The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

John

NT$5,121

NT$5,761 total

includes taxes & fees

Sep 30 - Oct 1

A bottle of Marc's Reserve 12 FL. OZ. on a coaster with a metal table.

A patio area with white metal tables and chairs, surrounded by potted plants and palm trees.

A potted yellow orchid plant in a garden setting with a brick pathway, palm trees, and a white building in the background.

A pool with a lion head sculpture in the center.

2. Artist House Key West

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

NATHAN

NT$3,226

NT$3,629 total

includes taxes & fees

Oct 11 - Oct 12

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A couple walking along a poolside pathway surrounded by lush greenery.

A bedroom with a large bed, a television on a dresser, and a view of the outdoors through a sliding door.

A bar area with a counter, chairs, and a clock.

3. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Forrest

NT$8,901

NT$10,014 total

includes taxes & fees

Oct 27 - Oct 28

A porch with a white railing, a bench, and a flag.

A spacious bedroom with a large bed, a sitting area with a sofa and armchairs, and a dining area with a table and chairs.

A two-story white house with green shutters, a wooden door, and a white picket fence.

A pool area with lounge chairs and a dining table, surrounded by palm trees and a house with a porch.

4. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

John

NT$6,021

NT$6,773 total

includes taxes & fees

Sep 28 - Sep 29

A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.

A pool area with lounge chairs, a pool, and a building with a balcony and outdoor seating.

A spacious living room with a sofa, chairs, and a dining table. There are large windows with blinds, a door leading to a patio, and a ceiling with exposed beams.

A narrow room with a bed, a potted plant, and a window with blinds.

5. Alexander's Guesthouse - Adult Exclusive

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Nestor

NT$2,834

NT$4,379 total

includes taxes & fees

Sep 28 - Sep 29

A modern outdoor area with a pool, lounge chairs, and a bar area.

A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.

A modern hotel with a prominent glass facade, palm trees, and a clear sky.

An outdoor seating area with a modern fire feature, surrounded by lush greenery and palm trees.

6. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Corey

NT$8,860

NT$12,111 total

includes taxes & fees

Sep 28 - Sep 29

A two-story house with a covered porch, a brick pathway, and a large tree.

A hotel room with two beds, a ceiling fan, a large window with a view of palm trees, and a painting on the wall.

A restaurant with multiple tables set for dining, a wine bottle, and a glass of wine on the table.

A poolside area with a swimming pool, a staircase leading to a deck, and a building with multiple windows and balconies.

7. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Darrell

NT$8,542

NT$11,396 total

includes taxes & fees

Sep 28 - Sep 29

A tropical outdoor area with palm trees, hanging plants, and string lights.

A wooden deck with lush greenery and a pool area.

A large, two-story building with a balcony, surrounded by dense tropical foliage.

An outdoor patio with a table and chairs, surrounded by lush greenery and string lights.

8. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

michael

NT$3,742

NT$4,631 total

includes taxes & fees

Sep 28 - Sep 29

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

A covered walkway with a wooden ceiling, white railings, and a brick path.

A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.

A pool area with lounge chairs and a wooden building with balconies.

9. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Osvaldo

NT$4,882

NT$5,493 total

includes taxes & fees

Sep 28 - Sep 29

A bedroom with a four-poster bed, a wooden desk, wicker chairs, and a view of the outdoors.

A cozy room with a wicker chair, a small table with a bottle and glasses, and a view of a yellow room through an open door.

A wooden door with glass panels, leading to an interior space with furniture and plants.

A pool area with lounge chairs and candles, surrounded by palm trees and a building in the background.

10. Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Molly

NT$3,063

NT$4,240 total

includes taxes & fees

Sep 28 - Sep 29

A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.

A bedroom with a bed, nightstand, lamp, air conditioning unit, and a no smoking sign.

A two-story building with a porch, a sign reading "The Grand Guesthouse," and a purple flag.

A row of blue bicycles parked under a tree, with a white fence and a building in the background.

11. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Travis

NT$3,582

NT$4,824 total

includes taxes & fees

Sep 30 - Oct 1

A room with a bed, a ceiling fan, and a window with blinds.

A poolside area with lounge chairs, a covered seating area, and a small pool.

A room with a yellow armchair, a glass coffee table, and a view of a wooden deck and tropical plants.

A spacious kitchen with wooden cabinets, a granite countertop, and a ceiling fan.

12. The Mermaid & Alligator

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

Brian

NT$5,716

NT$6,430 total

includes taxes & fees

Sep 28 - Sep 29

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

A lush garden with a variety of tropical plants and a paved walkway.

A hallway with a white door, a wooden bench, a blue sofa, and a staircase with a white railing.

13. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Christopher

NT$3,430

NT$4,541 total

includes taxes & fees

Oct 5 - Oct 6

A pool area with lounge chairs and palm trees.

A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.

A hotel named "Santa Maria" with a prominent illuminated sign, a glass entrance, and a view of the ocean.

