dining area with a large table set for six, surrounded by chairs, with a view of cacti and a stone wall outside.

A lounge area with a grand piano, blue seating, and a stone wall.

8. Wekopa Casino Resort

10.3 km from Mayo Clinic Scottsdale

Darrick

NT$3,499

NT$5,866 total

includes taxes & fees

Oct 4 - Oct 5

A modern infinity pool with a view of mountains and a sunset.

An outdoor seating area with fire pits and lounge chairs, surrounded by trees and a building with illuminated windows in the background.

A modern bar area with a unique ceiling design, a bar counter with multiple screens, and a patterned carpet.

A restaurant with high tables and booths, floral wall decorations, and a view of the mountains.

9. Talking Stick Resort

8.8 km from Mayo Clinic Scottsdale

Meghan Rebbecca

NT$6,243

NT$8,027 total

includes taxes & fees

Oct 5 - Oct 6

A courtyard with outdoor seating and a fire pit, surrounded by a building with multiple windows and doors.

A bar area with a bar counter, multiple chairs, and a sofa.

A swimming pool with a tiled edge, lounge chairs, and a fitness area with treadmills and exercise equipment.

A modern hotel lobby with a bar area, seating, a coffee machine, and a TV.

10. Aiden by Best Western Scottsdale North

8.7 km from Mayo Clinic Scottsdale

cody

NT$2,705

NT$3,083 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a large bed, a dining table with chairs, a sofa, a television, and a kitchenette.

A hotel gym with dumbbells on racks, a bench, and a mirror.

A swimming pool with lounge chairs and umbrellas, surrounded by a fence and palm trees.

A hotel room with a desk, chair, television, lamp, and a framed artwork on the wall.

11. Holiday Inn Express Scottsdale North by IHG

Central Scottsdale, 12 km from Mayo Clinic Scottsdale

Melanie

NT$2,899

NT$3,304 total

includes taxes & fees

Nov 1 - Nov 2

A circular fire feature with a stone border, surrounded by a landscaped garden with cacti and shrubs, under a sunset sky.

A pool area with lounge chairs and umbrellas, surrounded by buildings with balconies and outdoor seating.

A Courtyard by Marriott hotel with a modern design, featuring a covered entrance and stone pillars.

A modern bar area with seating, a digital menu display, and a beverage refrigerator.

12. Courtyard Scottsdale Salt River

12.2 km from Mayo Clinic Scottsdale

Karl

NT$4,651

NT$5,301 total

includes taxes & fees

Oct 11 - Oct 12

A modern outdoor lounge area with sofas, chairs, and a glass-top coffee table with a fire feature.

A bar area with a long counter, multiple stools, and overhead pendant lighting.

A spacious living area with a sofa, chairs, a coffee table, and a TV mounted on the wall.

A multi-story hotel with a central courtyard, parking, and a mountainous backdrop.

13. Hyatt House North Scottsdale

14.1 km from Mayo Clinic Scottsdale

Slyqavious

NT$4,301

NT$4,901 total

includes taxes & fees

Oct 8 - Oct 9

A hotel dining area with a table and chairs, patterned curtains, and a view through large windows.

A building entrance with a stone facade, large glass doors, and potted plants.

A hotel room with a large window, a desk, a bed, a TV, and a chair.

A hotel lobby with a bar area, seating, and a reception desk.

14. Hampton Inn & Suites Scottsdale at Talking Stick

9.1 km from Mayo Clinic Scottsdale

Mark

NT$3,683

NT$4,200 total

includes taxes & fees

Nov 1 - Nov 2

An outdoor patio area with round tables and chairs, a pool in the background, and a covered seating area.

A hotel reception area with a large bridge mural, a reception desk, and a snack bar.

A multi-story hotel with illuminated signage reading "Talking Stick" and "Resort".

A hotel room with a bed, a desk, a chair, a sofa, a small table, and a TV.

15. Staybridge Suites Scottsdale - Talking Stick by IHG

9.7 km from Mayo Clinic Scottsdale

Gentry

NT$5,256

NT$5,993 total

includes taxes & fees

Oct 26 - Oct 27

A hotel room with a bed, desk, chair, television, fireplace, and a dining area.

