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Find hotels in South Main, Houston from NT$2,003

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Discover 6,381 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.2 out of 10, Good, (1136)
"A well kept hotel with great service and atmosphere."
The price is NT$3,860
NT$4,516 total
includes taxes & fees
Aug 7 - Aug 8
Wyndham Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

3.0 star property
6.6 out of 10, (930)
"Great location, rooms were hot/warm. Needs a huge make over."
The price is NT$2,936
NT$3,435 total
includes taxes & fees
Aug 9 - Aug 10
Wingate Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.6 out of 10, (1001)
"Wonderful experience absolutely love my stay"
The price is NT$1,973
NT$2,308 total
includes taxes & fees
Aug 22 - Aug 23
Quality Inn & Suites NRG Park - Medical Center

Candlewood Suites Houston Medical Center by IHG

2.5 star property
7.4 out of 10, Good, (787)
"Will definitely be back again!"
The price is NT$2,484
NT$2,906 total
includes taxes & fees
Aug 17 - Aug 18
Candlewood Suites Houston Medical Center by IHG

Hyatt Regency Houston/Galleria

4.0 star property
9.0 out of 10, Wonderful, (1004)
"Great stay!"
The price is NT$3,787
NT$4,465 total
includes taxes & fees
Sep 1 - Sep 2
Hyatt Regency Houston/Galleria

Hyatt Place Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1871)
"Spacious, quiet, nice pool area and great breakfast."
The price is NT$3,322
NT$3,907 total
includes taxes & fees
Aug 17 - Aug 18
Hyatt Place Houston Medical Center

Omni Houston Hotel

4.0 star property
9.0 out of 10, Wonderful, (1001)
"Great restaurants nearby"
The price is NT$4,525
NT$5,373 total
includes taxes & fees
Aug 22 - Aug 23
Omni Houston Hotel

Blossom Hotel Houston

4.0 star property
9.0 out of 10, Wonderful, (3460)
"Amazing stay"
The price is NT$4,046
NT$4,733 total
includes taxes & fees
Sep 4 - Sep 5
Blossom Hotel Houston

Hyatt Regency Houston West

3.5 star property
8.6 out of 10, Excellent, (1135)
"Nice rooms, plenty of food choices."
The price is NT$3,322
NT$3,886 total
includes taxes & fees
Sep 5 - Sep 6
Hyatt Regency Houston West

The Whitehall Houston

4.0 star property
8.4 out of 10, Very Good, (1662)
"Great stay"
The price is NT$4,273
NT$4,999 total
includes taxes & fees
Aug 14 - Aug 15
The Whitehall Houston

The Lancaster Hotel

4.0 star property
9.6 out of 10, Exceptional, (1001)
"Wonderful hotel and great breakfast."
The price is NT$6,413
NT$7,503 total
includes taxes & fees
Aug 7 - Aug 8
The Lancaster Hotel

Holiday Inn Express & Suites Houston – Downtown North by IHG

2.5 star property
9.2 out of 10, Wonderful, (545)
"Great place to stay close to downtown "
The price is NT$2,843
NT$3,326 total
includes taxes & fees
Aug 17 - Aug 18
Holiday Inn Express & Suites Houston – Downtown North by IHG

Hyatt House Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1067)
"We loved our stay. Great room, staff, and service."
The price is NT$3,322
NT$3,907 total
includes taxes & fees
Aug 17 - Aug 18
Hyatt House Houston Medical Center

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4.0 star property
8.2 out of 10, Very Good, (2338)
"Enjoyed staff and location "
The price is NT$2,960
NT$3,487 total
includes taxes & fees
Sep 4 - Sep 5
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

Haven Inn & Suites Downtown Houston

2.5 star property
9.4 out of 10, Exceptional, (1002)
"Great stay"
Haven Inn & Suites Downtown Houston

La Quinta Inn & Suites by Wyndham Houston Southwest

3.0 star property
6.8 out of 10, (1005)
"Great breakfast!"
The price is NT$1,908
NT$2,232 total
includes taxes & fees
Aug 10 - Aug 11
La Quinta Inn & Suites by Wyndham Houston Southwest

Heights House Hotel - Houston Heights Downtown, Ascend Hotel Collection

3.0 star property
8.0 out of 10, Very Good, (1006)
"Very nice staff and clean property "
The price is NT$2,639
NT$3,087 total
includes taxes & fees
Sep 1 - Sep 2
Heights House Hotel - Houston Heights Downtown, Ascend Hotel Collection

The Royal Sonesta Houston Galleria

4.0 star property
8.4 out of 10, Very Good, (1170)
"Very nice hotel in a premium location!!!"
The price is NT$3,278
NT$4,605 total
includes taxes & fees
Aug 9 - Aug 10
The Royal Sonesta Houston Galleria

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4.0 star property
8.4 out of 10, Very Good, (405)
"Very nice place clean nice towels good shower"
The price is NT$3,447
NT$4,033 total
includes taxes & fees
Aug 17 - Aug 18
DoubleTree by Hilton Houston Medical Center Hotel & Suites

Club Quarters Hotel Downtown, Houston

4.0 star property
8.4 out of 10, Very Good, (3575)
"Great stay and breakfast was amazing "
The price is NT$3,142
NT$3,676 total
includes taxes & fees
Aug 8 - Aug 9
Club Quarters Hotel Downtown, Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.
Downtown Houston map

Downtown Houston

3 out of top 10 points of interest in this area

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria map

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center map

Texas Medical Center

1 out of top 10 points of interest in this area

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose map

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.

Houston Heights map

Houston Heights

You'll enjoy the coffeehouses and live music in Houston Heights. You might want to make time for a stop at The Heights Theater or Artcar Museum.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 57 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page.

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.