The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

John

NT$5,411

NT$6,088 total

includes taxes & fees

Sep 21 - Sep 22

A pool area with lounge chairs and a table, surrounded by palm trees.

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

A building with a neon sign that reads "Orchid Key Inn."

2. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Nicholas

NT$5,174

NT$5,821 total

includes taxes & fees

Sep 21 - Sep 22

A modern interior with a staircase, a sofa set, a wooden table, and a television.

A courtyard with two green lounge chairs, a palm tree, and a building with a white facade and lattice window design.

A pool area with a clear view of a house in the background, surrounded by palm trees and greenery.

A spacious room with a large bed, a sofa, a chair, a small table, and a television.

3. Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

Robin

NT$5,348

NT$6,016 total

includes taxes & fees

Sep 16 - Sep 17

A porch with a white railing, a bench, and a flag.

A two-story white house with green shutters, a wooden door, and a white picket fence.

A pool area with lounge chairs and a dining table, surrounded by palm trees and a house with a porch.

A spacious bedroom with a large bed, a sitting area with a sofa and armchairs, and a dining area with a table and chairs.

4. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

John

NT$5,262

NT$5,920 total

includes taxes & fees

Sep 29 - Sep 30

A covered porch with white railings, a ceiling fan, and a table with chairs.

A tree with green foliage and red flowers.

A two-story house with a porch, a large tree, and a fire hydrant.

A room with a wooden floor, a sofa with patterned cushions, a table, a chair, a lamp, and a window with blinds.

5. The Porch on Frances Inn

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Marcos

NT$3,702

NT$5,114 total

includes taxes & fees

Sep 16 - Sep 17

A two-story house with a covered porch, a brick pathway, and a large tree.

A restaurant with multiple tables set for dining, a wine bottle, and a glass of wine on the table.

A hotel room with two beds, a ceiling fan, a large window with a view of palm trees, and a painting on the wall.

A covered porch with white wicker furniture and a blue floor, surrounded by lush tropical plants.

6. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

"Our favorite place in Key West to stay - close enough to the center of all the things you want to do but just far enough not to have to deal with the late night loud parties. Nice upscale rooms very well maintained and 2 pools that give the tropical oasis feel. Their cafe is a high end restaurant that we tried - the food and drinks were good but not outstanding which is the way it is priced so we were disappointed. We will definitely stay here again but will skip the Cafe Marquesa - a better...

richard

NT$7,235

NT$9,920 total

includes taxes & fees

Sep 17 - Sep 18

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A couple walking along a poolside pathway surrounded by lush greenery.

A colonial-style building with a porch, surrounded by lush tropical vegetation.

A bar area with a counter, chairs, and a clock.

7. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Robert

NT$5,310

NT$5,974 total

includes taxes & fees

Sep 21 - Sep 22

A modern outdoor area with a pool, lounge chairs, and a bar area.

An outdoor seating area with a modern fire feature, surrounded by lush greenery and palm trees.

A modern hotel room with a bed, sofa, coffee table, and artwork.

A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.

8. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kourosh

NT$8,829

NT$12,068 total

includes taxes & fees

Sep 16 - Sep 17

A tropical outdoor area with palm trees, hanging plants, and string lights.

A large, two-story building with a balcony, surrounded by dense tropical foliage.

An outdoor patio with a table and chairs, surrounded by lush greenery and string lights.

A wooden deck with lush greenery and a pool area.

9. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

michael

NT$2,478

NT$3,066 total

includes taxes & fees

Sep 16 - Sep 17

A bedroom with a four-poster bed, a wooden desk, wicker chairs, and a view of the outdoors.

A pool area with lounge chairs and candles, surrounded by palm trees and a building in the background.

A breakfast buffet with a variety of fruits, pastries, and beverages on a wooden deck with a view of a lush garden and a pool.

A wooden door with glass panels, leading to an interior space with furniture and plants.

10. Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Anthony

NT$3,053

NT$4,225 total

includes taxes & fees

Sep 16 - Sep 17

A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.

A pool area with lounge chairs, a pool, and a building with a balcony and outdoor seating.

A spacious living room with a wooden ceiling, white sofas, a patterned armchair, a glass coffee table, and a large painting on the wall.

A spacious living room with a sofa, chairs, and a dining table. There are large windows with blinds, a door leading to a patio, and a ceiling with exposed beams.

11. Alexander's Guesthouse - Adult Exclusive

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Justin

NT$2,819

NT$4,359 total

includes taxes & fees

Sep 16 - Sep 17

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

A covered walkway with a wooden ceiling, white railings, and a brick path.

A garden with a pond, rocks, and various plants.

A pool area with lounge chairs and a wooden building with balconies.

12. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Osvaldo

NT$4,865

NT$5,473 total

includes taxes & fees

Sep 17 - Sep 18

A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.

A two-story building with a porch, a sign reading "The Grand Guesthouse," and a purple flag.

A covered outdoor area with a wooden staircase, seating, and potted plants.

A bedroom with a bed, nightstand, lamp, air conditioning unit, and a no smoking sign.

13. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Alissa

NT$3,570

NT$4,807 total

includes taxes & fees

Sep 21 - Sep 22

A gated entrance to Villas Key West with a brick pathway leading to the gate.

