The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

John

NT$7,145

NT$8,038 total

includes taxes & fees

Oct 5 - Oct 6

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A bar area with a counter, chairs, and a clock.

A bedroom with a large bed, a television on a dresser, and a view of the outdoors through a sliding door.

A couple walking along a poolside pathway surrounded by lush greenery.

2. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Forrest

NT$8,974

NT$10,095 total

includes taxes & fees

Oct 6 - Oct 7

A modern outdoor area with a pool, lounge chairs, and a bar area.

A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.

A modern hotel room with a bed, sofa, coffee table, and artwork.

A modern hotel with a prominent glass facade, palm trees, and a clear sky.

3. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Carmen

NT$8,858

NT$12,116 total

includes taxes & fees

Oct 4 - Oct 5

A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.

A spacious living room with a wooden ceiling, white sofas, a patterned armchair, a glass coffee table, and a large painting on the wall.

A spacious living room with a sofa, chairs, and a dining table. There are large windows with blinds, a door leading to a patio, and a ceiling with exposed beams.

A narrow room with a bed, a potted plant, and a window with blinds.

4. Alexander's Guesthouse - Adult Exclusive

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Nestor

NT$6,906

NT$9,079 total

includes taxes & fees

Oct 7 - Oct 8

A pool area with lounge chairs and a table, surrounded by palm trees.

A building with a neon sign that reads "Orchid Key Inn."

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

5. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Nicholas

NT$7,179

NT$8,076 total

includes taxes & fees

Oct 4 - Oct 5

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A hallway with a white door, a wooden bench, a blue sofa, and a staircase with a white railing.

A two-story building with a white picket fence, a mailbox, and a small tree in front.

A lush garden with a variety of tropical plants and a paved walkway.

6. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Christopher

NT$3,154

NT$4,234 total

includes taxes & fees

Oct 5 - Oct 6

A room with a bed, a ceiling fan, and a window with blinds.

A room with a yellow armchair, a glass coffee table, and a view of a wooden deck and tropical plants.

A cozy outdoor seating area with a wooden bench and a table, surrounded by potted plants and a coffee and tea sign.

A spacious kitchen with wooden cabinets, a granite countertop, and a ceiling fan.

7. The Mermaid & Alligator

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

Adam

NT$7,322

NT$8,238 total

includes taxes & fees

Oct 8 - Oct 9

A tropical outdoor area with palm trees, hanging plants, and string lights.

A hotel room with a bed, a wooden floor, a seating area with a table and chairs, and a view of greenery outside.

An outdoor patio with a table and chairs, surrounded by lush greenery and string lights.

A large, two-story building with a balcony, surrounded by dense tropical foliage.

8. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Maricela

NT$4,259

NT$5,270 total

includes taxes & fees

Oct 5 - Oct 6

A gated entrance with lush green foliage and a white picket fence.

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

A covered outdoor dining area with white chairs and tables, surrounded by lush greenery and a wooden deck.

A hotel room with a large bed, two bedside tables, a ceiling fan, and two framed pictures on the wall.

9. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

Riley

NT$5,258

NT$5,915 total

includes taxes & fees

Oct 5 - Oct 6

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

A grand staircase with ornate railings and a chandelier.

A large, two-story house with a prominent tower and a covered porch.

10. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

yessy

NT$4,459

NT$9,068 total

includes taxes & fees

Oct 26 - Oct 27

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

A cozy living room with a wooden ceiling, a sofa set, two side tables with lamps, and framed artwork on the wall.

A wicker outdoor seating area with two chairs and a table, surrounded by lush tropical foliage.

A hotel room with a bed, a nightstand, a chair, a small table, and a ceiling fan.

11. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Tricia

NT$4,755

NT$5,350 total

includes taxes & fees

Oct 4 - Oct 5

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

A two-story yellow house with a porch, white railings, and green shutters.

The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.

A hotel with a pool, bicycles, and lush greenery.

12. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

sam

NT$3,412

NT$5,990 total

includes taxes & fees

Oct 14 - Oct 15

A poolside area with lounge chairs, umbrellas, and a pergola.

A wooden bench with a cushion and a small table, surrounded by bamboo plants and a wooden deck.

An open door leading to a pool area with a wicker chair and a sofa inside a room with a view of the pool.

A living room with a spiral staircase, a sofa, a chair, a coffee table, and a view of an outdoor seating area.

13. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

tracy

NT$7,363

NT$9,904 total

includes taxes & fees

Oct 4 - Oct 5

A bright green porch with hanging planters, a wooden chair, and a railing.

A marina with multiple boats docked, wooden pilings, and a dock with ropes.

A bar area with a wooden counter, colorful decorations, and a sign with motivational ocean-themed text.

14. Caribbean House

Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary

David

NT$4,886

NT$6,298 total

includes taxes & fees

Oct 4 - Oct 5

A hotel with a covered entrance, multiple balconies, and palm trees.

A room with a stone wall, a wooden bench, a cactus, and a framed painting.

A waterfront hotel with multiple balconies, a dock, and boats.

A restaurant interior with wooden beams, a bar area, and a colorful ceiling mural.

15. Opal Key Resort & Marina, Key West

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Susan

NT$8,252

NT$10,538 total

includes taxes & fees

Oct 5 - Oct 6

A wooden deck with wicker furniture, a white staircase, and a lush garden area.

