The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Teresa

NT$8,457

NT$9,514 total

includes taxes & fees

Oct 26 - Oct 27

A tropical outdoor area with palm trees, hanging plants, and string lights.

An outdoor patio with a table and chairs, surrounded by lush greenery and string lights.

A large, two-story building with a balcony, surrounded by dense tropical foliage.

A wooden deck with lush greenery and a pool area.

2. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Maricela

NT$5,100

NT$6,311 total

includes taxes & fees

Oct 27 - Oct 28

A bottle of Marc's Reserve 12 FL. OZ. on a coaster with a metal table.

A patio area with white metal tables and chairs, surrounded by potted plants and palm trees.

A pool with a lion head sculpture in the center.

A potted yellow orchid plant in a garden setting with a brick pathway, palm trees, and a white building in the background.

3. Artist House Key West

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

Debbie

NT$6,430

NT$7,234 total

includes taxes & fees

Oct 29 - Oct 30

A modern outdoor area with a pool, lounge chairs, and a bar area.

A modern hotel with a prominent glass facade, palm trees, and a clear sky.

A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.

A modern hotel room with a bed, sofa, coffee table, and artwork.

4. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Carmen

NT$10,139

NT$13,594 total

includes taxes & fees

Oct 28 - Oct 29

A modern interior with a staircase, a sofa set, a wooden table, and a television.

A courtyard with two green lounge chairs, a palm tree, and a building with a white facade and lattice window design.

A pool area with a clear view of a house in the background, surrounded by palm trees and greenery.

A pathway flanked by lush green foliage leading to a gated entrance.

5. Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

William

NT$5,476

NT$6,160 total

includes taxes & fees

Oct 26 - Oct 27

A pool area with lounge chairs and a table, surrounded by palm trees.

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

A neon sign for Orchid Key Inn with a 'VACANCY' sign below it.

6. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

ben

NT$7,987

NT$8,985 total

includes taxes & fees

Oct 26 - Oct 27

A gated entrance to Villas Key West with a brick pathway leading to the gate.

A covered entrance with a brick pathway leading to a gated area, surrounded by lush greenery and plants.

A swimming pool with a hot tub, surrounded by a wooden deck and lush greenery.

A covered porch with wicker furniture, a large potted plant, and a sign for Villas Key West.

7. Key West Villas

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Margaret

NT$9,886

NT$11,122 total

includes taxes & fees

Nov 18 - Nov 19

A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.

A pool area with lounge chairs, a pool, and a building with a balcony and outdoor seating.

A spacious living room with a sofa, chairs, and a dining table. There are large windows with blinds, a door leading to a patio, and a ceiling with exposed beams.

A narrow room with a bed, a potted plant, and a window with blinds.

8. Alexander's Guesthouse - Adult Exclusive

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Nestor

NT$7,844

NT$10,179 total

includes taxes & fees

Oct 28 - Oct 29

A two-story house with a covered porch, a brick pathway, and a large tree.

A poolside area with a swimming pool, a staircase leading to a deck, and a building with multiple windows and balconies.

A restaurant with multiple tables set for dining, a wine bottle, and a glass of wine on the table.

A hotel room with two beds, a ceiling fan, a large window with a view of palm trees, and a painting on the wall.

9. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Josh

NT$13,192

NT$16,664 total

includes taxes & fees

Nov 3 - Nov 4

A porch with a white railing, a bench, and a flag.

A two-story white house with green shutters, a wooden door, and a white picket fence.

A pool area with lounge chairs and a dining table, surrounded by palm trees and a house with a porch.

A living room with a sofa, a glass coffee table, a TV, and a painting on the wall.

10. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

Jennifer

NT$9,254

NT$10,410 total

includes taxes & fees

Oct 25 - Oct 26

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

A hallway with a white door, a wooden bench, a blue sofa, and a staircase with a white railing.

A lush garden with a variety of tropical plants and a paved walkway.

11. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Cathrine

NT$5,443

NT$6,820 total

includes taxes & fees

Oct 20 - Oct 21

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

A garden with a pond, rocks, and various plants.

A covered walkway with a wooden ceiling, white railings, and a brick path.

A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.

12. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Elise

NT$7,043

NT$7,923 total

includes taxes & fees

Oct 21 - Oct 22

A pool area with lounge chairs and palm trees.

A neatly made bed with patterned pillows, a bedside table with a bottle and glasses, and a window with orchids.

A modern outdoor seating area with a sofa, chairs, and a small table, surrounded by glass doors and a view of greenery.

A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.

13. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Anthony

NT$9,688

NT$13,086 total

includes taxes & fees

Oct 26 - Oct 27

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A large, two-story house with a prominent tower and a covered porch.

A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

14. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Amy

NT$5,803

NT$10,629 total

includes taxes & fees

Oct 25 - Oct 26

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.

The exterior of the Silver Palms Inn with a two-story structure, a green awning over the entrance, and a palm tree to the right.

A hotel with a pool, bicycles, and lush greenery.

15. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

sam

NT$2,887

NT$5,435 total

includes taxes & fees

Oct 25 - Oct 26

A green house with a white porch, a flag, and a sign advertising a property for sale.

A covered porch with wicker furniture, potted plants, and a view of the house.

A room with a ceiling fan, an air conditioning unit, a window with blinds, a sofa with patterned cushions, a small round table, and a floor lamp.

A bedroom with a large bed, a sofa, a nightstand, and a painting on the wall.

16. L'Habitation Guest House - Adults Only

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Richard

NT$5,511

NT$6,201 total

includes taxes & fees

Oct 28 - Oct 29

A poolside area with lounge chairs, umbrellas, and a pergola.