A modern outdoor seating area with a sofa, chairs, and a small table, surrounded by glass doors and a view of greenery.

14. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Anthony

NT$7,907

NT$11,039 total

includes taxes & fees

Sep 28 - Sep 29

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

A room with a bed, a desk, a chair, a lamp, a painting of a boat on water, and a view of the sea.

A garden with a stone pathway, a wooden fence, and various tropical plants.

A yellow building with a door marked '7'.

15. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Andrew

NT$3,787

NT$4,260 total

includes taxes & fees

Sep 28 - Sep 29

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

A spacious living room with a high ceiling, a ceiling fan, a large painting, a sofa, a coffee table, and a dining area with a table and chairs.

A wicker outdoor seating area with two chairs and a table, surrounded by lush tropical foliage.

A cozy living room with a wooden ceiling, a sofa set, two side tables with lamps, and framed artwork on the wall.

16. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Tricia

NT$4,263

NT$4,796 total

includes taxes & fees

Sep 28 - Sep 29

A gated entrance with lush green foliage and a white picket fence.

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

A covered outdoor dining area with white chairs and tables, surrounded by lush greenery and a wooden deck.

A white colonial-style building with a balcony, surrounded by palm trees and a white picket fence.

17. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

Riley

NT$4,263

NT$4,796 total

includes taxes & fees

Sep 29 - Sep 30

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.

The exterior of the Silver Palms Inn with a two-story structure, a green awning over the entrance, and a palm tree to the right.

A hotel with a pool, bicycles, and lush greenery.

18. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

sam

NT$2,544

NT$5,005 total

includes taxes & fees

Sep 28 - Sep 29

A reception area with a curved marble counter, ceiling fans, large windows, and a staircase.

A breakfast table with a variety of food items, including fruits, pastries, and a coffee mug.

A bedroom with a bed, two bedside lamps, a ceiling fan, and a view of a balcony with plants.

A poolside area with lounge chairs and a clear blue pool surrounded by lush tropical vegetation.

19. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

Anthony

NT$4,430

NT$4,984 total

includes taxes & fees

Sep 28 - Sep 29

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.

A grand staircase with ornate railings and a chandelier.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

20. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

yessy

NT$4,423

NT$8,995 total

includes taxes & fees

Oct 25 - Oct 26

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,007 reviews	View
Artist House Key West	9.8 Exceptional 456 reviews	View
The Gardens Hotel	9.8 Exceptional 1,003 reviews	View
The Conch House Heritage Inn	9.8 Exceptional 190 reviews	View
Alexander's Guesthouse - Adult Exclusive	9.8 Exceptional 169 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

The Southernmost Inn - Adults Only

10/10 Excellent

"It was close to duval and convenient"

Douglas House - Adults Only

10/10 Excellent

"Amazing!"

Tranquility Guest House

10/10 Excellent

"Very quiet. Great location Def would stay here again"

Southernmost Beach Resort and Guesthouses

10/10 Excellent

"We loved the property, staff, room, but was unable to enjoy the beach at the hotel and was not notified beach was not going to be opened. We picked this hotel for the beach access and didn’t find out the beach was not available until we went down to the beach to relax."

La Concha Key West, Autograph Collection

10/10 Excellent

"Great location"

Lighthouse Hotel - Key West Historic Inns

8/10 Good

"Loved the breakfast. The restaurant by the pool was closed early afternoon did not have the happy hour lack of communication with anything to do with amenities need more signage regarding early closing of amenities"

Duval House

10/10 Excellent

"Fly in, Uber to and from the Duvall, fly home! Great place to have a fun time!"

Winslow's Bungalows - Key West Historic Inns

10/10 Excellent

"From before we arrived we already knew we chose the right place to stay! We had questions about parking our motorcycle on property and there was no hesitation to share information and also connect with us. The staff is great. We are recommending this location and properties to friends and family. Next time we’re in town, 100% this will be the place we stay. Location is great and the property is fun to explore. Thank you all for making our stay memorable!"

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Waterfront Playhouse, and Coffee Butler Amphitheater if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$3,629

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Artist House Key West

3. The Gardens Hotel

4. The Conch House Heritage Inn

5. Alexander's Guesthouse - Adult Exclusive

6. H2O Suites - Adults Only

7. The Marquesa Hotel

8. Douglas House - Adults Only

9. Island City House Hotel

10. Tropical Inn

11. The Grand Guesthouse

12. The Mermaid & Alligator

13. Duval House

14. Santa Maria Suites

15. Alexander Palms Court

16. Ambrosia Key West

17. Coco Plum Inn

18. Silver Palms Inn & Historic Homes

19. Westwinds Inn

20. Southernmost House - Adult Exclusive

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

The Southernmost Inn - Adults Only

Douglas House - Adults Only

Tranquility Guest House

Southernmost Beach Resort and Guesthouses

La Concha Key West, Autograph Collection

Lighthouse Hotel - Key West Historic Inns

Duval House

Winslow's Bungalows - Key West Historic Inns

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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