The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

John

NT$5,624

NT$6,327 total

includes taxes & fees

Sep 13 - Sep 14

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A bedroom with a large bed, a television on a dresser, and a view of the outdoors through a sliding door.

A couple walking along a poolside pathway surrounded by lush greenery.

A colonial-style building with a porch, surrounded by lush tropical vegetation.

2. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Jason

NT$5,903

NT$6,641 total

includes taxes & fees

Sep 13 - Sep 14

A pool area with lounge chairs and a table, surrounded by palm trees.

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

A building with a neon sign that reads "Orchid Key Inn."

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

3. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Nicholas

NT$5,624

NT$6,327 total

includes taxes & fees

Sep 13 - Sep 14

A modern interior with a staircase, a sofa set, a wooden table, and a television.

A courtyard with two green lounge chairs, a palm tree, and a building with a white facade and lattice window design.

A spacious room with a large bed, a sofa, a chair, a small table, and a television.

A pool area with a clear view of a house in the background, surrounded by palm trees and greenery.

4. Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

Robin

NT$4,714

NT$5,304 total

includes taxes & fees

Sep 9 - Sep 10

A two-story house with a covered porch, a brick pathway, and a large tree.

A hotel room with two beds, a ceiling fan, a large window with a view of palm trees, and a painting on the wall.

A covered porch with white wicker furniture and a blue floor, surrounded by lush tropical plants.

A restaurant with multiple tables set for dining, a wine bottle, and a glass of wine on the table.

5. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

LISA

NT$6,981

NT$9,633 total

includes taxes & fees

Sep 27 - Sep 28

A covered porch with white railings, a ceiling fan, and a table with chairs.

A room with a wooden floor, a sofa with patterned cushions, a table, a chair, a lamp, and a window with blinds.

A tree with green foliage and red flowers.

A bedroom with a wooden headboard, a bed with white bedding, a blue patterned throw, and a view through a window with blinds.

6. The Porch on Frances Inn

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Corrynne

NT$3,670

NT$5,078 total

includes taxes & fees

Sep 13 - Sep 14

A modern outdoor area with a pool, lounge chairs, and a bar area.

A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.

A modern hotel with a prominent glass facade, palm trees, and a clear sky.

A modern hotel room with a bed, sofa, coffee table, and artwork.

7. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kourosh

NT$8,828

NT$12,067 total

includes taxes & fees

Sep 8 - Sep 9

A tropical outdoor area with palm trees, hanging plants, and string lights.

A hotel room with a bed, a wooden floor, a seating area with a table and chairs, and a view of greenery outside.

A large, two-story building with a balcony, surrounded by dense tropical foliage.

A wooden deck with lush greenery and a pool area.

8. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

michael

NT$3,729

NT$4,614 total

includes taxes & fees

Sep 8 - Sep 9

A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.

A spacious living room with a sofa, chairs, and a dining table. There are large windows with blinds, a door leading to a patio, and a ceiling with exposed beams.

A pool area with lounge chairs, a pool, and a building with a balcony and outdoor seating.

A narrow room with a bed, a potted plant, and a window with blinds.

9. Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Jaime

NT$3,104

NT$4,687 total

includes taxes & fees

Sep 8 - Sep 9

A porch with a white railing, a bench, and a flag.

A living room with a sofa, a glass coffee table, a TV, and a painting on the wall.

A pool area with lounge chairs and a dining table, surrounded by palm trees and a house with a porch.

A two-story white house with green shutters, a wooden door, and a white picket fence.

10. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

John

NT$6,758

NT$7,603 total

includes taxes & fees

Sep 20 - Sep 21

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

A hallway with a white door, a wooden bench, a blue sofa, and a staircase with a white railing.

A lush garden with a variety of tropical plants and a paved walkway.

11. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Robert

NT$3,132

NT$4,204 total

includes taxes & fees

Sep 8 - Sep 9

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

A garden with a pond, rocks, and various plants.

A pool area with lounge chairs and a wooden building with balconies.

A covered walkway with a wooden ceiling, white railings, and a brick path.

12. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

NT$4,865

NT$5,473 total

includes taxes & fees

Sep 8 - Sep 9

A bedroom with a four-poster bed, a wooden desk, wicker chairs, and a view of the outdoors.

A wooden door with glass panels, leading to an interior space with furniture and plants.

A breakfast buffet with a variety of fruits, pastries, and beverages on a wooden deck with a view of a lush garden and a pool.

A pool area with lounge chairs and candles, surrounded by palm trees and a building in the background.

13. Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Anthony

NT$4,816

NT$6,209 total

includes taxes & fees

Sep 8 - Sep 9

A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.

A two-story building with a porch, a sign reading "The Grand Guesthouse," and a purple flag.

A covered outdoor area with a wooden staircase, seating, and potted plants.

A row of blue bicycles parked under a tree, with a white fence and a building in the background.

14. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Alissa

NT$4,879

NT$6,280 total

includes taxes & fees

Sep 8 - Sep 9

A room with a bed, a ceiling fan, and a window with blinds.

A spacious kitchen with wooden cabinets, a granite countertop, and a ceiling fan.

A cozy outdoor seating area with a wooden bench and a table, surrounded by potted plants and a coffee and tea sign.

