The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

John

NT$7,129

NT$8,020 total

includes taxes & fees

Oct 13 - Oct 14

A tropical outdoor area with palm trees, hanging plants, and string lights.

A wooden deck with lush greenery and a pool area.

A large, two-story building with a balcony, surrounded by dense tropical foliage.

A hotel room with a bed, a wooden floor, a seating area with a table and chairs, and a view of greenery outside.

2. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Maricela

NT$4,752

NT$5,881 total

includes taxes & fees

Oct 11 - Oct 12

A modern outdoor area with a pool, lounge chairs, and a bar area.

An outdoor seating area with a modern fire feature, surrounded by lush greenery and palm trees.

A modern hotel room with a bed, sofa, coffee table, and artwork.

A modern hotel with a prominent glass facade, palm trees, and a clear sky.

3. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Carmen

NT$10,141

NT$13,555 total

includes taxes & fees

Oct 12 - Oct 13

A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.

A narrow room with a bed, a potted plant, and a window with blinds.

A spacious living room with a sofa, chairs, and a dining table. There are large windows with blinds, a door leading to a patio, and a ceiling with exposed beams.

A spacious living room with a wooden ceiling, white sofas, a patterned armchair, a glass coffee table, and a large painting on the wall.

4. Alexander's Guesthouse - Adult Exclusive

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Nestor

NT$6,175

NT$8,234 total

includes taxes & fees

Oct 11 - Oct 12

A pool area with lounge chairs and a table, surrounded by palm trees.

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

A neon sign for Orchid Key Inn with a 'VACANCY' sign below it.

5. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Nicholas

NT$6,508

NT$7,321 total

includes taxes & fees

Oct 13 - Oct 14

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A couple walking along a poolside pathway surrounded by lush greenery.

A bar area with a counter, chairs, and a clock.

A colonial-style building with a porch, surrounded by lush tropical vegetation.

6. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Forrest

NT$8,911

NT$10,025 total

includes taxes & fees

Oct 14 - Oct 15

A two-story house with a covered porch, a brick pathway, and a large tree.

A hotel room with two beds, a ceiling fan, a large window with a view of palm trees, and a painting on the wall.

A covered porch with white wicker furniture and a blue floor, surrounded by lush tropical plants.

A restaurant with multiple tables set for dining, a wine bottle, and a glass of wine on the table.

7. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Darrell

NT$10,777

NT$13,913 total

includes taxes & fees

Oct 12 - Oct 13

A pool area with lounge chairs and palm trees.

A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.

A modern outdoor seating area with a sofa, chairs, and a small table, surrounded by glass doors and a view of greenery.

A sign for Santa Maria Resort surrounded by lush greenery and palm trees.

8. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Anthony

NT$9,823

NT$13,197 total

includes taxes & fees

Oct 25 - Oct 26

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A two-story building with a white picket fence, a mailbox, and a small tree in front.

A lush garden with a variety of tropical plants and a paved walkway.

A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

9. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Christopher

NT$6,009

NT$7,443 total

includes taxes & fees

Oct 14 - Oct 15

A gated entrance with lush green foliage and a white picket fence.

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

A white colonial-style building with a balcony, surrounded by palm trees and a white picket fence.

A covered outdoor dining area with white chairs and tables, surrounded by lush greenery and a wooden deck.

10. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

Riley

NT$4,506

NT$5,070 total

includes taxes & fees

Oct 12 - Oct 13

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

A yellow building with a door marked '7'.

A garden with a stone pathway, a wooden fence, and various tropical plants.

A pool area with a circular pool, lounge chairs, and a gazebo.

11. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Andrew

NT$4,506

NT$5,070 total

includes taxes & fees

Oct 11 - Oct 12

A green house with a white porch, a flag, and a sign advertising a property for sale.

A room with a ceiling fan, an air conditioning unit, a window with blinds, a sofa with patterned cushions, a small round table, and a floor lamp.

A bathroom with a vanity, a mirror, and a window with blinds.

A covered porch with wicker furniture, potted plants, and a view of the house.

12. L'Habitation Guest House - Adults Only

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Richard

NT$5,122

NT$5,762 total

includes taxes & fees

Oct 26 - Oct 27

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

A wicker outdoor seating area with two chairs and a table, surrounded by lush tropical foliage.

A spacious living room with a high ceiling, a ceiling fan, a large painting, a sofa, a coffee table, and a dining area with a table and chairs.

A hotel room with a bed, a nightstand, a chair, a small table, and a ceiling fan.

13. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Tricia

NT$4,649

NT$5,231 total

includes taxes & fees

Oct 11 - Oct 12

A building with a white exterior, a large red awning, and a gated entrance.

A small, enclosed porch with a chair and a table, surrounded by lush greenery and a white lattice fence.

A pool area with lounge chairs and a lifebuoy.

A spacious kitchen with a dining area, large windows, and a view of the outdoors.

14. Authors of Key West Guest House

The Meadows, 1.8 km from Florida Keys National Marine Sanctuary

Robbie

NT$2,837

NT$3,192 total

includes taxes & fees

Oct 12 - Oct 13

A hotel with a covered entrance, multiple balconies, and palm trees.

A waterfront hotel with multiple balconies, a dock, and boats.

A covered balcony with white Adirondack chairs and a small table with flowers, overlooking a turquoise sea and distant shoreline.

