What's it like in Uptown?

Travelers will be sure to enjoy their time in Beaufort's Uptown neighborhood.

How many hotels should I expect to find in the Uptown area?

If you're searching for places to stay in Beaufort, choose from one of Expedia's 12 hotels and other accommodations in Uptown.

If I need to cancel my hotel reservation in Uptown, will I receive a refund?

Yes! You'll find that most hotel reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer in Uptown.

Where can I learn more about changing or cancelling my trip to Uptown?

To find more details about updating your trip to Uptown or cancelling it, go to https://www.expedia.com/service/ .

What is there to do in this Beaufort neighborhood?

A few places to visit in the area around Uptown include Beaufort National Cemetery, USCB Center for the Arts, and St. Helena's Episcopal Church. Beaufort Museum and Henry C. Chambers Waterfront Park are also worth a visit when you're out sightseeing in Beaufort.

Find hotels in Uptown, Beaufort

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Dates

April 2026

May 2026

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Our top choices for Uptown hotels

Indoor pool, 2 outdoor pools, cabanas (surcharge), sun loungers

Marriott's SurfWatch

27 km from Uptown

Larisa

NT$18,052 total

includes taxes & fees

Apr 11 - Apr 12

Basic Room, Multiple Beds, Non Smoking | Free WiFi, bed sheets

Simple Rewards Inn

25.6 km from Uptown

brian

NT$4,003 total

includes taxes & fees

Mar 25 - Mar 26

Hampton Inn Yemassee/Point South

28.8 km from Uptown

Deborah

NT$4,976 total

includes taxes & fees

Apr 12 - Apr 13

Econo Lodge Yemassee

28.6 km from Uptown

Gregory

NT$1,839 total

includes taxes & fees

Apr 5 - Apr 6

Days Inn by Wyndham Ridgeland South Carolina

28.4 km from Uptown

Stephanie

NT$1,847 total

includes taxes & fees

Mar 30 - Mar 31

Best Western Sea Island Inn

The Bluff, 0.9 km from Uptown

Ellen

NT$5,877 total

includes taxes & fees

Mar 31 - Apr 1

Okatie Hilton Head Hotel

29.3 km from Uptown

David

NT$3,128 total

includes taxes & fees

Mar 26 - Mar 27

Holiday Inn Express Bluffton at Hilton Head Area by IHG

26.4 km from Uptown

Teresa

NT$3,862 total

includes taxes & fees

Mar 30 - Mar 31

Tru by Hilton Beaufort, SC

4.6 km from Uptown

Martha

NT$3,534 total

includes taxes & fees

Mar 30 - Mar 31

Super 8 by Wyndham Port Royal/Beaufort

4.7 km from Uptown

John

NT$2,537 total

includes taxes & fees

Mar 30 - Mar 31

Anchorage 1770

The Bluff, 0.8 km from Uptown

Carla

Beaufort Inn

Downtown Beaufort, 0.9 km from Uptown

Kristina

NT$7,096 total

includes taxes & fees

Apr 5 - Apr 6

Hilton Garden Inn Hilton Head

25.8 km from Uptown

Nick

NT$3,570 total

includes taxes & fees

Mar 29 - Mar 30

Quality Inn Yemassee - Point South I-95

28.6 km from Uptown

George

NT$2,299 total

includes taxes & fees

Apr 1 - Apr 2

SpringHill Suites by Marriott Beaufort

2.1 km from Uptown

Shawonna

NT$3,897 total

includes taxes & fees

Mar 29 - Mar 30

Marriott's Harbour Point and Sunset Pointe at Shelter Cove

29.3 km from Uptown

Alejandro

NT$10,139 total

includes taxes & fees

Apr 11 - Apr 12

Spark by Hilton Bluffton Hilton Head Island

25.7 km from Uptown

Richard

NT$3,311 total

includes taxes & fees

Apr 5 - Apr 6

Harbor Island Beach Retreat - Steps to Ocean!

23.2 km from Uptown

NT$12,253 total

includes taxes & fees

Apr 11 - Apr 12

Hampton Inn Hilton Head

25 km from Uptown

John

NT$4,382 total

includes taxes & fees

Mar 30 - Mar 31

Best Western Plus Bluffton / Hilton Head Hotel

29.7 km from Uptown

Alexandria

NT$3,932 total

includes taxes & fees

Mar 30 - Mar 31

View all properties

Where to stay in Uptown

Find the best Uptown areas and neighborhoods for the activities you enjoy most.

