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Find hotels in South Main, Houston from NT$1,907

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Check prices for these dates

Tonight
Apr 25 - Apr 26
Tomorrow
Apr 26 - Apr 27
This weekend
Apr 25 - Apr 27
Next weekend
May 2 - May 4

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Discover 6,233 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Comfort Suites near Texas Medical Center - NRG Stadium
Lobby

Comfort Suites near Texas Medical Center - NRG Stadium

2.5 star property
8.6 out of 10, Excellent, (844)
"Todo muy limpio! El servicio fue excelente. El área de desayuno estaba súper organizado y limpio. Los pasillos y el cuarto por igual. Me volvería a quedar sin pensarlo. "
The price is NT$3,171
NT$3,710 total
includes taxes & fees
May 23 - May 24
Comfort Suites near Texas Medical Center - NRG Stadium
Quality Inn & Suites NRG Park - Medical Center
Hypo-allergenic bedding, in-room safe, individually decorated

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.6 out of 10, (1002)
"The staff was absolutely amazing in the breakfast even better. Haven’t had a continental breakfast like that in a while.😎"
The price is NT$1,907
NT$2,231 total
includes taxes & fees
May 24 - May 25
Quality Inn & Suites NRG Park - Medical Center
Candlewood Suites Houston Medical Center by IHG
Exterior

Candlewood Suites Houston Medical Center by IHG

2.5 star property
7.6 out of 10, Good, (752)
"Good overall, there was no tv remote, no trash can in kitchen and chair was not clean. Some red water came out from bathtub faucet when opened first time. Overall good. "
The price is NT$2,601
NT$3,044 total
includes taxes & fees
Apr 27 - Apr 28
Candlewood Suites Houston Medical Center by IHG
Wyndham Houston near NRG Park/Medical Center
Lobby

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.2 out of 10, Good, (1027)
"Hotel was comfortable. Location was right beside a major freeway. Freeway noise was very loud but the comfort of the room made up for the noise. Will stay again but will request a room on the back of the hotel. "
The price is NT$4,847
NT$5,671 total
includes taxes & fees
Apr 27 - Apr 28
Wyndham Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center
Gazebo

Wingate Houston near NRG Park/Medical Center

3.0 star property
6.6 out of 10, (872)
"The property was quiet and secure. There is a lot of maintenance and upgrading of the facilities happening right now. Overall it is a good value."
The price is NT$3,871
NT$4,529 total
includes taxes & fees
Apr 27 - Apr 28
Wingate Houston near NRG Park/Medical Center
Americas Best Value Inn NRG Park Medical Center
Desk, iron/ironing board, free WiFi, bed sheets

Americas Best Value Inn NRG Park Medical Center

2.0 star property
7.6 out of 10, Good, (703)
"Peaceful!"
The price is NT$2,349
NT$2,749 total
includes taxes & fees
May 11 - May 12
Americas Best Value Inn NRG Park Medical Center
Hyatt Place Houston Medical Center
Exterior

Hyatt Place Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1576)
"Very excellent service "
The price is NT$3,611
NT$4,247 total
includes taxes & fees
May 1 - May 2
Hyatt Place Houston Medical Center
Hyatt House Houston Medical Center
Exterior

Hyatt House Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (950)
"Nice"
The price is NT$3,871
NT$4,553 total
includes taxes & fees
May 23 - May 24
Hyatt House Houston Medical Center
Blossom Hotel Houston
City view

Blossom Hotel Houston

4.0 star property
9.2 out of 10, Wonderful, (3259)
"A beautiful hotel with a very friendly staff"
The price is NT$6,018
NT$7,041 total
includes taxes & fees
May 2 - May 3
Blossom Hotel Houston
Extended Stay America Suites Houston Med Ctr Braeswood Bl
Lobby

Extended Stay America Suites Houston Med Ctr Braeswood Bl

2.5 star property
6.0 out of 10, (1005)
"Place is great and down the road from md Anderson except this time the ac on one side didn’t work. "
The price is NT$2,472
NT$2,902 total
includes taxes & fees
Apr 27 - Apr 28
Extended Stay America Suites Houston Med Ctr Braeswood Bl
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Lobby

