The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

John

NT$5,135

NT$5,777 total

includes taxes & fees

Sep 14 - Sep 15

2. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Jason

NT$5,280

NT$5,940 total

includes taxes & fees

Sep 21 - Sep 22

3. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

NT$6,060

NT$8,592 total

includes taxes & fees

Sep 28 - Sep 29

4. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Nicholas

NT$5,135

NT$5,777 total

includes taxes & fees

Sep 14 - Sep 15

Deluxe Suite, 1 King Bed, Personal Plunge Pool | View from room

5. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kourosh

NT$8,779

NT$12,000 total

includes taxes & fees

Sep 27 - Sep 28

Fish Tail Palm Premium King Suite, 1King bed, Large Patio area in Garden, Ground Floor

6. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

michael

NT$3,718

NT$4,601 total

includes taxes & fees

Sep 29 - Sep 30

Cigar House King Suite w/ Poolside porch | Balcony view

Cigar House Queen Suite w/ Poolside Balcony | Private kitchen

7. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Paul

NT$4,838

NT$5,443 total

includes taxes & fees

Sep 15 - Sep 16

Duval Duplex 2 bedrooms 25 ft Balcony (Adults Only) | Living area

8. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Robert

NT$3,115

NT$4,181 total

includes taxes & fees

Sep 16 - Sep 17

9. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Alissa

NT$3,550

NT$4,780 total

includes taxes & fees

Sep 14 - Sep 15

10. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

June Young

NT$8,779

NT$12,000 total

includes taxes & fees

Sep 13 - Sep 14

11. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Mark

NT$4,383

NT$8,914 total

includes taxes & fees

Sep 24 - Sep 25

12. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

Shawn

NT$2,520

NT$4,960 total

includes taxes & fees

Sep 13 - Sep 14

Deluxe Townhome, 1 King Bed w/Sofa bed - Parrot's Perch 103

Suite, 1 King Bed - Treetop Two 111 (2nd Floor, accessible via staircase)

Standard Room, 1 Queen Bed, Poolside - Poolside (some rooms located on 2nd floor, access by stairs)

13. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Kate

NT$4,224

NT$4,752 total

includes taxes & fees

Sep 27 - Sep 28

14. Weatherstation Inn

Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary

Svetlana

NT$5,318

NT$5,982 total

includes taxes & fees

Sep 14 - Sep 15

15. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Susannah

NT$6,293

NT$8,673 total

includes taxes & fees

Sep 14 - Sep 15

16. Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Michael

NT$6,909

NT$7,773 total

includes taxes & fees

Sep 23 - Sep 24

Williams Cottage, Stand Alone | Terrace/patio

17. Authors of Key West Guest House

The Meadows, 1.8 km from Florida Keys National Marine Sanctuary

Idamis

NT$2,343

NT$2,635 total

includes taxes & fees

Sep 28 - Sep 29

18. Heron House - Adult Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Natalia

NT$3,661

NT$5,166 total

includes taxes & fees

Sep 13 - Sep 14

King Suite #1, Full Kitchen, Ground Floor, Pool View, Private Bathroom | Room amenity

Queen Suite #6, Full Kitchen, Ground Floor, Pool View, Private Bathroom | Room amenity

19. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Andrew

NT$4,460

NT$5,018 total

includes taxes & fees

Sep 13 - Sep 14

20. Caribbean House

Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary

David

NT$3,742

NT$4,998 total

includes taxes & fees

Sep 22 - Sep 23

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,016 reviews	View
The Gardens Hotel	9.8 Exceptional 1,000 reviews	View
The Marquesa Hotel	9.8 Exceptional 1,004 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,015 reviews	View
H2O Suites - Adults Only	9.8 Exceptional 651 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Pier House Resort & Spa

10/10 Excellent

"What a great resort! Everything you need from a beach resort and more. The beautiful beach with NO sargassum. Clean, well maintained pool and common areas. Friendly staff. Delicious food and drinks. One of the best places I've ever stayed."

