Find hotels in Medical Center District, San Antonio from NT$1,527

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Dec 15 - Dec 16
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Dec 16 - Dec 17
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Dec 19 - Dec 21
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Dec 26 - Dec 28

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Our top choices for Medical Center District hotels

Lobby
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center
3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1006)
"Clean rooms Staff very nice "
United States
Yolanda
The price is NT$2,776
NT$3,299 total
includes taxes & fees
Dec 18 - Dec 19
San Antonio Marriott Northwest Medical Center
Front of property
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
Medical Center District
8.4 out of 10, Very Good, (3120)
"The hotel is clean and the staff are great "
United States
mazen t
The price is NT$2,770
NT$3,274 total
includes taxes & fees
Dec 16 - Dec 17
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Pool
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center
2.5 star property
Medical Center District
9.0 out of 10, Wonderful, (1003)
"Staff was super nice! "
United States
Fredric
The price is NT$2,589
NT$3,023 total
includes taxes & fees
Dec 22 - Dec 23
Fairfield Inn & Suites by Marriott San Antonio Medical Center
Lobby
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1291)
"Great place to stay and visit "
United States
Harry
The price is NT$2,807
NT$3,318 total
includes taxes & fees
Jan 1 - 2026/1/2
Drury Inn & Suites San Antonio Northwest Medical Center
Premium bedding, pillowtop beds, in-room safe, desk
SpringHill Suites by Marriott San Antonio Medical Center/NW

SpringHill Suites by Marriott San Antonio Medical Center/NW

SpringHill Suites by Marriott San Antonio Medical Center/NW
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1001)
"good staff. good stay"
United States
Divya
The price is NT$3,151
NT$3,724 total
includes taxes & fees
Dec 16 - Dec 17
SpringHill Suites by Marriott San Antonio Medical Center/NW
Exterior
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1002)
"Room was clean, staff was very friendly!!"
United States
Ray
The price is NT$2,776
NT$3,282 total
includes taxes & fees
Dec 21 - Dec 22
Courtyard by Marriott Medical Center San Antonio
Free daily on-the-go breakfast
Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3.0 star property
Medical Center District
6.8 out of 10, (1002)
"Easy check in"
United States
Violet
The price is NT$1,830
NT$2,136 total
includes taxes & fees
Jan 4 - 2026/1/5
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Exterior
OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio
2.0 star property
Medical Center District
7.2 out of 10, Good, (225)
"Always great stay"
United States
Juan
The price is NT$1,671
NT$2,060 total
includes taxes & fees
Dec 31 - 2026/1/1
OYO Inn & Suites Medical Center San Antonio
Desk, laptop workspace, blackout drapes, free WiFi
Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center
2.0 star property
Medical Center District
7.2 out of 10, Good, (215)
"Clean, and accommodating room was very a very good Choice!!"
United States
Jessica
The price is NT$1,653
NT$1,930 total
includes taxes & fees
Dec 16 - Dec 17
Studio 6 San Antonio, Tx - Northwest Medical Center
Reception
Park Inn by Radisson

Park Inn by Radisson

Park Inn by Radisson
2.0 star property
Medical Center District
7.2 out of 10, Good, (1005)
"Staff were amazing, and everything else was great too. "
United States
Maximilian
The price is NT$1,962
NT$2,291 total
includes taxes & fees
Dec 28 - Dec 29
Park Inn by Radisson
Desk, laptop workspace, free WiFi, bed sheets
Studio 6 San Antonio, TX - Medical Center

Studio 6 San Antonio, TX - Medical Center

Studio 6 San Antonio, TX - Medical Center
2.0 star property
Medical Center District
6.6 out of 10, (787)
"Staff and amenities "
United States
Keyshia
The price is NT$1,514
NT$1,852 total
includes taxes & fees
Dec 16 - Dec 17
Studio 6 San Antonio, TX - Medical Center
Front of property
Atria Inn & Suites

Atria Inn & Suites

Atria Inn & Suites
2.0 star property
Medical Center District
7.6 out of 10, Good, (275)
"Check-in was smooth, and the room was clean. It needs some repairs and the blanket was as thin as the sheet, but no complaints otherwise."
United States
Rachel
Atria Inn & Suites
Basic Room, Multiple Beds, Non Smoking | Desk, iron/ironing board, free WiFi, bed sheets
Flex Studios

