Photo by Jeff White

Uptown 4 Stars Hotels

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Uptown 4 Star Hotels

Next weekend
In two weeks

Our top choices for Uptown 4-star hotels

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (1169)
"Staff was helpful at suggesting places to eat and shop"
United States
Ann Marie
The price is NT$3,049
NT$3,626 total
includes taxes & fees
Jan 25 - 2026/1/26
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch
4.0 star property
Downtown St. Louis
8.4 out of 10, Very Good, (4031)
"Staff was supper nice and it all went so smooth."
United States
Brayden
The price is NT$3,112
NT$3,670 total
includes taxes & fees
Dec 30 - Dec 31
Hyatt Regency St. Louis at The Arch

21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (1510)
"Hotel was comfortable, clean and unique. All staff was wonderful "
United States
Sharon
The price is NT$4,498
NT$5,417 total
includes taxes & fees
Jan 4 - 2026/1/5
21C Museum Hotel St Louis

The Cheshire

The Cheshire
4.0 star property
Richmond Heights
8.6 out of 10, Excellent, (1000)
"Excellent place to stay. "
United States
Todd
The price is NT$3,709
NT$4,404 total
includes taxes & fees
Jan 18 - 2026/1/19
The Cheshire

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
4.0 star property
Grand Center
8.8 out of 10, Excellent, (1039)
"Great location and on-site food/beverage"
United States
Jennifer
The price is NT$4,098
NT$4,833 total
includes taxes & fees
Jan 1 - 2026/1/2
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Live by Loews - St.Louis

Live by Loews - St.Louis
4.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1103)
"Clean room, great restaurant and bar down stairs "
United States
Ambria
The price is NT$4,684
NT$5,570 total
includes taxes & fees
Dec 29 - Dec 30
Live by Loews - St.Louis

The Westin St. Louis

The Westin St. Louis
4.5 star property
Downtown St. Louis
8.6 out of 10, Excellent, (1003)
"Great location "
United States
Gregory
The price is NT$3,981
NT$4,655 total
includes taxes & fees
Jan 3 - 2026/1/4
The Westin St. Louis

DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park
4.0 star property
Central West End
8.2 out of 10, Very Good, (1003)
"Good breakfast and perfect location. "
United States
Chaquita
The price is NT$3,841
NT$4,529 total
includes taxes & fees
Jan 3 - 2026/1/4
DoubleTree by Hilton St. Louis Forest Park

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
St. Louis
9.0 out of 10, Wonderful, (1453)
"Everything was absolutely wonderfull"
United States
Suada
The price is NT$3,112
NT$4,079 total
includes taxes & fees
Jan 1 - 2026/1/2
River City Casino & Hotel

St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton
4.0 star property
Downtown West
8.6 out of 10, Excellent, (1002)
"The hotel itself was just beautiful and grand! Beautifully decorated for the holidays and the amenities and attractions surrounding Union station were perfect for our family of 4! Our room was spacious and clean and we loved our stay! "
United States
Kelly
The price is NT$4,923
NT$5,855 total
includes taxes & fees
Jan 4 - 2026/1/5
St. Louis Union Station Hotel, Curio Collection by Hilton

Marriott St. Louis Grand

Marriott St. Louis Grand
4.0 star property
Downtown St. Louis
8.2 out of 10, Very Good, (1002)
"Great location and always accommodating for early check in. "
United States
Lisa
The price is NT$3,992
NT$4,748 total
includes taxes & fees
Jan 3 - 2026/1/4
Marriott St. Louis Grand

Moonrise Hotel

Moonrise Hotel
4.0 star property
Delmar Loop
9.0 out of 10, Wonderful, (1916)
"Great place"
United States
Edward
The price is NT$3,710
NT$4,412 total
includes taxes & fees
Dec 29 - Dec 30
Moonrise Hotel

Hilton Pennywell St. Louis at the Arch

Hilton Pennywell St. Louis at the Arch
4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (1020)
"My second time staying there as always it was lovely "
United States
Nina
The price is NT$3,370
NT$3,974 total
includes taxes & fees
Jan 3 - 2026/1/4
Hilton Pennywell St. Louis at the Arch

Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton
4.0 star property
Clayton
8.8 out of 10, Excellent, (681)
"The gym was amazing! "
United States
Hannah
The price is NT$3,747
NT$4,412 total
includes taxes & fees
Jan 1 - 2026/1/2
Le Méridien St. Louis Clayton

Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (1254)
"Very cool hotel, rooms were clean and nice design, the food at the bar/restaurant was fantastic!!!"
United States
Cullin
The price is NT$3,454
NT$4,108 total
includes taxes & fees
Jan 3 - 2026/1/4
Embassy Suites by Hilton St. Louis Downtown

The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis
4.5 star property
Central West End
9.0 out of 10, Wonderful, (1002)
"Always, a great time and place to stay."
United States
Lubna
The price is NT$4,747
NT$6,524 total
includes taxes & fees
Jan 18 - 2026/1/19
The Royal Sonesta Chase Park Plaza St. Louis

AC Hotel St. Louis Central West End

AC Hotel St. Louis Central West End
4.0 star property
Central West End
9.0 out of 10, Wonderful, (686)
"Clean room, Helpful staff, Easy/cheap parking "
United States
Delaney
The price is NT$3,866
NT$4,560 total
includes taxes & fees
Jan 2 - 2026/1/3
AC Hotel St. Louis Central West End

Hotel Saint Louis, Autograph Collection

Hotel Saint Louis, Autograph Collection
4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (470)
"Great hotel. "
United States
Abby
The price is NT$4,872
NT$5,795 total
includes taxes & fees
Jan 2 - 2026/1/3
Hotel Saint Louis, Autograph Collection

Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark
4.0 star property
Downtown St. Louis
7.6 out of 10, Good, (1072)
"Clean room, this hotel is great for young people, night activity, 360 rooftop bar always crowded but pretty."
United States
Joan
The price is NT$4,614
NT$5,487 total
includes taxes & fees
Jan 3 - 2026/1/4
Hilton St. Louis at the Ballpark

The Last Hotel

The Last Hotel
4.5 star property
Downtown West
7.6 out of 10, Good, (1000)
"HaD a great stay "
United States
christine
The Last Hotel
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Uptown.
Still don't see what you're looking for?
See all properties in Uptown.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Uptown Hotel Reviews

Explore a world of travel with Expedia