The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Teresa

NT$10,589 total

includes taxes & fees

Nov 15 - Nov 16

A tropical outdoor area with palm trees, hanging plants, and string lights.

2. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Xiaojun

NT$9,213 total

includes taxes & fees

Nov 17 - Nov 18

An outdoor seating area with a modern fire feature, surrounded by lush greenery and palm trees.

3. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kimberly

NT$15,486 total

includes taxes & fees

Nov 30 - Dec 1

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

4. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Misty

NT$9,937 total

includes taxes & fees

Nov 18 - Nov 19

A covered entrance with a brick pathway leading to a gated area, surrounded by lush greenery and plants.

5. Key West Villas

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Margaret

NT$9,946 total

includes taxes & fees

Nov 18 - Nov 19

A pool area with lounge chairs and a table, surrounded by palm trees.

6. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Jessica

NT$10,311 total

includes taxes & fees

Nov 15 - Nov 16

A modern interior with a staircase, a sofa set, a wooden table, and a television.

7. Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

William

NT$12,529 total

includes taxes & fees

Nov 25 - Nov 26

A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.

8. Alexander's Guesthouse - Adult Exclusive

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Nestor

NT$8,958 total

includes taxes & fees

Nov 12 - Nov 13

A porch with a white railing, a bench, and a flag.

9. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

Jennifer

NT$12,329 total

includes taxes & fees

Nov 24 - Nov 25

A two-story house with a covered porch, a brick pathway, and a large tree.

10. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Josh

NT$16,896 total

includes taxes & fees

Nov 29 - Nov 30

A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.

11. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Justyn

NT$6,650 total

includes taxes & fees

Nov 23 - Nov 24

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

12. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Dennis

NT$7,285 total

includes taxes & fees

Nov 18 - Nov 19

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

13. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Elise

NT$7,724 total

includes taxes & fees

Nov 15 - Nov 16

A pool area with lounge chairs and palm trees.

14. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Anthony

NT$16,225 total

includes taxes & fees

Dec 2 - Dec 3

A pool area with lounge chairs and candles, surrounded by palm trees and a building in the background.

15. Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Kelley

NT$7,003 total

includes taxes & fees

Nov 15 - Nov 16

A room with a bed, a ceiling fan, and a window with blinds.

16. The Mermaid & Alligator

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

christine

NT$11,692 total

includes taxes & fees

Nov 29 - Nov 30

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

17. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Edward Lance

NT$11,893 total

includes taxes & fees

Nov 16 - Nov 17

A poolside area with lounge chairs and a clear blue pool surrounded by lush tropical vegetation.

18. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

Shari

NT$7,983 total

includes taxes & fees

Nov 29 - Nov 30

A poolside area with lounge chairs, umbrellas, and a pergola.

19. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Lisa and David

NT$9,794 total

includes taxes & fees

Nov 30 - Dec 1

A green house with a white porch, a flag, and a sign advertising a property for sale.

20. L'Habitation Guest House - Adults Only

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Callie

NT$8,094 total

includes taxes & fees

Nov 16 - Nov 17

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	3.5 star property	10.0 Exceptional 1,006 reviews	View
Douglas House - Adults Only	3.5 star property	9.8 Exceptional 587 reviews	View
H2O Suites - Adults Only	3.5 star property	9.8 Exceptional 674 reviews	View
The Gardens Hotel	4.0 star property	9.8 Exceptional 1,001 reviews	View
Key West Villas	3.5 star property	9.8 Exceptional 279 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Douglas House - Adults Only

10/10 Excellent

"Clean place, courteous staff, great location"

The Cabana Inn Key West - Adults Only

10/10 Excellent

"The Cabana Inn is a quaint stay and a few footsteps away from Duval Street. It is located within walking distance of Hemingway's House and the Little White House. The room was clean and bright with a continental breakfast each morning. A small pool and a hot tub were on the grounds to take a moment to relax. The only caveat is that the local Gypsy roosters will awaken you each morning."

The Reach Key West, Curio Collection by Hilton

8/10 Good

"We enjoyed our stay at the Reach and it was nice to be at the beach and within walking distance of the town. Breakfast package was good value both at the Reach and sister hotel. We felt for the cost a few more amenities would be welcome particularly a shuttle to the town. The cost of parking was also extremely high"

Duval House

8/10 Good

"Check in/out was easy. The location was key in booking walkable location. The room was small as advertised, no room to lay out and open 3 suitcases, one on desktop, one on short refrigerator and one on luggage stand in front of one side of French door, window coverings need to be upgraded to actually cover the French door outside entrance, closet was tiny, shower is small and some mildew on grout at corner."

Tranquility Guest House

10/10 Excellent

"While check in was a little confusing, everything after that was fantastic. Room was great, spacious, and clean. The location is fabulous. A short walk to the center of Duval st, giving easy access to everything you'd want to do. The staff was super friendly. I needed to let someone know the battery was low on our lock and it was immediately handled, with a very friendly follow up call to make sure everything was all set and if we needed anything. Also nice 2nd floor porch, great for a morning coffee or evening night cap. Would definitely stay at this location again."

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$6,650

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Douglas House - Adults Only

3. H2O Suites - Adults Only

4. The Gardens Hotel

5. Key West Villas

6. Orchid Key Inn - Adults Only

7. Simonton Court Historic Inn & Cottages

8. Alexander's Guesthouse - Adult Exclusive

9. The Conch House Heritage Inn

10. The Marquesa Hotel

11. The Grand Guesthouse

12. Duval House

13. Island City House Hotel

14. Santa Maria Suites

15. Tropical Inn

16. The Mermaid & Alligator

17. Southernmost House - Adult Exclusive

18. Westwinds Inn

19. Ella's Cottages - Key West Historic Inns

20. L'Habitation Guest House - Adults Only

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Douglas House - Adults Only

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Frequently asked questions

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