Top 10 Hotels in Santa Fe, FL from NT$2,143 - Competitive Prices

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Santa Fe

Pet friendly

Apartment

Pool

Condo

Hot tub

Family friendly

Cottage

Waterpark

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Santa Fe hotels

A spacious indoor dining area with multiple tables and chairs, large windows offering a view of palm trees and greenery outside.

A modern office space with a reception desk, several chairs, a large window, and a colorful abstract painting on the wall.

A hotel room with a bed, a desk with a chair, a television, and a blue sofa.

A Holiday Inn Express & Suites hotel with a modern design, multiple floors, and a parking lot.

1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Alachua

Tobias

NT$3,366

NT$3,787 total

includes taxes & fees

Oct 5 - Oct 6

A modern kitchen area with a central counter, various food stations, and a chalkboard menu.

A reception desk with a "Welcome to the Sun Shine State" sign, a "Treats" sign, and a minibar area with a "Hilton" sign.

2. Hampton Inn & Suites Alachua I-75

Alachua

Pamela

NT$3,359

NT$3,779 total

includes taxes & fees

Oct 4 - Oct 5

A large, multi-story hotel with a central courtyard, palm trees, and an American flag.

A living room with a brown leather sofa, a glass-top coffee table, and a framed picture on the wall.

A bar area with wooden chairs, a bar counter, and a television mounted on the wall.

A spacious dining area with multiple tables and chairs, a kitchen area with a coffee station, and large windows allowing natural light.

3. Best Western Gateway Grand

Gainesville

Jason

NT$2,938

NT$3,306 total

includes taxes & fees

Sep 28 - Sep 29

A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a well-maintained outdoor area with a parking lot.

A hotel lobby with a seating area featuring sofas and armchairs, a central coffee table, and a flat-screen TV mounted on the wall.

A modern kitchen with blue-tiled walls, stainless steel appliances, and a central island.

A modern lounge area with a flat-screen TV, a fireplace, teal and brown seating, patterned carpet, and a wall-mounted clock.

4. La Quinta by Wyndham Gainesville

Gainesville

Elizabeth

NT$3,029

NT$3,408 total

includes taxes & fees

Sep 28 - Sep 29

A hotel room with two beds, a desk, a chair, and a television.

A parking lot with marked lanes and a grassy area on one side.

A bathroom with a white sink, mirror, and towel rack.

A motel with a two-story structure, a covered front entrance, and a parking lot with several cars.

5. Royal Inn

Alachua

Alec

NT$2,286

NT$2,572 total

includes taxes & fees

Sep 28 - Sep 29

A cozy restaurant with wooden beams, yellow walls, and a bar area with coffee machines.

A reception desk with a sign reading "Quality by Choice Hotels," surrounded by various reptile decorations.

A spacious lobby with a dining area, a kitchen, and a large window providing a view of the outdoors.

A hotel room with a bed, a desk with a chair, a television, a mirror, and a wardrobe.

6. Quality Inn Alachua - Gainesville Area

Alachua

Deborah

NT$2,413

NT$2,715 total

includes taxes & fees

Oct 18 - Oct 19

A fitness center with treadmills, exercise bikes, and weights.

A modern hotel room with a large bed, a desk, a chair, a TV, and a mural of a landscape.

A motel with a covered entrance, multiple parking spaces, and a fire extinguisher on the wall.

A swimming pool with a clear blue water surface, surrounded by a brick deck and a metal fence.

7. Clarion Pointe Alachua - Gainesville Area

Alachua

María Teresa

NT$1,911

NT$2,308 total

includes taxes & fees

Oct 18 - Oct 19

A modern interior with a staircase, a seating area, and a colorful abstract wall design.

A modern hotel lobby with a round table featuring two drinks, a sofa, and a colorful wall art piece.

A modern bar area with a marble countertop, bar stools, and pendant lighting.

A spacious lobby with modern furniture, large windows, and a colorful abstract wall.

8. Hyatt Place Gainesville Downtown

Downtown Gainesville

HEIDI

NT$3,112

NT$3,501 total

includes taxes & fees

Oct 4 - Oct 5

A stone water feature with cascading water, surrounded by a brick wall and greenery.

A spacious living area with a wooden floor, a blue sofa, a round coffee table, and a ceiling fan.

A neatly arranged bedroom with a bed, bedside lamps, a TV, and a mirror.

A reception desk with a modern design, a ceiling fan, and a seating area with chairs and a table.

9. BlueGem Motel

High Springs

Wesley

NT$3,108

NT$3,497 total

includes taxes & fees

Oct 4 - Oct 5

A modern living room with a fireplace, comfortable seating, a flat-screen TV, and a large window.

A modern hotel lobby with a reception desk, seating area with chairs and ottomans, a large artwork, and a corridor leading to other rooms.

A hotel room with a bed, a desk, a chair, a sofa, and a window.

A fire pit area surrounded by stone tiles, with a metal fence in the background.

