The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Teresa

NT$8,007

NT$9,008 total

includes taxes & fees

Oct 25 - Oct 26

A modern outdoor area with a pool, lounge chairs, and a bar area.

An outdoor seating area with a modern fire feature, surrounded by lush greenery and palm trees.

A modern hotel room with a bed, sofa, coffee table, and artwork.

A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.

2. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kimberly

NT$9,761

NT$13,181 total

includes taxes & fees

Oct 28 - Oct 29

A pool area with lounge chairs and a table, surrounded by palm trees.

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

A neon sign for Orchid Key Inn with a 'VACANCY' sign below it.

3. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

ben

NT$8,251

NT$9,283 total

includes taxes & fees

Oct 25 - Oct 26

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A bar area with a counter, chairs, and a clock.

A colonial-style building with a porch, surrounded by lush tropical vegetation.

A bedroom with a large bed, a television on a dresser, and a view of the outdoors through a sliding door.

4. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Gisele

NT$7,299

NT$8,211 total

includes taxes & fees

Oct 27 - Oct 28

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

A hallway with a white door, a wooden bench, a blue sofa, and a staircase with a white railing.

A two-story building with a white picket fence, a mailbox, and a small tree in front.

5. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Cathrine

NT$4,166

NT$5,387 total

includes taxes & fees

Oct 26 - Oct 27

A gated entrance with lush green foliage and a white picket fence.

A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.

A hotel room with a large bed, two bedside tables, a ceiling fan, and two framed pictures on the wall.

A covered outdoor dining area with white chairs and tables, surrounded by lush greenery and a wooden deck.

6. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

August

NT$5,155

NT$5,799 total

includes taxes & fees

Oct 25 - Oct 26

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

A yellow building with a door marked '7'.

A garden with a stone pathway, a wooden fence, and various tropical plants.

A room with a bed, a desk, a chair, a lamp, a painting of a boat on water, and a view of the sea.

7. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Brenda

NT$5,252

NT$5,909 total

includes taxes & fees

Oct 27 - Oct 28

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

A grand staircase with ornate railings and a chandelier.

8. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Janet

NT$4,653

NT$9,354 total

includes taxes & fees

Oct 27 - Oct 28

A poolside area with lounge chairs, umbrellas, and a pergola.

An open door leading to a pool area with a wicker chair and a sofa inside a room with a view of the pool.

A living room with a spiral staircase, a sofa, a chair, a coffee table, and a view of an outdoor seating area.

A wooden bench with a cushion and a small table, surrounded by bamboo plants and a wooden deck.

9. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Lisa and David

NT$6,510

NT$8,971 total

includes taxes & fees

Oct 25 - Oct 26

A large, white, two-story building with a balcony and a sign reading "The Marker Resort."

A marina with various boats docked, including a green and white boat named 'Jolly Roger'.

A resort with a swimming pool, lounge chairs, umbrellas, and palm trees.

A covered outdoor area with a pool, palm trees, and lounge chairs.

10. The Marker Key West Harbor Resort

Historic Seaport, 1.3 km from Florida Keys National Marine Sanctuary

Lynne

NT$5,911

NT$8,777 total

includes taxes & fees

Oct 25 - Oct 26

A two-story building with a white picket fence, palm trees, and a sign that reads 'DUVAL GARDENS.'

A porch with wicker chairs and a table, white railings, and a window with a view of a palm tree.

A kitchen counter with a coffee maker, a bottle of champagne, and various fruits and pastries.

11. Duval Gardens - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

JoAnn

NT$4,959

NT$7,779 total

includes taxes & fees

Oct 25 - Oct 26

A pool area with a brick patio, potted plants, and a covered seating area.

A white picket fence, a palm tree, and a sign reading "Garden House Key West".

A view through a glass door with a metal handle, leading to a white fence and a blue car parked outside.

A porch with a white chair, a wooden door, and a small indoor dining area visible through the door.

12. The Garden House

Historic Seaport, 1.1 km from Florida Keys National Marine Sanctuary

Brad

NT$3,222

NT$4,325 total

includes taxes & fees

Oct 26 - Oct 27

A white building with green shutters and a white picket fence.

A pool area with lounge chairs, a small table, and a thatched umbrella.

A brick pathway leading to a green door, surrounded by lush tropical plants and a white fence.

A hotel room with a large bed, a sitting area, and multiple bookshelves filled with books.

13. Ridley House - Key West Historic Inns

Historic Seaport, 1.1 km from Florida Keys National Marine Sanctuary

Jeffrey

NT$6,510

NT$8,971 total

includes taxes & fees

Oct 25 - Oct 26

A covered porch with wicker furniture, potted plants, and a sign for the "Office" at the Palm Hotel.

A row of bicycles parked in front of a building with a white balcony and a palm tree.

A pink building with a white door, a balcony with a white railing, and a view of a pool area.

A compact kitchen with white cabinets, a microwave, and a small dining area with two wicker chairs.

14. The Palms Hotel

The Meadows, 1.7 km from Florida Keys National Marine Sanctuary

Jerry

NT$5,066

NT$6,431 total

includes taxes & fees

Oct 25 - Oct 26

A bedroom with a bed, bedside table, lamp, and a small kitchenette. There is a balcony with wicker chairs and a glass table.

A cozy cabin with a wooden interior, a bed, a TV, and a kitchenette.

A spacious living area with a wooden staircase, a ceiling fan, a TV, and a view of the beach through an open door.

A spacious living area with a gray sofa, wooden staircase, and a kitchen in the background.

15. Eden House

Historic Seaport, 1.6 km from Florida Keys National Marine Sanctuary

Michelle

NT$4,968

NT$6,259 total

includes taxes & fees

Oct 27 - Oct 28

A poolside area with lounge chairs, a small pool, and a white building with a balcony.

