South Main, TX
Houston
Visit South Main
Popular places to visit
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the entertainment choices and acclaimed art scene in this vibrant area.
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the entertainment choices and lively festivals in this vibrant area.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Space Center Houston
This iconic “mission control” was immortalized for its role in the first moon landing.
South Main Hotel Deals
Wyndham Houston near NRG Park/Medical Center
The parking was easy and secure. We had a hard time getting in our room, the card didn't work on the door that was marked with the room number, our neighbor had to tell us to try the door that wasn't marked because it was a suite. That was the only door that it worked. The room smelled of mold. Other ...
Reviewed on 2026/3/27
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Absolutely great place to stay.
Reviewed on 2026/3/29
Hotel Zaza Houston Museum District
Odd decor.
Reviewed on 2026/3/29
The Royal Sonesta Houston Galleria
Breakfast buffet is yummy and had a nice variety. Coffee very tasty.
Reviewed on 2026/3/29
Club Quarters Hotel Downtown, Houston
Ok
Reviewed on 2026/3/29
Blossom Hotel Houston, Curio Collection by Hilton
The stay was wonderful. We will make this a regular location to visit for our staycation!
Reviewed on 2026/3/29
Other neighborhoods around South Main
Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Astrodome and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
River Oaks
Gardens and monuments are just a few things travelers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area.