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Discover 6,381 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical Center

Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHG

Hyatt Regency Houston/Galleria
Hyatt Regency Houston/Galleria

Hyatt Place Houston Medical Center
Hyatt Place Houston Medical Center
Where to stay in South Main

Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.
Houston Heights
You'll enjoy the coffeehouses and live music in Houston Heights. You might want to make time for a stop at The Heights Theater or Artcar Museum.
Top South Main Hotel Reviews

Holiday Inn Houston Downtown by IHG
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top Houston neighborhoods
- Hotels in Downtown Houston
- Hotels in The Galleria
- Hotels in Texas Medical Center
- Hotels in Montrose
- Hotels in Houston Central Business District
- Hotels in Houston Heights
- Hotels in Southeast Houston
- Hotels in Washington Ave./ Memorial Park
- Hotels in Northside
- Hotels in South Central Houston
- Hotels in Midtown
- Hotels in Westchase
- Hotels in Northeast Houston
- Hotels in Houston Museum District
- Hotels in Atascocita
- Hotels in Greater Uptown
- Hotels in Clear Lake
- Hotels in North Houston
- Hotels in Memorial
- Hotels in Nassau Bay
Hotels near popular Houston Attractions
- Hotels near NRG Stadium
- Hotels near MD Anderson Cancer Center
- Hotels near George R. Brown Convention Center
- Hotels near Daikin Park
- Hotels near Toyota Center
- Hotels near Rice University
- Hotels near University of Houston
- Hotels near Houston Zoo
- Hotels near Westheimer Rd
- Hotels near Memorial City Mall
More Accommodation Types in South Main
South Main Hotels by Star Rating
Explore more hotels
- Blossom Hotel Houston
- Cambria Hotel Houston Downtown Convention Center
- Hyatt Place Houston Downtown
- Hilton Americas-Houston
- Hyatt Regency Houston/Galleria
- Marriott Marquis Houston
- Crowne Plaza Houston Med Ctr-Galleria Area by IHG
- Omni Houston Hotel
- Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
- The Westin Galleria Houston
- Hampton Inn & Suites Houston Heights I-10
- The Chifley Houston, Tapestry Collection by Hilton
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