South Main, TX
Houston
Visit South Main
Popular places to visit
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the entertainment choices and acclaimed art scene in this vibrant area.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the entertainment choices and lively festivals in this vibrant area.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Space Center Houston
This iconic “mission control” was immortalized for its role in the first moon landing.
South Main Hotel Deals
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
The property is in a great location for dinning and shopping.
Reviewed on 2026/3/10
Hotel Zaza Houston Museum District
Remember to have your room key (card) with you; so that you can operate the elevators.
Reviewed on 2026/3/9
The Royal Sonesta Houston Galleria
NA
Reviewed on 2026/3/9
Club Quarters Hotel Downtown, Houston
Good clean room good distance from the Daikin stadium.
Reviewed on 2026/3/10
Blossom Hotel Houston, Curio Collection by Hilton
This property was much better than expected. Not something you’d expect in the medical district but a pleasant surprise. There was a strong odor on the floor I was staying on but once inside the room it was no issue. My room was absolutely beautiful. The bed was exceptionally comfortable. I’ll definitely ...
Reviewed on 2026/3/10
The Whitehall Houston
Small rooms , uncomfortable beds by no means a 4 star hotel . Lobby is nice but really needs an update .bath is tiny . Not good Staff was really friendly. In not cheap either
Reviewed on 2026/3/9
Other neighborhoods around South Main
Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Astrodome and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
Greenway Plaza-Upper Kirby
Travelers come to Greenway Plaza-Upper Kirby for its abundant dining options, and you can see top attractions like Highland Village and Richmond Avenue while you're in town.
South Central Houston
If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
