The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

John

NT$5,150

NT$5,794 total

includes taxes & fees

Sep 15 - Sep 16

2. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Nicholas

NT$5,150

NT$5,794 total

includes taxes & fees

Sep 14 - Sep 15

3. Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

Robin

NT$5,981

NT$6,728 total

includes taxes & fees

Sep 15 - Sep 16

Queen Room with Balcony #3 | Living area

4. The Porch on Frances Inn

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Marcos

NT$3,671

NT$5,079 total

includes taxes & fees

Sep 16 - Sep 17

5. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

LISA

NT$6,078

NT$8,617 total

includes taxes & fees

Sep 28 - Sep 29

6. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Robert

NT$5,310

NT$5,974 total

includes taxes & fees

Sep 21 - Sep 22

Deluxe Suite, 1 King Bed, Personal Plunge Pool | View from room

7. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kourosh

NT$8,829

NT$12,068 total

includes taxes & fees

Sep 14 - Sep 15

8. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

John

NT$5,620

NT$6,322 total

includes taxes & fees

Sep 29 - Sep 30

Superior Studio Suite, 1 King Bed with Sofa bed, Accessible, Refrigerator & Microwave

Premier Suite, 1 King Bed with Sofa bed, Patio, Garden Area (Room 16) | Living area

Superior Room, 1 King Bed, Patio, Ground Floor (Room 10)

9. Alexander's Guesthouse - Adult Exclusive

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Justin

NT$2,819

NT$4,359 total

includes taxes & fees

Sep 14 - Sep 15

Fish Tail Palm Premium King Suite, 1King bed, Large Patio area in Garden, Ground Floor

10. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

michael

NT$2,478

NT$3,066 total

includes taxes & fees

Sep 15 - Sep 16

Poinciana Patio, Pool View, Patio - Adult Only | Terrace/patio

11. Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Anthony

NT$3,053

NT$4,225 total

includes taxes & fees

Sep 14 - Sep 15

12. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Robert

NT$3,133

NT$4,205 total

includes taxes & fees

Sep 16 - Sep 17

Cigar House King Suite w/ Poolside porch | Balcony view

13. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Paul

NT$4,865

NT$5,473 total

includes taxes & fees

Sep 14 - Sep 15

14. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Alissa

NT$3,570

NT$4,807 total

includes taxes & fees

Sep 14 - Sep 15

15. Key West Villas

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Margaret

NT$9,370

NT$10,541 total

includes taxes & fees

Oct 6 - Oct 7

Audubon Room - Adult Exclusive | Terrace/patio

16. The Mermaid & Alligator

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

Johnny

NT$5,696

NT$6,408 total

includes taxes & fees

Sep 14 - Sep 15

17. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

June Young

NT$8,829

NT$12,068 total

includes taxes & fees

Sep 14 - Sep 15

18. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

Alexey

NT$2,535

NT$4,988 total

includes taxes & fees

Sep 14 - Sep 15

19. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

Tricia

NT$3,679

NT$4,138 total

includes taxes & fees

Sep 14 - Sep 15

20. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Mark

NT$4,408

NT$8,964 total

includes taxes & fees

Oct 1 - Oct 2

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,002 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,002 reviews	View
Simonton Court Historic Inn & Cottages	9.8 Exceptional 1,000 reviews	View
The Porch on Frances Inn	9.8 Exceptional 143 reviews	View
The Marquesa Hotel	9.8 Exceptional 1,000 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Orchid Key Inn - Adults Only

10/10 Excellent

"Right on Duvall Street, close to everything. The staff here is top notch!!!! We will definitely be back!!!"

Hyatt Centric Key West Resort and Spa

10/10 Excellent

"Everything was great. the AC a little bit noisy,"

Lighthouse Hotel - Key West Historic Inns

10/10 Excellent

"Highly recommended this boutique resort!"

Southernmost Beach Resort and Guesthouses

8/10 Good

"The pool closest to our room was closed due to renovations. This made it very difficult to get to the beach and the beach bar as you couldn't go through that area. Also the nasty smelly seaweed was all over the beach and you couldn't use the beach or go into the water. The smell was horrible and you relly didn't want to be outside at this end of the resort. They finally started cleaning it up the second day we were there but you still could't use the beach or the water access because of the massive cleanup and the still was worse when they were cleaning it up. I didn't find this to be the case with the resort across the way and their guests were able to use their beach and go into the water there. They said they do a daily very early morning cleanup so their guest can enjoy the water access."

Pier House Resort & Spa

10/10 Excellent

"Best location in Key West. The private beach and service on the beach are the best"

Duval House

10/10 Excellent

"Everything and everyone was perfect"

Wicker Guesthouse

10/10 Excellent

"Awesome place to stay!"

The Cabana Inn Key West - Adults Only

10/10 Excellent

"Excellent spot to stay right off Duval street...authentic Key West vibe"

La Concha Key West, Autograph Collection

10/10 Excellent

"Love the history of La Concha, the vibe, bar, size and the location, almost mid-way on Duval Street, the hub of activity. It’s also one of the stops on the “hop-on hop-off “(every 30min) Old Town Trolley Key West Tours, which is a really big deal. There are no doubt other excellent properties in Key West, but La Concha was a great fit for me. I will definitely stay there on my next trip to the island."

Other attractions near Florida Keys National Marine Sanctuary

A yellow exhibit labeled 'NOAA's AQUARIUS UNDERSEA LAB' with a circular window and a door.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A brick corridor with arched ceilings and benches.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1495 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and Pier House Resort & Spa.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1495 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Waterfront Playhouse, and Coffee Butler Amphitheater if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$3,066

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Orchid Key Inn - Adults Only

3. Simonton Court Historic Inn & Cottages

4. The Porch on Frances Inn

5. The Marquesa Hotel

6. The Gardens Hotel

7. H2O Suites - Adults Only

8. The Conch House Heritage Inn

9. Alexander's Guesthouse - Adult Exclusive

10. Douglas House - Adults Only

11. Tropical Inn

12. Duval House

13. Island City House Hotel

14. The Grand Guesthouse

15. Key West Villas

16. The Mermaid & Alligator

17. Santa Maria Suites

18. Silver Palms Inn & Historic Homes

19. Westwinds Inn

20. Southernmost House - Adult Exclusive

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Orchid Key Inn - Adults Only

Hyatt Centric Key West Resort and Spa

Lighthouse Hotel - Key West Historic Inns

Southernmost Beach Resort and Guesthouses

Pier House Resort & Spa

Duval House

Wicker Guesthouse

The Cabana Inn Key West - Adults Only

La Concha Key West, Autograph Collection

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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