A covered entrance with a brick pathway leading to a gated area, surrounded by lush greenery and plants.

A swimming pool with a hot tub, surrounded by a wooden deck and lush greenery.

A house with a porch, a table, and a door with a number '6'.

14. Key West Villas

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Margaret

NT$8,265

NT$9,298 total

includes taxes & fees

Oct 15 - Oct 16

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

A hallway with a white door, a wooden bench, a blue sofa, and a staircase with a white railing.

A lush garden with a variety of tropical plants and a paved walkway.

15. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Robert

NT$3,133

NT$4,205 total

includes taxes & fees

Sep 16 - Sep 17

A room with a bed, a ceiling fan, and a window with blinds.

A cozy outdoor seating area with a wooden bench and a table, surrounded by potted plants and a coffee and tea sign.

A room with a yellow armchair, a glass coffee table, and a view of a wooden deck and tropical plants.

A spacious kitchen with wooden cabinets, a granite countertop, and a ceiling fan.

16. The Mermaid & Alligator

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

Johnny

NT$5,696

NT$6,408 total

includes taxes & fees

Sep 16 - Sep 17

A pool area with lounge chairs and palm trees.

A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.

A modern outdoor seating area with a sofa, chairs, and a small table, surrounded by glass doors and a view of greenery.

A sign for Santa Maria Resort surrounded by lush greenery and palm trees.

17. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

June Young

NT$8,829

NT$12,068 total

includes taxes & fees

Sep 21 - Sep 22

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

A two-story yellow house with a porch, white railings, and green shutters.

A hotel with a pool, bicycles, and lush greenery.

The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.

18. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

Alexey

NT$2,535

NT$4,988 total

includes taxes & fees

Sep 17 - Sep 18

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.

A large, two-story house with a prominent tower and a covered porch.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

19. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

yessy

NT$4,408

NT$8,964 total

includes taxes & fees

Sep 28 - Sep 29

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

A pool area with a covered seating area, palm trees, and a small pavilion.

A garden with a stone pathway, a wooden fence, and various tropical plants.

A yellow building with a door marked '7'.

20. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Andrew

NT$4,486

NT$5,047 total

includes taxes & fees

Sep 16 - Sep 17

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 1002 1,002 reviews	View
Orchid Key Inn - Adults Only	9.8 1002 1,002 reviews	View
Simonton Court Historic Inn & Cottages	9.8 1001 1,001 reviews	View
The Conch House Heritage Inn	9.8 189 189 reviews	View
The Porch on Frances Inn	9.8 144 144 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Casa Marina Key West, Curio Collection by Hilton

10/10 Excellent

"The resort is very nice. Enjoyed the pool bar in the evenings. The pool was too warm so not very refreshing. Wished there was a microwave in the room."

The Southernmost Inn - Adults Only

10/10 Excellent

"Very well located Inn with the right ammenities such as pool and jacuzzi. The included breakfast is enough to start your day mostly on the carbs side. Hopefully there were eggs. Comfy bed."

Southernmost Beach Resort and Guesthouses

10/10 Excellent

"It was beautiful. I didn’t like the $60 amenity fee or $50 parking but it was very nice"

Duval House

10/10 Excellent

"Beautiful and with fantastic service"

Winslow's Bungalows - Key West Historic Inns

8/10 Good

"Staff was great"

Pier House Resort & Spa

10/10 Excellent

"Offered ocean view at check in ! The 2 reception ladies offered us upgrade then when a person already checked In. Came back and wanted upgrades after seeing their room they declined us. The next morning went to complain and night manager gave us a free upgrade to ocean front ! She made my 70th birthday. They need to train those 2 ladies !!"

Orchid Key Inn - Adults Only

10/10 Excellent

"Right on Duvall Street, close to everything. The staff here is top notch!!!! We will definitely be back!!!"

Lighthouse Hotel - Key West Historic Inns

10/10 Excellent

"Highly recommended this boutique resort!"

The Cabana Inn Key West - Adults Only

10/10 Excellent

"Excellent spot to stay right off Duval street...authentic Key West vibe"

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A brick corridor with arched ceilings and benches.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1495 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and Pier House Resort & Spa.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1495 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Waterfront Playhouse, and Coffee Butler Amphitheater if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$3,066

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Orchid Key Inn - Adults Only

3. Simonton Court Historic Inn & Cottages

4. The Conch House Heritage Inn

5. The Porch on Frances Inn

6. The Marquesa Hotel

7. The Gardens Hotel

8. H2O Suites - Adults Only

9. Douglas House - Adults Only

10. Tropical Inn

11. Alexander's Guesthouse - Adult Exclusive

12. Island City House Hotel

13. The Grand Guesthouse

14. Key West Villas

15. Duval House

16. The Mermaid & Alligator

17. Santa Maria Suites

18. Silver Palms Inn & Historic Homes

19. Southernmost House - Adult Exclusive

20. Alexander Palms Court

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Casa Marina Key West, Curio Collection by Hilton

The Southernmost Inn - Adults Only

Southernmost Beach Resort and Guesthouses

Duval House

Winslow's Bungalows - Key West Historic Inns

Pier House Resort & Spa

Orchid Key Inn - Adults Only

Lighthouse Hotel - Key West Historic Inns

The Cabana Inn Key West - Adults Only

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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