Find hotels in Midtown, St. Louis from NT$3,113
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Discover 1,758 Midtown hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Element St. Louis Midtown
Element St. Louis Midtown

Residence Inn by Marriott St Louis Downtown
Residence Inn by Marriott St Louis Downtown

The Principal Hotel
The Principal Hotel

River City Casino & Hotel
River City Casino & Hotel

Drury Plaza Hotel St. Louis St. Charles
Drury Plaza Hotel St. Louis St. Charles

21C Museum Hotel St Louis
21C Museum Hotel St Louis
Where to stay in Midtown

Downtown St. Louis
Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Gateway Arch or Busch Stadium might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

Clayton
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
Creve Coeur
Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Saint Louis Abbey while you're in town.
St. Charles Historic District
Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.
Top Midtown Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch
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Frequently asked questions
Hotels in top St. Louis neighborhoods
- Hotels in Downtown St. Louis
- Hotels in Clayton
- Hotels in Central West End
- Hotels in Creve Coeur
- Hotels in St. Charles Historic District
- Hotels in Downtown West
- Hotels in The Hill
- Hotels in Soulard
- Hotels in University City
- Hotels in Midtown
- Hotels in Ladue
- Hotels in Dogtown
- Hotels in The Grove
- Hotels in Shaw
- Hotels in Tower Grove South
- Hotels in Lafayette Square
- Hotels in The Gate
- Hotels in Southwest Garden
- Hotels in Benton Park
- Hotels in Tower Grove East
Hotels near popular St. Louis Attractions
- Hotels near St. Louis University
- Hotels near Chaifetz Arena
- Hotels near Scott Joplin House State Historic Site
- Hotels near Museum of Contemporary Religious Art
- Hotels near Samuel Cupples House
- Hotels near Busch Stadium
- Hotels near St. Louis Union Station
- Hotels near Gateway Arch
- Hotels near Washington University in St. Louis
- Hotels near St. Louis Zoo
Hotels Close to Nearby Airports
Midtown Hotels by Star Rating
Explore more hotels
- Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
- Marriott St. Louis Grand
- River City Casino & Hotel
- Pear Tree Inn St. Louis Airport
- Forest Park Hotel by MDR
- Hilton St. Louis at the Ballpark
- Moonrise Hotel
- Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
- The Cheshire
- DoubleTree by Hilton St. Louis Forest Park
- Best Western St. Louis-Kirkwood Route 66
- Aloft St. Louis Cortex
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