The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

John

NT$7,145

NT$8,038 total

includes taxes & fees

Oct 5 - Oct 6

A tropical outdoor area with palm trees, hanging plants, and string lights.

A hotel room with a bed, a wooden floor, a seating area with a table and chairs, and a view of greenery outside.

A large, two-story building with a balcony, surrounded by dense tropical foliage.

An outdoor patio with a table and chairs, surrounded by lush greenery and string lights.

2. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Maricela

NT$4,259

NT$5,270 total

includes taxes & fees

Oct 5 - Oct 6

A modern outdoor area with a pool, lounge chairs, and a bar area.

A modern hotel with a prominent glass facade, palm trees, and a clear sky.

A modern hotel room with a bed, sofa, coffee table, and artwork.

An outdoor seating area with a modern fire feature, surrounded by lush greenery and palm trees.

3. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Corey

NT$9,845

NT$13,226 total

includes taxes & fees

Oct 5 - Oct 6

A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.

A pool area with lounge chairs, a pool, and a building with a balcony and outdoor seating.

A spacious living room with a wooden ceiling, white sofas, a patterned armchair, a glass coffee table, and a large painting on the wall.

A narrow room with a bed, a potted plant, and a window with blinds.

4. Alexander's Guesthouse - Adult Exclusive

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Nestor

NT$6,906

NT$9,079 total

includes taxes & fees

Oct 6 - Oct 7

A pool area with lounge chairs and a table, surrounded by palm trees.

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

A building with a neon sign that reads "Orchid Key Inn."

5. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Nicholas

NT$7,145

NT$8,038 total

includes taxes & fees

Oct 5 - Oct 6

A porch with a white railing, a bench, and a flag.

A living room with a sofa, a glass coffee table, a TV, and a painting on the wall.

A spacious bedroom with a large bed, a sitting area with a sofa and armchairs, and a dining area with a table and chairs.

A two-story white house with green shutters, a wooden door, and a white picket fence.

6. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

John

NT$6,041

NT$6,796 total

includes taxes & fees

Oct 6 - Oct 7

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A colonial-style building with a porch, surrounded by lush tropical vegetation.

A couple walking along a poolside pathway surrounded by lush greenery.

A bar area with a counter, chairs, and a clock.

7. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Forrest

NT$7,139

NT$8,031 total

includes taxes & fees

Oct 6 - Oct 7

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

A pool area with lounge chairs and a wooden building with balconies.

A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.

A garden with a pond, rocks, and various plants.

8. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Osvaldo

NT$5,793

NT$6,518 total

includes taxes & fees

Oct 11 - Oct 12

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A two-story building with a white picket fence, a mailbox, and a small tree in front.

A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

A hallway with a white door, a wooden bench, a blue sofa, and a staircase with a white railing.

9. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Christopher

NT$3,154

NT$4,234 total

includes taxes & fees

Oct 5 - Oct 6

A pool area with lounge chairs and palm trees.

A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.

A neatly made bed with patterned pillows, a bedside table with a bottle and glasses, and a window with orchids.

A sign for Santa Maria Resort surrounded by lush greenery and palm trees.

10. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Anthony

NT$9,845

NT$13,226 total

includes taxes & fees

Oct 25 - Oct 26

A room with a bed, a ceiling fan, and a window with blinds.

A room with a yellow armchair, a glass coffee table, and a view of a wooden deck and tropical plants.

A poolside area with lounge chairs, a covered seating area, and a small pool.

A spacious kitchen with wooden cabinets, a granite countertop, and a ceiling fan.

11. The Mermaid & Alligator

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

Adam

NT$7,322

NT$8,238 total

includes taxes & fees

Oct 8 - Oct 9

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.

A grand staircase with ornate railings and a chandelier.

A large, two-story house with a prominent tower and a covered porch.

12. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

yessy

NT$4,438

NT$9,025 total

includes taxes & fees

Oct 26 - Oct 27

A wooden deck with wicker furniture and a white railing, surrounded by lush tropical vegetation.

A breakfast tray with croissants, orange juice, and coffee on a table by a window with a view of a pool and greenery.

A two-story building with a white picket fence, palm trees, and a clear blue sky.

A pathway leading to a building with a white facade, surrounded by lush greenery and palm trees.

13. Weatherstation Inn

Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary

Svetlana

NT$5,703

NT$6,416 total

includes taxes & fees

Oct 5 - Oct 6

A reception area with a curved marble counter, ceiling fans, large windows, and a staircase.

A two-story house with a white exterior, a green roof, and a staircase leading to the upper floor.

A breakfast table with a variety of food items, including fruits, pastries, and a coffee mug.

A poolside area with lounge chairs and a clear blue pool surrounded by lush tropical vegetation.

14. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

Anthony

NT$5,161

NT$5,807 total

includes taxes & fees

Oct 6 - Oct 7

A gated entrance with lush green foliage and a white picket fence.

A covered outdoor dining area with white chairs and tables, surrounded by lush greenery and a wooden deck.

A hotel room with a large bed, two bedside tables, a ceiling fan, and two framed pictures on the wall.

A white colonial-style building with a balcony, surrounded by palm trees and a white picket fence.

15. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

Riley

NT$4,516

NT$5,081 total

includes taxes & fees

Oct 12 - Oct 13

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

A hotel room with a bed, a nightstand, a chair, a small table, and a ceiling fan.

A cozy living room with a wooden ceiling, a sofa set, two side tables with lamps, and framed artwork on the wall.

A spacious living room with a high ceiling, a ceiling fan, a large painting, a sofa, a coffee table, and a dining area with a table and chairs.

16. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Tricia

NT$4,660

NT$5,242 total

includes taxes & fees

Oct 5 - Oct 6

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

A pool area with a covered seating area, palm trees, and a small pavilion.

