The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

John

NT$5,925

NT$6,666 total

includes taxes & fees

Oct 5 - Oct 6

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A colonial-style building with a porch, surrounded by lush tropical vegetation.

A bar area with a counter, chairs, and a clock.

A bedroom with a large bed, a television on a dresser, and a view of the outdoors through a sliding door.

2. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Forrest

NT$8,943

NT$10,061 total

includes taxes & fees

Oct 6 - Oct 7

A porch with a white railing, a bench, and a flag.

A two-story white house with green shutters, a wooden door, and a white picket fence.

A spacious bedroom with a large bed, a sitting area with a sofa and armchairs, and a dining area with a table and chairs.

A pool area with lounge chairs and a dining table, surrounded by palm trees and a house with a porch.

3. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

John

NT$5,275

NT$5,935 total

includes taxes & fees

Oct 4 - Oct 5

A tropical outdoor area with palm trees, hanging plants, and string lights.

A wooden deck with lush greenery and a pool area.

An outdoor patio with a table and chairs, surrounded by lush greenery and string lights.

A hotel room with a bed, a wooden floor, a seating area with a table and chairs, and a view of greenery outside.

4. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

michael

NT$4,258

NT$5,269 total

includes taxes & fees

Oct 5 - Oct 6

A gated entrance to Villas Key West with a brick pathway leading to the gate.

A covered porch with wicker furniture, a large potted plant, and a sign for Villas Key West.

A covered entrance with a brick pathway leading to a gated area, surrounded by lush greenery and plants.

A swimming pool with a hot tub, surrounded by a wooden deck and lush greenery.

5. Key West Villas

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Margaret

NT$6,576

NT$7,398 total

includes taxes & fees

Oct 4 - Oct 5

A modern outdoor area with a pool, lounge chairs, and a bar area.

A modern hotel room with a bed, sofa, coffee table, and artwork.

A modern hotel with a prominent glass facade, palm trees, and a clear sky.

A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.

6. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Carmen

NT$9,844

NT$13,224 total

includes taxes & fees

Oct 4 - Oct 5

A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.

A spacious living room with a sofa, chairs, and a dining table. There are large windows with blinds, a door leading to a patio, and a ceiling with exposed beams.

A pool area with lounge chairs, a pool, and a building with a balcony and outdoor seating.

A spacious living room with a wooden ceiling, white sofas, a patterned armchair, a glass coffee table, and a large painting on the wall.

7. Alexander's Guesthouse - Adult Exclusive

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Nestor

NT$6,915

NT$9,091 total

includes taxes & fees

Oct 4 - Oct 5

A modern interior with a staircase, a sofa set, a wooden table, and a television.

A courtyard with two green lounge chairs, a palm tree, and a building with a white facade and lattice window design.

A spacious room with a large bed, a sofa, a chair, a small table, and a television.

A pool area with a clear view of a house in the background, surrounded by palm trees and greenery.

8. Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

William

NT$7,625

NT$8,578 total

includes taxes & fees

Oct 6 - Oct 7

A two-story house with a covered porch, a brick pathway, and a large tree.

A poolside area with a swimming pool, a staircase leading to a deck, and a building with multiple windows and balconies.

A restaurant with multiple tables set for dining, a wine bottle, and a glass of wine on the table.

A covered porch with white wicker furniture and a blue floor, surrounded by lush tropical plants.

9. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Darrell

NT$9,721

NT$12,728 total

includes taxes & fees

Oct 15 - Oct 16

A pool area with lounge chairs and a table, surrounded by palm trees.

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

A building with a neon sign that reads "Orchid Key Inn."

10. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Nicholas

NT$5,934

NT$6,676 total

includes taxes & fees

Oct 5 - Oct 6

A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.

A covered outdoor area with a wooden staircase, seating, and potted plants.

A row of blue bicycles parked under a tree, with a white fence and a building in the background.

A two-story building with a porch, a sign reading "The Grand Guesthouse," and a purple flag.

11. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Travis

NT$4,864

NT$6,270 total

includes taxes & fees

Oct 5 - Oct 6

A bedroom with a four-poster bed, a wooden desk, wicker chairs, and a view of the outdoors.

A cozy room with a wicker chair, a small table with a bottle and glasses, and a view of a yellow room through an open door.

A wooden door with glass panels, leading to an interior space with furniture and plants.

A pool area with lounge chairs and candles, surrounded by palm trees and a building in the background.

12. Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Natalie

NT$4,857

NT$6,261 total

includes taxes & fees

Oct 6 - Oct 7

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

A covered walkway with a wooden ceiling, white railings, and a brick path.

A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.

A garden with a pond, rocks, and various plants.

13. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Osvaldo

NT$5,935

NT$6,677 total

includes taxes & fees

Oct 4 - Oct 5

A room with a bed, a ceiling fan, and a window with blinds.

