The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Teresa

NT$11,934 total

includes taxes & fees

Nov 30 - Dec 1

A tropical outdoor area with palm trees, hanging plants, and string lights.

2. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Maricela

NT$9,208 total

includes taxes & fees

Nov 17 - Nov 18

An outdoor seating area with a modern fire feature, surrounded by lush greenery and palm trees.

3. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kimberly

NT$15,476 total

includes taxes & fees

Nov 30 - Dec 1

A pool area with lounge chairs and a table, surrounded by palm trees.

4. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

ben

NT$10,771 total

includes taxes & fees

Nov 30 - Dec 1

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

5. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Elise

NT$7,411 total

includes taxes & fees

Dec 2 - Dec 3

A porch with a white railing, a bench, and a flag.

6. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

Jennifer

NT$12,322 total

includes taxes & fees

Nov 24 - Nov 25

A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.

7. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Justyn

NT$8,001 total

includes taxes & fees

Dec 3 - Dec 4

A pool area with lounge chairs and palm trees.

8. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Anthony

NT$16,266 total

includes taxes & fees

Dec 2 - Dec 3

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

9. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Dennis

NT$7,281 total

includes taxes & fees

Nov 18 - Nov 19

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

10. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Janet

NT$9,300 total

includes taxes & fees

Nov 8 - Nov 9

A poolside area with lounge chairs and a clear blue pool surrounded by lush tropical vegetation.

11. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

Shari

NT$7,978 total

includes taxes & fees

Nov 30 - Dec 1

A green house with a white porch, a flag, and a sign advertising a property for sale.

12. L'Habitation Guest House - Adults Only

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Callie

NT$6,283 total

includes taxes & fees

Dec 1 - Dec 2

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

13. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

August

NT$9,790 total

includes taxes & fees

Nov 16 - Nov 17

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

14. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

Carleen

NT$7,834 total

includes taxes & fees

Dec 1 - Dec 2

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

15. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Brenda

NT$7,320 total

includes taxes & fees

Dec 1 - Dec 2

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

16. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

daniela

NT$9,127 total

includes taxes & fees

Nov 30 - Dec 1

A hotel room with two beds, a TV, a wooden dresser, a nightstand with a lamp, and a view of palm trees through the window.

17. Opal Key Resort & Marina, Key West

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

A

NT$10,860 total

includes taxes & fees

Nov 29 - Nov 30

A covered porch with white railings, wooden benches, and a hanging light fixture.

18. Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Jeffrey

NT$14,553 total

includes taxes & fees

Nov 22 - Nov 23

A building with a white exterior, a large red awning, and a gated entrance.

19. Authors of Key West Guest House

The Meadows, 1.8 km from Florida Keys National Marine Sanctuary

Perry

NT$5,286 total

includes taxes & fees

Nov 11 - Nov 12

A two-story building with a white picket fence, palm trees, and a sign that reads 'DUVAL GARDENS.'

20. Duval Gardens - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

JoAnn

NT$7,383 total

includes taxes & fees

Nov 19 - Nov 20

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	3.5 star property	10.0 Exceptional 1,002 reviews	View
Douglas House - Adults Only	3.5 star property	9.8 Exceptional 583 reviews	View
H2O Suites - Adults Only	3.5 star property	9.8 Exceptional 673 reviews	View
Orchid Key Inn - Adults Only	3.5 star property	9.8 Exceptional 1,002 reviews	View
Island City House Hotel	3.0 star property	9.6 Exceptional 999 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Duval House

10/10 Excellent

"Duval House was an excellent stay. Very clean rooms and common areas, attentive staff, complimentary breakfast, fair pricing and unbeatable location."

The Cabana Inn Key West - Adults Only

10/10 Excellent

"Great location and friendly staff. Room size varies greatly at this inn so be sure to you understand which accommodations you are booking. The pool, hot tub and room were clean and the breakfast offerings are good. We arrived after hours to check in but called the number indicated and got our room key without issue. This is our second stay, look forward to our next one. PS, if rooster crowing at 3 am is an issue for you, bring ear plugs."

Tranquility Guest House

10/10 Excellent

"While check in was a little confusing, everything after that was fantastic. Room was great, spacious, and clean. The location is fabulous. A short walk to the center of Duval st, giving easy access to everything you'd want to do. The staff was super friendly. I needed to let someone know the battery was low on our lock and it was immediately handled, with a very friendly follow up call to make sure everything was all set and if we needed anything. Also nice 2nd floor porch, great for a morning coffee or evening night cap. Would definitely stay at this location again."

Caribbean House

10/10 Excellent

"Check-in was super easy. The location was excellent. I got Lucky and was able to find parking nearby, but having the option to purchase a parking spot is super helpful. The room was small, but I didn’t spend much time there, so it didn’t really matter. The property owners did everything possible to make that small room everything I needed. The shower is very small. I’m short, so it didn’t bother me. But if you are big and tall, I would consider another room or another hotel. Thank you I would definitely book a room here again if I’m ever in Key West."

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$5,286

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Douglas House - Adults Only

3. H2O Suites - Adults Only

4. Orchid Key Inn - Adults Only

5. Island City House Hotel

6. The Conch House Heritage Inn

7. The Grand Guesthouse

8. Santa Maria Suites

9. Duval House

10. Southernmost House - Adult Exclusive

11. Westwinds Inn

12. L'Habitation Guest House - Adults Only

13. Coco Plum Inn

14. Silver Palms Inn & Historic Homes

15. Alexander Palms Court

16. Ambrosia Key West

17. Opal Key Resort & Marina, Key West

18. Marrero's Guest Mansion

19. Authors of Key West Guest House

20. Duval Gardens - Adults Only

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Duval House

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Frequently asked questions

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