Find hotels in South Main, Houston from NT$2,256

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Discover 6,620 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Comfort Suites Houston near Medical Center- NRG Stadium

2.5 star property
South Main
8.6 out of 10, Excellent, (1003)
"Was a great stay and rigjt next to the stadium all around recomended"
United States
Jason
The price is NT$2,828
NT$3,309 total
includes taxes & fees
Nov 28 - Nov 29
Comfort Suites Houston near Medical Center- NRG Stadium

Wyndham Houston near NRG Park/Medical Center

3.5 star property
South Main
7.2 out of 10, Good, (1191)
"Perfect "
United States
Maria
The price is NT$4,062
NT$4,752 total
includes taxes & fees
Nov 23 - Nov 24
Wyndham Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

3.0 star property
South Main
6.6 out of 10, (975)
"Great staff, excellent service and convenient to the area we were wanting to be. Room was clean and bed was very comfortable."
United States
Roy
The price is NT$4,030
NT$4,716 total
includes taxes & fees
Nov 23 - Nov 24
Wingate Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
South Main
6.4 out of 10, (1001)
"Everything was great"
United States
Yeimi
The price is NT$1,928
NT$2,256 total
includes taxes & fees
Dec 22 - Dec 23
Quality Inn & Suites NRG Park - Medical Center

Candlewood Suites Houston Medical Center by IHG

2.5 star property
South Main
7.4 out of 10, Good, (816)
"Yes the where"
United States
Robert
The price is NT$2,100
NT$2,457 total
includes taxes & fees
Nov 28 - Nov 29
Candlewood Suites Houston Medical Center by IHG

Hyatt Place Houston Medical Center

3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2136)
"Great stay"
United States
Vallie
The price is NT$3,608
NT$4,244 total
includes taxes & fees
Dec 1 - Dec 2
Hyatt Place Houston Medical Center

Blossom Hotel Houston, Curio Collection by Hilton

4.0 star property
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3579)
"Great property, beautiful room, great staff!"
United States
Lindsay
The price is NT$4,116
NT$4,816 total
includes taxes & fees
Dec 21 - Dec 22
Blossom Hotel Houston, Curio Collection by Hilton

The Whitehall Houston

4.0 star property
Houston Central Business District, 10 km from South Main
8.6 out of 10, Excellent, (1878)
"Great stay."
United States
Anita
The price is NT$3,652
NT$4,272 total
includes taxes & fees
Nov 29 - Nov 30
The Whitehall Houston

Hyatt House Houston Medical Center

3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1169)
"I had a great stay! I travel to Houston several times a year and this is one of my favorite places to stay."
United States
Star
The price is NT$3,608
NT$4,244 total
includes taxes & fees
Dec 1 - Dec 2
Hyatt House Houston Medical Center

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4.0 star property
8.9 km from South Main
8.2 out of 10, Very Good, (2943)
"Great location nice beds staff was amazing and good breakfast "
United States
Canyelle
The price is NT$3,482
NT$4,103 total
includes taxes & fees
Dec 21 - Dec 22
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

The Royal Sonesta Houston Galleria

4.0 star property
The Galleria, 8.8 km from South Main
8.4 out of 10, Very Good, (1389)
"Great place to stay!"
United States
Curtis
The price is NT$3,718
NT$4,350 total
includes taxes & fees
Nov 23 - Nov 24
The Royal Sonesta Houston Galleria

Hilton Garden Inn Houston Medical Center, TX

3.0 star property
Texas Medical Center, 4.7 km from South Main
9.4 out of 10, Exceptional, (1006)
"Clean room and nice staff"
Canada
Guillermo
The price is NT$3,243
NT$3,794 total
includes taxes & fees
Nov 30 - Dec 1
Hilton Garden Inn Houston Medical Center, TX

Hilton Houston Plaza/Medical Center

4.5 star property
4.4 km from South Main
8.4 out of 10, Very Good, (1681)
"Clean rooms, comfortable bed, & friendly staff"
United States
Thomas
The price is NT$2,165
NT$2,570 total
includes taxes & fees
Nov 24 - Nov 25
Hilton Houston Plaza/Medical Center

