The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Teresa

NT$10,744 total

includes taxes & fees

Nov 30 - Dec 1

A tropical outdoor area with palm trees, hanging plants, and string lights.

2. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Maricela

NT$9,213 total

includes taxes & fees

Nov 17 - Nov 18

An outdoor seating area with a modern fire feature, surrounded by lush greenery and palm trees.

3. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kimberly

NT$15,486 total

includes taxes & fees

Nov 30 - Dec 1

A pool area with lounge chairs and a table, surrounded by palm trees.

4. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Jessica

NT$10,744 total

includes taxes & fees

Nov 30 - Dec 1

A porch with a white railing, a bench, and a flag.

5. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

Jennifer

NT$12,329 total

includes taxes & fees

Nov 24 - Nov 25

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

6. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Dennis

NT$7,285 total

includes taxes & fees

Nov 18 - Nov 19

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

7. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Elise

NT$7,415 total

includes taxes & fees

Dec 2 - Dec 3

A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.

8. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Justyn

NT$8,006 total

includes taxes & fees

Dec 6 - Dec 7

A poolside area with lounge chairs and a clear blue pool surrounded by lush tropical vegetation.

9. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

Shari

NT$7,983 total

includes taxes & fees

Nov 29 - Nov 30

A green house with a white porch, a flag, and a sign advertising a property for sale.

10. L'Habitation Guest House - Adults Only

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Callie

NT$6,287 total

includes taxes & fees

Dec 1 - Dec 2

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

11. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

August

NT$9,796 total

includes taxes & fees

Nov 17 - Nov 18

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

12. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Edward Lance

NT$11,893 total

includes taxes & fees

Nov 16 - Nov 17

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

13. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

Carleen

NT$7,859 total

includes taxes & fees

Dec 1 - Dec 2

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

14. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Brenda

NT$7,324 total

includes taxes & fees

Dec 1 - Dec 2

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

15. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

daniela

NT$9,094 total

includes taxes & fees

Nov 30 - Dec 1

A covered porch with white railings, wooden benches, and a hanging light fixture.

16. Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Jeffrey

NT$14,562 total

includes taxes & fees

Nov 22 - Nov 23

17. The Independent Inn

Historic Seaport, 1.6 km from Florida Keys National Marine Sanctuary

Malcolm

NT$8,012 total

includes taxes & fees

Nov 10 - Nov 11

A covered balcony with white Adirondack chairs and a small table with flowers, overlooking a turquoise sea and distant shoreline.

18. Opal Key Resort & Marina, Key West

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

A

NT$10,894 total

includes taxes & fees

Nov 29 - Nov 30

A hotel with a swimming pool, balconies, and a view of the sea.

19. Hyatt Centric Key West Resort and Spa

Historic Seaport, 1.3 km from Florida Keys National Marine Sanctuary

Michael Joseph

NT$11,733 total

includes taxes & fees

Dec 1 - Dec 2

A building with a white exterior, a large red awning, and a gated entrance.

20. Authors of Key West Guest House

The Meadows, 1.8 km from Florida Keys National Marine Sanctuary

Perry

NT$5,303 total

includes taxes & fees

Nov 30 - Dec 1

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	3.5 star property	10.0 Exceptional 1,003 reviews	View
Douglas House - Adults Only	3.5 star property	9.8 Exceptional 584 reviews	View
H2O Suites - Adults Only	3.5 star property	9.8 Exceptional 674 reviews	View
Orchid Key Inn - Adults Only	3.5 star property	9.8 Exceptional 1,003 reviews	View
The Conch House Heritage Inn	3.5 star property	9.8 Exceptional 198 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Lighthouse Hotel - Key West Historic Inns

10/10 Excellent

"Awesome time!"

Tranquility Guest House

10/10 Excellent

"While check in was a little confusing, everything after that was fantastic. Room was great, spacious, and clean. The location is fabulous. A short walk to the center of Duval st, giving easy access to everything you'd want to do. The staff was super friendly. I needed to let someone know the battery was low on our lock and it was immediately handled, with a very friendly follow up call to make sure everything was all set and if we needed anything. Also nice 2nd floor porch, great for a morning coffee or evening night cap. Would definitely stay at this location again."

Caribbean House

10/10 Excellent

"Check-in was super easy. The location was excellent. I got Lucky and was able to find parking nearby, but having the option to purchase a parking spot is super helpful. The room was small, but I didn’t spend much time there, so it didn’t really matter. The property owners did everything possible to make that small room everything I needed. The shower is very small. I’m short, so it didn’t bother me. But if you are big and tall, I would consider another room or another hotel. Thank you I would definitely book a room here again if I’m ever in Key West."

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$5,303

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Douglas House - Adults Only

3. H2O Suites - Adults Only

4. Orchid Key Inn - Adults Only

5. The Conch House Heritage Inn

6. Duval House

7. Island City House Hotel

8. The Grand Guesthouse

9. Westwinds Inn

10. L'Habitation Guest House - Adults Only

11. Coco Plum Inn

12. Southernmost House - Adult Exclusive

13. Silver Palms Inn & Historic Homes

14. Alexander Palms Court

15. Ambrosia Key West

16. Marrero's Guest Mansion

17. The Independent Inn

18. Opal Key Resort & Marina, Key West

19. Hyatt Centric Key West Resort and Spa

20. Authors of Key West Guest House

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Lighthouse Hotel - Key West Historic Inns

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Frequently asked questions

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