The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Michelle

NT$5,543

NT$6,236 total

includes taxes & fees

Aug 23 - Aug 24

2. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Nicholas

NT$6,069

NT$6,828 total

includes taxes & fees

Aug 25 - Aug 26

Deluxe Suite, 1 King Bed, Private Pool | View from room

3. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Shermeka

NT$8,889

NT$12,150 total

includes taxes & fees

Sep 8 - Sep 9

Superior Studio Suite, 1 King Bed with Sofa bed, Accessible, Refrigerator & Microwave

Premier Suite, 1 King Bed with Sofa bed, Patio, Garden Area (Room 16) | Living area

4. Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Jaime

NT$4,859

NT$6,721 total

includes taxes & fees

Aug 23 - Aug 24

Duval Duplex 2 bedrooms 25 ft Balcony (Adults Only) | Living area

5. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Melissa

NT$3,258

NT$4,352 total

includes taxes & fees

Aug 31 - Sep 1

6. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Travis

NT$4,324

NT$5,663 total

includes taxes & fees

Aug 23 - Aug 24

7. Paradise Inn Key West - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Jaime

NT$3,205

NT$5,039 total

includes taxes & fees

Sep 2 - Sep 3

8. Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Michael

NT$6,977

NT$7,849 total

includes taxes & fees

Aug 31 - Sep 1

9. Opal Key Resort & Marina, Key West

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Melissa

NT$8,251

NT$10,538 total

includes taxes & fees

Sep 9 - Sep 10

10. Caribbean House

Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary

William

NT$3,899

NT$5,182 total

includes taxes & fees

Aug 27 - Aug 28

11. The Garden House

Historic Seaport, 1.1 km from Florida Keys National Marine Sanctuary

Pamela

NT$2,842

NT$3,885 total

includes taxes & fees

Aug 23 - Aug 24

12. Ocean Key Resort - A Noble House Resort

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Debbie

NT$7,014

NT$10,364 total

includes taxes & fees

Sep 9 - Sep 10

13. The Key West Hotel

Historic Seaport, 0.9 km from Florida Keys National Marine Sanctuary

Preston

NT$9,494

NT$13,011 total

includes taxes & fees

Aug 23 - Aug 24

14. Eden House

Historic Seaport, 1.6 km from Florida Keys National Marine Sanctuary

David

NT$3,432

NT$4,324 total

includes taxes & fees

Aug 23 - Aug 24

15. Seascape Tropical Inn - Adult Exclusive

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Donna

NT$2,953

NT$4,935 total

includes taxes & fees

Aug 23 - Aug 24

16. The Palms Hotel

The Meadows, 1.7 km from Florida Keys National Marine Sanctuary

Marcus

NT$4,097

NT$5,326 total

includes taxes & fees

Sep 9 - Sep 10

Premium Room, 1 King Bed, Ocean View | Terrace/patio

17. Hyatt Centric Key West Resort and Spa

Historic Seaport, 1.3 km from Florida Keys National Marine Sanctuary

Audra

NT$6,356

NT$9,378 total

includes taxes & fees

Sep 7 - Sep 8

18. The Independent Inn - Formerly Heron House Court

Historic Seaport, 1.6 km from Florida Keys National Marine Sanctuary

Kelly

NT$2,567

NT$3,921 total

includes taxes & fees

Aug 23 - Aug 24

Penthouse, 1 King Bed, Corner (View) | View from room

19. La Concha Key West, Autograph Collection

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Neil

NT$5,671

NT$7,455 total

includes taxes & fees

Sep 9 - Sep 10

20. The Saint Hotel Key West, Autograph Collection, Adult Only

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

R Frederick

NT$5,671

NT$6,380 total

includes taxes & fees

Aug 31 - Sep 1

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,020 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,017 reviews	View
H2O Suites - Adults Only	9.8 Exceptional 642 reviews	View
Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly	9.8 Exceptional 158 reviews	View
Duval House	9.6 Exceptional 1,091 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Heron House - Adult Only

10/10 Excellent

"Very nice place, friendly staff, great location."

Pier House Resort & Spa

8/10 Good

"This place was great! The rooms are dated and don't have smart TVs, so you can't catch up on anything streaming at night, but the private beach and pool area make up for it! Everyone was very nice. I'll say we brought our 7 year old and he was one of maybe 5 children there so it's not very child friendly but he had a great time."

Duval House

10/10 Excellent

"Fantastic location with parking. The property is like no other on Duval."

Southwinds Motel

10/10 Excellent

"This was day 16 of a US road trip and this was BY FAR my favorite stay. 1 block away from Duval St. Free drink tickets. Great bed and pillows. Microwave, fridge. Everything was GREAT! Only downside was we went to bed at 10 and the nearby bar was still playing loud live music, however the loud AC unit drowned it out lol. Ice machine could use something to make it look cleaner/better, but still produced ice just fine. Breakfast was pretty much entirely bread/muffins/cereal/bagels. Parking was not free, which is also a bummer. But being so close to everything we wanted made up for it."

The Reach Key West, Curio Collection by Hilton

10/10 Excellent

"Best customer service I ever had at a hotel. They have someone you can text for any needs and they answer right away. Rooms were nice only complaint about the room was the shower seemed to use to have a sliding glass door but it must of broke because they had a shower curtain there instead. Great other than that tho"

Orchid Key Inn - Adults Only

10/10 Excellent

"Excellent, free breakfast great atmosphere friendly staff, smaller motel not so busy. I like it be back."

Tranquility Guest House

10/10 Excellent

"We had a great stay. If you're looking for a quiet place of of Duval, I highly recommend this place. It's not a fancy place but the rooms are clean, the beds are comfortable and the pool is lovely. The location is fantastic! Walking distance to several nice restaurants and bars. Stores nearby. The hosts communicate very well. Anything we needed, they were on it right away with a text and let us know when to expect them. We will be booking here for our future stays."

Opal Key Resort & Marina, Key West

10/10 Excellent

"This hotel was really truly excellent. We thoroughly enjoyed our stay."

Weatherstation Inn

10/10 Excellent

"Nice place"

Other attractions near Florida Keys National Marine Sanctuary

A yellow exhibit labeled 'NOAA's AQUARIUS UNDERSEA LAB' with a circular window and a door.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A brick corridor with arched ceilings and benches.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the beautiful beaches or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its great live music.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its great live music.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1492 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1492 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Key West Historic Seaport are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$3,885

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Orchid Key Inn - Adults Only

3. H2O Suites - Adults Only

4. Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

5. Duval House

6. The Grand Guesthouse

7. Paradise Inn Key West - Adults Only

8. Marrero's Guest Mansion

9. Opal Key Resort & Marina, Key West

10. Caribbean House

11. The Garden House

12. Ocean Key Resort - A Noble House Resort

13. The Key West Hotel

14. Eden House

15. Seascape Tropical Inn - Adult Exclusive

16. The Palms Hotel

17. Hyatt Centric Key West Resort and Spa

18. The Independent Inn - Formerly Heron House Court

19. La Concha Key West, Autograph Collection

20. The Saint Hotel Key West, Autograph Collection, Adult Only

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Heron House - Adult Only

Pier House Resort & Spa

Duval House

Southwinds Motel

The Reach Key West, Curio Collection by Hilton

Orchid Key Inn - Adults Only

Tranquility Guest House

Opal Key Resort & Marina, Key West

Weatherstation Inn

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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