Photo by Tonette Pineda✈⛵🚌🚉🚃🚅🚀

Find Boutique Hotels in South San Francisco, CA

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on South San Francisco Boutique Hotels

This weekend
Next weekend

Top South San Francisco Boutique Hotels

Berkeley City Club

2.5 star property
Telegraph District
8.8 out of 10, Excellent, (695)
"Wonderful, beautiful, old world hotel, right in the heart of bustling Berkeley. "
United States
Peter
Berkeley City Club

Hotel Zephyr San Francisco

4.0 star property
Fisherman's Wharf
8.6 out of 10, Excellent, (2336)
"It was close to everything and had a great outdoor area with beautiful views of the harbor."
United States
Ramon J
The price is NT$4,180
NT$6,025 total
includes taxes & fees
Jan 4 - 2026/1/5
Hotel Zephyr San Francisco

The Clift Royal Sonesta San Francisco

4.0 star property
Union Square
9.2 out of 10, Wonderful, (1363)
"The hotel room was clean and above all else, the staff was incredible... We will only stay at this hotel when we come into town!"
United States
Jennie
The price is NT$4,665
NT$6,712 total
includes taxes & fees
Dec 14 - Dec 15
The Clift Royal Sonesta San Francisco

Argonaut Hotel

4.5 star property
Fisherman's Wharf
9.4 out of 10, Exceptional, (1192)
"Fantastic location, clean, large rooms. The staff are great. Met all of our requests and gave great advice on things to do and see in SF."
United States
Daniel
The price is NT$5,917
NT$8,291 total
includes taxes & fees
Dec 7 - Dec 8
Argonaut Hotel

Harbor Court Hotel

4.0 star property
Downtown San Francisco
9.0 out of 10, Wonderful, (1002)
"Favorite getaway- great staff, clean rooms very accommodating "
United States
Leticia
The price is NT$4,540
NT$6,781 total
includes taxes & fees
Dec 20 - Dec 21
Harbor Court Hotel

The Clancy, Autograph Collection by Marriott

4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (1000)
"cleanliness,good service, convenient location"
United States
Harry
The price is NT$5,012
NT$7,196 total
includes taxes & fees
Dec 12 - Dec 13
The Clancy, Autograph Collection by Marriott

Palihotel San Francisco

3.5 star property
Union Square
8.4 out of 10, Very Good, (621)
"Great vibe here and the rooms and so cute . Excellent bar and bar staff . "
United States
Lana
The price is NT$2,818
NT$4,100 total
includes taxes & fees
Dec 20 - Dec 21
Palihotel San Francisco

The Barnes San Francisco, Tapestry Collection by Hilton

4.0 star property
Union Square
8.2 out of 10, Very Good, (762)
"Great location, friendly staff."
Canada
Lucy
The price is NT$3,820
NT$4,496 total
includes taxes & fees
Dec 14 - Dec 15
The Barnes San Francisco, Tapestry Collection by Hilton

Hotel Emblem San Francisco

4.0 star property
Union Square
9.4 out of 10, Exceptional, (1000)
"Nice room, helpful staff and great location. "
United States
Okan
The price is NT$4,133
NT$6,117 total
includes taxes & fees
Jan 2 - 2026/1/3
Hotel Emblem San Francisco

The Marker Union Square San Francisco

4.0 star property
Union Square
9.0 out of 10, Wonderful, (1090)
"Nice room and courteous staff"
United States
JESUS
The price is NT$4,127
NT$4,857 total
includes taxes & fees
Dec 12 - Dec 13
The Marker Union Square San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top South San Francisco Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

What's there to see and do in South San Francisco?
The shopping, restaurants, and cafes are just some of the things to enjoy while you're in the area. While you're out and about in South San Francisco, popular attractions like Chase Center, Oracle Park, and Pier 39 are worth a visit. For even more to see and do, make a stop at San Francisco Bay, Santa Cruz Mountains, and See's Candies.
What kind of weather should I plan for when I travel to South San Francisco?
Having a good idea of the weather in South San Francisco is important when you plan your trip. The hottest months are usually September and August with an average temp of 62°F, while the coldest months are February and January with an average of 53°F. Average annual precipitation for South San Francisco is 23 inches.
What's the best way to get to my boutique hotel in South San Francisco?
You have a few options for traveling to and around South San Francisco. The closest major airport is San Francisco Intl. Airport (SFO), which is located 2.9 mi (4.6 km) from the heart of the city, but Oakland Intl. Airport (OAK) may also be an option. Make your way to South San Francisco Metro Station for metro transit. To venture out into the surrounding area, hop on a train at South San Francisco Station.