The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

NT$7,641

NT$8,597 total

includes taxes & fees

Oct 12 - Oct 13

A pool area with lounge chairs and a table, surrounded by palm trees.

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

A building with a neon sign that reads "Orchid Key Inn."

2. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Lisa

NT$7,402

NT$8,327 total

includes taxes & fees

Oct 12 - Oct 13

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A grand staircase with ornate railings and a chandelier.

A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

3. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

yessy

NT$4,449

NT$9,048 total

includes taxes & fees

Oct 25 - Oct 26

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

A hotel with a pool, bicycles, and lush greenery.

The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.

A two-story yellow house with a porch, white railings, and green shutters.

4. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

sam

NT$3,421

NT$6,005 total

includes taxes & fees

Oct 25 - Oct 26

A bedroom with a bed, bedside table, lamp, and a small kitchenette. There is a balcony with wicker chairs and a glass table.

A cozy cabin with a wooden interior, a bed, a TV, and a kitchenette.

A pool area with lounge chairs and umbrellas, surrounded by buildings with balconies and a clear blue sky.

A spacious living area with a wooden staircase, a ceiling fan, a TV, and a view of the beach through an open door.

5. Eden House

Historic Seaport, 1.6 km from Florida Keys National Marine Sanctuary

Angie

NT$4,072

NT$5,131 total

includes taxes & fees

Oct 11 - Oct 12

A hotel with a swimming pool, balconies, and a view of the sea.

A balcony with a view of the ocean, a table, chairs, and a railing.

A beach wedding setup with white chairs, a wooden arch, and lanterns.

A spacious bar area with a wooden counter and green bar stools, a seating area with a sofa and chairs, and a dining area with a table set for two.

6. Hyatt Centric Key West Resort and Spa

Historic Seaport, 1.3 km from Florida Keys National Marine Sanctuary

Jennifer

NT$7,697

NT$10,887 total

includes taxes & fees

Oct 25 - Oct 26

A breakfast setup with wine bottles, fruits, and pastries on a tray by a door with a view of a staircase and greenery.

A patio with sun loungers, a table with an umbrella, and potted plants.

A pool area with lounge chairs, a wicker basket, and a staircase leading to an upper level.

A spacious kitchen with wooden cabinets and a dining area with a round table and chairs.

7. The Cabana Inn Key West - Adults Only

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Donna

NT$5,424

NT$7,536 total

includes taxes & fees

Oct 12 - Oct 13

A two-story building with a porch, a brown door, and a sign for 'The Independent Inn'.

8. The Independent Inn - Formerly Heron House Court

Historic Seaport, 1.6 km from Florida Keys National Marine Sanctuary

NT$4,073

NT$5,663 total

includes taxes & fees

Oct 12 - Oct 13

A multi-story hotel with a pink facade, multiple balconies, and a prominent 'LA CONCHA' sign.

A spacious lobby with a checkered floor, a central seating area with wicker chairs, a large potted plant, and a staircase with a metal railing.

A beach with clear turquoise water, snorkelers, and a large building in the background.

A balcony with a sofa, a round table, and a view of the cityscape.

9. La Concha Key West, Autograph Collection

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

THOMAS

NT$6,983

NT$8,932 total

includes taxes & fees

Oct 12 - Oct 13

A swimming pool with clear water, surrounded by lush greenery and palm trees.

A yellow building with a blue door and shutters, a number '302' on the wall, and a small porch area.

A bedroom with a bed, a nightstand, a lamp, a window with shutters, and a wall with coral patterns.

A covered porch with white columns and wicker furniture.

10. Tranquility Guest House

Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary

Sandra

NT$4,188

NT$7,550 total

includes taxes & fees

Oct 14 - Oct 15

A poolside area with lounge chairs, a small pool, and a white building with a balcony.

A bedroom with a bed, a ceiling fan, a window with blinds, a painting, and a nightstand with a lamp.

A reception area with a wooden reception desk, a brown leather couch, and a mural of palm trees on the wall.

A white building with a sign reading "The StarCare Inn" and a "No Vacancies" sign.

11. Seascape Tropical Inn - Adult Exclusive

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Julia

NT$3,992

NT$6,108 total

includes taxes & fees

Oct 11 - Oct 12

A deck with sun loungers and a railing overlooking the sea.

A room with a view of the beach and ocean, a bed with a white and blue blanket, and a small table with a potted plant.

A beach scene with two people relaxing under a white umbrella, a palm tree, and a clear blue sky.

A beachside hotel with rows of blue lounge chairs and white umbrellas, palm trees, and a clear blue sky.

12. Southernmost Beach Resort and Guesthouses

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Krystle

NT$4,673

NT$7,592 total

includes taxes & fees

Oct 11 - Oct 12

A gated entrance with a gazebo, palm trees, and a brick pathway leading to a building with a red roof.

A poolside area with lounge chairs and umbrellas, a bar, and a staircase leading to a house.

A bedroom with a large bed, wooden headboard, two bedside lamps, and a floral wall art piece.

A waterfront property with a white facade, palm trees, and a street view.

13. Duval Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

NT$4,432

NT$6,600 total

includes taxes & fees

Oct 11 - Oct 12

A beach with a wooden pier, palm trees, and beach umbrellas.

An outdoor dining area with tables set for guests, overlooking a calm sea and a pier.

A modern bar area with a central island, white bar stools, and a view of the ocean.

An outdoor dining area with tables and chairs, overlooking the ocean.

14. The Reach Key West, Curio Collection by Hilton

Uptown - Upper Duval, 1.4 km from Florida Keys National Marine Sanctuary

Darlene

NT$5,674

NT$8,539 total

includes taxes & fees

Oct 25 - Oct 26

A wooden deck with wicker furniture and a glass balustrade overlooking a beach.

