The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A tropical outdoor area with palm trees, hanging plants, and string lights.

1. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Maricela

NT$5,709 total

includes taxes & fees

Oct 29 - Oct 30

A pool area with lounge chairs and a table, surrounded by palm trees.

2. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

ben

NT$8,771 total

includes taxes & fees

Oct 28 - Oct 29

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

3. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Gisele

NT$8,207 total

includes taxes & fees

Oct 28 - Oct 29

A porch with a white railing, a bench, and a flag.

4. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

Jennifer

NT$11,355 total

includes taxes & fees

Oct 28 - Oct 29

A gated entrance to Villas Key West with a brick pathway leading to the gate.

5. Key West Villas

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Margaret

NT$9,866 total

includes taxes & fees

Nov 2 - Nov 3

A modern interior with a staircase, a sofa set, a wooden table, and a television.

6. Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

William

NT$7,295 total

includes taxes & fees

Oct 28 - Oct 29

A two-story house with a covered porch, a brick pathway, and a large tree.

7. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Josh

NT$18,317 total

includes taxes & fees

Nov 11 - Nov 12

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

8. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Elise

NT$7,272 total

includes taxes & fees

Oct 28 - Oct 29

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

9. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Emily

NT$5,430 total

includes taxes & fees

Oct 29 - Oct 30

A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.

10. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Justyn

NT$6,510 total

includes taxes & fees

Oct 28 - Oct 29

A pool area with lounge chairs and palm trees.

11. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Anthony

NT$13,161 total

includes taxes & fees

Oct 28 - Oct 29

A sign with an alligator and a mermaid, surrounded by tropical plants and an American flag.

12. The Mermaid & Alligator

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

Adam

NT$8,150 total

includes taxes & fees

Oct 28 - Oct 29

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

13. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Janet

NT$10,690 total

includes taxes & fees

Nov 8 - Nov 9

A gated entrance with lush green foliage and a white picket fence.

14. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

August

NT$6,582 total

includes taxes & fees

Oct 28 - Oct 29

A reception area with a curved marble counter, ceiling fans, large windows, and a staircase.

15. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

Shari

NT$5,939 total

includes taxes & fees

Oct 28 - Oct 29

A poolside area with lounge chairs, umbrellas, and a pergola.

16. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Lisa and David

NT$10,082 total

includes taxes & fees

Oct 28 - Oct 29

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

17. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

daniela

NT$6,115 total

includes taxes & fees

Oct 28 - Oct 29

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

18. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

sam

NT$6,456 total

includes taxes & fees

Nov 1 - Nov 2

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

19. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Brenda

NT$5,247 total

includes taxes & fees

Oct 28 - Oct 29

A covered porch with white railings, wooden benches, and a hanging light fixture.

20. Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Michael

NT$11,883 total

includes taxes & fees

Oct 28 - Oct 29

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Douglas House - Adults Only	3.0 star property	9.8 Exceptional 569 reviews	View
Orchid Key Inn - Adults Only	3.5 star property	9.8 Exceptional 1,003 reviews	View
The Gardens Hotel	4.0 star property	9.8 Exceptional 1,000 reviews	View
The Conch House Heritage Inn	3.5 star property	9.8 Exceptional 195 reviews	View
Key West Villas	3.5 star property	9.8 Exceptional 279 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Lighthouse Hotel - Key West Historic Inns

8/10 Good

"Very convenient location a block from the center of Duval. Great restaurants nearby. Nice shade around the small pool made for a relaxing spot. Room small, but had everything needed and cozy."

Douglas House - Adults Only

10/10 Excellent

"If you are looking for a great place to stay in Key West, look no further than the Douglas House. We spent Saturday night here and were so impressed by the warm, welcoming, and extremely helpful host at the front desk. The room was excellent, featuring a nice layout and a very comfortable bed. Because we were in the Fantasy Fest parade, the location on the quiet end of Duval Street was absolutely flawless. It was close to the action but let us get a great night's sleep. We highly recommend it and will definitely stay here again!"

Tranquility Guest House

10/10 Excellent

"We arrived to the cutest guest houses the abundance of tropical foliage and brick landscaping we’re so welcoming the pool was a bit chilly with the trees over head but it was clean and still enjoyable. The lounge chairs were free the whole time and we didn’t expect the coffee service in the morning but it was a delightful surprise. The room… modern industrial nicer than a few of the big corp hotels nearby! Bed was soo comfortable ac worked great our tv didn’t work but I didn’t come to watch tv soo didn’t care. Easy 2 block walk to the Duvall st food/bars & entertainment !! We only stayed two nights but they were the best nights of our week! If I had to list something I didn’t like it would be how often the roosters woke us up before we were ready to get up. Honestly would stay here over many other locations"

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$5,247

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Douglas House - Adults Only

2. Orchid Key Inn - Adults Only

3. The Gardens Hotel

4. The Conch House Heritage Inn

5. Key West Villas

6. Simonton Court Historic Inn & Cottages

7. The Marquesa Hotel

8. Island City House Hotel

9. Duval House

10. The Grand Guesthouse

11. Santa Maria Suites

12. The Mermaid & Alligator

13. Southernmost House - Adult Exclusive

14. Coco Plum Inn

15. Westwinds Inn

16. Ella's Cottages - Key West Historic Inns

17. Ambrosia Key West

18. Silver Palms Inn & Historic Homes

19. Alexander Palms Court

20. Marrero's Guest Mansion

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Lighthouse Hotel - Key West Historic Inns

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Frequently asked questions

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