The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Michelle

NT$4,256

NT$4,788 total

includes taxes & fees

Aug 30 - Aug 31

A pool area with lounge chairs and a table, surrounded by palm trees.

A neon sign for Orchid Key Inn with a 'VACANCY' sign below it.

A building with a neon sign that reads "Orchid Key Inn."

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

2. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Nicholas

NT$4,495

NT$5,057 total

includes taxes & fees

Aug 30 - Aug 31

A modern interior with a staircase, a sofa set, a wooden table, and a television.

A pathway flanked by lush green foliage leading to a gated entrance.

A pool area with a clear view of a house in the background, surrounded by palm trees and greenery.

A courtyard with two green lounge chairs, a palm tree, and a building with a white facade and lattice window design.

3. Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

Robin

NT$4,742

NT$5,335 total

includes taxes & fees

Aug 31 - Sep 1

A covered porch with white railings, a ceiling fan, and a table with chairs.

A room with a wooden floor, a sofa with patterned cushions, a table, a chair, a lamp, and a window with blinds.

A tree with green foliage and red flowers.

A two-story house with a porch, a large tree, and a fire hydrant.

4. The Porch on Frances Inn

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Corrynne

NT$3,698

NT$5,117 total

includes taxes & fees

Sep 1 - Sep 2

A room with a bed, a ceiling fan, and a window with blinds.

A room with a yellow armchair, a glass coffee table, and a view of a wooden deck and tropical plants.

A spacious kitchen with wooden cabinets, a granite countertop, and a ceiling fan.

A cozy outdoor seating area with a wooden bench and a table, surrounded by potted plants and a coffee and tea sign.

5. The Mermaid & Alligator

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

Johnny

NT$6,280

NT$7,065 total

includes taxes & fees

Sep 2 - Sep 3

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A couple walking along a poolside pathway surrounded by lush greenery.

A colonial-style building with a porch, surrounded by lush tropical vegetation.

A bar area with a counter, chairs, and a clock.

6. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Brian

NT$6,409

NT$7,210 total

includes taxes & fees

Aug 31 - Sep 1

A two-story house with a covered porch, a brick pathway, and a large tree.

A poolside area with a swimming pool, a staircase leading to a deck, and a building with multiple windows and balconies.

A covered porch with white wicker furniture and a blue floor, surrounded by lush tropical plants.

A hotel room with two beds, a ceiling fan, a large window with a view of palm trees, and a painting on the wall.

7. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Darrell

NT$7,191

NT$9,880 total

includes taxes & fees

Sep 10 - Sep 11

A porch with a white railing, a bench, and a flag.

A two-story white house with green shutters, a wooden door, and a white picket fence.

A spacious bedroom with a large bed, a sitting area with a sofa and armchairs, and a dining area with a table and chairs.

A living room with a sofa, a glass coffee table, a TV, and a painting on the wall.

8. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

John

NT$6,034

NT$6,788 total

includes taxes & fees

Sep 2 - Sep 3

A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.

A spacious living room with a sofa, chairs, and a dining table. There are large windows with blinds, a door leading to a patio, and a ceiling with exposed beams.

A spacious living room with a wooden ceiling, white sofas, a patterned armchair, a glass coffee table, and a large painting on the wall.

A pool area with lounge chairs, a pool, and a building with a balcony and outdoor seating.

9. Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

RAFAEL

NT$3,701

NT$5,384 total

includes taxes & fees

Aug 30 - Aug 31

A modern outdoor area with a pool, lounge chairs, and a bar area.

A modern hotel with a prominent glass facade, palm trees, and a clear sky.

A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.

A modern hotel room with a bed, sofa, coffee table, and artwork.

10. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Shermeka

NT$8,879

NT$12,137 total

includes taxes & fees

Sep 7 - Sep 8

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A two-story building with a white picket fence, a mailbox, and a small tree in front.

A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

A lush garden with a variety of tropical plants and a paved walkway.

11. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Melissa

NT$3,151

NT$4,229 total

includes taxes & fees

Aug 31 - Sep 1

A bedroom with a four-poster bed, a wooden desk, wicker chairs, and a view of the outdoors.

A breakfast buffet with a variety of fruits, pastries, and beverages on a wooden deck with a view of a lush garden and a pool.

A cozy room with a wicker chair, a small table with a bottle and glasses, and a view of a yellow room through an open door.

A pool area with lounge chairs and candles, surrounded by palm trees and a building in the background.

12. Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Joel

NT$4,130

NT$5,443 total

includes taxes & fees

Aug 31 - Sep 1

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

A pool area with lounge chairs and a wooden building with balconies.

A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.

A covered walkway with a wooden ceiling, white railings, and a brick path.

13. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Paul

NT$5,026

NT$5,655 total

includes taxes & fees

Sep 16 - Sep 17

A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.

A bedroom with a bed, nightstand, lamp, air conditioning unit, and a no smoking sign.

A row of blue bicycles parked under a tree, with a white fence and a building in the background.

A covered outdoor area with a wooden staircase, seating, and potted plants.

14. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Travis

NT$5,235

NT$6,685 total

includes taxes & fees

Sep 1 - Sep 2

A pool area with lounge chairs and palm trees.

A hotel named "Santa Maria" with a prominent illuminated sign, a glass entrance, and a view of the ocean.

A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.

A sign for Santa Maria Resort surrounded by lush greenery and palm trees.

15. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

June Young

NT$8,879

NT$12,137 total

includes taxes & fees

Aug 31 - Sep 1

A tropical outdoor area with palm trees, hanging plants, and string lights.

A wooden deck with lush greenery and a pool area.

An outdoor patio with a table and chairs, surrounded by lush greenery and string lights.

A large, two-story building with a balcony, surrounded by dense tropical foliage.

16. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Dylan

NT$3,757

NT$4,649 total

includes taxes & fees

Aug 31 - Sep 1

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

A hotel with a pool, bicycles, and lush greenery.

A two-story yellow house with a porch, white railings, and green shutters.

The exterior of the Silver Palms Inn with a two-story structure, a green awning over the entrance, and a palm tree to the right.

17. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

Shawn

NT$2,406

NT$4,855 total

includes taxes & fees

Aug 31 - Sep 1

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

A grand staircase with ornate railings and a chandelier.

A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.

18. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Mark

NT$4,433

NT$9,015 total

includes taxes & fees

Sep 20 - Sep 21

A reception area with a curved marble counter, ceiling fans, large windows, and a staircase.

A two-story house with a white exterior, a green roof, and a staircase leading to the upper floor.

A breakfast table with a variety of food items, including fruits, pastries, and a coffee mug.

A poolside area with lounge chairs and a clear blue pool surrounded by lush tropical vegetation.

19. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

Karen

NT$4,439

NT$4,994 total

includes taxes & fees

Aug 31 - Sep 1

A wooden deck with wicker furniture and a white railing, surrounded by lush tropical vegetation.

A pathway leading to a building with a white facade, surrounded by lush greenery and palm trees.

A breakfast tray with croissants, orange juice, and coffee on a table by a window with a view of a pool and greenery.

A swimming pool with a white picket fence, surrounded by lounge chairs and potted plants.

20. Weatherstation Inn

Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary

Svetlana

NT$5,697

NT$6,409 total

includes taxes & fees

Sep 1 - Sep 2

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,024 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,021 reviews	View
Simonton Court Historic Inn & Cottages	9.8 Exceptional 1,007 reviews	View
The Porch on Frances Inn	9.8 Exceptional 138 reviews	View
The Mermaid & Alligator	9.8 Exceptional 314 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

La Concha Key West, Autograph Collection

10/10 Excellent

"Beautiful updated hotel, loved the bar and the lobby . Our room was perfect after we moved to the 6th floor . The first room was not great . We liked the newer section much better . Loved the bikes and the location. Elevators need to be updated and they need to add another one . Would stay here again ."

Douglas House - Adults Only

10/10 Excellent

"Great stay for couples in key west! Away from noisy duval, perfect location 👌"

Southwinds Motel

10/10 Excellent

"Nice little property, and great location!"

The Reach Key West, Curio Collection by Hilton

10/10 Excellent

"Rooms were very small book a suite"

Hyatt Centric Key West Resort and Spa

8/10 Good

"Inside of room was very nice, no view at all, I mean ground level and just bushes. Love the pool, drinks are not cheap. Free 2 hours on bikes was very enjoyable. Always seems to be something being repaired, drilling. Our Ac had to be replaced after first night. A lot of noise, up by about 330am. But, give em credit, they had it replaced within 2-3 hours of me going to office! Very good location. Have stayed at this place probably 8-10 times, one of my favorites."

Lighthouse Hotel - Key West Historic Inns

10/10 Excellent

"We flew down to Key West for a much needed relaxing getaway. The location of the Lighthouse is perfect - centrally located and easy to navigate all the island has to offer, yet tucked just off Duval St so you feel like you’re in a quiet area at night. The pool is refreshing and the rooms are small but clean and the entire place has a very island feel. We enjoyed each day and can’t wait to return."

Orchid Key Inn - Adults Only

10/10 Excellent

"Had a great time! Very nice place to stay!"

Weatherstation Inn

10/10 Excellent

"Great location, clean property. Continental breakfast was a plus!"

Tranquility Guest House

8/10 Good

"Nice place. Very quiet and peaceful. Some minor amenities would be helpful (coffee pot in the room, ice machine)."

Other attractions near Florida Keys National Marine Sanctuary

A yellow exhibit labeled 'NOAA's AQUARIUS UNDERSEA LAB' with a circular window and a door.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A brick corridor with arched ceilings and benches.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the beautiful beaches or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its great live music.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its great live music.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1494 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1494 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$4,229

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Orchid Key Inn - Adults Only

3. Simonton Court Historic Inn & Cottages

4. The Porch on Frances Inn

5. The Mermaid & Alligator

6. The Gardens Hotel

7. The Marquesa Hotel

8. The Conch House Heritage Inn

9. Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

10. H2O Suites - Adults Only

11. Duval House

12. Tropical Inn

13. Island City House Hotel

14. The Grand Guesthouse

15. Santa Maria Suites

16. Douglas House - Adults Only

17. Silver Palms Inn & Historic Homes

18. Southernmost House - Adult Exclusive

19. Westwinds Inn

20. Weatherstation Inn

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

La Concha Key West, Autograph Collection

Douglas House - Adults Only

Southwinds Motel

The Reach Key West, Curio Collection by Hilton

Hyatt Centric Key West Resort and Spa

Lighthouse Hotel - Key West Historic Inns

Orchid Key Inn - Adults Only

Weatherstation Inn

Tranquility Guest House

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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