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South Main 5 Stars Hotels
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Compare South Main 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Our top choices for South Main 5-star hotels

The Post Oak Hotel at Uptown Houston
The Post Oak Hotel at Uptown Houston
9.6 out of 10, Exceptional, (802)
The price is NT$16,631
NT$19,458 total
includes taxes & fees
Sep 17 - Sep 18

Four Seasons Hotel Houston
Four Seasons Hotel Houston
9.2 out of 10, Wonderful, (1002)
The price is NT$15,897
NT$18,751 total
includes taxes & fees
Sep 6 - Sep 7

JW Marriott Houston Downtown
JW Marriott Houston Downtown
9.0 out of 10, Wonderful, (1002)
The price is NT$6,334
NT$7,625 total
includes taxes & fees
Sep 5 - Sep 6

ACP Hotel Houston Westchase, MOD Collection by Sonesta
ACP Hotel Houston Westchase, MOD Collection by Sonesta
8.0 out of 10, Very Good, (1005)
The price is NT$2,064
NT$2,415 total
includes taxes & fees
Sep 1 - Sep 2

The St. Regis Houston
The St. Regis Houston
9.2 out of 10, Wonderful, (396)
The price is NT$13,726
NT$16,370 total
includes taxes & fees
Sep 5 - Sep 6

La Colombe d'Or Hotel
La Colombe d'Or Hotel
9.4 out of 10, Exceptional, (129)
The price is NT$13,746
NT$16,083 total
includes taxes & fees
Sep 3 - Sep 4

7550 Kirby Dr
7550 Kirby Dr
8.2 out of 10, Very Good, (45)

TUSCAN VILLA
TUSCAN VILLA
2.0 out of 10, (3)
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Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in South Main.

Hilton Houston Plaza/Medical Center
6633 Travis St, Houston, TX
The price is NT$2,660 per night from Sep 1 to Sep 2
NT$2,660
NT$3,147 total
Sep 1 - Sep 2
includes taxes & fees
8.2/10 Very Good! (1,540 reviews)
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South Main Hotels by Star Rating
Hotels in South Main Neighborhoods
Stay near popular South Main attractions
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- Hotels near MD Anderson Cancer Center
- Hotels near George R. Brown Convention Center
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- Hotels near Toyota Center
- Hotels near Rice University
- Hotels near University of Houston
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- Hotels near Texas Southern University
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- Hotels near Houston Natural Science Museum
- Hotels near Hobby Center for the Performing Arts
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