The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Teresa

NT$7,758

NT$8,728 total

includes taxes & fees

Oct 25 - Oct 26

A modern outdoor area with a pool, lounge chairs, and a bar area.

A modern hotel room with a bed, sofa, coffee table, and artwork.

An outdoor seating area with a modern fire feature, surrounded by lush greenery and palm trees.

A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.

2. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kimberly

NT$10,147

NT$13,605 total

includes taxes & fees

Oct 28 - Oct 29

A pool area with lounge chairs and a table, surrounded by palm trees.

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

A building with a neon sign that reads "Orchid Key Inn."

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

3. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

ben

NT$7,855

NT$8,837 total

includes taxes & fees

Oct 28 - Oct 29

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A colonial-style building with a porch, surrounded by lush tropical vegetation.

A bedroom with a large bed, a television on a dresser, and a view of the outdoors through a sliding door.

A bar area with a counter, chairs, and a clock.

4. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Gisele

NT$8,719

NT$9,809 total

includes taxes & fees

Oct 27 - Oct 28

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

A pool area with lounge chairs and a wooden building with balconies.

A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.

A covered walkway with a wooden ceiling, white railings, and a brick path.

5. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Elise

NT$6,432

NT$7,236 total

includes taxes & fees

Oct 25 - Oct 26

A pool area with lounge chairs and palm trees.

A neatly made bed with patterned pillows, a bedside table with a bottle and glasses, and a window with orchids.

A modern outdoor seating area with a sofa, chairs, and a small table, surrounded by glass doors and a view of greenery.

A sign for Santa Maria Resort surrounded by lush greenery and palm trees.

6. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Anthony

NT$9,696

NT$13,096 total

includes taxes & fees

Oct 26 - Oct 27

A gated entrance with lush green foliage and a white picket fence.

A covered outdoor dining area with white chairs and tables, surrounded by lush greenery and a wooden deck.

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

A white colonial-style building with a balcony, surrounded by palm trees and a white picket fence.

7. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

August

NT$7,258

NT$8,165 total

includes taxes & fees

Oct 26 - Oct 27

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A grand staircase with ornate railings and a chandelier.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.

8. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Amy

NT$5,808

NT$10,638 total

includes taxes & fees

Oct 26 - Oct 27

A green house with a white porch, a flag, and a sign advertising a property for sale.

A covered porch with wicker furniture, potted plants, and a view of the house.

A room with a ceiling fan, an air conditioning unit, a window with blinds, a sofa with patterned cushions, a small round table, and a floor lamp.

A bathroom with a vanity, a mirror, and a window with blinds.

9. L'Habitation Guest House - Adults Only

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Richard

NT$5,552

NT$6,246 total

includes taxes & fees

Oct 28 - Oct 29

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

A garden with a stone pathway, a wooden fence, and various tropical plants.

A room with a bed, a desk, a chair, a lamp, a painting of a boat on water, and a view of the sea.

A pool area with a circular pool, lounge chairs, and a gazebo.

10. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Brenda

NT$6,566

NT$7,388 total

includes taxes & fees

Oct 27 - Oct 28

A covered porch with white railings, wooden benches, and a hanging light fixture.

A bedroom with a four-poster bed, a wicker chair, a wooden dresser, and a television.

A living room with a large mirror, a wicker chair, a television on a wooden cabinet, and a window with a view of palm trees.

A sign for Marrero's Guest Mansion in Key West, FL, by Verdigris Hotels.

11. Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Michael

NT$10,506

NT$11,820 total

includes taxes & fees

Oct 25 - Oct 26

A wooden deck with wicker furniture and a white railing, surrounded by lush tropical vegetation.

A two-story building with a white picket fence, palm trees, and a clear blue sky.

A pathway leading to a building with a white facade, surrounded by lush greenery and palm trees.

A breakfast tray with croissants, orange juice, and coffee on a table by a window with a view of a pool and greenery.

12. Weatherstation Inn

Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary

Robert

NT$6,453

NT$7,260 total

includes taxes & fees

Oct 25 - Oct 26

A large, white, two-story building with a balcony and a sign reading "The Marker Resort."

A resort with a swimming pool, lounge chairs, umbrellas, and palm trees.

A covered outdoor area with a pool, palm trees, and lounge chairs.

A marina with various boats docked, including a green and white boat named 'Jolly Roger'.

13. The Marker Key West Harbor Resort

Historic Seaport, 1.3 km from Florida Keys National Marine Sanctuary

Lynne

NT$5,879

NT$8,657 total

includes taxes & fees

Oct 25 - Oct 26

A covered outdoor area with a pool, wicker furniture, and a red umbrella.

14. The Independent Inn

Historic Seaport, 1.6 km from Florida Keys National Marine Sanctuary

Michael

NT$5,653

NT$7,645 total

includes taxes & fees

Oct 25 - Oct 26

A two-story building with a covered entrance, palm trees, and a bench outside.

A white picket fence, a wooden bench with cushions, and a concrete pathway surrounded by lush greenery.

A bright room with a staircase, two windows overlooking a pool area, and two wicker chairs with cushions.

A poolside area with lounge chairs, umbrellas, and a covered seating area with hanging lights.

15. Winslow's Bungalows - Key West Historic Inns

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

Elizabeth

NT$6,527

NT$8,996 total

includes taxes & fees

Oct 27 - Oct 28

A two-story building with a white picket fence, palm trees, and a sign that reads 'DUVAL GARDENS.'