10. Comfort Suites Gainesville near University

Gainesville

thomas

NT$2,502

NT$2,911 total

includes taxes & fees

Oct 18 - Oct 19

A modern breakfast area with labeled dispensers for yogurt, eggs, and milk, a coffee machine, and a chalkboard menu.

An outdoor patio with tables and chairs, a stone wall, and a view of a street with trees and buildings.

A Holiday Inn Express building with a modern design, featuring multiple windows and a flat roof.

A hotel room with two beds, a TV, a desk, and a chair.

11. Holiday Inn Express Starke by IHG

Starke

Judy

NT$3,493

NT$3,877 total

includes taxes & fees

Oct 4 - Oct 5

A modern hotel with a flat roof, multiple floors, and a prominent 'aloft' sign.

A modern outdoor seating area with multiple sofas and chairs, a covered section with umbrellas, and a view of a building with large windows.

A modern dining area with a pool table, chairs, and a colorful rug.

A modern bar area with a bar counter, stools, and seating including a sofa and chairs.

12. Aloft by Marriott Gainesville University Area

Gainesville

Elizabeth H

NT$3,461

NT$3,894 total

includes taxes & fees

Sep 28 - Sep 29

A swimming pool with a metal ladder, surrounded by a white fence and green chairs.

A living room with a curved sofa, a wooden cabinet, and a fish tank.

A hotel room with a patterned carpet, a sofa, a small table, a lamp, and a door with a notice.

A hotel room with a bed, a sofa, a coffee table, and a small table with a lamp.

13. Best Western Waldo Inn and Suites

Waldo

Ana Laura

NT$4,318

NT$4,858 total

includes taxes & fees

Oct 4 - Oct 5

A room with a wooden ceiling, two beds with patterned bedding, a desk, and a chair.

A bedroom with a bed, a chair, a dresser, a ceiling fan, a window with blinds, and a wall-mounted air conditioner.

A row of motel buildings with a fire hydrant and trees in front.

A stone outdoor seating area with a table and benches, a trash bin, and a building in the background.

14. High Springs Country Inn

High Springs

Luis

NT$1,905

NT$2,143 total

includes taxes & fees

Sep 28 - Sep 29

A spacious lobby with a sectional sofa, a wooden cabinet, and a television mounted on the wall.

A hotel room with a large window offering a view of a cityscape, a blue armchair, and a small table with a lamp.

A modern kitchen with wooden cabinets, a granite countertop, and pendant lighting.

A hotel room with two beds, a large headboard, bedside lamps, and a view of the outdoors through sheer curtains.

15. Drury Inn & Suites Gainesville

Gainesville

Joan

NT$3,334

NT$3,751 total

includes taxes & fees

Oct 1 - Oct 2

A hotel room with two beds, a ceiling fan, a TV, and a desk with a chair.

A hotel with a modern facade, a covered entrance, and a palm tree in front.

A modern building with a gray facade, a large window, and a landscaped area with a crocodile sculpture.

16. HOM Hotel Gainesville, SureStay Collection by Best Western

Gainesville

LAWRENCE

NT$2,300

NT$2,588 total

includes taxes & fees

Oct 4 - Oct 5

A multi-story hotel with a central entrance, palm trees, and a clear sky.

A hotel room with a bed, a desk, a television, a sofa, and artwork on the wall.

A spacious hotel lobby with a modern staircase, a seating area with a sofa and chairs, and a dining area in the background.

A hotel room with a wooden floor, a red armchair, a beige sofa, a TV, and framed artwork on the wall.

17. Country Inn & Suites by Radisson, Gainesville, FL

Gainesville

sherry

NT$2,807

NT$3,158 total

includes taxes & fees

Oct 4 - Oct 5

A modern bar area with wooden bar stools, pendant lighting, and artwork on the walls.

A hotel reception desk with a wooden panel design, a digital kiosk, and a "Welcome to the Sun Shine State" sign.

A hotel hallway with carpeted floors, doors on both sides, and overhead lighting.

A hotel room with a kitchenette, a bed, a desk with a chair, and a bathroom.

18. Hampton Inn Gainesville

Gainesville

Phillip

NT$2,762

NT$3,108 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a bed, bedside tables, a desk, a chair, a mirror, and a window.

A building with a Coca-Cola vending machine, a window with a 'OPEN' sign, and a red awning.

A corner room with two checkered chairs, a small table, a framed picture on the wall, and a floor lamp.

A bathroom with a large mirror, a sink, and a towel rack.

19. Palms Garden Inn

Lake City

Sherry

NT$2,190

NT$2,463 total

includes taxes & fees

Sep 28 - Sep 29

A spacious hotel lobby with a curved sofa, a patterned carpet, and a large window with sheer curtains.

A large banquet hall with round tables, chairs, and floral centerpieces.

A bar area with multiple seating arrangements and a bar counter.

A hotel lobby with a blue patterned carpet, black round tables with candles, beige sofas, and a curved seating area.