A resort with a pool leading to a beach, surrounded by palm trees and white buildings.

A beach with white lounge chairs and umbrellas, a sandy shore, and a calm sea under a partly cloudy sky.

A spacious lobby with green sofas, a coffee table, and a dining area.

15. Casa Marina Key West, Curio Collection by Hilton

Casa Marina, 1.8 km from Florida Keys National Marine Sanctuary

Coni

NT$6,896

NT$9,913 total

includes taxes & fees

Oct 25 - Oct 26

A poolside area with lounge chairs, a staircase leading to a balcony, and a pool.

A Southernmost Inn with a porch, a sign indicating vacancy, and a staircase leading to the entrance.

A beige sofa with two pillows, flanked by two wooden side tables with lamps and potted plants, against a white wall with a framed picture of a tree.

An outdoor patio with tables and chairs, surrounded by trees and a house.

16. The Southernmost Inn - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Anthony

NT$3,801

NT$5,713 total

includes taxes & fees

Oct 14 - Oct 15

A balcony with a view of a street, a bench, and a potted plant.

A multi-story building with a ground-level commercial space featuring a brightly lit storefront.

A bar area with a Pegasus International Hotel sign, round tables, and metal chairs.

A hotel lobby with a bar area, seating, and a fireplace.

17. Pegasus International Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Karla

NT$3,529

NT$5,587 total

includes taxes & fees

Oct 11 - Oct 12

A neatly made bed with white linens and a blue throw blanket, a bedside table with a lamp, and an air conditioning unit mounted on the wall.

A motel sign, parked bicycles, and a building with a covered porch.

A shower with white subway tiles and a black shower curtain.

A room with a wooden floor, a white door with horizontal slats, a wooden wall, and a small shelf with a black object.

18. Seashell Motel

Casa Marina, 1.5 km from Florida Keys National Marine Sanctuary

NT$3,801

NT$4,276 total

includes taxes & fees

Oct 12 - Oct 13

A covered outdoor seating area with wicker chairs and a glass table, overlooking a lush garden with palm trees and a pool.

A wooden door with a fire alarm, a white door with shutters, and a patterned carpet.

A bedroom with a bed, nightstands, a ceiling fan, and a door with a window.

A covered outdoor area with wicker furniture, a pool, and surrounding palm trees.

19. Curry House

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

NT$2,961

NT$8,541 total

includes taxes & fees

Oct 14 - Oct 15

A pool area with lounge chairs and palm trees, overlooking the ocean.

A bedroom with a bed, desk, chair, ceiling fan, and a view of the outdoors through a sliding door.

A beach view with palm trees and lounge chairs.

20. Coconut Beach Resort Timeshare

Casa Marina, 1.5 km from Florida Keys National Marine Sanctuary

Wayne

NT$48,775

NT$54,872 total

includes taxes & fees

Oct 10 - Oct 11

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,000 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,000 reviews	View
Southernmost House - Adult Exclusive	9.4 Exceptional 1,000 reviews	View
Silver Palms Inn & Historic Homes	9.4 Exceptional 1,042 reviews	View
Eden House	9.0 Wonderful 1,002 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Opal Key Resort & Marina, Key West

10/10 Excellent

"Very clean well-maintained property in a great location. I would highly recommend it any of my friends or family."

Lighthouse Hotel - Key West Historic Inns

10/10 Excellent

"Location, location, location. Nice, clean place to stay, walkable to Duval Street. No car needed."

Southwinds Motel

10/10 Excellent

"Close to a lot of places I wanted to see. The ice cream and doughnuts bar was awesome! The was really comfortable."

Pier House Resort & Spa

8/10 Good

"Guest BEWARE, didn't think there would be a surcharge, but there was. A total of $262. and no one said anything. When we checked in and the asked for a credit card, I asked why, they said for unexpectedly occurred charges, nothing about surcharges. So PLEASE beware"

The Cabana Inn Key West - Adults Only

10/10 Excellent

"Our room was spacious and clean. We loved the uniqueness of the hotel and the proximity to all the bars and restaurants on Duvall street."

Paradise Inn Key West - Adults Only

10/10 Excellent

"The staff were friendly and helpful."

Douglas House - Adults Only

10/10 Excellent

"It’s like a little private oasis once you’re inside. Super relaxing yet close to everything."

Southernmost Beach Resort and Guesthouses

10/10 Excellent

"Perfect! Great surroundings, staff & people! Convenient to get to everything!"

La Concha Key West, Autograph Collection

10/10 Excellent

"Wonderful place at a great location"

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$4,276

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Orchid Key Inn - Adults Only

3. Southernmost House - Adult Exclusive

4. Silver Palms Inn & Historic Homes

5. Eden House

6. Hyatt Centric Key West Resort and Spa

7. The Cabana Inn Key West - Adults Only

8. The Independent Inn - Formerly Heron House Court

9. La Concha Key West, Autograph Collection

10. Tranquility Guest House

11. Seascape Tropical Inn - Adult Exclusive

12. Southernmost Beach Resort and Guesthouses

13. Duval Inn

14. The Reach Key West, Curio Collection by Hilton

15. Casa Marina Key West, Curio Collection by Hilton

16. The Southernmost Inn - Adults Only

17. Pegasus International Hotel

18. Seashell Motel

19. Curry House

20. Coconut Beach Resort Timeshare

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Opal Key Resort & Marina, Key West

Lighthouse Hotel - Key West Historic Inns

Southwinds Motel

Pier House Resort & Spa

The Cabana Inn Key West - Adults Only

Paradise Inn Key West - Adults Only

Douglas House - Adults Only

Southernmost Beach Resort and Guesthouses

La Concha Key West, Autograph Collection

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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