Photo by Michael True

Find hotels in Defiance, MO from NT$1,864

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Compare 841 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Crowne Plaza St. Louis Airport by IHG

3.5 star property
8.0 out of 10, Very Good, (1013)
"Great hotel and friendly staff "
The price is NT$3,254
NT$3,871 total
includes taxes & fees
Aug 24 - Aug 25
Crowne Plaza St. Louis Airport by IHG

MainStay Suites St Louis Airport

3.0 star property
8.2 out of 10, Very Good, (292)
"Quiet , clean, friendly staff"
The price is NT$2,929
NT$3,493 total
includes taxes & fees
Aug 11 - Aug 12
MainStay Suites St Louis Airport

Comfort Inn St. Louis Airport

3.0 star property
8.6 out of 10, Excellent, (880)
"This hotel was excellent. Would definitely stay here again!"
The price is NT$2,769
NT$3,307 total
includes taxes & fees
Aug 11 - Aug 12
Comfort Inn St. Louis Airport

Embassy Suites by Hilton St. Louis Airport

3.5 star property
7.6 out of 10, Good, (1001)
"Staff was awesome, from the moment we checked in till we checked out. Front desk staff always greeted us with a smile going in/out of the hotel. Good breakfast selection, easy parking, close to restaurants and stores. Will stay at this property again if ever in the St Louis area."
The price is NT$4,415
NT$5,221 total
includes taxes & fees
Aug 10 - Aug 11
Embassy Suites by Hilton St. Louis Airport

Extended Stay America Select Suites - St. Louis - Airport - Central

2.5 star property
7.0 out of 10, Good, (984)
"Clean and had good accommodation "
The price is NT$2,405
NT$2,885 total
includes taxes & fees
Aug 10 - Aug 11
Extended Stay America Select Suites - St. Louis - Airport - Central

Hilton St. Louis Frontenac

4.0 star property
8.8 out of 10, Excellent, (1000)
"Great place to stay during my business trip. Clean room, quiet and great dining options. Will definitely stay here again on my next business trip,"
The price is NT$4,501
NT$5,243 total
includes taxes & fees
Aug 10 - Aug 11
Hilton St. Louis Frontenac

La Quinta Inn & Suites by Wyndham St. Louis Westport

3.0 star property
7.2 out of 10, Good, (1036)
"Great place"
The price is NT$2,529
NT$2,934 total
includes taxes & fees
Aug 10 - Aug 11
La Quinta Inn & Suites by Wyndham St. Louis Westport

Extended Stay America Select Suites - St. Louis - Westport - E Lackland Rd

2.5 star property
5.8 out of 10, (1001)
"The staff was wonderful and polite and helpful they need a raise!!!"
The price is NT$2,210
NT$2,563 total
includes taxes & fees
Aug 23 - Aug 24
Extended Stay America Select Suites - St. Louis - Westport - E Lackland Rd

Red Roof Inn St Louis - Westport/ Maryland Heights

2.0 star property
5.4 out of 10, (1000)
"Nice stay"
The price is NT$2,049
NT$2,377 total
includes taxes & fees
Aug 3 - Aug 4
Red Roof Inn St Louis - Westport/ Maryland Heights

The Lodge Hotel and Banquets

2.0 star property
5.0 out of 10, (369)
"Very nice pool area kids enjoyed! Nice clean room as well."
The price is NT$2,263
NT$2,719 total
includes taxes & fees
Jul 31 - Aug 1
The Lodge Hotel and Banquets

Courtyard by Marriott St Louis Westport Plaza

3.0 star property
8.8 out of 10, Excellent, (1000)
"We were just there to sleep but nice property."
The price is NT$3,178
NT$3,686 total
includes taxes & fees
Aug 22 - Aug 23
Courtyard by Marriott St Louis Westport Plaza

Residence Inn St Louis Westport

3.0 star property
9.2 out of 10, Wonderful, (411)
"Loved it "
The price is NT$5,032
NT$5,837 total
includes taxes & fees
Aug 16 - Aug 17
Residence Inn St Louis Westport

