The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Teresa

NT$8,485

NT$9,545 total

includes taxes & fees

Oct 26 - Oct 27

A tropical outdoor area with palm trees, hanging plants, and string lights.

A large, two-story building with a balcony, surrounded by dense tropical foliage.

An outdoor patio with a table and chairs, surrounded by lush greenery and string lights.

A hotel room with a bed, a wooden floor, a seating area with a table and chairs, and a view of greenery outside.

2. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Maricela

NT$5,116

NT$6,332 total

includes taxes & fees

Nov 3 - Nov 4

A pool area with lounge chairs and a table, surrounded by palm trees.

A neon sign for Orchid Key Inn with a 'VACANCY' sign below it.

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

A building with a neon sign that reads "Orchid Key Inn."

3. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

ben

NT$8,013

NT$9,015 total

includes taxes & fees

Oct 26 - Oct 27

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A bedroom with a large bed, a television on a dresser, and a view of the outdoors through a sliding door.

A colonial-style building with a porch, surrounded by lush tropical vegetation.

A couple walking along a poolside pathway surrounded by lush greenery.

4. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Gisele

NT$8,741

NT$9,833 total

includes taxes & fees

Oct 27 - Oct 28

A modern interior with a staircase, a sofa set, a wooden table, and a television.

A pool area with a clear view of a house in the background, surrounded by palm trees and greenery.

A courtyard with two green lounge chairs, a palm tree, and a building with a white facade and lattice window design.

A spacious room with a large bed, a sofa, a chair, a small table, and a television.

5. Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

William

NT$5,494

NT$6,181 total

includes taxes & fees

Oct 25 - Oct 26

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

A pool area with lounge chairs and a wooden building with balconies.

A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.

A covered walkway with a wooden ceiling, white railings, and a brick path.

6. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Elise

NT$6,448

NT$7,254 total

includes taxes & fees

Oct 25 - Oct 26

A two-story house with a covered porch, a brick pathway, and a large tree.

A poolside area with a swimming pool, a staircase leading to a deck, and a building with multiple windows and balconies.

A hotel room with two beds, a ceiling fan, a large window with a view of palm trees, and a painting on the wall.

A restaurant with multiple tables set for dining, a wine bottle, and a glass of wine on the table.

7. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Josh

NT$13,946

NT$17,518 total

includes taxes & fees

Oct 26 - Oct 27

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A two-story building with a white picket fence, a mailbox, and a small tree in front.

A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

A lush garden with a variety of tropical plants and a paved walkway.

8. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Cathrine

NT$4,863

NT$6,172 total

includes taxes & fees

Oct 25 - Oct 26

A pool area with lounge chairs and palm trees.

A neatly made bed with patterned pillows, a bedside table with a bottle and glasses, and a window with orchids.

A sign for Santa Maria Resort surrounded by lush greenery and palm trees.

A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.

9. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Anthony

NT$9,720

NT$13,129 total

includes taxes & fees

Oct 26 - Oct 27

A reception area with a curved marble counter, ceiling fans, large windows, and a staircase.

A breakfast table with a variety of food items, including fruits, pastries, and a coffee mug.

A poolside area with lounge chairs and a clear blue pool surrounded by lush tropical vegetation.

A two-story house with a white exterior, a green roof, and a staircase leading to the upper floor.

10. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

Anthony

NT$5,266

NT$5,925 total

includes taxes & fees

Oct 25 - Oct 26

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.

A grand staircase with ornate railings and a chandelier.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

11. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Amy

NT$5,822

NT$10,664 total

includes taxes & fees

Oct 25 - Oct 26

A gated entrance with lush green foliage and a white picket fence.

A white colonial-style building with a balcony, surrounded by palm trees and a white picket fence.

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

A covered outdoor dining area with white chairs and tables, surrounded by lush greenery and a wooden deck.

12. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

August

NT$6,510

NT$7,324 total

includes taxes & fees

Oct 25 - Oct 26

A wooden deck with wicker furniture and a white railing, surrounded by lush tropical vegetation.

A swimming pool with a white picket fence, surrounded by lounge chairs and potted plants.

A two-story building with a white picket fence, palm trees, and a clear blue sky.

A pathway leading to a building with a white facade, surrounded by lush greenery and palm trees.

13. Weatherstation Inn

Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary

Robert

NT$8,420

NT$9,472 total

includes taxes & fees

Nov 11 - Nov 12

A green house with a white porch, a flag, and a sign advertising a property for sale.

A bedroom with a large bed, a sofa, a nightstand, and a painting on the wall.

A covered porch with wicker furniture, potted plants, and a view of the house.

A room with a ceiling fan, an air conditioning unit, a window with blinds, a sofa with patterned cushions, a small round table, and a floor lamp.

14. L'Habitation Guest House - Adults Only

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Richard

NT$5,530

NT$6,221 total

includes taxes & fees

Oct 28 - Oct 29

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

A cozy living room with a wooden ceiling, a sofa set, two side tables with lamps, and framed artwork on the wall.

A spacious living room with a high ceiling, a ceiling fan, a large painting, a sofa, a coffee table, and a dining area with a table and chairs.

A wicker outdoor seating area with two chairs and a table, surrounded by lush tropical foliage.

15. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

RICHARD

NT$7,072

NT$7,956 total

includes taxes & fees

Oct 26 - Oct 27

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

The exterior of the Silver Palms Inn with a two-story structure, a green awning over the entrance, and a palm tree to the right.

