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Jul 28 - Jul 29
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Aug 1 - Aug 3
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Discover 8,824 Serra Mesa hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Sycuan Casino Resort
3 outdoor pools, cabanas (surcharge), pool umbrellas

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1430)
"We had a wonderful stay, will definitely visit again!"
Sycuan Casino Resort
Best Western Premier Hotel Del Mar
Front of property

Best Western Premier Hotel Del Mar

3.0 star property
9.2 out of 10, Wonderful, (1015)
"I love this hotel"
The price is NT$3,384
NT$3,830 total
includes taxes & fees
Aug 3 - Aug 4
Best Western Premier Hotel Del Mar
La Quinta Inn by Wyndham San Diego Chula Vista
Exterior

La Quinta Inn by Wyndham San Diego Chula Vista

3.0 star property
8.6 out of 10, Excellent, (1322)
"Love the breakfast and convenient location. "
The price is NT$3,577
NT$3,935 total
includes taxes & fees
Jul 29 - Jul 30
La Quinta Inn by Wyndham San Diego Chula Vista
Hotel Palmeras Chula Vista
Front of property

Hotel Palmeras Chula Vista

2.0 star property
7.0 out of 10, Good, (1800)
"It’s was good experience staying in hotel "
The price is NT$2,335
NT$2,568 total
includes taxes & fees
Jul 29 - Jul 30
Hotel Palmeras Chula Vista
Hercor Hotel - Urban Boutique
Deluxe Room, 1 King Bed | 1 bedroom, premium bedding, down comforters, pillowtop beds

Hercor Hotel - Urban Boutique

3.0 star property
8.6 out of 10, Excellent, (1216)
"Great place to stay!"
The price is NT$3,108
NT$3,425 total
includes taxes & fees
Jul 29 - Jul 30
Hercor Hotel - Urban Boutique
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Desk, blackout drapes, iron/ironing board, free WiFi

Studio 6 Suites San Ysidro, CA -San Diego South Bay

2.5 star property
7.8 out of 10, Good, (1156)
"Nice hotel to stay in "
The price is NT$2,355
NT$2,684 total
includes taxes & fees
Jul 29 - Jul 30
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Sea Harbor Hotel
Marina

Sea Harbor Hotel

2.0 star property
8.6 out of 10, Excellent, (906)
"Great location, very customer friendly staff."
The price is NT$4,308
NT$4,857 total
includes taxes & fees
Jul 29 - Jul 30
Sea Harbor Hotel
Valli Hi Motel
Desk, blackout drapes, soundproofing, free WiFi

Valli Hi Motel

2.5 star property
8.2 out of 10, Very Good, (1030)
"Staff was friendly hotel was clean and easy day trips back and forth throughout San Diego area."
Valli Hi Motel
Bay Club Hotel & Marina
Exterior

Bay Club Hotel & Marina

3.5 star property
9.0 out of 10, Wonderful, (2769)
"Great place to stay"
The price is NT$5,008
NT$5,757 total
includes taxes & fees
Aug 19 - Aug 20
Bay Club Hotel & Marina
Granger Hotel Gaslamp Quarter, A Member Of Design Hotels
Exterior

Granger Hotel Gaslamp Quarter, A Member Of Design Hotels

4.0 star property
9.2 out of 10, Wonderful, (433)
"The breakfast was great."
The price is NT$4,478
NT$5,184 total
includes taxes & fees
Aug 3 - Aug 4
Granger Hotel Gaslamp Quarter, A Member Of Design Hotels
Legacy Resort Hotel & Spa
Garden

Legacy Resort Hotel & Spa

4.0 star property
9.2 out of 10, Wonderful, (2893)
"Great stay"
The price is NT$3,868
NT$4,446 total
includes taxes & fees
Aug 24 - Aug 25
Legacy Resort Hotel & Spa
The Horton Grand, Downtown/Gaslamp Quarter
Serves dinner and happy hour

The Horton Grand, Downtown/Gaslamp Quarter

3.5 star property
9.0 out of 10, Wonderful, (2432)
"Would stay there again when in town"
The Horton Grand, Downtown/Gaslamp Quarter
The Encinitan Hotel & Suites
Outdoor spa tub