Hyatt Regency Houston West

3.5 star property
23.2 km from South Main
8.6 out of 10, Excellent, (1232)
"Great room and staff."
United States
Brad
The price is NT$3,349
NT$3,919 total
includes taxes & fees
Nov 25 - Nov 26
Hyatt Regency Houston West

Holiday Inn Express & Suites Houston - Memorial City Centre by IHG

2.5 star property
Memorial City, 18.4 km from South Main
8.8 out of 10, Excellent, (1010)
"Clean, friendly staff, good breakfast, and all around great stay! "
United States
Rebecca
The price is NT$2,991
NT$3,516 total
includes taxes & fees
Dec 14 - Dec 15
Holiday Inn Express & Suites Houston - Memorial City Centre by IHG

InterContinental Houston by IHG

4.0 star property
Texas Medical Center, 4.1 km from South Main
9.2 out of 10, Wonderful, (1002)
"Clean room, excellent staff, kind and respectful."
United States
DIANA
The price is NT$3,464
NT$4,678 total
includes taxes & fees
Nov 27 - Nov 28
InterContinental Houston by IHG

Haven Inn & Suites Downtown Houston

2.5 star property
North Houston, 18.8 km from South Main
9.4 out of 10, Exceptional, (1002)
"Very clean and safe, would stay again"
United States
Krimson
Haven Inn & Suites Downtown Houston

Club Quarters Hotel Downtown, Houston

4.0 star property
Houston Central Business District, 10.9 km from South Main
8.4 out of 10, Very Good, (3903)
"Hotel was beautiful, room was great for the price"
United States
Sonya
The price is NT$2,513
NT$2,940 total
includes taxes & fees
Nov 24 - Nov 25
Club Quarters Hotel Downtown, Houston

Home2 Suites by Hilton at the Galleria

3.0 star property
Greater Uptown, 8 km from South Main
8.8 out of 10, Excellent, (968)
" Clean room , comfortable Good breakfast "
United States
Yelyzaveta
The price is NT$3,305
NT$3,867 total
includes taxes & fees
Dec 1 - Dec 2
Home2 Suites by Hilton at the Galleria

Holiday Inn Express Houston - Galleria Area by IHG

2.5 star property
The Galleria, 8.6 km from South Main
9.4 out of 10, Exceptional, (1009)
"This Holiday Inn Express was one of the nicest with the friendliest staff and best breakfast I have experienced in a long time travelling!"
United States
Melissa
The price is NT$3,349
NT$3,919 total
includes taxes & fees
Nov 25 - Nov 26
Holiday Inn Express Houston - Galleria Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Top South Main Hotel Reviews

Find out more about South Main

Top reasons to visit South Main

  • Vibrant Cultural Scene: South Main boasts a rich mix of sports, arts, and educational experiences, perfect for culture enthusiasts.
  • Exciting Entertainment: Enjoy live music, movie screenings, and campus events, ensuring a fun-filled vacation.
  • Family-Friendly Atmosphere: The neighborhood is ideal for families, with plenty of attractions that appeal to all ages.
  • Shopping and Dining: Explore diverse shops and eateries along the main street, enhancing your urban experience.
  • Variety of Accommodations: From pet-friendly hotels to business-focused options, South Main offers something for every traveler.

Find great hotels near South Main

Discover a variety of accommodation options in South Main, Houston, perfect for every traveler. Whether you're seeking a pet-friendly hotel, an aparthotel for extended stays, or business-friendly amenities, you'll find it all here. South Main offers top-rated hotels that cater to diverse preferences, ensuring a welcoming experience for everyone, including LGBTQIA travelers. With a selection of the best hotels and convenient access to local attractions, your stay in South Main promises to be enjoyable and memorable.

