The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Teresa

NT$8,007

NT$9,008 total

includes taxes & fees

Oct 25 - Oct 26

A rooftop pool area with lounge chairs and palm trees.

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

A pool area with lounge chairs and a table, surrounded by palm trees.

A building with a neon sign that reads "Orchid Key Inn."

2. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

ben

NT$8,251

NT$9,283 total

includes taxes & fees

Oct 25 - Oct 26

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A lush garden with a variety of tropical plants and a paved walkway.

A two-story building with a white picket fence, a mailbox, and a small tree in front.

A hallway with a white door, a wooden bench, a blue sofa, and a staircase with a white railing.

3. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Cathrine

NT$4,166

NT$5,387 total

includes taxes & fees

Oct 25 - Oct 26

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A large, two-story house with a prominent tower and a covered porch.

A grand staircase with ornate railings and a chandelier.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

4. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Janet

NT$5,808

NT$10,638 total

includes taxes & fees

Oct 25 - Oct 26

A green house with a white porch, a flag, and a sign advertising a property for sale.

A bathroom with a vanity, a mirror, and a window with blinds.

A bedroom with a large bed, a sofa, a nightstand, and a painting on the wall.

A room with a ceiling fan, an air conditioning unit, a window with blinds, a sofa with patterned cushions, a small round table, and a floor lamp.

5. L'Habitation Guest House - Adults Only

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Richard

NT$4,625

NT$5,204 total

includes taxes & fees

Oct 27 - Oct 28

A poolside area with lounge chairs, umbrellas, and a pergola.

An open door leading to a pool area with a wicker chair and a sofa inside a room with a view of the pool.

A bright kitchen with white cabinetry, a white island, wicker pendant lights, and geometric patterned backsplash.

A living room with a spiral staircase, a sofa, a chair, a coffee table, and a view of an outdoor seating area.

6. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Lisa and David

NT$6,510

NT$8,971 total

includes taxes & fees

Oct 26 - Oct 27

A two-story building with a white picket fence, palm trees, and a sign that reads 'DUVAL GARDENS.'

A porch with wicker chairs and a table, white railings, and a window with a view of a palm tree.

7. Duval Gardens - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

JoAnn

NT$4,951

NT$7,767 total

includes taxes & fees

Oct 25 - Oct 26

A pool area with a brick patio, potted plants, and a covered seating area.

A view through a glass door with a metal handle, leading to a white fence and a blue car parked outside.

A white picket fence, a palm tree, and a sign reading "Garden House Key West".

A house with a porch, a sign reading "Garden House," and a number "329" on the door.

8. The Garden House

Historic Seaport, 1.1 km from Florida Keys National Marine Sanctuary

Brad

NT$3,515

NT$4,655 total

includes taxes & fees

Oct 25 - Oct 26

A covered porch with wicker furniture, potted plants, and a sign for the "Office" at the Palm Hotel.

A compact kitchen with white cabinets, a microwave, and a small dining area with two wicker chairs.

A pink building with a white door, a balcony with a white railing, and a view of a pool area.

A row of bicycles parked in front of a building with a white balcony and a palm tree.

9. The Palms Hotel

The Meadows, 1.7 km from Florida Keys National Marine Sanctuary

Jerry

NT$5,066

NT$6,431 total

includes taxes & fees

Oct 25 - Oct 26

A swimming pool with clear water, surrounded by lush greenery and palm trees.

A bedroom with a bed, a ceiling fan, a TV, and a blue door.

A yellow building with a blue door and shutters, a number '302' on the wall, and a small porch area.

A covered porch with white columns and wicker furniture.

10. Tranquility Guest House

Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary

Sandra

NT$3,911

NT$7,282 total

includes taxes & fees

Oct 25 - Oct 26

A bedroom with a bed, bedside table, lamp, and a small kitchenette. There is a balcony with wicker chairs and a glass table.

