Medical Center District, TX

San Antonio

A cityscape with a prominent tower, a large body of water, and a sunset.
A canal with colorful umbrellas and trees along the banks.
A riverside café with colorful umbrellas and tables.
A tranquil waterway flanked by lush greenery and stone pathways.
A canal with a boat, surrounded by lush greenery and a stone bridge.

Stay near popular Medical Center District attractions


Medical Center District Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is NT$2,915 per night from Nov 15 to Nov 16
NT$2,915
NT$3,478 total
Nov 15 - Nov 16
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (3,778 reviews)
"Overdue for a refresh. While nothing was broken or unsanitary, everything seemed dull and tired and in need of new paint and/or deep cleaning. This impression was exacerbated by dim lighting and over-worked front desk staff."

Reviewed on 2026/11/10

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is NT$2,826 per night from Dec 11 to Dec 12
NT$2,826
NT$3,390 total
Dec 11 - Dec 12
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy room service, a 24-hour fitness center, and WiFi (surcharge). Our guests praise the helpful ...
San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
The price is NT$2,954 per night from Nov 15 to Nov 16
NT$2,954
NT$3,525 total
Nov 15 - Nov 16
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,537 reviews)
"Clean room, friendly staff, clean hotel, breakfast, dinner snack provided, which is a nice addition compared to other hotels, free parking, gated parking, security lock after 10."

Reviewed on 2026/11/11

Drury Inn & Suites San Antonio Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
The price is NT$2,925 per night from Nov 26 to Nov 27
NT$2,925
NT$3,490 total
Nov 26 - Nov 27
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,000 reviews)
"Honestly, the location was nice and ducked off and peaceful. It was so quiet, clean and just overall peaceful."

Reviewed on 2026/11/8

Courtyard by Marriott Medical Center San Antonio
Hotel Valencia Riverwalk, Valencia Collection

Hotel Valencia Riverwalk, Valencia Collection

4.5 out of 5
150 E Houston St San Antonio TX
The price is NT$3,696 per night from Nov 26 to Nov 27
NT$3,696
NT$5,348 total
Nov 26 - Nov 27
includes taxes & fees
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (3,314 reviews)
"Absolutely loved this warm cozy hotel! The staff were amazing and everything felt close to luxury but homey at the same time. Loved the location as well. Will definitely be back!"

Reviewed on 2026/11/11

Hotel Valencia Riverwalk, Valencia Collection
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
The price is NT$4,201 per night from Nov 15 to Nov 16
NT$4,201
NT$5,013 total
Nov 15 - Nov 16
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
9.4/10 Exceptional! (5,494 reviews)
"Clean room, comfortable bed, convenient to the river walk"

Reviewed on 2026/11/11

Drury Plaza Hotel San Antonio Riverwalk
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
Learn more about Medical Center District

Downtown San Antonio

The stunning river views and popular shops are just a few highlights of Downtown San Antonio. Make a stop by Alamo or Alamodome while you're exploring the area.

Uptown Central

While visiting Uptown Central, you might make a stop by sights like Marion Koogler McNay Art Museum and Alamo Quarry Market.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Northwest Side

While visiting Northwest Side, you might make a stop by sights like Huebner Oaks and Crystal Ice Palace.

Stone Oak

Travelers come to Stone Oak for its abundant dining options, and you can see top attractions like Shops at Hardy Oak and Alta Vista at Stone Oak while you're in town.



Medical Center District, TX

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