Find hotels in South Main, Houston

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for South Main hotels

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (840 reviews)
"This is a safe, friendly hotel close to MDA Cancer Center"
United States
Myra
The price is NT$2,477
NT$2,898 total
includes taxes & fees
Apr 9 - Apr 10
Candlewood Suites Houston Medical Center by IHG

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,006 reviews)
"Clean room, helpful staff and good location to hospital."
United States
George
The price is NT$3,258
NT$3,812 total
includes taxes & fees
Mar 25 - Mar 26
Comfort Suites Houston near Medical Center- NRG Stadium

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,000 reviews)
"Courteous staff, clean room, quite property"
United States
Javier
The price is NT$2,160
NT$2,528 total
includes taxes & fees
Apr 5 - Apr 6
Quality Inn & Suites NRG Park - Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,012 reviews)
"Easy access to stadium "
United States
Richard
The price is NT$2,223
NT$2,601 total
includes taxes & fees
Mar 23 - Mar 24
Wingate Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.0 out of 10, Good, (1,232 reviews)
"Front desk staff was very professional and kind."
United States
MARINA
The price is NT$2,858
NT$3,344 total
includes taxes & fees
Mar 23 - Mar 24
Wyndham Houston near NRG Park/Medical Center

Fairfield Inn & Suites Houston Intercontinental Airport

Fairfield Inn & Suites Houston Intercontinental Airport
3.0 star property
30.6 km from South Main
8.6 out of 10, Excellent, (1,001 reviews)
"Nice stay and friendy staff."
United States
Stephanie
The price is NT$2,271
NT$2,708 total
includes taxes & fees
Apr 4 - Apr 5
Fairfield Inn & Suites Houston Intercontinental Airport

Drury Inn & Suites Houston Near the Galleria

Drury Inn & Suites Houston Near the Galleria
3.0 star property
The Galleria, 9.4 km from South Main
9.4 out of 10, Exceptional, (1,323 reviews)
"Perfect stays here! Friendly staff, wonderful amenities! Will definitely stay here again"
Canada
wanda
The price is NT$2,984
NT$3,492 total
includes taxes & fees
Apr 5 - Apr 6
Drury Inn & Suites Houston Near the Galleria

Four Points by Sheraton Houston Intercontinental Airport

Four Points by Sheraton Houston Intercontinental Airport
3.0 star property
29.9 km from South Main
8.4 out of 10, Very Good, (1,002 reviews)
"The staff was friendly and the hotel was clean"
United States
Lisa
The price is NT$2,672
NT$3,126 total
includes taxes & fees
Mar 29 - Mar 30
Four Points by Sheraton Houston Intercontinental Airport

Holiday Inn Express & Suites Houston SW - Galleria Area by IHG

Holiday Inn Express & Suites Houston SW - Galleria Area by IHG
2.5 star property
9.6 km from South Main
8.0 out of 10, Very Good, (1,000 reviews)
"Clean room, friendly and responsive staff"
United States
Clara
The price is NT$3,144
NT$3,678 total
includes taxes & fees
Apr 5 - Apr 6
Holiday Inn Express & Suites Houston SW - Galleria Area by IHG

Comfort Suites Houston West at Clay Road

Comfort Suites Houston West at Clay Road
2.5 star property
22.8 km from South Main
8.4 out of 10, Very Good, (1,007 reviews)
"Friendly staff, breakfast excellent perfect location! Will definitely stay here again"
Canada
wanda
The price is NT$2,429
NT$2,842 total
includes taxes & fees
Apr 5 - Apr 6
Comfort Suites Houston West at Clay Road

Sonesta Simply Suites Houston – NASA Clear Lake

Sonesta Simply Suites Houston – NASA Clear Lake
2.5 star property
31.8 km from South Main
8.2 out of 10, Very Good, (1,019 reviews)
"Clean room and very courteous staff."
United States
Fazlur
The price is NT$1,905
NT$2,229 total
includes taxes & fees
Mar 17 - Mar 18
Sonesta Simply Suites Houston – NASA Clear Lake

Hilton Garden Inn Houston NW America Plaza

Hilton Garden Inn Houston NW America Plaza
3.5 star property
25 km from South Main
8.6 out of 10, Excellent, (1,003 reviews)
"It was very relaxing and the staff are very friendly and helpful. "
United States
Chantel
The price is NT$2,656
NT$3,073 total
includes taxes & fees
Apr 11 - Apr 12
Hilton Garden Inn Houston NW America Plaza