A spacious living area with a gray sofa, wooden staircase, and a kitchen in the background.

A cozy cabin with a wooden interior, a bed, a TV, and a kitchenette.

A pool area with lounge chairs and umbrellas, surrounded by buildings with balconies and a clear blue sky.

11. Eden House

Historic Seaport, 1.6 km from Florida Keys National Marine Sanctuary

Michelle

NT$4,968

NT$6,259 total

includes taxes & fees

Oct 27 - Oct 28

A white building with a grey roof, surrounded by potted plants and a blue umbrella.

A patio with sun loungers, a table with an umbrella, and potted plants.

A spacious kitchen with wooden cabinets and a dining area with a round table and chairs.

A breakfast setup with wine bottles, fruits, and pastries on a tray by a door with a view of a staircase and greenery.

12. The Cabana Inn Key West - Adults Only

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Donna

NT$5,244

NT$7,363 total

includes taxes & fees

Oct 25 - Oct 26

A deck with sun loungers and a railing overlooking the sea.

A beachside hotel with rows of blue lounge chairs and white umbrellas, palm trees, and a clear blue sky.

A beach scene with two people relaxing under a white umbrella, a palm tree, and a clear blue sky.

A poolside area with lounge chairs and umbrellas, palm trees, and a view of the sea.

13. Southernmost Beach Resort and Guesthouses

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Jacob Stuart

NT$3,851

NT$6,822 total

includes taxes & fees

Oct 25 - Oct 26

A beach with a wooden pier, palm trees, and beach umbrellas.

An outdoor dining area with tables and chairs, overlooking the ocean.

A resort with a pool, lounge chairs, umbrellas, palm trees, and a view of the ocean.

A modern bar area with a central island, white bar stools, and a view of the ocean.

14. The Reach Key West, Curio Collection by Hilton

Uptown - Upper Duval, 1.4 km from Florida Keys National Marine Sanctuary

Brett

NT$5,826

NT$8,752 total

includes taxes & fees

Oct 26 - Oct 27

A wooden deck with wicker furniture and a glass balustrade overlooking a beach.

A beachside spa with two massage tables under a canopy, overlooking the sea and a pier.

A resort with a pool leading to a beach, surrounded by palm trees and white buildings.

A spacious lobby with green sofas, a coffee table, and a dining area.

15. Casa Marina Key West, Curio Collection by Hilton

Casa Marina, 1.8 km from Florida Keys National Marine Sanctuary

Jaime

NT$7,996

NT$11,192 total

includes taxes & fees

Nov 1 - Nov 2

A poolside area with lounge chairs, a staircase leading to a balcony, and a pool.

A dining area with round tables and wicker chairs, a ceiling fan, and a bar area in the background.

A Southernmost Inn with a porch, a sign indicating vacancy, and a staircase leading to the entrance.

A beige sofa with two pillows, flanked by two wooden side tables with lamps and potted plants, against a white wall with a framed picture of a tree.

16. The Southernmost Inn - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Craig

NT$3,548

NT$5,456 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a bed, bedside table, lamp, and a view of the bathroom and kitchen.

A living room with a sofa and a dining area with a table and chairs.

A room with a wooden floor, a white door with horizontal slats, a wooden wall, and a small shelf with a black object.

A motel sign, parked bicycles, and a building with a covered porch.

17. Seashell Motel

Casa Marina, 1.5 km from Florida Keys National Marine Sanctuary

Yuliya

NT$4,422

NT$4,974 total

includes taxes & fees

Oct 25 - Oct 26

A two-story Victorian-style house with a prominent tower, a balcony, and a front porch.

A wooden deck with lounge chairs and a small pool, surrounded by lush greenery and a brick building.

A staircase with wooden balusters and a white console table with two lamps and decorative items.

A modern living room with teal walls, a marble countertop, and blue upholstered sofas.

