Find hotels in South Main, Houston from NT$1,774
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Discover 6,472 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Hotel Park Place
Hotel Park Place

Americas Best Value Inn NRG Park Medical Center
Americas Best Value Inn NRG Park Medical Center

Days Inn & Suites by Wyndham Downtown/University of Houston
Days Inn & Suites by Wyndham Downtown/University of Houston

Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical Center
Where to stay in South Main

Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Main Street Square Station.

Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top Houston neighborhoods
- Hotels in Downtown Houston
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- Hotels in Texas Medical Center
- Hotels in Houston Central Business District
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- Hotels in Southeast Houston
- Hotels in Midtown
- Hotels in Washington Ave./ Memorial Park
- Hotels in South Central Houston
- Hotels in Theater District
- Hotels in Westchase
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- Hotels in Houston Museum District
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Hotels near popular Houston Attractions
- Hotels near NRG Stadium
- Hotels near MD Anderson Cancer Center
- Hotels near George R. Brown Convention Center
- Hotels near Daikin Park
- Hotels near Toyota Center
- Hotels near Rice University
- Hotels near University of Houston
- Hotels near Houston Zoo
- Hotels near Westheimer Road
- Hotels near Memorial City Mall
More Accommodation Types in South Main
South Main Hotels by Star Rating
Explore more hotels
- The Royal Sonesta Houston Galleria
- Magnolia Hotel Houston, A Tribute Portfolio Hotel
- Cambria Hotel Houston Downtown Convention Center
- Holiday Inn Houston Downtown by IHG
- Crowne Plaza Houston Med Ctr-Galleria Area by IHG
- The Westin Galleria Houston
- Hyatt Place Houston Downtown
- The Chifley Houston, Tapestry Collection by Hilton
- Hyatt Place Houston Medical Center
- Hilton Houston Plaza/Medical Center
- Hampton Inn & Suites Houston Heights I-10
- Hilton Houston North
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