Hampton Inn Houston-Brookhollow

Hampton Inn Houston-Brookhollow
2.5 star property
20.4 km from South Main
8.2 out of 10, Very Good, (1,001 reviews)
"The staff is awesome! What a great place to stay! "
United States
Cynthia
The price is NT$2,421
NT$2,832 total
includes taxes & fees
Apr 5 - Apr 6
Hampton Inn Houston-Brookhollow

GreenTree Inn Houston IAH Airport

GreenTree Inn Houston IAH Airport
2.0 star property
31.4 km from South Main
6.6 out of 10, (1,037 reviews)
"Staff was very friendly , room was very clean "
Canada
Charlette
The price is NT$1,715
NT$2,006 total
includes taxes & fees
Mar 12 - Mar 13
GreenTree Inn Houston IAH Airport

Crystal Inn - NorthWest - 290

Crystal Inn - NorthWest - 290
2.0 star property
24.8 km from South Main
9.8 out of 10, Exceptional, (35 reviews)
"The best hotel I’ve been in excellent rooms perfect customer service rooms are phenomenal"
United States
Michael
The price is NT$3,403
NT$3,913 total
includes taxes & fees
Mar 16 - Mar 17
Crystal Inn - NorthWest - 290

Homewood Suites By Hilton Houston IAH Airport Beltway 8

Homewood Suites By Hilton Houston IAH Airport Beltway 8
3.0 star property
29.9 km from South Main
8.4 out of 10, Very Good, (955 reviews)
"I really like the hotel We stayed (5 family members) The breakfast have a really good taste."
United States
Saul
The price is NT$2,421
NT$2,832 total
includes taxes & fees
Apr 5 - Apr 6
Homewood Suites By Hilton Houston IAH Airport Beltway 8

Holiday Inn NW Houston Beltway 8 by IHG

Holiday Inn NW Houston Beltway 8 by IHG
3.0 star property
29.9 km from South Main
8.8 out of 10, Excellent, (492 reviews)
"The staff was gracious, the room was clean and comfortable, and the building was well maintained. I highly recommend staying here."
United States
Laura
The price is NT$2,537
NT$2,918 total
includes taxes & fees
Apr 5 - Apr 6
Holiday Inn NW Houston Beltway 8 by IHG

Hilton Houston North

Hilton Houston North
3.5 star property
30.5 km from South Main
8.4 out of 10, Very Good, (1,013 reviews)
"I had a great stay at this hotel. The room was clean and comfortable."
United States
Victor
The price is NT$3,689
NT$4,316 total
includes taxes & fees
Apr 10 - Apr 11
Hilton Houston North

Holiday Inn Express Houston - Galleria Area by IHG

Holiday Inn Express Houston - Galleria Area by IHG
2.5 star property
The Galleria, 8.6 km from South Main
9.4 out of 10, Exceptional, (1,012 reviews)
"Clean room, great staff, great breakfast, comfortable bed. "
United States
Sabine
The price is NT$4,255
NT$4,978 total
includes taxes & fees
Apr 5 - Apr 6
Holiday Inn Express Houston - Galleria Area by IHG

Doubletree by Hilton Houston Hobby Airport

Doubletree by Hilton Houston Hobby Airport
4.0 star property
Southeast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,017 reviews)
"Excellent stay! The room was very clean and comfortable, and the staff went above and beyond to be friendly and helpful. Check-in was smooth, the amenities were great, and the overall atmosphere made it a relaxing experience. I’d definitely stay here again!"
United States
Wayne
The price is NT$3,229
NT$3,814 total
includes taxes & fees
Apr 3 - Apr 4
Doubletree by Hilton Houston Hobby Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Top South Main Hotel Reviews

Find out more about South Main

Top reasons to visit South Main

  • Vibrant Cultural Scene: South Main boasts a rich mix of sports, arts, and educational experiences, perfect for culture enthusiasts.
  • Exciting Entertainment: Enjoy live music, movie screenings, and campus events, ensuring a fun-filled vacation.
  • Family-Friendly Atmosphere: The neighborhood is ideal for families, with plenty of attractions that appeal to all ages.
  • Shopping and Dining: Explore diverse shops and eateries along the main street, enhancing your urban experience.
  • Variety of Accommodations: From pet-friendly hotels to business-focused options, South Main offers something for every traveler.

