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Medical Center District 5 Stars Hotels
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Compare Medical Center District 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Our top choices for Medical Center District 5-star hotels

Thompson San Antonio - Riverwalk, by Hyatt
Thompson San Antonio - Riverwalk, by Hyatt
9.0 out of 10, Wonderful, (843)
The price is NT$5,301
NT$7,299 total
includes taxes & fees
Sep 21 - Sep 22

The Luxury Suites at Arrive Eilan
The Luxury Suites at Arrive Eilan
7.4 out of 10, Good, (129)
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Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Medical Center District.

Riverwalk Plaza
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
8/10 Very Good! (5,773 reviews)
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Medical Center District Hotels by Star Rating
Hotels in Medical Center District Neighborhoods
Stay near popular Medical Center District attractions
- Hotels near USAA Corporate Office Headquarters
- Hotels near South Texas Medical Center
- Hotels near University of Texas Health and Science Center at San Antonio
- Hotels near CHRISTUS Santa Rosa Hospital - Medical Center
- Hotels near Oak Hills Country Club
- Hotels near The San Antonio Art Institute
- Hotels near River Walk
- Hotels near Lackland Air Force Base
- Hotels near Six Flags Fiesta Texas
- Hotels near Alamodome
- Hotels near Alamo
- Hotels near Henry B. González Convention Center
- Hotels near San Antonio Zoo and Aquarium
- Hotels near San Antonio River
- Hotels near Frost Bank Center
- Hotels near Market Square
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