Photo by Hazem Abdul

Find hotels in South Main, Houston from NT$1,804

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Aug 31 - Sep 1
Tomorrow
Sep 1 - Sep 2
Next weekend
Sep 5 - Sep 7
In two weeks
Sep 12 - Sep 14

Filter by

Guest rating
Guest rating
Star rating

Discover 6,410 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Bluestar Inn
1 bedroom, individually furnished, desk, iron/ironing board

Bluestar Inn

2.5 star property
9.0 out of 10, Wonderful, (260)
"Nice will go again "
The price is NT$2,232
NT$2,611 total
includes taxes & fees
Sep 1 - Sep 2
Bluestar Inn
Signature Inn Houston Galleria
Lobby

Signature Inn Houston Galleria

2.5 star property
8.4 out of 10, Very Good, (533)
"The room was stinky and comfortable looked thin, itchy and unsanitary. The hotel give motels vibes."
The price is NT$2,109
NT$2,468 total
includes taxes & fees
Sep 1 - Sep 2
Signature Inn Houston Galleria
Hyatt House Houston Medical Center
Lobby

Hyatt House Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1088)
"We loved our stay. Great room, staff, and service."
The price is NT$3,588
NT$4,220 total
includes taxes & fees
Sep 6 - Sep 7
Hyatt House Houston Medical Center
Quality Inn & Suites NRG Park - Medical Center
1 bedroom, hypo-allergenic bedding, in-room safe, individually decorated

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.6 out of 10, (1007)
"Wonderful experience absolutely love my stay"
The price is NT$1,898
NT$2,221 total
includes taxes & fees
Sep 16 - Sep 17
Quality Inn & Suites NRG Park - Medical Center
Wyndham Houston near NRG Park/Medical Center
Lobby

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.2 out of 10, Good, (1134)
"It was quiet and close to our event. It was very clean and staff was helpful "
The price is NT$3,027
NT$3,541 total
includes taxes & fees
Sep 1 - Sep 2
Wyndham Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center
Gazebo

Wingate Houston near NRG Park/Medical Center

3.0 star property
6.6 out of 10, (932)
"Great location, rooms were hot/warm. Needs a huge make over."
The price is NT$2,415
NT$2,826 total
includes taxes & fees
Sep 1 - Sep 2
Wingate Houston near NRG Park/Medical Center
Candlewood Suites Houston Medical Center by IHG
Exterior

Candlewood Suites Houston Medical Center by IHG

2.5 star property
7.4 out of 10, Good, (792)
"Will definitely be back again!"
The price is NT$2,385
NT$2,790 total
includes taxes & fees
Sep 2 - Sep 3
Candlewood Suites Houston Medical Center by IHG
Moxy Houston Downtown
Front of property - evening/night

Moxy Houston Downtown

3.0 star property
9.0 out of 10, Wonderful, (557)
"Beautiful stay !"
The price is NT$3,092
NT$3,689 total
includes taxes & fees
Sep 7 - Sep 8
Moxy Houston Downtown
Americas Best Value Inn & Suites NE Houston Downtown I-610
Suite, 2 Queen Beds, Non Smoking, Kitchenette | Room amenity

Americas Best Value Inn & Suites NE Houston Downtown I-610

2.0 star property
8.6 out of 10, Excellent, (610)
"Love my stay! Will def come back"
The price is NT$2,036
NT$2,382 total
includes taxes & fees
Sep 1 - Sep 2
Americas Best Value Inn & Suites NE Houston Downtown I-610
Palace Inn Blue Edgebrook
Free daily on-the-go breakfast

Palace Inn Blue Edgebrook

3.0 star property
9.4 out of 10, Exceptional, (135)
"Absolutely beautiful hotel, safe and quiet. Very clean."
The price is NT$2,707
NT$3,263 total
includes taxes & fees
Sep 1 - Sep 2
Palace Inn Blue Edgebrook
Hotel Granduca Houston
Courtyard

Hotel Granduca Houston

4.0 star property
9.2 out of 10, Wonderful, (1002)
"Beautiful hotel and the staff was lovely. We had a wonderful stay. "
Hotel Granduca Houston
Hyatt Place Houston Medical Center
Lobby

Hyatt Place Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1932)
"Nice place to stay."
The price is NT$3,345
NT$3,935 total
includes taxes & fees
Sep 6 - Sep 7
Hyatt Place Houston Medical Center
Hotel Park Place
Deluxe Room, 1 King Bed, Non Smoking, Kitchenette | 1 bedroom, premium bedding, desk, laptop workspace

Hotel Park Place

2.5 star property
8.6 out of 10, Excellent, (177)
"Great place highly recomend"
The price is NT$1,953
NT$2,286 total
includes taxes & fees
Sep 2 - Sep 3
Hotel Park Place
Americas Best Value Inn NRG Park Medical Center
Free self parking

Americas Best Value Inn NRG Park Medical Center

2.0 star property
7.8 out of 10, Good, (774)
"Decent place to stay for a night. "
The price is NT$1,949
NT$2,280 total
includes taxes & fees
Sep 20 - Sep 21
Americas Best Value Inn NRG Park Medical Center
Prestige Inn
Lobby sitting area

Prestige Inn

2.5 star property
8.6 out of 10, Excellent, (242)
"Staff is nice and property is clean !!!"
Prestige Inn
WoodSpring Suites Houston Northwest
Full-size fridge, microwave, oven, stovetop

WoodSpring Suites Houston Northwest

2.5 star property
7.6 out of 10, Good, (479)
"Enjoy the stay"
The price is NT$2,017
NT$2,320 total
includes taxes & fees
Sep 1 - Sep 2
WoodSpring Suites Houston Northwest
Hilton Garden Inn Houston/Bush Intercontinental Airport
Lobby

Hilton Garden Inn Houston/Bush Intercontinental Airport

3.0 star property
8.2 out of 10, Very Good, (1010)
"Good Hotel clean and comfortable."
The price is NT$2,453
NT$2,886 total
includes taxes & fees
Sep 6 - Sep 7
Hilton Garden Inn Houston/Bush Intercontinental Airport
Americas Best Value Inn Medical Center Downtown
Desk, free WiFi, bed sheets, alarm clocks

Americas Best Value Inn Medical Center Downtown

2.0 star property
7.8 out of 10, Good, (1003)
"Cheap, quiet, clean, and friendly staff"
The price is NT$2,284
NT$2,672 total
includes taxes & fees
Sep 1 - Sep 2
Americas Best Value Inn Medical Center Downtown
Palace Inn 290 & Jones Rd
Room, 1 King Bed, Non Smoking | View from room

Palace Inn 290 & Jones Rd

2.5 star property
8.8 out of 10, Excellent, (460)
"Always a great stay "
The price is NT$1,804
NT$2,110 total
includes taxes & fees
Sep 1 - Sep 2
Palace Inn 290 & Jones Rd
The Lancaster Hotel
Exterior

The Lancaster Hotel

4.0 star property
9.8 out of 10, Exceptional, (1008)
"Beautiful hotel with Ana amazing room! Really enjoyed our stay and the staff was excellent!"
The price is NT$7,126
NT$8,338 total
includes taxes & fees
Sep 1 - Sep 2
The Lancaster Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.
Discovery Green which includes a city, central business district and a high rise building

Downtown Houston

3 out of top 10 points of interest in this area

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center

1 out of top 10 points of interest in this area

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Theater District

Travelers enjoy Theater District for its restaurants and seafood restaurants. Consider checking out Wortham Center while you're in the area.

Houston featuring a city and a high rise building

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Main Street Square Station.

Top South Main Hotel Reviews

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 61 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page.

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.