The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

John

NT$5,785

NT$6,508 total

includes taxes & fees

Sep 9 - Sep 10

A covered porch with white railings, a ceiling fan, and a table with chairs.

A two-story house with a porch, a large tree, and a fire hydrant.

A room with a wooden floor, a sofa with patterned cushions, a table, a chair, a lamp, and a window with blinds.

A bedroom with a wooden headboard, a bed with white bedding, a blue patterned throw, and a view through a window with blinds.

2. The Porch on Frances Inn

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Corrynne

NT$3,611

NT$5,016 total

includes taxes & fees

Sep 7 - Sep 8

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A couple walking along a poolside pathway surrounded by lush greenery.

A bar area with a counter, chairs, and a clock.

A colonial-style building with a porch, surrounded by lush tropical vegetation.

3. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Brian

NT$5,332

NT$5,999 total

includes taxes & fees

Sep 21 - Sep 22

A two-story house with a covered porch, a brick pathway, and a large tree.

A hotel room with two beds, a ceiling fan, a large window with a view of palm trees, and a painting on the wall.

A restaurant with multiple tables set for dining, a wine bottle, and a glass of wine on the table.

A covered porch with white wicker furniture and a blue floor, surrounded by lush tropical plants.

4. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

LISA

NT$6,097

NT$8,644 total

includes taxes & fees

Sep 23 - Sep 24

A pool area with lounge chairs and a table, surrounded by palm trees.

A neon sign for Orchid Key Inn with a 'VACANCY' sign below it.

A building with a neon sign that reads "Orchid Key Inn."

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

5. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Nicholas

NT$5,690

NT$6,401 total

includes taxes & fees

Sep 8 - Sep 9

A modern outdoor area with a pool, lounge chairs, and a bar area.

A modern hotel with a prominent glass facade, palm trees, and a clear sky.

An outdoor seating area with a modern fire feature, surrounded by lush greenery and palm trees.

A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.

6. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kourosh

NT$8,856

NT$12,106 total

includes taxes & fees

Sep 8 - Sep 9

A tropical outdoor area with palm trees, hanging plants, and string lights.

A wooden deck with lush greenery and a pool area.

A large, two-story building with a balcony, surrounded by dense tropical foliage.

An outdoor patio with a table and chairs, surrounded by lush greenery and string lights.

7. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

savannah

NT$3,238

NT$4,008 total

includes taxes & fees

Sep 9 - Sep 10

A room with a bed, a ceiling fan, and a window with blinds.

A cozy outdoor seating area with a wooden bench and a table, surrounded by potted plants and a coffee and tea sign.

A poolside area with lounge chairs, a covered seating area, and a small pool.

A spacious kitchen with wooden cabinets, a granite countertop, and a ceiling fan.

8. The Mermaid & Alligator

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

Johnny

NT$5,714

NT$6,428 total

includes taxes & fees

Sep 7 - Sep 8

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A hallway with a white door, a wooden bench, a blue sofa, and a staircase with a white railing.

A lush garden with a variety of tropical plants and a paved walkway.

A two-story building with a white picket fence, a mailbox, and a small tree in front.

9. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Robert

NT$3,142

NT$4,218 total

includes taxes & fees

Sep 16 - Sep 17

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.

A covered walkway with a wooden ceiling, white railings, and a brick path.

A pool area with lounge chairs and a wooden building with balconies.

10. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Paul

NT$4,880

NT$5,490 total

includes taxes & fees

Sep 13 - Sep 14

A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.

A two-story building with a porch, a sign reading "The Grand Guesthouse," and a purple flag.

A covered outdoor area with a wooden staircase, seating, and potted plants.

A row of blue bicycles parked under a tree, with a white fence and a building in the background.

11. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Travis

NT$4,895

NT$6,301 total

includes taxes & fees

Sep 7 - Sep 8

A pool area with lounge chairs and palm trees.

A sign for Santa Maria Resort surrounded by lush greenery and palm trees.

A modern outdoor seating area with a sofa, chairs, and a small table, surrounded by glass doors and a view of greenery.

A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.

12. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

June Young

NT$8,856

NT$12,106 total

includes taxes & fees

Sep 7 - Sep 8

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A grand staircase with ornate railings and a chandelier.

A large, two-story house with a prominent tower and a covered porch.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

13. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Mark

NT$4,422

NT$8,992 total

includes taxes & fees

Sep 17 - Sep 18

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

A hotel with a pool, bicycles, and lush greenery.

The exterior of the Silver Palms Inn with a two-story structure, a green awning over the entrance, and a palm tree to the right.

The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.

14. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

Shawn

NT$2,543

NT$5,003 total

includes taxes & fees

Sep 9 - Sep 10

A gated entrance with lush green foliage and a white picket fence.

A white colonial-style building with a balcony, surrounded by palm trees and a white picket fence.

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

A hotel room with a large bed, two bedside tables, a ceiling fan, and two framed pictures on the wall.

15. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

Jake

NT$4,261

NT$4,794 total

includes taxes & fees

Sep 15 - Sep 16

A reception area with a curved marble counter, ceiling fans, large windows, and a staircase.

A breakfast table with a variety of food items, including fruits, pastries, and a coffee mug.

A poolside area with lounge chairs and a clear blue pool surrounded by lush tropical vegetation.

A bedroom with a bed, two bedside lamps, a ceiling fan, and a view of a balcony with plants.

16. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

John

NT$3,690

NT$4,151 total

includes taxes & fees

Sep 21 - Sep 22

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

A hotel room with a bed, a nightstand, a chair, a small table, and a ceiling fan.

A cozy living room with a wooden ceiling, a sofa set, two side tables with lamps, and framed artwork on the wall.

A spacious living room with a high ceiling, a ceiling fan, a large painting, a sofa, a coffee table, and a dining area with a table and chairs.

17. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Kate

NT$4,261

NT$4,794 total

includes taxes & fees

Sep 27 - Sep 28

A wooden deck with wicker furniture and a white railing, surrounded by lush tropical vegetation.

A swimming pool with a white picket fence, surrounded by lounge chairs and potted plants.

A two-story building with a white picket fence, palm trees, and a clear blue sky.

A breakfast tray with croissants, orange juice, and coffee on a table by a window with a view of a pool and greenery.

18. Weatherstation Inn

Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary

Svetlana

NT$5,364

NT$6,035 total

includes taxes & fees

Sep 8 - Sep 9

A poolside area with lounge chairs, umbrellas, and a pergola.

A wooden bench with a cushion and a small table, surrounded by bamboo plants and a wooden deck.

A bright kitchen with white cabinetry, a white island, wicker pendant lights, and geometric patterned backsplash.

An open door leading to a pool area with a wicker chair and a sofa inside a room with a view of the pool.

19. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Susannah

NT$6,190

NT$8,571 total

includes taxes & fees

Sep 7 - Sep 8

A covered porch with white railings, wooden benches, and a hanging light fixture.

A pool area with lounge chairs and a small palm tree.

A sign for Marrero's Guest Mansion in Key West, FL, by Verdigris Hotels.

A bedroom with a four-poster bed, a wicker chair, a wooden dresser, and a television.

20. Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Michael

NT$6,952

NT$7,821 total

includes taxes & fees

Sep 9 - Sep 10

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,010 reviews	View
The Porch on Frances Inn	9.8 Exceptional 138 reviews	View
The Gardens Hotel	9.8 Exceptional 1,001 reviews	View
The Marquesa Hotel	9.8 Exceptional 1,002 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,006 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

The Reach Key West, Curio Collection by Hilton

10/10 Excellent

"Staff was very helpful and nice"

Duval House

10/10 Excellent

"Duval House is a beautiful historic Caribbean styled property. It is charming, lush, private and full of charm. The rooms are quaint, clean and updated. The grounds are lush and tropical. The staff is very nice and helpful. The continental breakfast is set in the beautiful garden. The Duval House is a wonderful place."

Southwinds Motel

8/10 Good

"Great location. Nice pool. Parking. Thirsty Rooster 🐓 bar out front was so much fun and a great vibe. Not to mention a close distance to Duval St. Where the action is. Deli and groceries across the street as well. We will be back"

Tranquility Guest House

10/10 Excellent

"The room was clean and the staff was very friendly. Highly recommended"

Pier House Resort & Spa

10/10 Excellent

"Great location. Staff were very nice. Room clean. Food good."

Heron House - Adult Only

10/10 Excellent

"We love staying here. Other guests have always been friendly and it’s so relaxed it’s always a great time!"

Douglas House - Adults Only

10/10 Excellent

"Loved this property. Have been coming to KW for last 40+ years and never stayed here? Great location. Our room was more like and apartment. We were down from Miami for rum festival and were close to all of the different events at Douglas. The property was meticulously kept. The staff was helpful. Plenty of parking on street and close to the moondog cafe and so many other places to eat and drink. Highly recommend this property. Will be back."

Hyatt Centric Key West Resort and Spa

10/10 Excellent

"The staff were outstanding, especially Anna at the front desk. They all were so warm and welcoming. The rooms were spacious and clean. The pool was clean and mostly quiet (which was nice and relaxing)."

The Cabana Inn Key West - Adults Only

10/10 Excellent

"Property was close to Duval and conveniently located with pool and hot tub access. Breakfast and happy hour offerings were an added bonus. We had booked the owner's suite and it exceeded our expecations."

Other attractions near Florida Keys National Marine Sanctuary

A yellow exhibit labeled 'NOAA's AQUARIUS UNDERSEA LAB' with a circular window and a door.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A brick corridor with arched ceilings and benches.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its great live music.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its great live music.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1492 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1492 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$4,008

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. The Porch on Frances Inn

3. The Gardens Hotel

4. The Marquesa Hotel

5. Orchid Key Inn - Adults Only

6. H2O Suites - Adults Only

7. Douglas House - Adults Only

8. The Mermaid & Alligator

9. Duval House

10. Island City House Hotel

11. The Grand Guesthouse

12. Santa Maria Suites

13. Southernmost House - Adult Exclusive

14. Silver Palms Inn & Historic Homes

15. Coco Plum Inn

16. Westwinds Inn

17. Ambrosia Key West

18. Weatherstation Inn

19. Ella's Cottages - Key West Historic Inns

20. Marrero's Guest Mansion

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

The Reach Key West, Curio Collection by Hilton

Duval House

Southwinds Motel

Tranquility Guest House

Pier House Resort & Spa

Heron House - Adult Only

Douglas House - Adults Only

Hyatt Centric Key West Resort and Spa

The Cabana Inn Key West - Adults Only

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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