Find great hotels near South Main

Discover a variety of accommodation options in South Main, Houston, perfect for every traveler. Whether you're seeking a pet-friendly hotel, an aparthotel for extended stays, or business-friendly amenities, you'll find it all here. South Main offers top-rated hotels that cater to diverse preferences, ensuring a welcoming experience for everyone, including LGBTQIA travelers. With a selection of the best hotels and convenient access to local attractions, your stay in South Main promises to be enjoyable and memorable.

  • Club Quarters Hotel Downtown, Houston: This 4-star hotel offers a contemporary lodging experience ideal for shopping enthusiasts and business travelers. Nestled in the vibrant shopping district, it is a pet-friendly haven, welcoming dogs with amenities such as food and water bowls. The hotel's atmosphere is modern and professional, catering to those who appreciate a blend of convenience and comfort. Guests can enjoy a variety of services tailored for corporate needs, making it an excellent choice for business trips while still being close to local attractions.
  • DoubleTree by Hilton Hotel & Suites Houston by the Galleria: A perfect blend of family-friendly comforts and business amenities, this 4-star hotel is situated within 8.0km of South Main. Known for its warm hospitality, guests are greeted with a signature cookie upon arrival. The hotel features special amenities for children, ensuring a delightful stay for families. Located in a bustling shopping district, it also provides easy access to the Galleria's upscale stores, making it an excellent choice for travelers seeking both leisure and convenience.
  • The Royal Sonesta Houston Galleria: This elegant 4-star hotel combines a luxurious ambiance with pet-friendly policies, making it perfect for both leisure and business travelers. Located near South Main, it features a sophisticated design and a range of amenities tailored for guest comfort. The hotel allows pets with certain restrictions and offers a welcoming environment for those traveling with furry companions. Its prime location in the shopping district means guests can indulge in retail therapy while enjoying fine dining and upscale accommodations.

Where to stay near South Main

South Main, Houston, offers a vibrant blend of culture, sports, and business experiences. Visitors can enjoy the lively atmosphere of downtown, with its convenient location and family-friendly vibe. Explore the main street's shops and eateries while soaking in the urban energy. Nearby neighborhoods provide additional cultural attractions and friendly locals, making it an ideal destination for a memorable vacation.

  • Houston: As a bustling metropolis, Houston serves as the heart of South Main. The city offers a diverse travel experience, attracting visitors year-round with its vibrant mix of family-friendly activities, business opportunities, and entertainment options. From shopping malls to music concerts, there’s something for everyone. Key attractions include major sports stadiums and event venues, making it a hub for both leisure and professional events. The best time to visit is during peak months like March, May, and July when the city's energy is at its highest.
  • Braeswood Place: Located just 3.2km from South Main, Braeswood Place is a charming neighborhood that blends business and leisure. Visitors flock here for its educational institutions, shopping centers, and sports venues. The area boasts a lively atmosphere with access to modern college universities and research facilities, making it an excellent spot for those interested in academics or athletics. Similar to Houston, peak travel months are seen in March, May, and July, ensuring a vibrant community experience.
  • Texas Medical Center: Also situated 3.2km away from South Main, the Texas Medical Center is renowned for its focus on health and education. This neighborhood attracts visitors for its cultural offerings, business opportunities, and innovative research facilities. With shopping malls and centers nearby, it provides a well-rounded experience for tourists. The area is especially vibrant in April, July, and September, making it an ideal destination for those interested in medicine, education, and culture.

Things to do near South Main

South Main in Houston, Texas, offers a vibrant mix of sports, culture, and business-themed activities. Visitors can enjoy engaging experiences such as movie showings, live music concerts, and educational opportunities, all while exploring shopping mall centers. With a variety of entertainment choices and campus events, South Main is an ideal destination for those seeking a well-rounded vacation filled with excitement and learning.

Shopping

In South Main, Houston, you can shop at The Galleria, a vibrant shopping mall with entertainment and family vibes, located 8.0km away. River Oaks District offers a stylish public market with a city atmosphere, also 8.0km away, while Highland Village combines shopping and family-friendly fun, just 8.0km from South Main.

Recreation

At NRG Stadium, immerse yourself in the excitement of live sports, just 1.6km from South Main. For a vibrant night out, head to the House of Blues Houston, seven miles away, offering fantastic live music. Golf enthusiasts will enjoy the scenic Wildcat Golf Club, only two miles away.