Flex Studios

Flex Studios
2.5 star property
Medical Center District
6.0 out of 10, (497)
"heb is nearby. "
United States
Sayeed
The price is NT$1,291
NT$1,527 total
includes taxes & fees
Dec 16 - Dec 17
Flex Studios
Free WiFi, bed sheets
Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center
2.0 star property
Medical Center District
6.0 out of 10, (1002)
"Staff courteous."
United States
Kathleeen
The price is NT$1,334
NT$1,576 total
includes taxes & fees
Jan 1 - 2026/1/2
Motel 6 San Antonio, TX - Northwest Medical Center
Free daily buffet breakfast
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3.0 star property
Downtown San Antonio, 13 km from Medical Center District
7.8 out of 10, Good, (3759)
"Had an amazing time at the hotel "
United States
Uriel
The price is NT$2,360
NT$3,336 total
includes taxes & fees
Dec 21 - Dec 22
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Game room
Riverwalk Plaza

Riverwalk Plaza

Riverwalk Plaza
4.0 star property
12.3 km from Medical Center District
8.2 out of 10, Very Good, (6196)
"Very clean super friendly staff"
United States
Jenifer
Riverwalk Plaza
Water park
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
3.5 star property
Far West Side, 11.3 km from Medical Center District
9.0 out of 10, Wonderful, (1297)
"Beautiful location and great staff"
United States
Miguel
The price is NT$2,221
NT$3,914 total
includes taxes & fees
Jan 14 - 2026/1/15
Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Terrace/patio
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

Hotel Valencia Riverwalk
4.5 star property
Downtown San Antonio, 12.1 km from Medical Center District
9.4 out of 10, Exceptional, (2244)
"Beautful hotel would definitely recommend "
United States
Christina Ashley
The price is NT$3,267
NT$4,754 total
includes taxes & fees
Jan 13 - 2026/1/14
Hotel Valencia Riverwalk
View from property
Hyatt Regency San Antonio Riverwalk

Hyatt Regency San Antonio Riverwalk

Hyatt Regency San Antonio Riverwalk
4.0 star property
Downtown San Antonio, 12.4 km from Medical Center District
9.2 out of 10, Wonderful, (1927)
"Great stay overall "
United States
Melissa
The price is NT$4,746
NT$6,710 total
includes taxes & fees
Dec 17 - Dec 18
Hyatt Regency San Antonio Riverwalk
Lobby
Menger Hotel

Menger Hotel

Menger Hotel
3.5 star property
Downtown San Antonio, 12.6 km from Medical Center District
9.0 out of 10, Wonderful, (3579)
"Best little hotel in San Antonio "
United States
Michael
The price is NT$3,119
NT$3,687 total
includes taxes & fees
Dec 29 - Dec 30
Menger Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
Learn more about Medical Center District
Downtown - Riverwalk which includes heritage architecture, boating and a river or creek

Downtown San Antonio

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

Marion Koogler McNay Art Museum featuring art and interior views

Uptown

While visiting Uptown, you might make a stop by sights like Marion Koogler McNay Art Museum and Alamo Quarry Market.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Stone Oak

Travelers come to Stone Oak for its abundant dining options, and you can see top attractions like Shops at Hardy Oak and Alta Vista while you're in town.

Northwest Side

While visiting Northwest Side, you might make a stop by sights like Huebner Oaks and Convocation Center.

Top Medical Center District Hotel Reviews

Hilton Palacio Del Rio

Hilton Palacio Del Rio

10/10 Excellent
"The room was.super clean and everyone working there was really nice and helpful. Would stay there again for sure. "
Darell 1-night trip
Posted 12 hours ago
Hilton Palacio Del Rio

Explore a world of travel with Expedia

Frequently asked questions

What is Medical Center District like?
Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.
What's a favorite place to stay in Medical Center District?
Based on Expedia customer reviews, Drury Inn & Suites San Antonio Northwest Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and an indoor pool. Other favorite options in the area include SpringHill Suites by Marriott San Antonio Medical Center/NW and Fairfield Inn & Suites by Marriott San Antonio Medical Center.
How many hotels will I be able to find in Medical Center District?
Expedia has 122 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.
Where can I learn more about changing or cancelling my trip to Medical Center District?
For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.
What can I see and do in this San Antonio neighborhood?
USAA Corporate Office Headquarters, The San Antonio Art Institute, and Cinemark San Antonio 16 are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.