A hotel room with a bed, a desk with a TV, a sofa, and a coffee table.

A reception area with a counter, two armchairs, and a round table.

An outdoor patio with a grill, table, and chairs.

16. Sonesta ES Suites Scottsdale Paradise Valley

14 km from Mayo Clinic Scottsdale

Eriel

NT$3,855

NT$4,393 total

includes taxes & fees

Oct 14 - Oct 15

A resort with multiple buildings, a large pool area, and surrounding mountains.

Three people in a swimming pool with rocks and a red umbrella in the background.

A dining area with a table set for six, overlooking a scenic landscape.

An outdoor wedding reception with round tables set with white chairs, floral centerpieces, and a view of the city in the background.

17. ADERO Scottsdale Resort, Autograph Collection

3.6 km from Mayo Clinic Scottsdale

Karen

NT$7,678

NT$10,039 total

includes taxes & fees

Oct 2 - Oct 3

A breakfast bar with a variety of baked goods and a sign indicating fresh baked items.

A hotel room with a flat-screen TV, a fireplace, a sofa, a coffee table, and a large window with a view.

A reception area with a blue counter, a television screen, and a modern interior design.

A Holiday Inn & Suites building with a curved facade, multiple balconies, and a well-lit entrance.

18. Holiday Inn & Suites Scottsdale North - Airpark by IHG

9.7 km from Mayo Clinic Scottsdale

Ally Marie

NT$4,428

NT$5,047 total

includes taxes & fees

Oct 25 - Oct 26

A modern breakfast area with a counter displaying various food items and a sign reading "TOP IT BREAKFAST".

A hotel pool area with multiple lounge chairs, a small pool, and a building with a sign.

A modern hotel lobby with a curved reception desk, seating area with sofas and chairs, and a large wall with a 'HOME2' sign.

An outdoor patio with round tables and white wicker chairs, red umbrellas, and a brick building in the background.

19. Tru By Hilton Scottsdale Salt River

8.9 km from Mayo Clinic Scottsdale

Colleen

NT$3,817

NT$4,352 total

includes taxes & fees

Nov 1 - Nov 2

A modern hotel lobby with a long bar area, multiple seating options, and large windows offering views of palm trees and a pool.

An outdoor patio area with stone pillars, fire pit seating, and tables.

A swimming pool with lounge chairs and palm trees, surrounded by a building with multiple windows and a covered patio area.

A Hampton Inn & Suites with a stone facade, a welcoming entrance, and a clear sky at dusk.

20. Hampton Inn & Suites Phoenix/Scottsdale on Shea Boulevard

Central Scottsdale, 12.3 km from Mayo Clinic Scottsdale

Dana

NT$5,068

NT$5,776 total

includes taxes & fees

Oct 25 - Oct 26

View all properties

Compare popular hotels close to Mayo Clinic Scottsdale

Property	Property class	Guest rating
Inn at Eagle Mountain	9.0 Wonderful 1,020 reviews	View
Sonesta Select Scottsdale at Mayo Clinic Campus	8.4 Very good 1,103 reviews	View
Comfort Suites Scottsdale Talking Stick Entertainment District	9.2 Wonderful 2,036 reviews	View
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale	8.8 Excellent 1,850 reviews	View
Home2 Suites by Hilton Mesa Longbow, AZ	9.6 Exceptional 906 reviews	View

Top Mayo Clinic Scottsdale Hotel Reviews

Comfort Suites Scottsdale Talking Stick Entertainment District

10/10 Excellent

"Clean large rooms. Great staff. Friendly. Breakfast definitely a great value. Location was great."

Inn at Eagle Mountain

10/10 Excellent

"⭐️⭐️⭐️⭐️⭐️ A Hidden Gem! The Inn at Eagle Mountain is truly a hidden gem! We have stayed here several times, and it is always quiet, clean, comfortable, and welcoming. The staff is wonderful, and the location is very convenient, with a grocery store and other necessities nearby. A special thank you to Jorge at the front desk today. He was absolutely awesome! His customer service was excellent—friendly, helpful, and genuinely welcoming. Thank you, Inn at Eagle Mountain, for always making our stays so enjoyable. We look forward to coming back again!"