A yellow building with a door marked '7'.

A room with a bed, a desk, a chair, a lamp, a painting of a boat on water, and a view of the sea.

17. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Andrew

NT$3,799

NT$4,274 total

includes taxes & fees

Oct 5 - Oct 6

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

A two-story yellow house with a porch, white railings, and green shutters.

The exterior of the Silver Palms Inn with a two-story structure, a green awning over the entrance, and a palm tree to the right.

The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.

18. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

sam

NT$3,412

NT$5,990 total

includes taxes & fees

Oct 5 - Oct 6

A poolside area with lounge chairs, umbrellas, and a pergola.

A bright kitchen with white cabinetry, a white island, wicker pendant lights, and geometric patterned backsplash.

A living room with a spiral staircase, a sofa, a chair, a coffee table, and a view of an outdoor seating area.

A wooden bench with a cushion and a small table, surrounded by bamboo plants and a wooden deck.

19. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

tracy

NT$7,328

NT$9,857 total

includes taxes & fees

Oct 5 - Oct 6

A bedroom with a four-poster bed, a wooden desk, wicker chairs, and a view of the outdoors.

A pool area with lounge chairs and candles, surrounded by palm trees and a building in the background.

A wooden door with glass panels, leading to an interior space with furniture and plants.

A cozy room with a wicker chair, a small table with a bottle and glasses, and a view of a yellow room through an open door.

20. Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Natalie

NT$4,850

NT$6,252 total

includes taxes & fees

Oct 6 - Oct 7

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,001 reviews	View
Douglas House - Adults Only	9.8 Exceptional 546 reviews	View
H2O Suites - Adults Only	9.8 Exceptional 662 reviews	View
Alexander's Guesthouse - Adult Exclusive	9.8 Exceptional 170 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,002 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Winslow's Bungalows - Key West Historic Inns

10/10 Excellent

"I felt we got the feel of Key West by staying here. Located about two blocks off Duval Street, but so many trees and plants around the property, it seems so private. We stayed in a bungalow with our own private patio. There were 3 pools, free continental breakfast and the cutest bar area that we loved to hang out at. The bartenders were so personable and helpful with giving ideas of things to see and do in the Keys. I was extremely glad we chose to stay here! Was located within a mile or less of everything we wanted to do so we were able to walk everywhere. I miss it already!"

Lighthouse Hotel - Key West Historic Inns

10/10 Excellent

"Charming"

Casa Marina Key West, Curio Collection by Hilton

10/10 Excellent

"Clear room, great views"

Douglas House - Adults Only

10/10 Excellent

"It was simple, clean, organized, and in a great location"

Tranquility Guest House

10/10 Excellent

"Great, calm space. I loved the pool and grabbing a cup of coffee and sitting in this tropical sanctuary while slowly waking up. The location is amazing. Most everything in the main part of Key West for visitors is within easy walk. Soledad and Karina kept the whole property nice and tidy. And the manager Federico was incredibly responsive. Once I arrived I received a text making sure I didn't need anything. It was a perfect way to spend a peaceful week away from my weird life."

Wicker Guesthouse

10/10 Excellent

"Whenever I stay at the Wicker Guesthouse, the staff is always friendly and helpful. They can suggest activities, as well as book them, give discount coupons and easy directions. The cleaning staff are friendly and helpful too. My room was great, accommodations are older, so expect a noisy air conditioner. But the bathrooms were updated and everything was very clean-the sheets and towels smelled so fresh. Breakfast buffet has a large variety, pools were clean with lots of seating. This is the first time I brought my pet and they have a minimal fee. You really have to look for some green space but about 1.5 miles away there is a dog park down at Higgins Beach. Dogs have a tendency to compensate for their environment 😃. I love that the Wicker Guesthouse is walking distance to all the restaurants, bars, shopping, Mallory Square and the southernmost point. There’s so much to do and so little time. I would recommend staying there. I had a great stay!"

Pier House Resort & Spa

10/10 Excellent

"Great location and clean room! Easy to walk to restaurants, bars, and Mallory Square. The Chart Room Cocktail Lounge in hotel was also a fun late night stop."

Southwinds Motel

10/10 Excellent

"Great location. Third stay here. Will return again Rooms are small but clean fresh coffee every morning."

La Concha Key West, Autograph Collection

10/10 Excellent

"The location on Duval is perfect, the hotel is top notch, and the staff can't do enough for you. Everyone from the GM to the housekeeping staff always wish you a good day and ask if there is anything they can do for you no matter how many times they see you. Perfect place to stay in Key West and we will be returning for sure!"

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

See properties

A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

See properties

A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

See properties

The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

See properties

Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

See properties

USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

See properties

Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

See properties

We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

See properties

Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$4,234

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Douglas House - Adults Only

3. H2O Suites - Adults Only

4. Alexander's Guesthouse - Adult Exclusive

5. Orchid Key Inn - Adults Only

6. The Conch House Heritage Inn

7. The Gardens Hotel

8. Island City House Hotel

9. Duval House

10. Santa Maria Suites

11. The Mermaid & Alligator

12. Southernmost House - Adult Exclusive

13. Weatherstation Inn

14. Westwinds Inn

15. Coco Plum Inn

16. Ambrosia Key West

17. Alexander Palms Court

18. Silver Palms Inn & Historic Homes

19. Ella's Cottages - Key West Historic Inns

20. Tropical Inn

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Winslow's Bungalows - Key West Historic Inns

Lighthouse Hotel - Key West Historic Inns

Casa Marina Key West, Curio Collection by Hilton

Douglas House - Adults Only

Tranquility Guest House

Wicker Guesthouse

Pier House Resort & Spa

Southwinds Motel

La Concha Key West, Autograph Collection

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

Explore a world of travel with Expedia