A restaurant interior with wooden beams, a bar area, and a colorful ceiling mural.

15. Opal Key Resort & Marina, Key West

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Susan

NT$8,234

NT$10,515 total

includes taxes & fees

Oct 11 - Oct 12

A bright green porch with hanging planters, a wooden chair, and a railing.

A brightly colored Caribbean house with a balcony, a sign indicating it's for rent, and bicycles parked outside.

A marina with multiple boats docked, wooden pilings, and a dock with ropes.

16. Caribbean House

Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary

Kelsie

NT$3,781

NT$5,049 total

includes taxes & fees

Oct 11 - Oct 12

A spacious room with a wooden floor, white furniture, and large windows.

A covered outdoor area with a table and chairs, surrounded by white railings and green foliage.

A paved pathway surrounded by lush greenery and palm trees.

A white building with a covered porch, potted plants, and a white picket fence.

17. Paradise Inn Key West - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Mary

NT$4,485

NT$6,627 total

includes taxes & fees

Oct 15 - Oct 16

A large, white, two-story building with a balcony and a sign reading "The Marker Resort."

A marina with various boats docked, including a green and white boat named 'Jolly Roger'.

A resort with a swimming pool, lounge chairs, umbrellas, and palm trees.

A tropical setting with palm trees and a building with a white facade and dark roof.

18. The Marker Key West Harbor Resort

Historic Seaport, 1.3 km from Florida Keys National Marine Sanctuary

Keith

NT$6,431

NT$9,238 total

includes taxes & fees

Oct 26 - Oct 27

A wooden deck with wicker furniture, a white staircase, and a lush garden area.

A two-story house with a balcony, surrounded by palm trees and a clear blue sky.

A hotel room with a large bed, a view of a swimming pool, and a balcony with outdoor seating.

A bedroom with a large bed, a view of a swimming pool, and an open door leading to an outdoor seating area.

19. Heron House - Adult Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Amanda

NT$3,829

NT$5,369 total

includes taxes & fees

Oct 11 - Oct 12

A pool area with lounge chairs and a cabana.

A hotel room with a bed, a sofa, a desk with a computer, a chair, and a view of the sea through large windows.

A dining area with a glass table, clear glass bottles, a bowl of fruit, and a wicker chair.

A balcony with a table set for breakfast, overlooking the sea.

20. Ocean Key Resort - A Noble House Resort

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Patrick

NT$9,971

NT$13,793 total

includes taxes & fees

Oct 26 - Oct 27

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,005 reviews	View
Douglas House - Adults Only	9.8 Exceptional 550 reviews	View
H2O Suites - Adults Only	9.8 Exceptional 664 reviews	View
Alexander's Guesthouse - Adult Exclusive	9.8 Exceptional 171 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,004 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Duval House

10/10 Excellent

"Fun place to stay!! Very nice staff."

The Cabana Inn Key West - Adults Only

10/10 Excellent

"Our room was spacious and clean. We loved the uniqueness of the hotel and the proximity to all the bars and restaurants on Duvall street."

Opal Key Resort & Marina, Key West

10/10 Excellent

"Overall, nice stay. Some of the rooms and hotel areas are showing some age, but the property appeared to be very clean. The location of the hotel is fantastic. Within walking distance of all that Duvall St. has to offer and a great coffee shop very close by. The hotel restaurant was fantastic and the room pricing is very reasonable. I would definitely stay at this property again."

Winslow's Bungalows - Key West Historic Inns

10/10 Excellent

"We always love staying here"

Casa Marina Key West, Curio Collection by Hilton

10/10 Excellent

"I did hear roosters, but that's part of the charm of Key West. There was occasional chicken poop on the floors outside, so that's why I gave a 4 for cleanliness, but they do seem to clean it up fairly quickly. Overall I loved the stay. I will go again."

Paradise Inn Key West - Adults Only

10/10 Excellent

"The staff were friendly and helpful."

Douglas House - Adults Only

10/10 Excellent

"It’s like a little private oasis once you’re inside. Super relaxing yet close to everything."

Southwinds Motel

10/10 Excellent

"Be prepared to pay for parking onsite,thought it was included."

Lighthouse Hotel - Key West Historic Inns

10/10 Excellent

"Nice hotel Clean rooms Cute pool and bar area Would stay again"

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$3,192

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Douglas House - Adults Only

3. H2O Suites - Adults Only

4. Alexander's Guesthouse - Adult Exclusive

5. Orchid Key Inn - Adults Only

6. The Gardens Hotel

7. The Marquesa Hotel

8. Santa Maria Suites

9. Duval House

10. Coco Plum Inn

11. Alexander Palms Court

12. L'Habitation Guest House - Adults Only

13. Ambrosia Key West

14. Authors of Key West Guest House

15. Opal Key Resort & Marina, Key West

16. Caribbean House

17. Paradise Inn Key West - Adults Only

18. The Marker Key West Harbor Resort

19. Heron House - Adult Only

20. Ocean Key Resort - A Noble House Resort

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Duval House

The Cabana Inn Key West - Adults Only

Opal Key Resort & Marina, Key West

Winslow's Bungalows - Key West Historic Inns

Casa Marina Key West, Curio Collection by Hilton

Paradise Inn Key West - Adults Only

Douglas House - Adults Only

Southwinds Motel

Lighthouse Hotel - Key West Historic Inns

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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