A bedroom with a bed, a ceiling fan, a window with blinds, a painting, and a nightstand with a lamp.

A white building with a sign reading "The StarCare Inn" and a "No Vacancies" sign.

A pool area with lounge chairs, a hot tub, and a deck with a railing.

16. Seascape Tropical Inn - Adult Exclusive

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Evan

NT$6,184

NT$8,605 total

includes taxes & fees

Nov 1 - Nov 2

A pool area with lounge chairs and umbrellas, surrounded by palm trees and a building with a white facade.

A table with chairs in a lush indoor garden setting.

A modern kitchen with a wooden counter, two stools, a wicker chair, and a hanging light fixture.

A pathway leading to a white gazebo with a view of a lighthouse in the distance.

17. Lighthouse Hotel - Key West Historic Inns

Bahama Village, 0.6 km from Florida Keys National Marine Sanctuary

Jill

NT$6,510

NT$8,971 total

includes taxes & fees

Oct 26 - Oct 27

A swimming pool with clear water, surrounded by lush greenery and palm trees.

A covered porch with white columns and wicker furniture.

A yellow building with a blue door and shutters, a number '302' on the wall, and a small porch area.

A hotel room with a bed, a nightstand, a lamp, a ceiling fan, a mirror, a TV, a wardrobe, and a small table.

18. Tranquility Guest House

Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary

Sandra

NT$3,926

NT$7,310 total

includes taxes & fees

Oct 25 - Oct 26

A breakfast setup with wine bottles, fruits, and pastries on a tray by a door with a view of a staircase and greenery.

A pool area with lounge chairs, a wicker basket, and a staircase leading to an upper level.

A spacious kitchen with wooden cabinets and a dining area with a round table and chairs.

A white building with a grey roof, surrounded by potted plants and a blue umbrella.

19. The Cabana Inn Key West - Adults Only

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Donna

NT$5,244

NT$7,363 total

includes taxes & fees

Oct 25 - Oct 26

A deck with sun loungers and a railing overlooking the sea.

A room with a view of the beach and ocean, a bed with a white and blue blanket, and a small table with a potted plant.

A beach scene with two people relaxing under a white umbrella, a palm tree, and a clear blue sky.

A beachside hotel with rows of blue lounge chairs and white umbrellas, palm trees, and a clear blue sky.

20. Southernmost Beach Resort and Guesthouses

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Jacob Stuart

NT$3,851

NT$6,822 total

includes taxes & fees

Oct 26 - Oct 27

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,005 reviews	View
H2O Suites - Adults Only	9.8 Exceptional 669 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,003 reviews	View
The Gardens Hotel	9.8 Exceptional 1,000 reviews	View
Duval House	9.6 Exceptional 1,126 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

The Southernmost Inn - Adults Only

10/10 Excellent

"Quiet room walking distance to Duvall st and the party area. Well maintained. Small but enough for a single or couple."

Opal Key Resort & Marina, Key West

10/10 Excellent

"Proximity to downtown and perfect walking distance to restaurants. Great pool."

Winslow's Bungalows - Key West Historic Inns

10/10 Excellent

"The resort was amazing. Staff was friendly and went out of their way to make you feel welcomed all week, not just when you checked in. The property was clean and the room was very comfortable. I would definitely go back."

Paradise Inn Key West - Adults Only

10/10 Excellent

"Convenient location"

Tranquility Guest House

10/10 Excellent

"We arrived to the cutest guest houses the abundance of tropical foliage and brick landscaping we’re so welcoming the pool was a bit chilly with the trees over head but it was clean and still enjoyable. The lounge chairs were free the whole time and we didn’t expect the coffee service in the morning but it was a delightful surprise. The room… modern industrial nicer than a few of the big corp hotels nearby! Bed was soo comfortable ac worked great our tv didn’t work but I didn’t come to watch tv soo didn’t care. Easy 2 block walk to the Duvall st food/bars & entertainment !! We only stayed two nights but they were the best nights of our week! If I had to list something I didn’t like it would be how often the roosters woke us up before we were ready to get up. Honestly would stay here over many other locations"

Pier House Resort & Spa

10/10 Excellent

"Wonderful vacation. Pier House is the only resort that I’ll stay at. I have been staying there for years. Everything about it is perfect."

Douglas House - Adults Only

10/10 Excellent

"The porch was amazing and tranquil. Loved the location and accommodations. 10/10 will be back here next trip"

Heron House - Adult Only

10/10 Excellent

"Great location. Nice place. Would absolutely stay again"

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$4,325

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. H2O Suites - Adults Only

3. Orchid Key Inn - Adults Only

4. The Gardens Hotel

5. Duval House

6. Coco Plum Inn

7. Alexander Palms Court

8. Southernmost House - Adult Exclusive

9. Ella's Cottages - Key West Historic Inns

10. The Marker Key West Harbor Resort

11. Duval Gardens - Adults Only

12. The Garden House

13. Ridley House - Key West Historic Inns

14. The Palms Hotel

15. Eden House

16. Seascape Tropical Inn - Adult Exclusive

17. Lighthouse Hotel - Key West Historic Inns

18. Tranquility Guest House

19. The Cabana Inn Key West - Adults Only

20. Southernmost Beach Resort and Guesthouses

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

The Southernmost Inn - Adults Only

Opal Key Resort & Marina, Key West

Winslow's Bungalows - Key West Historic Inns

Paradise Inn Key West - Adults Only

Tranquility Guest House

Pier House Resort & Spa

Douglas House - Adults Only

Heron House - Adult Only

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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