The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

John

NT$5,135

NT$5,777 total

includes taxes & fees

Sep 14 - Sep 15

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A couple walking along a poolside pathway surrounded by lush greenery.

A colonial-style building with a porch, surrounded by lush tropical vegetation.

A bedroom with a large bed, a television on a dresser, and a view of the outdoors through a sliding door.

2. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Jason

NT$5,294

NT$5,956 total

includes taxes & fees

Sep 21 - Sep 22

A pool area with lounge chairs and a table, surrounded by palm trees.

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

A building with a neon sign that reads "Orchid Key Inn."

A neon sign for Orchid Key Inn with a 'VACANCY' sign below it.

3. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Nicholas

NT$5,135

NT$5,777 total

includes taxes & fees

Sep 14 - Sep 15

A two-story house with a covered porch, a brick pathway, and a large tree.

A hotel room with two beds, a ceiling fan, a large window with a view of palm trees, and a painting on the wall.

A covered porch with white wicker furniture and a blue floor, surrounded by lush tropical plants.

A restaurant with multiple tables set for dining, a wine bottle, and a glass of wine on the table.

4. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

LISA

NT$6,060

NT$8,592 total

includes taxes & fees

Sep 28 - Sep 29

A modern outdoor area with a pool, lounge chairs, and a bar area.

A modern hotel room with a bed, sofa, coffee table, and artwork.

A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.

A modern hotel with a prominent glass facade, palm trees, and a clear sky.

5. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kourosh

NT$8,802

NT$12,032 total

includes taxes & fees

Sep 13 - Sep 14

A tropical outdoor area with palm trees, hanging plants, and string lights.

A wooden deck with lush greenery and a pool area.

A large, two-story building with a balcony, surrounded by dense tropical foliage.

A hotel room with a bed, a wooden floor, a seating area with a table and chairs, and a view of greenery outside.

6. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

michael

NT$3,718

NT$4,601 total

includes taxes & fees

Sep 29 - Sep 30

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

A covered walkway with a wooden ceiling, white railings, and a brick path.

A garden with a pond, rocks, and various plants.

A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.

7. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Paul

NT$4,851

NT$5,457 total

includes taxes & fees

Sep 13 - Sep 14

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A lush garden with a variety of tropical plants and a paved walkway.

A two-story building with a white picket fence, a mailbox, and a small tree in front.

A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

8. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Robert

NT$3,123

NT$4,192 total

includes taxes & fees

Sep 20 - Sep 21

A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.

A covered outdoor area with a wooden staircase, seating, and potted plants.

A two-story building with a porch, a sign reading "The Grand Guesthouse," and a purple flag.

A bedroom with a bed, nightstand, lamp, air conditioning unit, and a no smoking sign.

9. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Alissa

NT$3,550

NT$4,780 total

includes taxes & fees

Sep 16 - Sep 17

A pool area with lounge chairs and palm trees.

A sign for Santa Maria Resort surrounded by lush greenery and palm trees.

A hotel named "Santa Maria" with a prominent illuminated sign, a glass entrance, and a view of the ocean.

A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.

10. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

June Young

NT$8,802

NT$12,032 total

includes taxes & fees

Sep 13 - Sep 14

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A grand staircase with ornate railings and a chandelier.

A large, two-story house with a prominent tower and a covered porch.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

11. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Mark

NT$4,395

NT$8,937 total

includes taxes & fees

Sep 27 - Sep 28

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.

The exterior of the Silver Palms Inn with a two-story structure, a green awning over the entrance, and a palm tree to the right.

A two-story yellow house with a porch, white railings, and green shutters.

12. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

Shawn

NT$2,527

NT$4,973 total

includes taxes & fees

Sep 14 - Sep 15

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

A cozy living room with a wooden ceiling, a sofa set, two side tables with lamps, and framed artwork on the wall.

A hotel room with a bed, a nightstand, a chair, a small table, and a ceiling fan.

A spacious living room with a high ceiling, a ceiling fan, a large painting, a sofa, a coffee table, and a dining area with a table and chairs.

13. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Kate

NT$4,236

NT$4,765 total

includes taxes & fees

Sep 27 - Sep 28

A wooden deck with wicker furniture and a white railing, surrounded by lush tropical vegetation.

A pathway leading to a building with a white facade, surrounded by lush greenery and palm trees.

A swimming pool with a white picket fence, surrounded by lounge chairs and potted plants.

A two-story building with a white picket fence, palm trees, and a clear blue sky.

14. Weatherstation Inn

Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary

Svetlana

NT$5,332

NT$5,998 total

includes taxes & fees

Sep 14 - Sep 15

A poolside area with lounge chairs, umbrellas, and a pergola.

A wooden bench with a cushion and a small table, surrounded by bamboo plants and a wooden deck.

A bright kitchen with white cabinetry, a white island, wicker pendant lights, and geometric patterned backsplash.

An open door leading to a pool area with a wicker chair and a sofa inside a room with a view of the pool.

15. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Susannah

NT$6,310

NT$8,696 total

includes taxes & fees

Sep 13 - Sep 14

A covered porch with white railings, wooden benches, and a hanging light fixture.

A living room with a large mirror, a wicker chair, a television on a wooden cabinet, and a window with a view of palm trees.

A bedroom with a four-poster bed, a wicker chair, a wooden dresser, and a television.

A pool area with lounge chairs and a small palm tree.

16. Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Michael

NT$6,909

NT$7,773 total

includes taxes & fees

Sep 23 - Sep 24

A building with a white exterior, a large red awning, and a gated entrance.

A pool area with lounge chairs and a lifebuoy.

