The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

John

NT$5,832

NT$6,561 total

includes taxes & fees

Sep 17 - Sep 18

2. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Nicholas

NT$5,211

NT$5,862 total

includes taxes & fees

Sep 20 - Sep 21

3. Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

Robin

NT$6,024

NT$6,777 total

includes taxes & fees

Sep 29 - Sep 30

4. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Robert

NT$5,332

NT$5,999 total

includes taxes & fees

Sep 21 - Sep 22

5. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

John

NT$5,278

NT$5,938 total

includes taxes & fees

Sep 29 - Sep 30

6. The Porch on Frances Inn

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Marcos

NT$3,718

NT$5,136 total

includes taxes & fees

Sep 21 - Sep 22

7. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

LISA

NT$7,266

NT$9,961 total

includes taxes & fees

Sep 28 - Sep 29

Deluxe Suite, 1 King Bed, Personal Plunge Pool | View from room

8. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kourosh

NT$8,866

NT$12,119 total

includes taxes & fees

Sep 27 - Sep 28

Duval Duplex 2 bedrooms 25 ft Balcony (Adults Only) | Living area

9. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Robert

NT$3,028

NT$4,091 total

includes taxes & fees

Sep 20 - Sep 21

Fish Tail Palm Premium King Suite, 1King bed, Large Patio area in Garden, Ground Floor

10. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

michael

NT$2,496

NT$3,088 total

includes taxes & fees

Sep 21 - Sep 22

Poinciana Patio, Pool View, Patio - Adult Only | Terrace/patio

11. Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Anthony

NT$3,075

NT$4,256 total

includes taxes & fees

Sep 17 - Sep 18

Superior Studio Suite, 1 King Bed with Sofa bed, Accessible, Refrigerator & Microwave

Premier Suite, 1 King Bed with Sofa bed, Patio, Garden Area (Room 16) | Living area

12. Alexander's Guesthouse - Adult Exclusive

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Justin

NT$4,274

NT$6,044 total

includes taxes & fees

Sep 20 - Sep 21

Cigar House King Suite w/ Poolside porch | Balcony view

Cigar House Queen Suite w/ Poolside Balcony | Private kitchen

13. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Osvaldo

NT$4,900

NT$5,513 total

includes taxes & fees

Sep 17 - Sep 18

14. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Alissa

NT$3,585

NT$4,827 total

includes taxes & fees

Sep 24 - Sep 25

Audubon Room - Adult Exclusive | Terrace/patio

15. The Mermaid & Alligator

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

Johnny

NT$5,720

NT$6,435 total

includes taxes & fees

Sep 21 - Sep 22

16. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

June Young

NT$8,866

NT$12,119 total

includes taxes & fees

Sep 28 - Sep 29

17. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

Alexey

NT$2,545

NT$5,009 total

includes taxes & fees

Sep 27 - Sep 28

18. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

yessy

NT$4,426

NT$9,001 total

includes taxes & fees

Sep 29 - Sep 30

19. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

Jake

NT$4,279

NT$4,813 total

includes taxes & fees

Sep 17 - Sep 18

Suite, 1 King Bed - Treetop Two 111 (2nd Floor, accessible via staircase)

Standard Room, 1 Queen Bed, Poolside - Poolside (some rooms located on 2nd floor, access by stairs)

Deluxe Cottage, Multiple Beds - Katie's Kottage 101 (bedroom access via spiral staircase) | Living area

20. Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Kate

NT$4,279

NT$4,814 total

includes taxes & fees

Sep 29 - Sep 30

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,003 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,002 reviews	View
Simonton Court Historic Inn & Cottages	9.8 Exceptional 1,001 reviews	View
The Gardens Hotel	9.8 Exceptional 1,000 reviews	View
The Conch House Heritage Inn	9.8 Exceptional 189 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Winslow's Bungalows - Key West Historic Inns

8/10 Good

"We had a nice stay overall. The breakfast was wonderful. The pools were amazing. The property was beautiful and you could see that the staff realt tried hard to make it nice. The staff was very helpful with any issues. We would stay here again. A few things were misnleading such as the water at the bedside looks complimentary until you open it and realize it’s 5 dollars. We had to request our room to be cleaned a few days which should be an automatic since we paid an extra 45 dollars a day for this service. Overall great stay."

