South Main, TX
Houston
Visit South Main
Popular places to visit
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the entertainment choices and acclaimed art scene in this vibrant area.
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the acclaimed art scene and great live music in this vibrant area.
MD Anderson Cancer Center
Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed art scene and lively festivals in this vibrant area.
South Main Hotel Deals
Wyndham Houston near NRG Park/Medical Center
Roaches in the room. Curtains black from grim. Broken blinds. Just nasty!
Reviewed on 2026/4/2
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
It was fast check in and friendly stuff.
Reviewed on 2026/4/7
Hotel Zaza Houston Museum District
This was a good, hotel in a great district with some very nice amenities. The staff are lovely and the shuttle is fantastic. I didn’t use the pool or spa so can’t speak to this. The rooms are not as luxury boutique as I was expecting but they were certainly comfortable, just a bit in need of renovation- ...
Reviewed on 2026/4/6
The Royal Sonesta Houston Galleria
The stay was good however I had to depart early due to a deaf in my family abd was able to contact Ezpedia for a refund afwr several attempts.
Reviewed on 2026/4/6
Club Quarters Hotel Downtown, Houston
All good
Reviewed on 2026/4/7
Blossom Hotel Houston, Curio Collection by Hilton
The place is clean and beautiful. Food at the restaurant was great. The massive rain shower head was phenomenal. I only had a few issues in my room, the front door was jammed and had to shoulder check it to open and close, the shower wand didnt work. Besides that, for the price it was great and close ...
Reviewed on 2026/4/7
Other neighborhoods around South Main
Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Astrodome and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
River Oaks
Gardens and monuments are just a few things travelers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area.