  • Club Quarters Hotel Downtown, Houston: This 4-star hotel offers a contemporary lodging experience ideal for shopping enthusiasts and business travelers. Nestled in the vibrant shopping district, it is a pet-friendly haven, welcoming dogs with amenities such as food and water bowls. The hotel's atmosphere is modern and professional, catering to those who appreciate a blend of convenience and comfort. Guests can enjoy a variety of services tailored for corporate needs, making it an excellent choice for business trips while still being close to local attractions.
  • DoubleTree by Hilton Hotel & Suites Houston by the Galleria: A perfect blend of family-friendly comforts and business amenities, this 4-star hotel is situated within 8.0km of South Main. Known for its warm hospitality, guests are greeted with a signature cookie upon arrival. The hotel features special amenities for children, ensuring a delightful stay for families. Located in a bustling shopping district, it also provides easy access to the Galleria's upscale stores, making it an excellent choice for travelers seeking both leisure and convenience.
  • The Royal Sonesta Houston Galleria: This elegant 4-star hotel combines a luxurious ambiance with pet-friendly policies, making it perfect for both leisure and business travelers. Located near South Main, it features a sophisticated design and a range of amenities tailored for guest comfort. The hotel allows pets with certain restrictions and offers a welcoming environment for those traveling with furry companions. Its prime location in the shopping district means guests can indulge in retail therapy while enjoying fine dining and upscale accommodations.

Where to stay near South Main

South Main, Houston, offers a vibrant blend of culture, sports, and business experiences. Visitors can enjoy the lively atmosphere of downtown, with its convenient location and family-friendly vibe. Explore the main street's shops and eateries while soaking in the urban energy. Nearby neighborhoods provide additional cultural attractions and friendly locals, making it an ideal destination for a memorable vacation.

  • Houston: As a bustling metropolis, Houston serves as the heart of South Main. The city offers a diverse travel experience, attracting visitors year-round with its vibrant mix of family-friendly activities, business opportunities, and entertainment options. From shopping malls to music concerts, there’s something for everyone. Key attractions include major sports stadiums and event venues, making it a hub for both leisure and professional events. The best time to visit is during peak months like March, May, and July when the city's energy is at its highest.
  • Braeswood Place: Located just 3.2km from South Main, Braeswood Place is a charming neighborhood that blends business and leisure. Visitors flock here for its educational institutions, shopping centers, and sports venues. The area boasts a lively atmosphere with access to modern college universities and research facilities, making it an excellent spot for those interested in academics or athletics. Similar to Houston, peak travel months are seen in March, May, and July, ensuring a vibrant community experience.
  • Texas Medical Center: Also situated 3.2km away from South Main, the Texas Medical Center is renowned for its focus on health and education. This neighborhood attracts visitors for its cultural offerings, business opportunities, and innovative research facilities. With shopping malls and centers nearby, it provides a well-rounded experience for tourists. The area is especially vibrant in April, July, and September, making it an ideal destination for those interested in medicine, education, and culture.

Things to do near South Main

South Main in Houston, Texas, offers a vibrant mix of sports, culture, and business-themed activities. Visitors can enjoy engaging experiences such as movie showings, live music concerts, and educational opportunities, all while exploring shopping mall centers. With a variety of entertainment choices and campus events, South Main is an ideal destination for those seeking a well-rounded vacation filled with excitement and learning.

Shopping

In South Main, Houston, you can shop at The Galleria, a vibrant shopping mall with entertainment and family vibes, located 8.0km away. River Oaks District offers a stylish public market with a city atmosphere, also 8.0km away, while Highland Village combines shopping and family-friendly fun, just 8.0km from South Main.

Recreation

At NRG Stadium, immerse yourself in the excitement of live sports, just 1.6km from South Main. For a vibrant night out, head to the House of Blues Houston, seven miles away, offering fantastic live music. Golf enthusiasts will enjoy the scenic Wildcat Golf Club, only two miles away.

Adventure

Experience the thrill of indoor skydiving at iFLY Indoor Skydiving, located 16.1km from South Main. For family fun, visit the Chancellors Family Center, 8.0km away, offering various adventure activities. Additionally, enjoy tennis at the Homer Ford Tennis Center, also 8.0km from South Main, with a vibrant atmosphere.