Aiden by Best Western Scottsdale North

10/10 Excellent

"Very nice hotel and close to the hospital. Wonderful and caring staff"

ADERO Scottsdale Resort, Autograph Collection

10/10 Excellent

"Great rooms and hotel, staff very helpful at all times and the relaxation was perfect."

Home2 Suites by Hilton Scottsdale Salt River

8/10 Good

"Quiet location and great staff."

Great Wolf Lodge Arizona

10/10 Excellent

"Facilities are amazing for families with kids. Please note there’s no in-room safe for your money,passports belonging."

Fountain Park Hotel, BW Signature Collection

10/10 Excellent

"We will return to this hotel."

Sonesta Simply Suites Phoenix Scottsdale

10/10 Excellent

"The microwave didn't have a rotating plate. There was a coffee pot but no coffee. Only one cup for two people. One bowl, no plates. Therefore, kitchen amenities were incomplete."

Staybridge Suites Scottsdale - Talking Stick by IHG

10/10 Excellent

"The breakfast was fantastic!!"

Frequently asked questions

What's the area like around Mayo Clinic Scottsdale?

Mayo Clinic Scottsdale is located in a welcoming area of Scottsdale known for its array of dining options and sporting events. If you're looking for a convenient place to stay, check out the 22 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Mayo Clinic Scottsdale?

Adjacent to Mayo Clinic Scottsdale, Sonesta Select Scottsdale at Mayo Clinic Campus is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices within 5 miles include ADERO Scottsdale Resort, Autograph Collection and Inn at Eagle Mountain.

How many hotels will I be able to find close to Mayo Clinic Scottsdale?

Expedia has 22 hotels and other accommodations within a mile from Mayo Clinic Scottsdale.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Scottsdale, will I receive a refund?

Yes! The majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to view top deals close to Mayo Clinic Scottsdale.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Scottsdale?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Scottsdale, go to https://www.expedia.com/service/.

What can I see and do near Mayo Clinic Scottsdale?

You might spend a leisurely day outdoors at Scottsdale Ranch Park and Fountain Hills Botanical Garden. Explore nature at Desert Sonoran Botanical Garden Trailhead and Golden Eagle Trailhead. Eagle Mountain Golf Course, Golf Club at Eagle Mountain, or SunRidge Canyon Golf Club are some local sights worth checking out.

Find hotels near Mayo Clinic Scottsdale, Phoenix

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Treat yourself

Be picky

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Our top choices for Mayo Clinic Scottsdale hotels

1. Inn at Eagle Mountain

2. Sonesta Select Scottsdale at Mayo Clinic Campus

3. Comfort Suites Scottsdale Talking Stick Entertainment District

4. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

5. Home2 Suites by Hilton Mesa Longbow, AZ

6. Fountain Park Hotel, BW Signature Collection

7. Spark by Hilton Fountain Hills Scottsdale

8. Wekopa Casino Resort

9. Talking Stick Resort

10. Aiden by Best Western Scottsdale North

11. Holiday Inn Express Scottsdale North by IHG

12. Courtyard Scottsdale Salt River

13. Hyatt House North Scottsdale

14. Hampton Inn & Suites Scottsdale at Talking Stick

15. Staybridge Suites Scottsdale - Talking Stick by IHG

16. Sonesta ES Suites Scottsdale Paradise Valley

17. ADERO Scottsdale Resort, Autograph Collection

18. Holiday Inn & Suites Scottsdale North - Airpark by IHG

19. Tru By Hilton Scottsdale Salt River

20. Hampton Inn & Suites Phoenix/Scottsdale on Shea Boulevard

Compare popular hotels close to Mayo Clinic Scottsdale

Top Mayo Clinic Scottsdale Hotel Reviews

Comfort Suites Scottsdale Talking Stick Entertainment District

Inn at Eagle Mountain

Aiden by Best Western Scottsdale North

ADERO Scottsdale Resort, Autograph Collection

Home2 Suites by Hilton Scottsdale Salt River

Great Wolf Lodge Arizona

Fountain Park Hotel, BW Signature Collection

Sonesta Simply Suites Phoenix Scottsdale

Staybridge Suites Scottsdale - Talking Stick by IHG

Frequently asked questions

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