A two-story yellow house with a porch, white railings, and green shutters.

A hotel with a pool, bicycles, and lush greenery.

16. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

sam

NT$2,896

NT$5,453 total

includes taxes & fees

Oct 25 - Oct 26

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

A pool area with a circular pool, lounge chairs, and a gazebo.

A room with a bed, a desk, a chair, a lamp, a painting of a boat on water, and a view of the sea.

A yellow building with a door marked '7'.

17. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Brenda

NT$10,503

NT$11,817 total

includes taxes & fees

Oct 25 - Oct 26

A poolside area with lounge chairs, umbrellas, and a pergola.

A bright kitchen with white cabinetry, a white island, wicker pendant lights, and geometric patterned backsplash.

An open door leading to a pool area with a wicker chair and a sofa inside a room with a view of the pool.

A living room with a spiral staircase, a sofa, a chair, a coffee table, and a view of an outdoor seating area.

18. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Lisa and David

NT$8,127

NT$10,789 total

includes taxes & fees

Oct 25 - Oct 26

A covered porch with white railings, wooden benches, and a hanging light fixture.

A pool area with lounge chairs and a small palm tree.

A bedroom with a four-poster bed, a wicker chair, a wooden dresser, and a television.

A sign for Marrero's Guest Mansion in Key West, FL, by Verdigris Hotels.

19. Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Michael

NT$10,533

NT$11,849 total

includes taxes & fees

Oct 25 - Oct 26

A large, white, two-story building with a balcony and a sign reading "The Marker Resort."

A tropical setting with palm trees and a building with a white facade and dark roof.

A resort with a swimming pool, lounge chairs, umbrellas, and palm trees.

A covered outdoor area with a pool, palm trees, and lounge chairs.

20. The Marker Key West Harbor Resort

Historic Seaport, 1.3 km from Florida Keys National Marine Sanctuary

Dana Nicole

NT$6,121

NT$8,934 total

includes taxes & fees

Oct 25 - Oct 26

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,003 reviews	View
Douglas House - Adults Only	9.8 Exceptional 563 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,001 reviews	View
The Gardens Hotel	9.8 Exceptional 1,006 reviews	View
Simonton Court Historic Inn & Cottages	9.8 Exceptional 1,007 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Pier House Resort & Spa

10/10 Excellent

"Close to everything!!"

Weatherstation Inn

10/10 Excellent

"The location is amazing...quiet neighborhood and walkable to everything, Amazing Free parking is also so great in Key West..each room gets one free parking space and it is wonderful, We stayed three nights and did not move the car because we could walk everywhere. Close to Duval street, shopping, restaurants, and all of the attractions. Close to the museums too and the aquarium. Staff were fabulous, kind helpful and attentive. Lovely Room was clean and amenities are great. Very pretty room. They offer cold bottled water which is great in a tropical environment. I would highly recommend...if we come back to Key West, I will absolutely stay at the Weatherstation Inn. They do have a few breakfast items..yogurt and bakery items that are nice. They also offer bottled lemonade. Just an FYI for those with mobility issues: I do not believe they have an elevator, so if you are on the second floor, the steps are steep. And we hand carried our duffle bags up approximately 25-30 steps. The stairs are also outdoors. Thank you to the Weatherstation Inn...thank you for a great stay."

Douglas House - Adults Only

10/10 Excellent

"Our stay was amazing! Exceptional accommodations, great location and amazing staff! We loved how our room had space and a balcony. They offer coffee, tea and water (juices too) the pool area was amazing and tropical."

Opal Key Resort & Marina, Key West

10/10 Excellent

"We had no issues. Room clean, restaurant good!"

Duval House

10/10 Excellent

"Amazing location balcony was great to see gombay parade come by will be back"

Casa Marina Key West, Curio Collection by Hilton

8/10 Good

"Great location on the water"

The Cabana Inn Key West - Adults Only

8/10 Good

"Everything was pretty good except couldn’t get tv to work properly to watch playoffs. Would stay again close to everything"

Southwinds Motel

8/10 Good

"Tipsey Rooster out front is an EXCELLENT little outdoor bar....GREAT Music daily! Daytime Front Desk Ladies are Super sweet. Muffins are Amazing!"

Paradise Inn Key West - Adults Only

10/10 Excellent

"Fantastic property! Quiet, clean and close to everything. Wonderful pool area and the landscaping and grounds make you feel secluded."

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$5,453

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Douglas House - Adults Only

3. Orchid Key Inn - Adults Only

4. The Gardens Hotel

5. Simonton Court Historic Inn & Cottages

6. Island City House Hotel

7. The Marquesa Hotel

8. Duval House

9. Santa Maria Suites

10. Westwinds Inn

11. Southernmost House - Adult Exclusive

12. Coco Plum Inn

13. Weatherstation Inn

14. L'Habitation Guest House - Adults Only

15. Ambrosia Key West

16. Silver Palms Inn & Historic Homes

17. Alexander Palms Court

18. Ella's Cottages - Key West Historic Inns

19. Marrero's Guest Mansion

20. The Marker Key West Harbor Resort

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Pier House Resort & Spa

Weatherstation Inn

Douglas House - Adults Only

Opal Key Resort & Marina, Key West

Duval House

Casa Marina Key West, Curio Collection by Hilton

The Cabana Inn Key West - Adults Only

Southwinds Motel

Paradise Inn Key West - Adults Only

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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