Nightlife

Experience the vibrant nightlife of South Main by visiting the Main Street Theater for a romantic show, or enjoy family fun at Zuma Fun Center. For a cultural evening, head to the Hobby Center for the Performing Arts and catch a captivating performance.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for South Main

To save money during your visit to South Main, consider traveling in August or December to January, when prices are lower. Sundays offer the cheapest accommodation rates, while Saturdays are typically the most expensive. Use Expedia to compare hotel prices, ensuring to sort by lowest rates, and consider booking a package deal that combines your hotel, flights, and activities for additional savings. Look for free local events and attractions to enjoy, and utilize public transportation options to keep travel costs down.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around South Main are August and December to January, where the prices are slightly lower. This is in comparison to March to May, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around South Main is Sunday. The most expensive day to stay around South Main is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to tailor your options based on your budget, desired location, and preferred hotel type. To find the best prices and offers, sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel stay at South Main with your flights and activities when you book an Expedia package.

Find the best attractions near South Main

South Main in Houston offers a vibrant mix of sports, business, and cultural experiences, featuring attractions like historic and modern colleges and art museums. Travelers can enjoy a rich cultural atmosphere, perfect for families and city explorers alike. Don’t miss the Stockton Arena and nearby Stockton Ballpark for exciting events, alongside the best local attractions that showcase the area's unique charm.

  • Rice University: Located 4.8km from South Main, Rice University offers a blend of modern architecture and lush green spaces. Stroll through its beautiful campus, known for its stunning gardens and art installations, while soaking in the vibrant city atmosphere.
  • University of Houston: About 9.7km away, the University of Houston is rich in history and cultural significance. Explore its diverse art galleries and museums, and enjoy the lively atmosphere created by its students and community events.
  • NRG Park: Just 1.6km from South Main, NRG Park is a historic sports stadium that hosts a variety of events, from football games to concerts. Experience the energetic vibe and immerse yourself in the local sports culture.

Best time to go to South Main

The best time to visit South Main can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around South Main falls in August, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature around South Main falls in January, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January54.1°F (12.3°C)Light RainMostly SunnyAverageSlightly Low
February57.0°F (13.9°C)Light RainMostly CloudyAverageAverage
March63.9°F (17.7°C)Light RainMostly SunnyAverageSlightly High
April69.6°F (20.9°C)Light RainMostly SunnyModerately HighSlightly High
May76.6°F (24.8°C)Light RainMostly SunnyAverageSlightly High
June82.8°F (28.2°C)Light RainMostly SunnyModerately HighAverage
July84.2°F (29.0°C)Light RainMostly SunnyModerately HighAverage
August84.9°F (29.4°C)Light RainMostly SunnyAverageSlightly Low
September80.6°F (27.0°C)Light RainMostly SunnyAverageAverage
October72.7°F (22.6°C)Light RainMostly SunnyModerately LowAverage
November62.8°F (17.1°C)Light RainMostly SunnyModerately LowAverage
December57.4°F (14.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to South Main

When visiting South Main in Houston, you have several airport options. Houston, TX (IAH-George Bush Intercontinental) is 35.4km away, with nearby hotels like DoubleTree by Hilton (4.8km) and Sonesta Hotel (8.0km), both offering airport shuttle services. Houston, TX (HOU-William P. Hobby) is closer at 14.5km, featuring luxurious choices like JW Marriott and Four Seasons Hotel. Lastly, Houston, TX (EFD-Ellington Field) is 25.7km away, with Doubletree by Hilton (11.3km) and Houston Marriott South (9.7km) as comfortable stays. Each airport is well-connected, making your travel seamless.

Explore a world of travel with Expedia

Frequently asked questions

What is South Main like?
You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness center. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels will I be able to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.
Where can I learn more about changing or cancelling my trip to South Main?
For more details about changing or cancelling your trip to South Main, head over to our customer service page.
What can I see and do in this Houston neighborhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.