Visit South Main
Popular places to visit
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the great live music and acclaimed art scene in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed art scene and lively festivals in this vibrant area.
Rice University
Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's acclaimed art scene and lively festivals.
University of Houston
Enjoy the collegiate vibe around University of Houston, a top university in Houston. Experience the great live music and acclaimed art scene in this vibrant area.
South Main Hotel Deals
Wyndham Houston near NRG Park/Medical Center
Reviewed on 2025/8/19
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Reviewed on 2025/8/20
Club Quarters Hotel Downtown, Houston
Reviewed on 2025/8/19
Hilton Houston Plaza/Medical Center
Reviewed on 2025/8/16
The Whitehall Houston
Reviewed on 2025/8/18
Holiday Inn Houston Downtown by IHG
Reviewed on 2025/8/17
Other neighborhoods around South Main
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Houston Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Houston Museum District. You can visit top attractions like Houston Zoo and Children's Museum of Houston, and jump on the metro at M. D. Anderson Station or Museum District Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Houston Zoo or Continental Club and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.
Midtown
Characterized by a vibrant nightlife and young residents, this central Houston neighborhood boasts Ensemble Theatre, the largest African-American theater company in the US, and various parks like Midtown Park and Elizabeth Baldwin Park. Easily accessible via METRORail Red Line.
- MD Anderson Cancer Center
- George R. Brown Convention Center
- Daikin Park
- Toyota Center
- Rice University
- Houston Zoo
- Downtown Aquarium
- CityCentre
- NRG Park
- Smart Financial Centre at Sugar Land
- Sugar Land Town Square
- Discovery Green
- Houston Natural Science Museum
- Hobby Center for the Performing Arts
- House of Blues Houston
- Houston Methodist Hospital
- Houston Museum of Fine Arts
- Children's Museum of Houston
- Sam Houston Race Park
- Memorial Park
- Pearland Town Center