Southernmost Beach Resort and Guesthouses

8/10 Good

"Booked this place for the location and how many pools they had. Didn’t know until we got there that the largest pool was under renovation and completely out of service. Not the end of the world but this made the other 2 pools (combined they were the size of the 1 that was closed) more cramped. Then I booked an ocean view room. Always do. Only to find out when we get there that the beach access is closed due to the awful smelling seaweed (sargassum) that is washing up. Again, not the end of the world but it smells gross! Overall, stay was relaxing but could’ve been better. Sheets always felt like they had sand in them after the cleaning crew would come in and make the bed up so I always had to wipe them out before we got in for the evening. Older rooms but you can tell they are trying to renovate and make them nicer/newer. Overall pretty happy with the place"

The Cabana Inn Key West - Adults Only

10/10 Excellent

"This place was very clean and tried their best to accommodate you. Fun Happy Hour & Quick Tasty Breakfast with good coffee. Our room was very spacious and had everything we needed. The location is perfect. Just a few steps and you are on Duval and a few steps the other direction and you are on Whitehead St, which has the Green Parrott Bar and multiple dining options"

Weatherstation Inn

10/10 Excellent

"The staff and the location are perfect"

The Southernmost Inn - Adults Only

10/10 Excellent

"We had an awesome stay. Staff were kind and helpful. Pool was very nice and clean. We will definatley book here again on our next trip to Key West."

Opal Key Resort & Marina, Key West

8/10 Good

"Location is great. Right on the waterfront by the harbor. Check in went well. Needed help with getting our luggage to our room. The doorman would only assist with getting us a mobile cart to load our own bags and transport to our room which was a bit of a trek. The building we were assigned to was ‘next door’. The resort needs to offer a shuttle or cart to assist with luggage. Was disappointed there was no help. Also there can be a cruise ship docked right in the way of the sunset viewing, although they are usually gone before the sun goes down (summer). However Mallory Square is right next door and has great views. Pool was nice, a little small but on par for Key West. The topside bar area is a great place to watch the sunset. Nice giveaways at the pool, ice cold water, free sun screen lotion, ice cold cooling rags, free eye glass cleaner and wipe cloths. The room was very clean and bed very comfortable. Nice robes and slippers! Did not eat at the hotel as we wanted to experience several places in Key West that were recommended."

Duval House

10/10 Excellent

"Beautiful and with fantastic service"

Orchid Key Inn - Adults Only

10/10 Excellent

"Right on Duvall Street, close to everything. The staff here is top notch!!!! We will definitely be back!!!"

Lighthouse Hotel - Key West Historic Inns

10/10 Excellent

"Highly recommended this boutique resort!"

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A brick corridor with arched ceilings and benches.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1501 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1501 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Waterfront Playhouse, and Coffee Butler Amphitheater if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from NT$3,088

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Orchid Key Inn - Adults Only

3. Simonton Court Historic Inn & Cottages

4. The Gardens Hotel

5. The Conch House Heritage Inn

6. The Porch on Frances Inn

7. The Marquesa Hotel

8. H2O Suites - Adults Only

9. Duval House

10. Douglas House - Adults Only

11. Tropical Inn

12. Alexander's Guesthouse - Adult Exclusive

13. Island City House Hotel

14. The Grand Guesthouse

15. The Mermaid & Alligator

16. Santa Maria Suites

17. Silver Palms Inn & Historic Homes

18. Southernmost House - Adult Exclusive

19. Coco Plum Inn

20. Ambrosia Key West

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Winslow's Bungalows - Key West Historic Inns

Southernmost Beach Resort and Guesthouses

The Cabana Inn Key West - Adults Only

Weatherstation Inn

The Southernmost Inn - Adults Only

Opal Key Resort & Marina, Key West

Duval House

Orchid Key Inn - Adults Only

Lighthouse Hotel - Key West Historic Inns

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

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