Visit South Main
Popular places to visit
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the entertainment choices and great live music in this vibrant area.
Rice University
Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's lively festivals and fascinating museums.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the acclaimed art scene and entertainment choices in this vibrant area.
Space Center Houston
This iconic “mission control” was immortalized for its role in the first moon landing.
South Main Hotel Deals
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Very cozy and clean!
Reviewed on 2025/12/2
The Royal Sonesta Houston Galleria
Excellent.
Reviewed on 2025/12/3
Club Quarters Hotel Downtown, Houston
NOICE!
Reviewed on 2025/12/3
The Whitehall Houston
Perfection 👌
Reviewed on 2025/11/29
Blossom Hotel Houston, Curio Collection by Hilton
Everything about our stay was excellent.
Reviewed on 2025/12/3
Magnolia Hotel Houston, A Tribute Portfolio Hotel
I have never slept so good and felt more relaxed. I would recommend this hotel a million times over. Great Southern Hospitality from the moment of check in at the front desk to the time I checked out. Beautiful place with clean rooms and hallways. A second level with a piano and buffet bar too was ...
Reviewed on 2025/12/3
Other neighborhoods around South Main
Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Astrodome and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at M. D. Anderson Station or Museum District Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Midtown Arts and Theater Center Houston or Children's Museum of Houston and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.
River Oaks
Gardens and monuments are just a few things travelers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area.
South Main, TX
- George R. Brown Convention Center
- MD Anderson Cancer Center
- Toyota Center
- Rice University
- Daikin Park
- Houston Zoo
- CityCentre
- Downtown Aquarium
- NRG Park
- Smart Financial Centre at Sugar Land
- Sugar Land Town Square
- House of Blues Houston
- Discovery Green
- Houston Natural Science Museum
- Hobby Center for the Performing Arts
- Houston Methodist Hospital
- Sam Houston Race Park
- Houston Museum of Fine Arts
- Arena Theater
- Pearland Town Center