Downtown Beaufort

If you're spending some time in Downtown Beaufort, Henry C. Chambers Waterfront Park and Bay Street are top sights worth seeing.

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Aerial panorama of Beaufort, South Carolina with cruise ship in port.

Historic District

If you're spending some time in Historic District, Bay Street and Henry C. Chambers Waterfront Park are top sights worth seeing.

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Habersham

While there might not be top attractions in Habersham, you can explore the larger area and discover places like Highway 21 Drive-In Theater and Ocean Creek.

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Northwest Quadrant

While there might not be top attractions in Northwest Quadrant, you can explore the larger area and discover places like Beaufort National Cemetery and Henry C. Chambers Waterfront Park.

See properties

Historic Downtown

While visiting Historic Downtown, you might make a stop by sights like Henry C. Chambers Waterfront Park and Bay Street.

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Top Uptown Hotel Reviews

Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG

10/10 Excellent

"Super nice hotel and excellent staff, the breakfast was really good! "

Best Western Plus Bluffton / Hilton Head Hotel

10/10 Excellent

"Very pet friendly! Room was extremely clean. Staff was so friendly and helpful. The breakfast had super options and was amazing. Beds were comfortable. Shower pressure was the best! This is one of the best hotels we ever stayed at. Would most definite stay again. "

Best Western Sea Island Inn

10/10 Excellent

"Excellent spacious room, parking, good breakfast options, safe, centrally located in Beaufort & a swimming pool as well (tho it was a little dusty due adjacent road works). Only minor error was the absence of mirror with decent light outside of bathroom setup, the ladies will winge, fellas who cares?"

Hilton Garden Inn Beaufort

6/10 Okay

"Front desk did not answer the phone. Pillows thrown at the bottom of the bed- no pillow cases on them. A pair of socks had been left on a shelf. Shampoo and lotion pumps almost empty. No hot water- barely warm in the shower. Of the 3 front desk employees we had contact with, only one was pleasant. Need to get their act together."

Hotel Carolina

8/10 Good

"The staff was amazing it is no contact so we only saw one lady who was incredibly helpful! The bathroom door didn’t shut or lock in our room and the bathtub was clogged so the water wouldn’t drain very fast. They had towels and 2 little soap bars in the room but that’s it. Honestly though would stay here again the room isn’t that spacious but wasn’t terrible either!"

Home2 Suites by Hilton Hilton Head

6/10 Okay

"Good and bad. We had 2queen beds. One was fine but the other was too soft and needs to be replaced. Roller shades were broken. And I did not complain as it was just one night Room had a horrible chemical fragrance which I found nauseating. Perhaps others wouldnt mind. Room is spacious with a full kitchen for long term stays or traveling with kids. Room could easily sleep 6 with pull out sofa. Staff were nice. Included breakfast was fine. "

Find hotels in Uptown, Beaufort

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Uptown hotels

Marriott's SurfWatch

Simple Rewards Inn

Hampton Inn Yemassee/Point South

Econo Lodge Yemassee

Days Inn by Wyndham Ridgeland South Carolina

Best Western Sea Island Inn

Okatie Hilton Head Hotel

Holiday Inn Express Bluffton at Hilton Head Area by IHG

Tru by Hilton Beaufort, SC

Super 8 by Wyndham Port Royal/Beaufort

Anchorage 1770

Beaufort Inn

Hilton Garden Inn Hilton Head

Quality Inn Yemassee - Point South I-95

SpringHill Suites by Marriott Beaufort

Marriott's Harbour Point and Sunset Pointe at Shelter Cove

Spark by Hilton Bluffton Hilton Head Island

Harbor Island Beach Retreat - Steps to Ocean!

Hampton Inn Hilton Head

Best Western Plus Bluffton / Hilton Head Hotel

Where to stay in Uptown

Downtown Beaufort

Historic District

Habersham

Northwest Quadrant

Historic Downtown

Top Uptown Hotel Reviews

Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG

Frequently asked questions

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