20. Hilton University of Florida Conference Center Gainesville

Gainesville

Nandini

NT$3,359

NT$3,779 total

includes taxes & fees

Oct 4 - Oct 5

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top Santa Fe Hotel Reviews

Hilton University of Florida Conference Center Gainesville

10/10 Excellent

"Only thing I didn’t like was the breakfast vouchers that essentially cover nothing so don’t feel like you’re getting any perk all I really want you to do is go down and buy their breakfast"

Drury Inn & Suites Gainesville

10/10 Excellent

"Had a wonderful stay! The room was very clean!"

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"♥️❤️"

Red Roof Inn PLUS+ Gainesville

10/10 Excellent

"Clean and safe good bedding good staff."

Comfort Suites Gainesville near University

8/10 Good

"Good breakfast but the trash bins by the elevators weren't cleaned out regularly and therefore smelled a bit funky."

More cheap stays in Santa Fe

Red Roof Inn PLUS+ Gainesville

3500 Southwest 42nd St Gainesville FL

NT$1,915

NT$2,154 total

Oct 1 - Oct 2

includes taxes & fees

7.4/10 Good! (1,327 reviews)

Days Inn by Wyndham Gainesville University I-75

920 Nw 69th Ter Gainesville FL

NT$2,294

NT$2,581 total

Sep 29 - Sep 30

includes taxes & fees

HOM Hotel Gainesville, SureStay Collection by Best Western

3905 Sw 43Rd St Gainesville FL

NT$2,300

NT$2,588 total

Oct 4 - Oct 5

includes taxes & fees

Comfort Inn Gainesville - University Area

3440 SW 40th Blvd Gainesville FL

NT$2,349

NT$2,821 total

Oct 26 - Oct 27

includes taxes & fees

8.2/10 Very Good! (1,100 reviews)

Sleep Inn & Suites University/Shands

4110 SW 40th Boulevard Gainesville FL

NT$2,402

NT$2,881 total

Oct 18 - Oct 19

includes taxes & fees

Comfort Suites Gainesville near University

2603 SW 13TH STREET Gainesville FL

NT$2,502

NT$2,911 total

Oct 18 - Oct 19

includes taxes & fees

9.2/10 Wonderful! (1,504 reviews)

Hotels in Santa Fe with star-rating

Frequently asked questions

What's the best place for a stay in Santa Fe?

Located 18.6 mi (30 km) from the heart of Santa Fe, Drury Inn & Suites Gainesville is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Sleep Inn & Suites University/Shands and Country Inn & Suites by Radisson, Gainesville, FL. See all available top hotels, or vacation rentals in Santa Fe.

If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?

Yes, most hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Fe.

Where can I learn more about changing or cancelling my trip to Santa Fe?

To access more information about picking new dates or cancelling your trip to Santa Fe, go to https://www.expedia.com/service/.

What is staying in Santa Fe like?

Travelers to Santa Fe will find plenty to explore and enjoy. There are 802 hotels and other accommodations in the surrounding area. Find out more about Santa Fe.

What are the top places to visit in Santa Fe?

Places to visit in the wider area include O'Leno State Park, San Felasco Hammock Preserve State Park, and Devil's Milhopper Geological State Park. You'll also find Gainesville Raceway and Poe Springs Park in the area. Check out what more to see and do in Expedia's Santa Fe guide.

What's the seasonal weather like in Santa Fe?

The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 59°F. The rainiest months in Santa Fe are August, June, July, and September, with each month seeing an average of 7 inches of rainfall.

Explore a world of travel with Expedia

Book Hotels in Santa Fe on Expedia.com

Find hotels in Santa Fe, FL from NT$2,143

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Santa Fe

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Santa Fe hotels

1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

2. Hampton Inn & Suites Alachua I-75

3. Best Western Gateway Grand

4. La Quinta by Wyndham Gainesville

5. Royal Inn

6. Quality Inn Alachua - Gainesville Area

7. Clarion Pointe Alachua - Gainesville Area

8. Hyatt Place Gainesville Downtown

9. BlueGem Motel

10. Comfort Suites Gainesville near University

11. Holiday Inn Express Starke by IHG

12. Aloft by Marriott Gainesville University Area

13. Best Western Waldo Inn and Suites

14. High Springs Country Inn

15. Drury Inn & Suites Gainesville

16. HOM Hotel Gainesville, SureStay Collection by Best Western

17. Country Inn & Suites by Radisson, Gainesville, FL

18. Hampton Inn Gainesville

19. Palms Garden Inn

20. Hilton University of Florida Conference Center Gainesville

Top Santa Fe Hotel Reviews

Hilton University of Florida Conference Center Gainesville

Drury Inn & Suites Gainesville

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Red Roof Inn PLUS+ Gainesville

Comfort Suites Gainesville near University

More cheap stays in Santa Fe

Red Roof Inn PLUS+ Gainesville

Days Inn by Wyndham Gainesville University I-75

HOM Hotel Gainesville, SureStay Collection by Best Western

Comfort Inn Gainesville - University Area

Sleep Inn & Suites University/Shands

Comfort Suites Gainesville near University

Hotels in Santa Fe with star-rating

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app