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4.0 star property
8.4 out of 10, Very Good, (313)
"Good traveling experience."
The price is NT$3,877
NT$4,537 total
includes taxes & fees
May 18 - May 19
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Americas Best Value Inn Medical Center Downtown
Desk, free WiFi, bed sheets, alarm clocks

Americas Best Value Inn Medical Center Downtown

2.0 star property
7.8 out of 10, Good, (999)
"Very well kept. "
The price is NT$2,736
NT$3,201 total
includes taxes & fees
May 12 - May 13
Americas Best Value Inn Medical Center Downtown
Extended Stay America Suites Houston Med Ctr Greenway Plaza
Studio, 2 Double Beds, Non Smoking | Desk, iron/ironing board, free WiFi

Extended Stay America Suites Houston Med Ctr Greenway Plaza

2.5 star property
6.8 out of 10, (1004)
"Good location for downtown "
The price is NT$2,254
NT$2,637 total
includes taxes & fees
Apr 28 - Apr 29
Extended Stay America Suites Houston Med Ctr Greenway Plaza
WoodSpring Suites Houston 288 South Medical Center
Fridge, microwave, stovetop, dishwasher

WoodSpring Suites Houston 288 South Medical Center

2.5 star property
7.4 out of 10, Good, (361)
"Front desk closes at 9pm you have to call to get in the building "
The price is NT$2,146
NT$2,511 total
includes taxes & fees
May 8 - May 9
WoodSpring Suites Houston 288 South Medical Center
HYATT house Houston/Galleria
Outdoor pool

HYATT house Houston/Galleria

3.0 star property
7.6 out of 10, Good, (1001)
"We love the convenience of the Post Oak Grill Cafe that is the corner we walk there great food and service "
The price is NT$3,284
NT$3,843 total
includes taxes & fees
May 18 - May 19
HYATT house Houston/Galleria
Sonesta ES Suites Houston Galleria
Lobby

Sonesta ES Suites Houston Galleria

3.0 star property
8.2 out of 10, Very Good, (1003)
"The property had a homelike feeling to it. It was comfortable and spacious. The property is starting to show its age a little by the wear and tear signs on furniture and corners of doors, etc. Nevertheless, I would stay there again."
The price is NT$3,871
NT$4,529 total
includes taxes & fees
Apr 26 - Apr 27
Sonesta ES Suites Houston Galleria
Hyatt Regency Houston/Galleria
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, sun loungers

Hyatt Regency Houston/Galleria

4.0 star property
8.8 out of 10, Excellent, (1002)
"Great hotel"
The price is NT$3,916
NT$4,620 total
includes taxes & fees
May 18 - May 19
Hyatt Regency Houston/Galleria
Hyatt Place Houston/Galleria
Lobby

Hyatt Place Houston/Galleria

3.0 star property
8.6 out of 10, Excellent, (1001)
"We stayed here on Easter Sunday when our flight was canceled. If I’m ever in Houston again, I won’t look for another hotel. This hotel was recommended to us by an employee at IAH. Great location but, more importantly, the staff made our stay absolutely amazing. Everyone was so helpful and so friendly. We used the beautiful pool and enjoyed a glass of wine at the bar and then breakfast the next day. Really loved it here. Thank you! "
The price is NT$3,871
NT$4,550 total
includes taxes & fees
May 18 - May 19
Hyatt Place Houston/Galleria
The Chifley Houston, Tapestry Collection by Hilton
Lobby

The Chifley Houston, Tapestry Collection by Hilton

4.0 star property
9.0 out of 10, Wonderful, (1002)
"Needs more energy"
The price is NT$4,949
NT$5,790 total
includes taxes & fees
May 23 - May 24
The Chifley Houston, Tapestry Collection by Hilton
The Royal Sonesta Houston Galleria
Lobby sitting area

The Royal Sonesta Houston Galleria

4.0 star property
8.2 out of 10, Very Good, (1003)
"Great place. "
The price is NT$5,238
NT$6,966 total
includes taxes & fees
May 23 - May 24
The Royal Sonesta Houston Galleria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 65 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page.

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.