South Main, TX
Houston
Visit South Main
South Main Hotel Deals
Wyndham Houston near NRG Park/Medical Center
Property is older, but it was convenient and not a bad place to stay.
Reviewed on 2026/4/29
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Everything was great elevator 1 had some technical issues other than that everything was perfect!
Reviewed on 2026/4/29
Club Quarters Hotel Downtown, Houston
Great stay in a good location. Room was clean. Staff was friendly and helpful. Only negative is the Wi-Fi is spotty at best.
Reviewed on 2026/4/29
The Whitehall Houston
The food was great, everything was clean, the room was very clean and comfortable, and my husband and I will certainly stay there again.
Reviewed on 2026/4/28
Blossom Hotel Houston, Curio Collection by Hilton
Every staff member that we encountered was helpful and personable: the man who checked us in, Jordan the bartender at the Skybar, and our server and her assistant at the restaurant. Our room was lovely. All in all, our stay was a great value for the money.
Reviewed on 2026/4/29
Hilton Houston Plaza/Medical Center
Your shower head needed some attention. The bracket was off from the wall
Reviewed on 2026/4/29
Other neighborhoods around South Main
Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Arena and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Continental Club or Children's Museum of Houston and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
River Oaks
Gardens and monuments are just a few things travelers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area.