La Concha Key West, Autograph Collection

10/10 Excellent

"Love the history of La Concha, the vibe, bar, size and the location, almost mid-way on Duval Street, the hub of activity. It’s also one of the stops on the “hop-on hop-off “(every 30min) Old Town Trolley Key West Tours, which is a really big deal. There are no doubt other excellent properties in Key West, but La Concha was a great fit for me. I will definitely stay there on my next trip to the island."

Southernmost Beach Resort and Guesthouses

10/10 Excellent

"We've stayed here before and really enjoyed it. The property location is great walking to Duval Street and other restaurants around. The rooms were clean, the bed was pretty comfortable. Free espresso pods available in the rooms, I think I saw some tea too. There are 2 coffee shops in a 3-5 minute walking distance too. Bottles of water (to purchase) but the pool has a water machine. 2/3 pools open (the main one closed for renovations) but with music, the vibe was fun. There are also fun daily activities. The cafe is located right on the beach, which is nice, but sadly the smell of old, wet seaweed is off- putting, Front desk staff were friendly and accomodating ( we were able to check in an hour earlier - granted it's not in season). Only downfall is the expensive overnight parking fee!"

Opal Key Resort & Marina, Key West

10/10 Excellent

"Beautiful resort right on the water and very close to everything. Super clean room and hotel, professional and very friendly staff. Huge pool, restaurant and multiple bars on site. We loved our stay!"

Winslow's Bungalows - Key West Historic Inns

8/10 Good

"Check in was very easy and the front desk staff was very friendly. I loved the landscaping of the grounds and how each dwelling felt private and secluded. Our bungalow was nice. I wish there was a coffee maker in the room though, that was a little disappointing. The free breakfast was better than I expected with lots of things to choose from. The bartenders were super friendly and the bar/pool area was relaxing. We were able to easily walk anywhere we wanted to go and we could be on Duval Street in less than 10 minutes. There was also a CVS about 1/2 a block away for any things you need to pick up. I would definitely want to stay here again and I would recommend to anyone else visiting Key West."

Caribbean House

10/10 Excellent

"Ashley is the best! Caribbean House is home away from home."

Southwinds Motel

10/10 Excellent

"SOUTHWINDS MOTEL WAS AN ABSOLUTELY PERFECT TO STAY IN KW!!!! The amenities were perfect, the moring breakfast was just perfect, and thee LOCATION IS SUPER GREAT. Literally minutes from everywhere. WE WILL BE BACK, FOR SURE!!!!!"

Duval House

10/10 Excellent

"Cold rooms!"

Hyatt Centric Key West Resort and Spa

10/10 Excellent

"Loved the stay. Definitely will be back"

Other attractions near Florida Keys National Marine Sanctuary

A yellow exhibit labeled 'NOAA's AQUARIUS UNDERSEA LAB' with a circular window and a door.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A brick corridor with arched ceilings and benches.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1494 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1494 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$2,635

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. The Gardens Hotel

3. The Marquesa Hotel

4. Orchid Key Inn - Adults Only

5. H2O Suites - Adults Only

6. Douglas House - Adults Only

7. Island City House Hotel

8. Duval House

9. The Grand Guesthouse

10. Santa Maria Suites

11. Southernmost House - Adult Exclusive

12. Silver Palms Inn & Historic Homes

13. Ambrosia Key West

14. Weatherstation Inn

15. Ella's Cottages - Key West Historic Inns

16. Marrero's Guest Mansion

17. Authors of Key West Guest House

18. Heron House - Adult Only

19. Alexander Palms Court

20. Caribbean House

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Pier House Resort & Spa

La Concha Key West, Autograph Collection

Southernmost Beach Resort and Guesthouses

Opal Key Resort & Marina, Key West

Winslow's Bungalows - Key West Historic Inns

Caribbean House

Southwinds Motel

Duval House

Hyatt Centric Key West Resort and Spa

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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