Adventure

Experience the thrill of indoor skydiving at iFLY Indoor Skydiving, located 16.1km from South Main. For family fun, visit the Chancellors Family Center, 8.0km away, offering various adventure activities. Additionally, enjoy tennis at the Homer Ford Tennis Center, also 8.0km from South Main, with a vibrant atmosphere.

Nightlife

Experience the vibrant nightlife of South Main by visiting the Main Street Theater for a romantic show, or enjoy family fun at Zuma Fun Center. For a cultural evening, head to the Hobby Center for the Performing Arts and catch a captivating performance.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for South Main

To save money during your visit to South Main, consider traveling in August or December to January, when prices are lower. Sundays offer the cheapest accommodation rates, while Saturdays are typically the most expensive. Use Expedia to compare hotel prices, ensuring to sort by lowest rates, and consider booking a package deal that combines your hotel, flights, and activities for additional savings. Look for free local events and attractions to enjoy, and utilize public transportation options to keep travel costs down.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around South Main are August and December to January, where the prices are slightly lower. This is in comparison to March to May, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around South Main is Sunday. The most expensive day to stay around South Main is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to tailor your options based on your budget, desired location, and preferred hotel type. To find the best prices and offers, sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel stay at South Main with your flights and activities when you book an Expedia package.

Find the best attractions near South Main

South Main in Houston offers a vibrant mix of sports, business, and cultural experiences, featuring attractions like historic and modern colleges and art museums. Travelers can enjoy a rich cultural atmosphere, perfect for families and city explorers alike. Don’t miss the Stockton Arena and nearby Stockton Ballpark for exciting events, alongside the best local attractions that showcase the area's unique charm.

  • Rice University: Located 4.8km from South Main, Rice University offers a blend of modern architecture and lush green spaces. Stroll through its beautiful campus, known for its stunning gardens and art installations, while soaking in the vibrant city atmosphere.
  • University of Houston: About 9.7km away, the University of Houston is rich in history and cultural significance. Explore its diverse art galleries and museums, and enjoy the lively atmosphere created by its students and community events.
  • NRG Park: Just 1.6km from South Main, NRG Park is a historic sports stadium that hosts a variety of events, from football games to concerts. Experience the energetic vibe and immerse yourself in the local sports culture.

Best time to go to South Main

The best time to visit South Main can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around South Main falls in August, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature around South Main falls in January, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January54.1°F (12.3°C)Light RainMostly SunnyAverageSlightly Low
February57.0°F (13.9°C)Light RainMostly CloudyAverageAverage
March63.9°F (17.7°C)Light RainMostly SunnyAverageSlightly High
April69.6°F (20.9°C)Light RainMostly SunnyModerately HighSlightly High
May76.6°F (24.8°C)Light RainMostly SunnyAverageSlightly High
June82.8°F (28.2°C)Light RainMostly SunnyModerately HighAverage
July84.2°F (29.0°C)Light RainMostly SunnyModerately HighAverage
August84.9°F (29.4°C)Light RainMostly SunnyAverageSlightly Low
September80.6°F (27.0°C)Light RainMostly SunnyAverageAverage
October72.7°F (22.6°C)Light RainMostly SunnyModerately LowAverage
November62.8°F (17.1°C)Light RainMostly SunnyModerately LowAverage
December57.4°F (14.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to South Main

When visiting South Main in Houston, you have several airport options. Houston, TX (IAH-George Bush Intercontinental) is 35.4km away, with nearby hotels like DoubleTree by Hilton (4.8km) and Sonesta Hotel (8.0km), both offering airport shuttle services. Houston, TX (HOU-William P. Hobby) is closer at 14.5km, featuring luxurious choices like JW Marriott and Four Seasons Hotel. Lastly, Houston, TX (EFD-Ellington Field) is 25.7km away, with Doubletree by Hilton (11.3km) and Houston Marriott South (9.7km) as comfortable stays. Each airport is well-connected, making your travel seamless.

Frequently asked questions

What is South Main like?
You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness center. Other top choices in the neighborhood include Quality Inn & Suites NRG Park - Medical Center and Wyndham Houston near NRG Park/Medical Center.
How many hotels will I be able to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.
Where can I learn more about changing or cancelling my trip to South Main?
For more details about changing or cancelling your trip to South Main, head over to our customer service page.
What can I see and do in this Houston neighborhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

Explore a world of travel with Expedia