Find hotels in Downtown South San Francisco, San Francisco from NT$2,792

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Dec 13 - Dec 14
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Our top choices for Downtown South San Francisco hotels

Exterior
La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
3.0 star property
Downtown South San Francisco
8.0 out of 10, Very Good, (2013)
"Breakfast is great. Staff is great."
United States
Trina
The price is NT$3,155
NT$3,706 total
includes taxes & fees
Jan 4 - 2026/1/5
La Quinta Inn & Suites by Wyndham San Francisco Airport N
Interior detail
Airport Inn

Airport Inn

Airport Inn
2.0 star property
Downtown South San Francisco
8.8 out of 10, Excellent, (972)
"Very clean room, friendly staff and secure parking."
United States
Christopher
The price is NT$3,088
NT$3,622 total
includes taxes & fees
Dec 14 - Dec 15
Airport Inn
Fridge, microwave, coffee/tea maker, dining tables
Miller Apartments

Miller Apartments

Miller Apartments
2.0 star property
Downtown South San Francisco
7.4 out of 10, Good, (15)
"Own bedroom was quiet and tidy, shared bathroom clean and tidy, good communication "
Australia
Kasey
The price is NT$1,872
NT$4,552 total
includes taxes & fees
Dec 15 - Dec 16
Miller Apartments
Lobby
Inn By The SFO

Inn By The SFO

Inn By The SFO
2.0 star property
Downtown South San Francisco
7.8 out of 10, Good, (1000)
"Excellent property!!! I would definitely recommend!!! Great stay!!! "
United States
David
Inn By The SFO
Lobby sitting area
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf
4.0 star property
16.7 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (7189)
"Good location and great hotel to stay, the bed was very comfortable and the breakfast was good with lots of options! "
Canada
Veronica
The price is NT$3,820
NT$5,781 total
includes taxes & fees
Dec 17 - Dec 18
Hotel Riu Plaza Fisherman's Wharf
Breakfast, lunch, dinner served; local cuisine
DoubleTree by Hilton San Francisco Airport

DoubleTree by Hilton San Francisco Airport

DoubleTree by Hilton San Francisco Airport
4.0 star property
9.3 km from Downtown South San Francisco
8.6 out of 10, Excellent, (1358)
"Nice hotel and area "
Canada
Robert
The price is NT$2,993
NT$3,403 total
includes taxes & fees
Dec 14 - Dec 15
DoubleTree by Hilton San Francisco Airport
Front of property - evening/night
Hilton San Francisco Financial District

Hilton San Francisco Financial District

Hilton San Francisco Financial District
4.0 star property
15.4 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2119)
"Great stay "
United States
Samantha
The price is NT$2,916
NT$3,432 total
includes taxes & fees
Dec 21 - Dec 22
Hilton San Francisco Financial District
Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds
Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf
4.0 star property
16.7 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (3827)
"We stay here a lot, great place and safe."
United States
Albert
The price is NT$3,622
NT$5,694 total
includes taxes & fees
Dec 16 - Dec 17
Hotel Caza Fisherman's Wharf
Breakfast served, American cuisine
Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront
4.0 star property
9.9 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2726)
"Nice airport hotel…staff was great, breakfast was amazing "
United States
Lynne
The price is NT$2,916
NT$3,315 total
includes taxes & fees
Dec 22 - Dec 23
Hilton San Francisco Airport Bayfront
Exterior
Hotel Aluxor SFO

Hotel Aluxor SFO

Hotel Aluxor SFO
2.5 star property
3.8 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2567)
"Clean room, close to airport, quiet. "
Canada
Jana
The price is NT$2,541
NT$3,091 total
includes taxes & fees
Jan 3 - 2026/1/4
Hotel Aluxor SFO
Free daily buffet breakfast
Holiday Inn Express and Suites Fisherman's Wharf by IHG

Holiday Inn Express and Suites Fisherman's Wharf by IHG

Holiday Inn Express and Suites Fisherman's Wharf by IHG
3.0 star property
16.6 km from Downtown South San Francisco
9.2 out of 10, Wonderful, (2216)
"spotless, breakfast, location, all excellent I will come back!"
United States
Oscar
The price is NT$3,712
NT$5,305 total
includes taxes & fees
Jan 4 - 2026/1/5
Holiday Inn Express and Suites Fisherman's Wharf by IHG
Outdoor pool
The Marina Inn on San Francisco Bay

