The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Teresa

NT$8,338

NT$9,380 total

includes taxes & fees

Oct 26 - Oct 27

A modern outdoor area with a pool, lounge chairs, and a bar area.

A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.

An outdoor seating area with a modern fire feature, surrounded by lush greenery and palm trees.

A modern hotel with a prominent glass facade, palm trees, and a clear sky.

2. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kimberly

NT$9,761

NT$13,181 total

includes taxes & fees

Oct 28 - Oct 29

A pool area with lounge chairs and a table, surrounded by palm trees.

A neon sign for Orchid Key Inn with a 'VACANCY' sign below it.

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

A building with a neon sign that reads "Orchid Key Inn."

3. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

ben

NT$8,338

NT$9,380 total

includes taxes & fees

Oct 26 - Oct 27

A tropical outdoor area with palm trees, hanging plants, and string lights.

A hotel room with a bed, a wooden floor, a seating area with a table and chairs, and a view of greenery outside.

An outdoor patio with a table and chairs, surrounded by lush greenery and string lights.

A large, two-story building with a balcony, surrounded by dense tropical foliage.

4. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Maricela

NT$4,615

NT$5,712 total

includes taxes & fees

Oct 26 - Oct 27

A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.

A spacious living room with a wooden ceiling, white sofas, a patterned armchair, a glass coffee table, and a large painting on the wall.

A narrow room with a bed, a potted plant, and a window with blinds.

A spacious living room with a sofa, chairs, and a dining table. There are large windows with blinds, a door leading to a patio, and a ceiling with exposed beams.

5. Alexander's Guesthouse - Adult Exclusive

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Nestor

NT$7,893

NT$10,242 total

includes taxes & fees

Oct 28 - Oct 29

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A bar area with a counter, chairs, and a clock.

A colonial-style building with a porch, surrounded by lush tropical vegetation.

A couple walking along a poolside pathway surrounded by lush greenery.

6. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Gisele

NT$7,299

NT$8,211 total

includes taxes & fees

Oct 27 - Oct 28

A gated entrance to Villas Key West with a brick pathway leading to the gate.

A swimming pool with a hot tub, surrounded by a wooden deck and lush greenery.

A covered porch with wicker furniture, a large potted plant, and a sign for Villas Key West.

A house with a porch, a table, and a door with a number '6'.

7. Key West Villas

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Margaret

NT$8,773

NT$9,870 total

includes taxes & fees

Nov 2 - Nov 3

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A two-story building with a white picket fence, a mailbox, and a small tree in front.

A lush garden with a variety of tropical plants and a paved walkway.

A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

8. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Cathrine

NT$4,173

NT$5,395 total

includes taxes & fees

Oct 26 - Oct 27

A two-story house with a covered porch, a brick pathway, and a large tree.

A hotel room with two beds, a ceiling fan, a large window with a view of palm trees, and a painting on the wall.

A restaurant with multiple tables set for dining, a wine bottle, and a glass of wine on the table.

A poolside area with a swimming pool, a staircase leading to a deck, and a building with multiple windows and balconies.

9. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Josh

NT$13,986

NT$17,568 total

includes taxes & fees

Oct 26 - Oct 27

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

A garden with a pond, rocks, and various plants.

A covered walkway with a wooden ceiling, white railings, and a brick path.

A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.

10. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Elise

NT$6,467

NT$7,275 total

includes taxes & fees

Oct 26 - Oct 27

A pool area with lounge chairs and palm trees.

A sign for Santa Maria Resort surrounded by lush greenery and palm trees.

A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.

A modern outdoor seating area with a sofa, chairs, and a small table, surrounded by glass doors and a view of greenery.

11. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Anthony

NT$9,748

NT$13,167 total

includes taxes & fees

Oct 26 - Oct 27

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A large, two-story house with a prominent tower and a covered porch.

A grand staircase with ornate railings and a chandelier.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

12. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Janet

NT$4,660

NT$9,369 total

includes taxes & fees

Oct 27 - Oct 28

A green house with a white porch, a flag, and a sign advertising a property for sale.

A bathroom with a vanity, a mirror, and a window with blinds.

A covered porch with wicker furniture, potted plants, and a view of the house.

A bedroom with a large bed, a sofa, a nightstand, and a painting on the wall.

13. L'Habitation Guest House - Adults Only

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Richard

NT$4,727

NT$5,318 total

includes taxes & fees

Oct 27 - Oct 28

A gated entrance with lush green foliage and a white picket fence.

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

A covered outdoor dining area with white chairs and tables, surrounded by lush greenery and a wooden deck.

A hotel room with a large bed, two bedside tables, a ceiling fan, and two framed pictures on the wall.

14. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

August

NT$5,854

NT$6,585 total

includes taxes & fees

Oct 26 - Oct 27

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

A pool area with a circular pool, lounge chairs, and a gazebo.

A room with a bed, a desk, a chair, a lamp, a painting of a boat on water, and a view of the sea.

A yellow building with a door marked '7'.

15. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Brenda

NT$4,665

NT$5,249 total

includes taxes & fees

Oct 26 - Oct 27

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

A spacious living room with a high ceiling, a ceiling fan, a large painting, a sofa, a coffee table, and a dining area with a table and chairs.

A cozy living room with a wooden ceiling, a sofa set, two side tables with lamps, and framed artwork on the wall.

