The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

John

NT$7,145

NT$8,038 total

includes taxes & fees

Oct 6 - Oct 7

A tropical outdoor area with palm trees, hanging plants, and string lights.

An outdoor patio with a table and chairs, surrounded by lush greenery and string lights.

A large, two-story building with a balcony, surrounded by dense tropical foliage.

A wooden deck with lush greenery and a pool area.

2. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Maricela

NT$3,251

NT$4,023 total

includes taxes & fees

Oct 6 - Oct 7

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A colonial-style building with a porch, surrounded by lush tropical vegetation.

A bar area with a counter, chairs, and a clock.

A bedroom with a large bed, a television on a dresser, and a view of the outdoors through a sliding door.

3. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Forrest

NT$7,139

NT$8,031 total

includes taxes & fees

Oct 6 - Oct 7

A porch with a white railing, a bench, and a flag.

A spacious bedroom with a large bed, a sitting area with a sofa and armchairs, and a dining area with a table and chairs.

A pool area with lounge chairs and a dining table, surrounded by palm trees and a house with a porch.

A two-story white house with green shutters, a wooden door, and a white picket fence.

4. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

John

NT$6,041

NT$6,796 total

includes taxes & fees

Oct 6 - Oct 7

A pool area with lounge chairs and a table, surrounded by palm trees.

A neon sign for Orchid Key Inn with a 'VACANCY' sign below it.

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

A building with a neon sign that reads "Orchid Key Inn."

5. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Nicholas

NT$7,145

NT$8,038 total

includes taxes & fees

Oct 6 - Oct 7

A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.

A pool area with lounge chairs, a pool, and a building with a balcony and outdoor seating.

A spacious living room with a sofa, chairs, and a dining table. There are large windows with blinds, a door leading to a patio, and a ceiling with exposed beams.

A spacious living room with a wooden ceiling, white sofas, a patterned armchair, a glass coffee table, and a large painting on the wall.

6. Alexander's Guesthouse - Adult Exclusive

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Nestor

NT$6,906

NT$9,079 total

includes taxes & fees

Oct 6 - Oct 7

A two-story house with a covered porch, a brick pathway, and a large tree.

A poolside area with a swimming pool, a staircase leading to a deck, and a building with multiple windows and balconies.

A restaurant with multiple tables set for dining, a wine bottle, and a glass of wine on the table.

A hotel room with two beds, a ceiling fan, a large window with a view of palm trees, and a painting on the wall.

7. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Darrell

NT$10,801

NT$13,943 total

includes taxes & fees

Oct 12 - Oct 13

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

A garden with a pond, rocks, and various plants.

A pool area with lounge chairs and a wooden building with balconies.

A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.

8. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Osvaldo

NT$5,793

NT$6,518 total

includes taxes & fees

Oct 11 - Oct 12

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

A hallway with a white door, a wooden bench, a blue sofa, and a staircase with a white railing.

A lush garden with a variety of tropical plants and a paved walkway.

9. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Christopher

NT$4,429

NT$5,667 total

includes taxes & fees

Oct 14 - Oct 15

A pool area with lounge chairs and palm trees.

A modern outdoor seating area with a sofa, chairs, and a small table, surrounded by glass doors and a view of greenery.

A neatly made bed with patterned pillows, a bedside table with a bottle and glasses, and a window with orchids.

A sign for Santa Maria Resort surrounded by lush greenery and palm trees.

10. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Anthony

NT$9,845

NT$13,226 total

includes taxes & fees

Oct 25 - Oct 26

A room with a bed, a ceiling fan, and a window with blinds.

A poolside area with lounge chairs, a covered seating area, and a small pool.

A cozy outdoor seating area with a wooden bench and a table, surrounded by potted plants and a coffee and tea sign.

A spacious kitchen with wooden cabinets, a granite countertop, and a ceiling fan.

11. The Mermaid & Alligator

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

Adam

NT$7,322

NT$8,238 total

includes taxes & fees

Oct 8 - Oct 9

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

A large, two-story house with a prominent tower and a covered porch.

12. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

yessy

NT$4,438

NT$9,025 total

includes taxes & fees

Oct 26 - Oct 27

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

A wicker outdoor seating area with two chairs and a table, surrounded by lush tropical foliage.

A hotel room with a bed, a nightstand, a chair, a small table, and a ceiling fan.

A spacious living room with a high ceiling, a ceiling fan, a large painting, a sofa, a coffee table, and a dining area with a table and chairs.

13. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Tricia

NT$4,660

NT$5,242 total

includes taxes & fees

Oct 6 - Oct 7

A reception area with a curved marble counter, ceiling fans, large windows, and a staircase.

A poolside area with lounge chairs and a clear blue pool surrounded by lush tropical vegetation.

A two-story house with a white exterior, a green roof, and a staircase leading to the upper floor.

A breakfast table with a variety of food items, including fruits, pastries, and a coffee mug.

14. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

Anthony

NT$5,161

NT$5,807 total

includes taxes & fees

Oct 6 - Oct 7

A gated entrance with lush green foliage and a white picket fence.

A white colonial-style building with a balcony, surrounded by palm trees and a white picket fence.

A covered outdoor dining area with white chairs and tables, surrounded by lush greenery and a wooden deck.

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

15. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

Riley

NT$4,516

NT$5,081 total

includes taxes & fees

Oct 12 - Oct 13

A hotel with a covered entrance, multiple balconies, and palm trees.

A restaurant interior with wooden beams, a bar area, and a colorful ceiling mural.

A room with a stone wall, a wooden bench, a cactus, and a framed painting.