Fairfield Inn & Suites St Louis Westport

2.5 star property
9.2 out of 10, Wonderful, (784)
"Fairfiled Inn has always been very reliable, clean and comfortable and great breakfast options"
The price is NT$3,967
NT$4,601 total
includes taxes & fees
Aug 3 - Aug 4
Fairfield Inn & Suites St Louis Westport

Extended Stay America Select Suites St Louis Westport Craig

2.5 star property
6.4 out of 10, (755)
"The property was quiet, clean, and accessible. Since we used the local Metro Bus and rail, having a Bus stop almost in front of the Hotel."
The price is NT$2,130
NT$2,470 total
includes taxes & fees
Aug 1 - Aug 2
Extended Stay America Select Suites St Louis Westport Craig

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

2.5 star property
4.6 out of 10, (1020)
"Enjoyed staying "
The price is NT$2,012
NT$2,333 total
includes taxes & fees
Aug 10 - Aug 11
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Courtyard by Marriott St Louis Creve Coeur

3.0 star property
8.6 out of 10, Excellent, (1000)
"Very nice room & stay"
The price is NT$3,372
NT$3,920 total
includes taxes & fees
Aug 10 - Aug 11
Courtyard by Marriott St Louis Creve Coeur

Comfort Inn St. Louis - Westport Event Center

3.0 star property
7.0 out of 10, Good, (1002)
"James the front desk assistant was so helpful and kind. The staff were very kind. Beautiful area and great rooms. I give them 10/10!!! Thanks for a great stay. "
The price is NT$2,503
NT$2,903 total
includes taxes & fees
Aug 10 - Aug 11
Comfort Inn St. Louis - Westport Event Center

Best Western Plus St. Louis West-Westport

2.5 star property
8.0 out of 10, Very Good, (1024)
"Nice stay"
The price is NT$2,929
NT$3,397 total
includes taxes & fees
Jul 31 - Aug 1
Best Western Plus St. Louis West-Westport

Hampton Inn St. Louis/Westport

2.5 star property
7.8 out of 10, Good, (951)
"We had a great stay for our 14th Wedding Anniversary! The only 2 complaint we had was the slow draining sink in the bathroom and the limited lighting in the bedroom! "
The price is NT$2,741
NT$3,179 total
includes taxes & fees
Aug 24 - Aug 25
Hampton Inn St. Louis/Westport

Staybridge Suites St Louis - Westport by IHG

3.0 star property
8.8 out of 10, Excellent, (595)
"Room was very spacious and clean, free breakfast was nice. Only "bad" part was the pool being under renovations so it was closed our whole stay. They did have vouchers to go to a pool at another hotel so all in all, great stay"
The price is NT$4,207
NT$4,880 total
includes taxes & fees
Aug 17 - Aug 18
Staybridge Suites St Louis - Westport by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Defiance attractions

Learn more about Defiance

Trip time! Discover the wineries, parks, and history in Defiance.

Top Defiance Hotel Reviews

Frequently asked questions

What's the best place to stay in Defiance?

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Hollywood Casino & Hotel St. Louis and Days Inn and Suites by Wyndham St. Louis/Westport Plaza. See all available top hotels, or vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

Where can I learn more about changing or cancelling my trip to Defiance?

For more information about changing or cancelling your trip to Defiance, head over to our customer service page.

Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?

Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.

What about the best place to stay near Chandler Hill Vineyards?

One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.

What are some accommodations with pools in Defiance?

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool, and buffet. Days Inn and Suites by Wyndham St. Louis/Westport Plaza and Wingate by Wyndham St. Louis/Fenton Route 66 are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.

What's the best place to stay near Lambert-St. Louis International Airport (STL)?

Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.

What's it like to stay in Defiance?

Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium, and Gateway Arch. In Defiance, there are 20 hotels and other accommodations to choose from. Find out more about Defiance.

What is there to see in Defiance?

Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area, and Missouri River. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.

What's the seasonal weather like in Defiance?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.