The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Teresa

NT$11,934 total

includes taxes & fees

Nov 30 - Dec 1

A tropical outdoor area with palm trees, hanging plants, and string lights.

2. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Maricela

NT$9,208 total

includes taxes & fees

Nov 17 - Nov 18

A covered entrance with a brick pathway leading to a gated area, surrounded by lush greenery and plants.

3. Key West Villas

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Margaret

NT$9,940 total

includes taxes & fees

Nov 18 - Nov 19

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

4. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Misty

NT$9,931 total

includes taxes & fees

Nov 18 - Nov 19

A pool area with lounge chairs and a table, surrounded by palm trees.

5. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

ben

NT$11,934 total

includes taxes & fees

Nov 30 - Dec 1

An outdoor seating area with a modern fire feature, surrounded by lush greenery and palm trees.

6. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kimberly

NT$15,476 total

includes taxes & fees

Nov 30 - Dec 1

A porch with a white railing, a bench, and a flag.

7. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

Jennifer

NT$12,322 total

includes taxes & fees

Nov 24 - Nov 25

A two-story house with a covered porch, a brick pathway, and a large tree.

8. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Josh

NT$16,871 total

includes taxes & fees

Nov 29 - Nov 30

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

9. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Elise

NT$7,411 total

includes taxes & fees

Dec 2 - Dec 3

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

10. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Dennis

NT$7,281 total

includes taxes & fees

Nov 18 - Nov 19

A pool area with lounge chairs and palm trees.

11. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Anthony

NT$16,215 total

includes taxes & fees

Dec 2 - Dec 3

A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.

12. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Justyn

NT$8,001 total

includes taxes & fees

Dec 3 - Dec 4

A green house with a white porch, a flag, and a sign advertising a property for sale.

13. L'Habitation Guest House - Adults Only

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Callie

NT$6,283 total

includes taxes & fees

Dec 1 - Dec 2

A poolside area with lounge chairs, umbrellas, and a pergola.

14. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Lisa and David

NT$10,887 total

includes taxes & fees

Nov 17 - Nov 18

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

15. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Brenda

NT$7,320 total

includes taxes & fees

Dec 1 - Dec 2

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

16. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

August

NT$9,782 total

includes taxes & fees

Nov 16 - Nov 17

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

17. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

daniela

NT$9,127 total

includes taxes & fees

Nov 30 - Dec 1

A poolside area with lounge chairs and a clear blue pool surrounded by lush tropical vegetation.

18. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

Shari

NT$7,978 total

includes taxes & fees

Nov 30 - Dec 1

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

19. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

Carleen

NT$7,828 total

includes taxes & fees

Dec 1 - Dec 2

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

20. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Janet

NT$9,300 total

includes taxes & fees

Nov 8 - Nov 9

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	3.5 star property	10.0 Exceptional 1,002 reviews	View
Douglas House - Adults Only	3.5 star property	9.8 Exceptional 582 reviews	View
Key West Villas	3.5 star property	9.8 Exceptional 279 reviews	View
The Gardens Hotel	4.0 star property	9.8 Exceptional 1,000 reviews	View
Orchid Key Inn - Adults Only	3.5 star property	9.8 Exceptional 1,001 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Winslow's Bungalows - Key West Historic Inns

10/10 Excellent

"Reception girl Sonja was excellent and extremely helpful and courteous"

Douglas House - Adults Only

10/10 Excellent

"We absolutely loved our stay at Douglas House in Key West! The property was wonderful, but what truly made our experience unforgettable was the gentleman at the front desk. I wish I could remember his name because he deserves some recognition! He was incredibly friendly, welcoming, informative, and had such a great personality. He went above and beyond to make us feel at home and made our stay that much more enjoyable. We enjoyed our experience so much that we actually extended our stay by an extra night! That speaks volumes about how much we loved this place. I cannot recommend Douglas House highly enough! If you’re planning a trip to Key West, do yourself a favor and book your stay here. Between the atmosphere, the experience, and the outstanding hospitality, you won’t be disappointed. We will absolutely be back!"

The Cabana Inn Key West - Adults Only

10/10 Excellent

"Great location and friendly staff. Room size varies greatly at this inn so be sure to you understand which accommodations you are booking. The pool, hot tub and room were clean and the breakfast offerings are good. We arrived after hours to check in but called the number indicated and got our room key without issue. This is our second stay, look forward to our next one. PS, if rooster crowing at 3 am is an issue for you, bring ear plugs."

Tranquility Guest House

10/10 Excellent

"While check in was a little confusing, everything after that was fantastic. Room was great, spacious, and clean. The location is fabulous. A short walk to the center of Duval st, giving easy access to everything you'd want to do. The staff was super friendly. I needed to let someone know the battery was low on our lock and it was immediately handled, with a very friendly follow up call to make sure everything was all set and if we needed anything. Also nice 2nd floor porch, great for a morning coffee or evening night cap. Would definitely stay at this location again."

Caribbean House

10/10 Excellent

"Check-in was super easy. The location was excellent. I got Lucky and was able to find parking nearby, but having the option to purchase a parking spot is super helpful. The room was small, but I didn’t spend much time there, so it didn’t really matter. The property owners did everything possible to make that small room everything I needed. The shower is very small. I’m short, so it didn’t bother me. But if you are big and tall, I would consider another room or another hotel. Thank you I would definitely book a room here again if I’m ever in Key West."

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$6,283

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Douglas House - Adults Only

3. Key West Villas

4. The Gardens Hotel

5. Orchid Key Inn - Adults Only

6. H2O Suites - Adults Only

7. The Conch House Heritage Inn

8. The Marquesa Hotel

9. Island City House Hotel

10. Duval House

11. Santa Maria Suites

12. The Grand Guesthouse

13. L'Habitation Guest House - Adults Only

14. Ella's Cottages - Key West Historic Inns

15. Alexander Palms Court

16. Coco Plum Inn

17. Ambrosia Key West

18. Westwinds Inn

19. Silver Palms Inn & Historic Homes

20. Southernmost House - Adult Exclusive

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Winslow's Bungalows - Key West Historic Inns

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Frequently asked questions

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