An open door leading to a pool area with a wicker chair and a sofa inside a room with a view of the pool.

A bright kitchen with white cabinetry, a white island, wicker pendant lights, and geometric patterned backsplash.

A wooden bench with a cushion and a small table, surrounded by bamboo plants and a wooden deck.

17. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Henry

NT$7,452

NT$10,024 total

includes taxes & fees

Oct 27 - Oct 28

A gated entrance with lush green foliage and a white picket fence.

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

A covered outdoor dining area with white chairs and tables, surrounded by lush greenery and a wooden deck.

A white colonial-style building with a balcony, surrounded by palm trees and a white picket fence.

18. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

August

NT$6,489

NT$7,300 total

includes taxes & fees

Oct 20 - Oct 21

A reception area with a curved marble counter, ceiling fans, large windows, and a staircase.

A two-story house with a white exterior, a green roof, and a staircase leading to the upper floor.

A breakfast table with a variety of food items, including fruits, pastries, and a coffee mug.

A bedroom with a bed, two bedside lamps, a ceiling fan, and a view of a balcony with plants.

19. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

Anthony

NT$5,249

NT$5,905 total

includes taxes & fees

Oct 25 - Oct 26

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

A cozy living room with a wooden ceiling, a sofa set, two side tables with lamps, and framed artwork on the wall.

A wicker outdoor seating area with two chairs and a table, surrounded by lush tropical foliage.

A spacious living room with a high ceiling, a ceiling fan, a large painting, a sofa, a coffee table, and a dining area with a table and chairs.

20. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

RICHARD

NT$7,049

NT$7,930 total

includes taxes & fees

Oct 25 - Oct 26

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,002 reviews	View
Douglas House - Adults Only	9.8 Exceptional 560 reviews	View
Artist House Key West	9.8 Exceptional 464 reviews	View
H2O Suites - Adults Only	9.8 Exceptional 669 reviews	View
Simonton Court Historic Inn & Cottages	9.8 Exceptional 1,006 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Paradise Inn Key West - Adults Only

10/10 Excellent

"Fantastic property! Quiet, clean and close to everything. Wonderful pool area and the landscaping and grounds make you feel secluded."

The Southernmost Inn - Adults Only

10/10 Excellent

"Booked here last minute due to our Vrbo being canceled - Can't say enough nice things about it! - Yes, the rooms are very small and the hallways are a bit older but this place is gorgeous! Pools are excellent and the staff is too. Only thing is if you like breakfast, go out. It's bland and boring at best."

Casa Marina Key West, Curio Collection by Hilton

10/10 Excellent

"Beautiful property, beach was perfect, pools were great. The staff are very helpful and knowledgeable"

Opal Key Resort & Marina, Key West

10/10 Excellent

"Great hotel will definitely stay again"

Tranquility Guest House

10/10 Excellent

"Tranquility is just that. Quiet except for local roosters, safe, peaceful and private. There’s no front desk but the manager was in touch and checked in frequently. Great neighborhood nestled between Duval and the state park with fabulous beach."

Pier House Resort & Spa

10/10 Excellent

"Everything was exceptional at Pier House. Breakfast by the water every morning great music and drinks from the bar, well maintained property and beach! Staff went out of their way and were very kimd. Our room with lanai was fantastic! Thank you Pier House!"

Douglas House - Adults Only

8/10 Good

"Loved staying at Douglas House, very nice property, and quiet. The room was nice, had great amenities, however the shower in the room I stayed in was rotting and rusted in all corners, and no water pressure at bathroom faucet. Hopefully maintenance can take care of the issue in shower and bathroom faucet."

Weatherstation Inn

10/10 Excellent

"Our stay was for two nights in October 2026. This is a beautiful property in a wonderful neighborhood, the Truman Annex section of Key West. The hotel is historic, quite classic, with property filled with tropical plantings, all well maintained. The staff was so friendly, professional, polite and very helpful. Our room was spotless and nicely appointed, with extra thoughtful touches...cozy terry robes, and slippers. Bathroom was lovely, large and cheery. Additional cotton blankets and beach towels were so nice to have on hand. The self-serve breakfast included an assortment of croissant pastries and doughnuts, yogurt, fresh fruit and of course coffee, including hot chocolate and various teas. So delicious! The pool area is charming. Bicycles for rent were just inside the gate. The location couldn't be better. Quiet yet so close to everything. We love staying at historic properties. The Weatherstation Inn did not disappoint! We will definitely be back again. One more thing! Parking is included on property."

Wicker Guesthouse

8/10 Good

"Nice property clean room and pool area good breakfast each morning great location"

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$5,435

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Douglas House - Adults Only

3. Artist House Key West

4. H2O Suites - Adults Only

5. Simonton Court Historic Inn & Cottages

6. Orchid Key Inn - Adults Only

7. Key West Villas

8. Alexander's Guesthouse - Adult Exclusive

9. The Marquesa Hotel

10. The Conch House Heritage Inn

11. Duval House

12. Island City House Hotel

13. Santa Maria Suites

14. Southernmost House - Adult Exclusive

15. Silver Palms Inn & Historic Homes

16. L'Habitation Guest House - Adults Only

17. Ella's Cottages - Key West Historic Inns

18. Coco Plum Inn

19. Westwinds Inn

20. Ambrosia Key West

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Paradise Inn Key West - Adults Only

The Southernmost Inn - Adults Only

Casa Marina Key West, Curio Collection by Hilton

Opal Key Resort & Marina, Key West

Tranquility Guest House

Pier House Resort & Spa

Douglas House - Adults Only

Weatherstation Inn

Wicker Guesthouse

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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