A covered balcony with white Adirondack chairs and a small table with flowers, overlooking a turquoise sea and distant shoreline.

16. Opal Key Resort & Marina, Key West

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Susan

NT$8,252

NT$10,538 total

includes taxes & fees

Oct 6 - Oct 7

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

A room with a bed, a desk, a chair, a lamp, a painting of a boat on water, and a view of the sea.

A garden with a stone pathway, a wooden fence, and various tropical plants.

A yellow building with a door marked '7'.

17. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Andrew

NT$3,799

NT$4,274 total

includes taxes & fees

Oct 7 - Oct 8

A poolside area with lounge chairs, umbrellas, and a pergola.

A living room with a spiral staircase, a sofa, a chair, a coffee table, and a view of an outdoor seating area.

A bright kitchen with white cabinetry, a white island, wicker pendant lights, and geometric patterned backsplash.

An open door leading to a pool area with a wicker chair and a sofa inside a room with a view of the pool.

18. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

tracy

NT$7,328

NT$9,857 total

includes taxes & fees

Oct 6 - Oct 7

A building with a white exterior, a large red awning, and a gated entrance.

A small, enclosed porch with a chair and a table, surrounded by lush greenery and a white lattice fence.

A pool area with lounge chairs and a lifebuoy.

A spacious kitchen with a dining area, large windows, and a view of the outdoors.

19. Authors of Key West Guest House

The Meadows, 1.8 km from Florida Keys National Marine Sanctuary

Robbie

NT$2,844

NT$3,199 total

includes taxes & fees

Oct 8 - Oct 9

A covered porch with white railings, wooden benches, and a hanging light fixture.

A bedroom with a four-poster bed, a wicker chair, a wooden dresser, and a television.

A sign for Marrero's Guest Mansion in Key West, FL, by Verdigris Hotels.

A pool area with lounge chairs and a small palm tree.

20. Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Michael

NT$10,004

NT$11,255 total

includes taxes & fees

Oct 7 - Oct 8

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,001 reviews	View
Douglas House - Adults Only	9.8 Exceptional 548 reviews	View
The Gardens Hotel	9.8 Exceptional 1,006 reviews	View
The Conch House Heritage Inn	9.8 Exceptional 191 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,002 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Douglas House - Adults Only

10/10 Excellent

"Booked this place for my family in early October. Douglas House is in a great location. Close enough to walk to restaurants, shops, and attractions, but away from most of the bar noise. Our rooms were spacious and clean. Balcony was nice for just hanging out. Pool looked nice but we didn't get a chance to use it. Overall, a great place and we would come back again."

Caribbean House

10/10 Excellent

"We had a great experience here. We booked a last minute one day vacation and were pleasantly surprised!"

Weatherstation Inn

8/10 Good

"Beautiful historic property! Loved our stay. Great location within walking distance of many local attractions. Just steps away from Little Whitehouse. Loved the spa like toiletries in large shower & the breakfast pastries from local bakery were wonderful as well."

The Southernmost Inn - Adults Only

10/10 Excellent

"This place was great quiet and close to everything"

Lighthouse Hotel - Key West Historic Inns

10/10 Excellent

"Charming"

Casa Marina Key West, Curio Collection by Hilton

10/10 Excellent

"Clear room, great views"

Tranquility Guest House

10/10 Excellent

"Great, calm space. I loved the pool and grabbing a cup of coffee and sitting in this tropical sanctuary while slowly waking up. The location is amazing. Most everything in the main part of Key West for visitors is within easy walk. Soledad and Karina kept the whole property nice and tidy. And the manager Federico was incredibly responsive. Once I arrived I received a text making sure I didn't need anything. It was a perfect way to spend a peaceful week away from my weird life."

Wicker Guesthouse

10/10 Excellent

"Whenever I stay at the Wicker Guesthouse, the staff is always friendly and helpful. They can suggest activities, as well as book them, give discount coupons and easy directions. The cleaning staff are friendly and helpful too. My room was great, accommodations are older, so expect a noisy air conditioner. But the bathrooms were updated and everything was very clean-the sheets and towels smelled so fresh. Breakfast buffet has a large variety, pools were clean with lots of seating. This is the first time I brought my pet and they have a minimal fee. You really have to look for some green space but about 1.5 miles away there is a dog park down at Higgins Beach. Dogs have a tendency to compensate for their environment 😃. I love that the Wicker Guesthouse is walking distance to all the restaurants, bars, shopping, Mallory Square and the southernmost point. There’s so much to do and so little time. I would recommend staying there. I had a great stay!"

Southwinds Motel

10/10 Excellent

"Great location. Third stay here. Will return again Rooms are small but clean fresh coffee every morning."

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$3,199

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Douglas House - Adults Only

3. The Gardens Hotel

4. The Conch House Heritage Inn

5. Orchid Key Inn - Adults Only

6. Alexander's Guesthouse - Adult Exclusive

7. The Marquesa Hotel

8. Island City House Hotel

9. Duval House

10. Santa Maria Suites

11. The Mermaid & Alligator

12. Southernmost House - Adult Exclusive

13. Ambrosia Key West

14. Westwinds Inn

15. Coco Plum Inn

16. Opal Key Resort & Marina, Key West

17. Alexander Palms Court

18. Ella's Cottages - Key West Historic Inns

19. Authors of Key West Guest House

20. Marrero's Guest Mansion

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Douglas House - Adults Only

Caribbean House

Weatherstation Inn

The Southernmost Inn - Adults Only

Lighthouse Hotel - Key West Historic Inns

Casa Marina Key West, Curio Collection by Hilton

Tranquility Guest House

Wicker Guesthouse

Southwinds Motel

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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