A room with a yellow armchair, a glass coffee table, and a view of a wooden deck and tropical plants.

A cozy outdoor seating area with a wooden bench and a table, surrounded by potted plants and a coffee and tea sign.

A spacious kitchen with wooden cabinets, a granite countertop, and a ceiling fan.

14. The Mermaid & Alligator

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

Adam

NT$8,040

NT$9,045 total

includes taxes & fees

Oct 5 - Oct 6

A pool area with lounge chairs and palm trees.

A modern outdoor seating area with a sofa, chairs, and a small table, surrounded by glass doors and a view of greenery.

A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.

A sign for Santa Maria Resort surrounded by lush greenery and palm trees.

15. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Anthony

NT$9,525

NT$12,866 total

includes taxes & fees

Oct 13 - Oct 14

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A two-story building with a white picket fence, a mailbox, and a small tree in front.

A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

A hallway with a white door, a wooden bench, a blue sofa, and a staircase with a white railing.

16. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Christopher

NT$3,440

NT$4,555 total

includes taxes & fees

Oct 5 - Oct 6

A gated entrance with lush green foliage and a white picket fence.

A covered outdoor dining area with white chairs and tables, surrounded by lush greenery and a wooden deck.

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

A hotel room with a large bed, two bedside tables, a ceiling fan, and two framed pictures on the wall.

17. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

Riley

NT$5,240

NT$5,895 total

includes taxes & fees

Oct 12 - Oct 13

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

A room with a bed, a desk, a chair, a lamp, a painting of a boat on water, and a view of the sea.

A yellow building with a door marked '7'.

A pool area with a covered seating area, palm trees, and a small pavilion.

18. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Andrew

NT$3,805

NT$4,280 total

includes taxes & fees

Oct 5 - Oct 6

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A grand staircase with ornate railings and a chandelier.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

A large, two-story house with a prominent tower and a covered porch.

19. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

yessy

NT$4,444

NT$9,038 total

includes taxes & fees

Oct 14 - Oct 15

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

A wicker outdoor seating area with two chairs and a table, surrounded by lush tropical foliage.

A hotel room with a bed, a nightstand, a chair, a small table, and a ceiling fan.

A spacious living room with a high ceiling, a ceiling fan, a large painting, a sofa, a coffee table, and a dining area with a table and chairs.

20. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Tricia

NT$5,145

NT$5,788 total

includes taxes & fees

Oct 11 - Oct 12

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,008 reviews	View
The Gardens Hotel	9.8 Exceptional 1,000 reviews	View
The Conch House Heritage Inn	9.8 Exceptional 190 reviews	View
Douglas House - Adults Only	9.6 Exceptional 542 reviews	View
Key West Villas	9.8 Exceptional 278 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Winslow's Bungalows - Key West Historic Inns

10/10 Excellent

"Had a great time!"

Southernmost Beach Resort and Guesthouses

10/10 Excellent

"We like it"

Weatherstation Inn

10/10 Excellent

"The home is a old classic style built in 1911. It is on the historical registry. It was a very unique special experience. Will do it again."

Duval House

10/10 Excellent

"Clean and quiet."

Tranquility Guest House

10/10 Excellent

"Cute place right with great location. The staff are also very responsive and helpful. The room is small but all we needed was a place to sleep and a bathroom."

Casa Marina Key West, Curio Collection by Hilton

10/10 Excellent

"Amazing place to stay for vacation."

The Southernmost Inn - Adults Only

8/10 Good

"Nice stay and location for the price"

The Cabana Inn Key West - Adults Only

10/10 Excellent

"Room was great breakfast was plentiful and staff great. Would definitely recommend and stay there again"

Southwinds Motel

10/10 Excellent

"Me and my fiancé had a great time"

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$4,280

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. The Gardens Hotel

3. The Conch House Heritage Inn

4. Douglas House - Adults Only

5. Key West Villas

6. H2O Suites - Adults Only

7. Alexander's Guesthouse - Adult Exclusive

8. Simonton Court Historic Inn & Cottages

9. The Marquesa Hotel

10. Orchid Key Inn - Adults Only

11. The Grand Guesthouse

12. Tropical Inn

13. Island City House Hotel

14. The Mermaid & Alligator

15. Santa Maria Suites

16. Duval House

17. Coco Plum Inn

18. Alexander Palms Court

19. Southernmost House - Adult Exclusive

20. Ambrosia Key West

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Winslow's Bungalows - Key West Historic Inns

Southernmost Beach Resort and Guesthouses

Weatherstation Inn

Duval House

Tranquility Guest House

Casa Marina Key West, Curio Collection by Hilton

The Southernmost Inn - Adults Only

The Cabana Inn Key West - Adults Only

Southwinds Motel

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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