A hotel entrance with a sign reading "Heron House Office."

A bedroom with a large bed, a view of a swimming pool, and an open door leading to an outdoor seating area.

A hotel room with a large bed, a view of a swimming pool, and a balcony with outdoor seating.

16. Heron House - Adult Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Amanda

NT$3,838

NT$5,381 total

includes taxes & fees

Oct 4 - Oct 5

A large, white, two-story building with a balcony and a sign reading "The Marker Resort."

A tropical setting with palm trees and a building with a white facade and dark roof.

A resort with a swimming pool, lounge chairs, umbrellas, and palm trees.

A marina with various boats docked, including a green and white boat named 'Jolly Roger'.

17. The Marker Key West Harbor Resort

Historic Seaport, 1.3 km from Florida Keys National Marine Sanctuary

Keith

NT$7,419

NT$10,354 total

includes taxes & fees

Oct 27 - Oct 28

A pool area with lounge chairs and a cabana.

A dining area with a glass table, clear glass bottles, a bowl of fruit, and a wicker chair.

A hotel room with a bed, a sofa, a desk with a computer, a chair, and a view of the sea through large windows.

A waterfront hotel with a long pier, multiple balconies, and a view of the ocean.

18. Ocean Key Resort - A Noble House Resort

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Patrick

NT$9,208

NT$12,832 total

includes taxes & fees

Oct 7 - Oct 8

A spacious room with a wooden floor, white furniture, and large windows.

A white building with a covered porch, potted plants, and a white picket fence.

A covered outdoor area with a table and chairs, surrounded by white railings and green foliage.

A paved pathway surrounded by lush greenery and palm trees.

19. Paradise Inn Key West - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Mary

NT$4,058

NT$6,142 total

includes taxes & fees

Oct 4 - Oct 5

A white building with green shutters and a white picket fence.

A pool area with lounge chairs, a small table, and a thatched umbrella.

A hotel room with a large bed, a sitting area, and multiple bookshelves filled with books.

A modern kitchen with white cabinetry, a central island, and a view of the outdoors.

20. Ridley House - Key West Historic Inns

Historic Seaport, 1.1 km from Florida Keys National Marine Sanctuary

STEVEN

NT$7,363

NT$9,904 total

includes taxes & fees

Oct 4 - Oct 5

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,001 reviews	View
The Gardens Hotel	9.8 Exceptional 1,002 reviews	View
H2O Suites - Adults Only	9.8 Exceptional 661 reviews	View
Alexander's Guesthouse - Adult Exclusive	9.8 Exceptional 170 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,000 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Southernmost Beach Resort and Guesthouses

10/10 Excellent

"Amazing!"

Pier House Resort & Spa

8/10 Good

"Location is great if you want to be close to the action. But, it is also quite and laid out well for beach bumming. Iguanas and chickens are everywhere!"

Hyatt Centric Key West Resort and Spa

10/10 Excellent

"Location is excellent. Very quiet. Pool and bar are quite relaxing and convenient."

The Southernmost Inn - Adults Only

8/10 Good

"Very close to all the action"

Douglas House - Adults Only

10/10 Excellent

"I stayed in the Christmas Palm room and really enjoyed the large balcony overlooking the garden. Unfortunately, the property directly beside us were doing construction and the noise in tge morning kept me from having coffee outside. Thankfully, the Cuban Coffee Queen is only 2 minutes down on Duval to grab breakfast. The water, coffee and juice bar by the pool is available around the clock and a great little perk. The only complaint I have is that the mattress and pillows were extremely hard and uncomfortable. Otherwise this place is convenient, affordable and centrally located ."

Southwinds Motel

10/10 Excellent

"Clean room, nice pool, nice staff. Good little Cuban restaurant and grocery store across the street. Loved it."

Lighthouse Hotel - Key West Historic Inns

10/10 Excellent

"Staff was great"

Tranquility Guest House

10/10 Excellent

"Cute place right with great location. The staff are also very responsive and helpful. The room is small but all we needed was a place to sleep and a bathroom."

The Cabana Inn Key West - Adults Only

10/10 Excellent

"Room was great breakfast was plentiful and staff great. Would definitely recommend and stay there again"

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$4,234

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. The Gardens Hotel

3. H2O Suites - Adults Only

4. Alexander's Guesthouse - Adult Exclusive

5. Orchid Key Inn - Adults Only

6. Duval House

7. The Mermaid & Alligator

8. Douglas House - Adults Only

9. Coco Plum Inn

10. Southernmost House - Adult Exclusive

11. Ambrosia Key West

12. Silver Palms Inn & Historic Homes

13. Ella's Cottages - Key West Historic Inns

14. Caribbean House

15. Opal Key Resort & Marina, Key West

16. Heron House - Adult Only

17. The Marker Key West Harbor Resort

18. Ocean Key Resort - A Noble House Resort

19. Paradise Inn Key West - Adults Only

20. Ridley House - Key West Historic Inns

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Southernmost Beach Resort and Guesthouses

Pier House Resort & Spa

Hyatt Centric Key West Resort and Spa

The Southernmost Inn - Adults Only

Douglas House - Adults Only

Southwinds Motel

Lighthouse Hotel - Key West Historic Inns

Tranquility Guest House

The Cabana Inn Key West - Adults Only

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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