A small, enclosed porch with a chair and a table, surrounded by lush greenery and a white lattice fence.

A spacious kitchen with a dining area, large windows, and a view of the outdoors.

17. Authors of Key West Guest House

The Meadows, 1.8 km from Florida Keys National Marine Sanctuary

Idamis

NT$2,343

NT$2,635 total

includes taxes & fees

Sep 28 - Sep 29

A wooden deck with wicker furniture, a white staircase, and a lush garden area.

A bedroom with a large bed, a view of a swimming pool, and an open door leading to an outdoor seating area.

A hotel entrance with a sign reading "Heron House Office."

A two-story house with a balcony, surrounded by palm trees and a clear blue sky.

18. Heron House - Adult Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Natalia

NT$3,661

NT$5,166 total

includes taxes & fees

Sep 13 - Sep 14

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

A yellow building with a door marked '7'.

A room with a bed, a desk, a chair, a lamp, a painting of a boat on water, and a view of the sea.

A pool area with a covered seating area, palm trees, and a small pavilion.

19. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Andrew

NT$4,472

NT$5,032 total

includes taxes & fees

Sep 13 - Sep 14

A bright green porch with hanging planters, a wooden chair, and a railing.

A bar area with a wooden counter, colorful decorations, and a sign with motivational ocean-themed text.

A marina with multiple boats docked, wooden pilings, and a dock with ropes.

20. Caribbean House

Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary

David

NT$3,742

NT$4,998 total

includes taxes & fees

Sep 14 - Sep 15

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,000 reviews	View
The Gardens Hotel	9.8 Exceptional 1,000 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,000 reviews	View
The Marquesa Hotel	9.8 Exceptional 1,004 reviews	View
H2O Suites - Adults Only	9.8 Exceptional 652 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Opal Key Resort & Marina, Key West

8/10 Good

"This is a lovely hotel. The property is nice, the pool a nice size with attendants there for towels, water and to bring you food and drinks from the bar area. We booked a king ocean view and when we got there they apologized and said they didn't have any more King ocean view rooms for that night. Mind you, we were early but they were not going to have one. They gave us a double queen for that night. The room itself was nice but it had a barn door for the bathroom, which i don't like. It didn't cover the opening completely. The next day we got moved to the king ocean view. This had a regular door for the bath, the housekeeping was good and we enjoyed the rest of our stay. I would have given a 5 star if they had accounted for their rooms correctly. How does this happen? It shouldn't, especially for a hotel of this caliper. There is an adjoining restaurant with a bar. The food was very good. We had a Carnival cruise ship come one day, and I did read people complaining about it blocking the view. It had left before sunset so it didn't bother us."

Southwinds Motel

10/10 Excellent

"Great property and the staff very helpful and friendly."

The Cabana Inn Key West - Adults Only

10/10 Excellent

"Excellent spot to stay right off Duval street...authentic Key West vibe"

Southernmost Beach Resort and Guesthouses

10/10 Excellent

"It was close to everything! Justin at the front desk and the lady that rented us the golf cart were amazing!"

Winslow's Bungalows - Key West Historic Inns

10/10 Excellent

"Very nice room. Bed was very comfortable. Property offered privacy even though rooms and bungalows were very close together. Bungalow bar was great. Food and drinks were great. Had to ask to have room cleaned. 45$ per day amenities fee seemed excessive. Amenities should be part of room rate."

Pier House Resort & Spa

10/10 Excellent

"What a great resort! Everything you need from a beach resort and more. The beautiful beach with NO sargassum. Clean, well maintained pool and common areas. Friendly staff. Delicious food and drinks. One of the best places I've ever stayed."

La Concha Key West, Autograph Collection

10/10 Excellent

"Love the history of La Concha, the vibe, bar, size and the location, almost mid-way on Duval Street, the hub of activity. It’s also one of the stops on the “hop-on hop-off “(every 30min) Old Town Trolley Key West Tours, which is a really big deal. There are no doubt other excellent properties in Key West, but La Concha was a great fit for me. I will definitely stay there on my next trip to the island."

Caribbean House

10/10 Excellent

"Ashley is the best! Caribbean House is home away from home."

Duval House

10/10 Excellent

"Cold rooms!"

Other attractions near Florida Keys National Marine Sanctuary

A yellow exhibit labeled 'NOAA's AQUARIUS UNDERSEA LAB' with a circular window and a door.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

See properties

A brick corridor with arched ceilings and benches.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

See properties

A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

See properties

The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

See properties

Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

See properties

USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

See properties

Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

See properties

We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

See properties

Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1495 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and Pier House Resort & Spa.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1495 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Waterfront Playhouse, and Coffee Butler Amphitheater if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$2,635

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. The Gardens Hotel

3. Orchid Key Inn - Adults Only

4. The Marquesa Hotel

5. H2O Suites - Adults Only

6. Douglas House - Adults Only

7. Island City House Hotel

8. Duval House

9. The Grand Guesthouse

10. Santa Maria Suites

11. Southernmost House - Adult Exclusive

12. Silver Palms Inn & Historic Homes

13. Ambrosia Key West

14. Weatherstation Inn

15. Ella's Cottages - Key West Historic Inns

16. Marrero's Guest Mansion

17. Authors of Key West Guest House

18. Heron House - Adult Only

19. Alexander Palms Court

20. Caribbean House

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Opal Key Resort & Marina, Key West

Southwinds Motel

The Cabana Inn Key West - Adults Only

Southernmost Beach Resort and Guesthouses

Winslow's Bungalows - Key West Historic Inns

Pier House Resort & Spa

La Concha Key West, Autograph Collection

Caribbean House

Duval House

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

Explore a world of travel with Expedia