Photo by Michael True

Find hotels in Defiance, MO

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Compare 826 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Defiance hotels

Super 8 by Wyndham Eureka/Six Flags Nearby

2.0 star property
7.0 out of 10, Good, (1005)
"The check in was super easy, there was a lady being trained, and they were both so nice! It was super fast, in the selection for the continental breakfast was good!! The area felt good.I would definitely stay here again!! Hotel stuff was super friendly :)"
Super 8 by Wyndham Eureka/Six Flags Nearby

Super 8 by Wyndham St. Clair MO

2.0 star property
7.2 out of 10, Good, (899)
"Nice location amd staff were very nice would go there again!"
Super 8 by Wyndham St. Clair MO

Drury Plaza Hotel St. Louis Chesterfield

3.0 star property
9.6 out of 10, Exceptional, (1013)
"Great place to stay! "
Drury Plaza Hotel St. Louis Chesterfield

Wingate by Wyndham St. Louis/Fenton Route 66

3.0 star property
8.2 out of 10, Very Good, (1014)
"Good hotel! "
Wingate by Wyndham St. Louis/Fenton Route 66

Comfort Inn St. Louis Airport

3.0 star property
8.4 out of 10, Very Good, (898)
"Good experience during our stay. "
Comfort Inn St. Louis Airport

WoodSpring Suites St Peters-OFallon

2.5 star property
WoodSpring Suites St Peters-OFallon

Holiday Inn Express & Suites St Peters by IHG

2.5 star property
9.2 out of 10, Wonderful, (343)
"Very nice place. Clean... quiet and very friendly staff!! We will definitely stay here again!!"
Holiday Inn Express & Suites St Peters by IHG

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
7.6 out of 10, Good, (1003)
"And nice hotel at a nice price "
Comfort Inn & Suites St. Louis - O'Fallon

Best Western Plus St. Louis West-Westport

2.5 star property
8.0 out of 10, Very Good, (1016)
"I STAY HERE ALOT ALWAYS A GOOD STAY"
Best Western Plus St. Louis West-Westport

Super 8 by Wyndham Warrenton

2.0 star property
7.4 out of 10, Good, (584)
"Staff was extremely accommodating and friendly."
Super 8 by Wyndham Warrenton

Relax Inn Saint Charles

2.0 star property
6.4 out of 10, (1006)
"Price and location is excellent "
Relax Inn Saint Charles

Baymont by Wyndham Warrenton

2.5 star property
7.4 out of 10, Good, (992)
"Very nice accommodations!"
Baymont by Wyndham Warrenton

Best Western Plus The Charles Hotel

3.0 star property
8.0 out of 10, Very Good, (1008)
"I enjoyed my stay the food was good!"
Best Western Plus The Charles Hotel

La Quinta Inn & Suites by Wyndham St. Louis Westport

3.0 star property
7.2 out of 10, Good, (1043)
"Great stay"
La Quinta Inn & Suites by Wyndham St. Louis Westport

Economy Inn Wentzville

2.0 star property
6.4 out of 10, (453)
"Best value around this location. Not going to be as nice as holiday Inn , but way better than most budget friendly places."
Economy Inn Wentzville

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
8.4 out of 10, Very Good, (1010)
"Very good hotel for the price"
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Extended Stay America Suites St Louis Westport Central

2.5 star property
7.4 out of 10, Good, (987)
"Good place to stay."
Extended Stay America Suites St Louis Westport Central

Fairfield Inn & Suites by Marriott St. Louis Chesterfield

3.0 star property
9.0 out of 10, Wonderful, (1003)
"Great hotel, very clean"
Fairfield Inn & Suites by Marriott St. Louis Chesterfield

Fairfield Inn & Suites St Louis Westport

2.5 star property
9.2 out of 10, Wonderful, (789)
"Great place to stay. Friendly staff. Spacious room and hearty yummy breakfast. "
Fairfield Inn & Suites St Louis Westport

Hilton Garden Inn St. Louis/O'Fallon MO

3.0 star property
8.8 out of 10, Excellent, (695)
"Nice location, with a couple restaurants nearby. Quiet, clean, nice beds/pillows."
Hilton Garden Inn St. Louis/O'Fallon MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Top Defiance Hotel Reviews

More cheap stays in Defiance

More cheap stays in Defiance

Hotels in Defiance with star-rating

Hotels in Defiance with star-rating

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Where can I learn more about changing or cancelling my trip to Defiance?

For more information about changing or cancelling your trip to Defiance, head over to our customer service page.

What's the seasonal weather like in Defiance?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.