A porch with wicker chairs and a table, white railings, and a window with a view of a palm tree.

16. Duval Gardens - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

JoAnn

NT$6,514

NT$9,517 total

includes taxes & fees

Nov 15 - Nov 16

A pool area with a brick patio, potted plants, and a covered seating area.

A white picket fence, a palm tree, and a sign reading "Garden House Key West".

A house with a porch, a sign reading "Garden House," and a number "329" on the door.

A porch with a white chair, a wooden door, and a small indoor dining area visible through the door.

17. The Garden House

Historic Seaport, 1.1 km from Florida Keys National Marine Sanctuary

Brad

NT$3,210

NT$4,309 total

includes taxes & fees

Oct 26 - Oct 27

A pool area with lounge chairs and umbrellas, surrounded by palm trees and a building with a white facade.

A modern kitchen with a wooden counter, two stools, a wicker chair, and a hanging light fixture.

A bedroom with a sloped ceiling, a bed, two chairs, a hanging light fixture, and a window with a view of greenery.

A table with chairs in a lush indoor garden setting.

18. Lighthouse Hotel - Key West Historic Inns

Bahama Village, 0.6 km from Florida Keys National Marine Sanctuary

Jill

NT$7,458

NT$10,032 total

includes taxes & fees

Oct 25 - Oct 26

A covered porch with wicker furniture, potted plants, and a sign for the "Office" at the Palm Hotel.

A hotel with a white facade, multiple balconies, and lush tropical landscaping.

A row of bicycles parked in front of a building with a white balcony and a palm tree.

A pink building with a white door, a balcony with a white railing, and a view of a pool area.

19. The Palms Hotel

The Meadows, 1.7 km from Florida Keys National Marine Sanctuary

Jerry

NT$5,047

NT$6,407 total

includes taxes & fees

Oct 25 - Oct 26

A bedroom with a bed, bedside table, lamp, and a small kitchenette. There is a balcony with wicker chairs and a glass table.

A pool area with lounge chairs and umbrellas, surrounded by buildings with balconies and a clear blue sky.

A spacious living area with a wooden staircase, a ceiling fan, a TV, and a view of the beach through an open door.

A cozy cabin with a wooden interior, a bed, a TV, and a kitchenette.

20. Eden House

Historic Seaport, 1.6 km from Florida Keys National Marine Sanctuary

Michelle

NT$4,949

NT$6,236 total

includes taxes & fees

Oct 27 - Oct 28

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,003 reviews	View
H2O Suites - Adults Only	9.8 Exceptional 669 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,003 reviews	View
The Gardens Hotel	9.8 Exceptional 1,000 reviews	View
Island City House Hotel	9.6 Exceptional 1,000 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Southwinds Motel

10/10 Excellent

"GREAT VALUE FOR THE MONEY"

Southernmost Beach Resort and Guesthouses

8/10 Good

"Loved the wristband key to the room. The room was clean, the bed was comfortable. The noise from the A/C was annoying…off and on all night long. The water/ice machine outside our room did not work, however, we loved the fruit flavored water in the lobby. Coffee machine in room was nice feature. We visited all 3 pools. They were nice but not cleaned as should be. One was pretty cloudy so we didn’t go back to that one. Seems like the drinkers didn’t take time out to use restrooms. All in all, it was a nice place at the southern end of Duval St."

Douglas House - Adults Only

10/10 Excellent

"."

Casa Marina Key West, Curio Collection by Hilton

10/10 Excellent

"All I can say is all aspects were fantastic"

Duval House

10/10 Excellent

"Great location on Duval. Our room was quiet, clean, and comfortable. Beautiful garden. Very convenient to start the day with available caffeine and a light breakfast. Staff very nice."

Wicker Guesthouse

8/10 Good

"We loved our stay. Great location. Good privacy. Good parking. Nice staff. The only issue was the bright lights in the porche kept the room too bright at night. Other than that, I would stay there again."

Weatherstation Inn

10/10 Excellent

"Location, Everything within walking distance"

The Cabana Inn Key West - Adults Only

8/10 Good

"Everything was pretty good except couldn’t get tv to work properly to watch playoffs. Would stay again close to everything"

Paradise Inn Key West - Adults Only

10/10 Excellent

"Fantastic property! Quiet, clean and close to everything. Wonderful pool area and the landscaping and grounds make you feel secluded."

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$4,309

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. H2O Suites - Adults Only

3. Orchid Key Inn - Adults Only

4. The Gardens Hotel

5. Island City House Hotel

6. Santa Maria Suites

7. Coco Plum Inn

8. Southernmost House - Adult Exclusive

9. L'Habitation Guest House - Adults Only

10. Alexander Palms Court

11. Marrero's Guest Mansion

12. Weatherstation Inn

13. The Marker Key West Harbor Resort

14. The Independent Inn

15. Winslow's Bungalows - Key West Historic Inns

16. Duval Gardens - Adults Only

17. The Garden House

18. Lighthouse Hotel - Key West Historic Inns

19. The Palms Hotel

20. Eden House

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Southwinds Motel

Southernmost Beach Resort and Guesthouses

Douglas House - Adults Only

Casa Marina Key West, Curio Collection by Hilton

Duval House

Wicker Guesthouse

Weatherstation Inn

The Cabana Inn Key West - Adults Only

Paradise Inn Key West - Adults Only

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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