The Encinitan Hotel & Suites

3.0 star property
8.0 out of 10, Very Good, (1064)
"Great location / family friendly "
The Encinitan Hotel & Suites
Gaslamp Plaza Suites
Lobby

Gaslamp Plaza Suites

3.5 star property
8.8 out of 10, Excellent, (1019)
"I loved staying at this property! The hotel room was clean and the decor was beautiful. All dining was in walking distance as well."
The price is NT$3,209
NT$3,651 total
includes taxes & fees
Aug 7 - Aug 8
Gaslamp Plaza Suites
La Quinta Inn & Suites by Wyndham San Diego Mission Bay
Free daily buffet breakfast

La Quinta Inn & Suites by Wyndham San Diego Mission Bay

3.0 star property
8.0 out of 10, Very Good, (1333)
"Nestled in a great area close to pacific beach and I-5. "
The price is NT$3,178
NT$3,654 total
includes taxes & fees
Aug 17 - Aug 18
La Quinta Inn & Suites by Wyndham San Diego Mission Bay
Humphreys Half Moon Inn
Outdoor pool

Humphreys Half Moon Inn

3.5 star property
9.2 out of 10, Wonderful, (2449)
"Great place to stay!!"
The price is NT$4,743
NT$6,041 total
includes taxes & fees
Aug 18 - Aug 19
Humphreys Half Moon Inn
Best Western San Diego Pacific Beach/Mission Bay
Outdoor pool

Best Western San Diego Pacific Beach/Mission Bay

2.5 star property
7.2 out of 10, Good, (1260)
"Excellent hotel !! "
The price is NT$2,623
NT$3,016 total
includes taxes & fees
Jul 29 - Jul 30
Best Western San Diego Pacific Beach/Mission Bay
Best Western Plus Marina Gateway Hotel
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace

Best Western Plus Marina Gateway Hotel

3.5 star property
9.2 out of 10, Wonderful, (3176)
"This location was great for our family get away"
The price is NT$4,479
NT$4,935 total
includes taxes & fees
Aug 3 - Aug 4
Best Western Plus Marina Gateway Hotel
Pleasant Inn
1 bedroom, desk, laptop workspace, blackout drapes

Pleasant Inn

2.5 star property
8.4 out of 10, Very Good, (1092)
"night staff awesome and welcoming, convenient to airport "
The price is NT$2,692
NT$3,089 total
includes taxes & fees
Aug 11 - Aug 12
Pleasant Inn
Handlery Hotel
Outdoor pool, pool umbrellas, sun loungers

Handlery Hotel

3.5 star property
8.2 out of 10, Very Good, (1921)
"The pool area is great and I loved the convenience of the restaurants. "
Handlery Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas and neighborhoods for the activities you enjoy most.
US Grant Hotel
Downtown San Diego map

Downtown San Diego

2 out of top 10 points of interest in this area

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Belmont Park showing rides and a garden
Mission Beach map

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

Pacific Beach Park showing a beach
Pacific Beach map

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

Gaslamp Quarter showing signage, night scenes and street scenes
Gaslamp Quarter map

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Ocean Beach
Ocean Beach map

Ocean Beach

Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach Pier and Dog Beach, you won't get bored spending a day wandering around this part of San Diego.

Top Serra Mesa Hotel Reviews

The Dana on Mission Bay

The Dana on Mission Bay

10/10 Excellent
"Wonderful place!"
Dawne 4-night trip
Posted 5 hours ago
The Dana on Mission Bay

Frequently asked questions

What's it like in Serra Mesa?

Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighborhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.

How many hotels will I be able to find in the Serra Mesa area?

Expedia has 36 hotels and other accommodations in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.

If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?

Yes, you'll find most hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Add your dates and click on "Search", then filter by "fully refundable" to view the top deals on offer in Serra Mesa.

Where can I learn more about changing or cancelling my trip to Serra Mesa?

For more information about picking new dates or cancelling your trip to Serra Mesa, click here.

What can I see and do in this San Diego neighborhood?

Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.