18. Grand Maloney Hotel

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

James

NT$6,796

NT$13,220 total

includes taxes & fees

Oct 27 - Oct 28

A pool area with lounge chairs and palm trees, overlooking the ocean.

A bedroom with a bed, desk, chair, ceiling fan, and a view of the outdoors through a sliding door.

A beachfront hotel with multiple buildings, palm trees, and a clear view of the ocean.

19. Coconut Beach Resort Timeshare

Casa Marina, 1.5 km from Florida Keys National Marine Sanctuary

Wayne

NT$49,604

NT$55,805 total

includes taxes & fees

Oct 26 - Oct 27

A modern kitchen with white cabinets, stainless steel appliances, and a wooden door.

A modern kitchen with white cabinets, a stainless steel refrigerator, and a dishwasher.

A two-story house with a porch, surrounded by a green fence and dense foliage.

A narrow brick pathway leading to a gated entrance with a sign reading "533 Caroline The Bartlum".

20. The Bartlum Luxury Studio In Prime Location

Historic Seaport, 1.1 km from Florida Keys National Marine Sanctuary

NT$9,598

NT$18,385 total

includes taxes & fees

Oct 27 - Oct 28

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,005 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,003 reviews	View
Duval House	9.6 Exceptional 1,125 reviews	View
Southernmost House - Adult Exclusive	9.4 Exceptional 1,001 reviews	View
L'Habitation Guest House - Adults Only	9.4 Exceptional 1,000 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Paradise Inn Key West - Adults Only

8/10 Good

"The property was clean . The rooms were nice but unfortunately did not have dressers only a closet so it made unpacking our clothes difficult. The pool was nice. They did have music playing but it was same sound track on repeat every day and when we asked the staff members to switch it, they said they couldn’t. Location is perfect! One block from Duval"

Pier House Resort & Spa

10/10 Excellent

"Wonderful vacation. Pier House is the only resort that I’ll stay at. I have been staying there for years. Everything about it is perfect."

Duval House

10/10 Excellent

"Great stay!"

Douglas House - Adults Only

10/10 Excellent

"The porch was amazing and tranquil. Loved the location and accommodations. 10/10 will be back here next trip"

The Southernmost Inn - Adults Only

10/10 Excellent

"Close to Duval Street"

Heron House - Adult Only

10/10 Excellent

"Great location. Nice place. Would absolutely stay again"

Weatherstation Inn

10/10 Excellent

"Location, Everything within walking distance"

The Cabana Inn Key West - Adults Only

8/10 Good

"Everything was pretty good except couldn’t get tv to work properly to watch playoffs. Would stay again close to everything"

Tranquility Guest House

10/10 Excellent

"Tranquility is just that. Quiet except for local roosters, safe, peaceful and private. There’s no front desk but the manager was in touch and checked in frequently. Great neighborhood nestled between Duval and the state park with fabulous beach."

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$4,655

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Orchid Key Inn - Adults Only

3. Duval House

4. Southernmost House - Adult Exclusive

5. L'Habitation Guest House - Adults Only

6. Ella's Cottages - Key West Historic Inns

7. Duval Gardens - Adults Only

8. The Garden House

9. The Palms Hotel

10. Tranquility Guest House

11. Eden House

12. The Cabana Inn Key West - Adults Only

13. Southernmost Beach Resort and Guesthouses

14. The Reach Key West, Curio Collection by Hilton

15. Casa Marina Key West, Curio Collection by Hilton

16. The Southernmost Inn - Adults Only

17. Seashell Motel

18. Grand Maloney Hotel

19. Coconut Beach Resort Timeshare

20. The Bartlum Luxury Studio In Prime Location

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Paradise Inn Key West - Adults Only

Pier House Resort & Spa

Duval House

Douglas House - Adults Only

The Southernmost Inn - Adults Only

Heron House - Adult Only

Weatherstation Inn

The Cabana Inn Key West - Adults Only

Tranquility Guest House

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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