A wicker outdoor seating area with two chairs and a table, surrounded by lush tropical foliage.

16. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

RICHARD

NT$5,854

NT$6,585 total

includes taxes & fees

Oct 26 - Oct 27

A poolside area with lounge chairs, umbrellas, and a pergola.

A bright kitchen with white cabinetry, a white island, wicker pendant lights, and geometric patterned backsplash.

A wooden bench with a cushion and a small table, surrounded by bamboo plants and a wooden deck.

An open door leading to a pool area with a wicker chair and a sofa inside a room with a view of the pool.

17. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Lisa and David

NT$6,520

NT$8,986 total

includes taxes & fees

Oct 26 - Oct 27

A wooden deck with wicker furniture and a white railing, surrounded by lush tropical vegetation.

A two-story building with a white picket fence, palm trees, and a clear blue sky.

A pathway leading to a building with a white facade, surrounded by lush greenery and palm trees.

A breakfast tray with croissants, orange juice, and coffee on a table by a window with a view of a pool and greenery.

18. Weatherstation Inn

Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary

Robert

NT$5,836

NT$6,565 total

includes taxes & fees

Oct 27 - Oct 28

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.

A two-story yellow house with a porch, white railings, and green shutters.

A hotel with a pool, bicycles, and lush greenery.

19. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

sam

NT$3,492

NT$6,129 total

includes taxes & fees

Oct 26 - Oct 27

A covered porch with white railings, wooden benches, and a hanging light fixture.

A living room with a large mirror, a wicker chair, a television on a wooden cabinet, and a window with a view of palm trees.

A bedroom with a four-poster bed, a wicker chair, a wooden dresser, and a television.

A sign for Marrero's Guest Mansion in Key West, FL, by Verdigris Hotels.

20. Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Michael

NT$12,845

NT$14,450 total

includes taxes & fees

Nov 25 - Nov 26

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,008 reviews	View
H2O Suites - Adults Only	9.8 Exceptional 670 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,003 reviews	View
Douglas House - Adults Only	9.8 Exceptional 568 reviews	View
Alexander's Guesthouse - Adult Exclusive	9.8 Exceptional 172 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

The Reach Key West, Curio Collection by Hilton

10/10 Excellent

"I wouldn’t choose another place to stay other than here. Total first class from check in to check out. Stayed here over ten times the past three years. Believe me, it’s worth it. Cheers"

Duval House

10/10 Excellent

"Room was very clean and well maintained. Nice continental breakfast."

Pier House Resort & Spa

10/10 Excellent

"Great parking. Very central. Room was big and staying in the Spa building was quiet and great!"

Winslow's Bungalows - Key West Historic Inns

8/10 Good

"Property is just a short walk to Duval Street. Grounds are very nice with lush vegetation and palm trees. There are 3 pools. They are small but very well maintained. Outside bar is near one pool."

Southernmost Beach Resort and Guesthouses

10/10 Excellent

"Easy check in, huge property, great location and beautiful grounds."

Douglas House - Adults Only

10/10 Excellent

"Had another fantastic day thank you for your hospitality☀️☀️☀️"

The Southernmost Inn - Adults Only

8/10 Good

"Wonderfully situated & quiet suite on United. Cleaning could have been better if more attention had been paid. Warm & hot water took forever. Shower could be much better if it had an attached hose for all around water. Water pressure sucked! Maudia (check in person) was excellent. Kitchen staff appeared angry & was less than helpful. Pool surroundings not kept up. Temperatures of both hot tub & pools were good."

Paradise Inn Key West - Adults Only

10/10 Excellent

"Convenient location"

Tranquility Guest House

10/10 Excellent

"We arrived to the cutest guest houses the abundance of tropical foliage and brick landscaping we’re so welcoming the pool was a bit chilly with the trees over head but it was clean and still enjoyable. The lounge chairs were free the whole time and we didn’t expect the coffee service in the morning but it was a delightful surprise. The room… modern industrial nicer than a few of the big corp hotels nearby! Bed was soo comfortable ac worked great our tv didn’t work but I didn’t come to watch tv soo didn’t care. Easy 2 block walk to the Duvall st food/bars & entertainment !! We only stayed two nights but they were the best nights of our week! If I had to list something I didn’t like it would be how often the roosters woke us up before we were ready to get up. Honestly would stay here over many other locations"

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$5,249

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. H2O Suites - Adults Only

3. Orchid Key Inn - Adults Only

4. Douglas House - Adults Only

5. Alexander's Guesthouse - Adult Exclusive

6. The Gardens Hotel

7. Key West Villas

8. Duval House

9. The Marquesa Hotel

10. Island City House Hotel

11. Santa Maria Suites

12. Southernmost House - Adult Exclusive

13. L'Habitation Guest House - Adults Only

14. Coco Plum Inn

15. Alexander Palms Court

16. Ambrosia Key West

17. Ella's Cottages - Key West Historic Inns

18. Weatherstation Inn

19. Silver Palms Inn & Historic Homes

20. Marrero's Guest Mansion

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

The Reach Key West, Curio Collection by Hilton

Duval House

Pier House Resort & Spa

Winslow's Bungalows - Key West Historic Inns

Southernmost Beach Resort and Guesthouses

Douglas House - Adults Only

The Southernmost Inn - Adults Only

Paradise Inn Key West - Adults Only

Tranquility Guest House

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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