The Marina Inn on San Francisco Bay

The Marina Inn on San Francisco Bay
2.5 star property
20.6 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2291)
"Clean, cozy, great staff!"
United States
Stacie
The Marina Inn on San Francisco Bay
Lobby sitting area
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square
3.5 star property
14.7 km from Downtown South San Francisco
9.4 out of 10, Exceptional, (3063)
"Best location, friendly staff, had a wonderful time stayed! "
United States
Kalinda
The price is NT$2,363
NT$2,792 total
includes taxes & fees
Dec 14 - Dec 15
Chancellor Hotel on Union Square
Terrace/patio
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco
4.0 star property
15.4 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2801)
"Clean and comfortable room, good staff, great location. "
United Kingdom
David
The price is NT$3,128
NT$3,682 total
includes taxes & fees
Dec 14 - Dec 15
Club Quarters Hotel in San Francisco
Exterior
The Westin San Francisco Airport

The Westin San Francisco Airport

The Westin San Francisco Airport
4.0 star property
6.8 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2033)
"Room great, location and shuttle were excellent Enjoyed 2 restaurants and Starbucks on site. "
United States
Robert
The price is NT$3,210
NT$4,603 total
includes taxes & fees
Dec 27 - Dec 28
The Westin San Francisco Airport
Exterior
King George Hotel

King George Hotel

King George Hotel
3.0 star property
14.5 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2103)
"What a wonderful stay completely recommend Daya was amazing"
United States
Glenda
The price is NT$2,694
NT$3,638 total
includes taxes & fees
Dec 20 - Dec 21
King George Hotel
Lobby
Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel
3.0 star property
1.8 km from Downtown South San Francisco
8.4 out of 10, Very Good, (1695)
"Great place to stay "
United States
Florence
The price is NT$2,849
NT$3,369 total
includes taxes & fees
Dec 28 - Dec 29
Best Western Plus Grosvenor Airport Hotel
Premium bedding, pillowtop beds, in-room safe, desk
Hotel 1550

Hotel 1550

Hotel 1550
3.5 star property
5.1 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (1042)
"Great front desk experience, nice room and very convenient to the airport. "
United States
Elmaz
The price is NT$3,126
NT$3,701 total
includes taxes & fees
Dec 20 - Dec 21
Hotel 1550
Terrace/patio
Bay Landing San Francisco Airport Hotel

Bay Landing San Francisco Airport Hotel

Bay Landing San Francisco Airport Hotel
3.0 star property
7.8 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (4762)
"The room was very clean, staff courteous and breakfast was good. "
United States
Donna
The price is NT$3,778
NT$4,259 total
includes taxes & fees
Jan 2 - 2026/1/3
Bay Landing San Francisco Airport Hotel
Lobby
Best Western Inn & Suites San Mateo - San Francisco Airport

Best Western Inn & Suites San Mateo - San Francisco Airport

Best Western Inn & Suites San Mateo - San Francisco Airport
2.5 star property
11.8 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1259)
"Staff was great and check in was perfect."
United States
FLORENCE CARMELA
The price is NT$2,948
NT$3,388 total
includes taxes & fees
Dec 21 - Dec 22
Best Western Inn & Suites San Mateo - San Francisco Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas and neighborhoods for the activities you enjoy most.
Union Square which includes a high rise building and a city

Union Square

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

Downtown San Francisco featuring railway items

Downtown San Francisco

Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

Fisherman\'s Wharf featuring a bay or harbor

Fisherman's Wharf

Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

South of Market featuring skyline, a city and city views

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

Nob Hill showing a city and street scenes

Nob Hill

Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.

Top Downtown South San Francisco Hotel Reviews

The Marker Union Square San Francisco

The Marker Union Square San Francisco

10/10 Excellent
"Staff was wonderful, room was clean, great restaurant"
Althea 1-night trip
Posted 17 hours ago
The Marker Union Square San Francisco

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Frequently asked questions

What's it like in Downtown South San Francisco?
You'll be sure to have fun visiting South San Francisco's Downtown South San Francisco neighborhood.
What's a favorite place to stay in Downtown South San Francisco?
Based on Expedia customer reviews, La Quinta Inn & Suites by Wyndham San Francisco Airport N is a highly ranked property in Downtown South San Francisco. This hotel offers free breakfast and an outdoor pool. Other favorite options in the area include Airport Inn and Inn By The SFO.
How many hotels will I find in the Downtown South San Francisco area?
When you want to kick up your feet after a day of exploring the sights in South San Francisco, you can choose from 13 Expedia hotels and other accommodations in Downtown South San Francisco.
If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?
Yes, the majority of room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to get the best deals available in Downtown South San Francisco.
Where can I learn more about changing or cancelling my trip to Downtown South San Francisco?
To find more details about picking new dates or cancelling your trip to Downtown South San Francisco, head over to our customer service page.
What can I see and do in this South San Francisco neighborhood?
See's Candies, Cinemark Century at Tanforan, and K1 Speed are just a few of the places to visit in and around Downtown South San Francisco. K1 Speed San Francisco and The Shops at Tanforan are also worth a visit when you're out sightseeing in South San Francisco.