A poolside area with lounge chairs, a covered seating area, and a small pool.

15. The Mermaid & Alligator

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

Johnny

NT$5,695

NT$6,407 total

includes taxes & fees

Sep 14 - Sep 15

A pool area with lounge chairs and palm trees.

A sign for Santa Maria Resort surrounded by lush greenery and palm trees.

A hotel named "Santa Maria" with a prominent illuminated sign, a glass entrance, and a view of the ocean.

A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.

16. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

June Young

NT$8,828

NT$12,067 total

includes taxes & fees

Sep 8 - Sep 9

A reception area with a curved marble counter, ceiling fans, large windows, and a staircase.

A breakfast table with a variety of food items, including fruits, pastries, and a coffee mug.

A two-story house with a white exterior, a green roof, and a staircase leading to the upper floor.

A poolside area with lounge chairs and a clear blue pool surrounded by lush tropical vegetation.

17. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

John

NT$3,678

NT$4,138 total

includes taxes & fees

Sep 13 - Sep 14

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

A two-story yellow house with a porch, white railings, and green shutters.

The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.

A hotel with a pool, bicycles, and lush greenery.

18. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

Shawn

NT$2,534

NT$4,987 total

includes taxes & fees

Sep 8 - Sep 9

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.

A grand staircase with ornate railings and a chandelier.

19. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Mark

NT$4,407

NT$8,963 total

includes taxes & fees

Sep 21 - Sep 22

A gated entrance with lush green foliage and a white picket fence.

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

A white colonial-style building with a balcony, surrounded by palm trees and a white picket fence.

A hotel room with a large bed, two bedside tables, a ceiling fan, and two framed pictures on the wall.

20. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

Jake

NT$4,248

NT$4,779 total

includes taxes & fees

Sep 8 - Sep 9

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,012 reviews	View
The Gardens Hotel	9.8 Exceptional 1,004 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,008 reviews	View
Simonton Court Historic Inn & Cottages	9.8 Exceptional 1,005 reviews	View
The Marquesa Hotel	9.8 Exceptional 1,002 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Weatherstation Inn

10/10 Excellent

"Awesome spot"

The Reach Key West, Curio Collection by Hilton

10/10 Excellent

"It was great and convenient to all hot spots including the wedding venue we went for..awesome place to stay"

Pier House Resort & Spa

10/10 Excellent

"Beautiful and so convenient, right on the strip."

Heron House - Adult Only

10/10 Excellent

"Wonderful stay at Heron House! The staff was incredibly welcoming and even allowed me to check in two hours early. The location is fantastic and perfect for exploring Old Town. We had a thunderstorm and lost power for about an hour, but it didn’t take away from the experience at all. I’d definitely stay here again!"

Winslow's Bungalows - Key West Historic Inns

10/10 Excellent

"Beautiful property. Walking distance to Duval. Friendly helpful staff. Highly recommend!!"

Douglas House - Adults Only

10/10 Excellent

"First time In KW for me We arrived and got checked in fine After that we came and went as we pleased . Room was cleaned when we asked For it with no hitches Everything thing was great and we had a wonderful trip and will try and book again Good location right off Duval and the Rum House( best pina colada I’ve ever had ) and very quiet"

Hyatt Centric Key West Resort and Spa

10/10 Excellent

"Excellent place to stay it keys west"

Southwinds Motel

8/10 Good

"It was small and old fashioned, but it had an old Florida vibe that we loved. Everything we needed was there. The staff were very helpful."

Lighthouse Hotel - Key West Historic Inns

10/10 Excellent

"Loved the look and feel of the property, an oasis within Old Town. Walkable, near everything. Loved the ability to use the bikes, which we used constantly the whole time. Lovely grounds, pool, room, staff. I will be coming back to this property over and over again."

Other attractions near Florida Keys National Marine Sanctuary

A yellow exhibit labeled 'NOAA's AQUARIUS UNDERSEA LAB' with a circular window and a door.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

See properties

A brick corridor with arched ceilings and benches.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

See properties

A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

See properties

The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

See properties

Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

See properties

USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

See properties

Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its great live music.

See properties

We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

See properties

Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1494 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1494 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. The Gardens Hotel

3. Orchid Key Inn - Adults Only

4. Simonton Court Historic Inn & Cottages

5. The Marquesa Hotel

6. The Porch on Frances Inn

7. H2O Suites - Adults Only

8. Douglas House - Adults Only

9. Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

10. The Conch House Heritage Inn

11. Duval House

12. Island City House Hotel

13. Tropical Inn

14. The Grand Guesthouse

15. The Mermaid & Alligator

16. Santa Maria Suites

17. Westwinds Inn

18. Silver Palms Inn & Historic Homes

19. Southernmost House - Adult Exclusive

20. Coco Plum Inn

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Weatherstation Inn

The Reach Key West, Curio Collection by Hilton

Pier House Resort & Spa

Heron House - Adult Only

Winslow's Bungalows - Key West Historic Inns

Douglas House - Adults Only

Hyatt Centric Key West Resort and Spa

Southwinds Motel

Lighthouse Hotel - Key West Historic Inns

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

Explore a world of travel with Expedia