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Discover 6,867 Uptown hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Holiday Inn Express & Suites Houston – Downtown North by IHG
Holiday Inn Express & Suites Houston – Downtown North by IHG

Days Inn & Suites by Wyndham Downtown/University of Houston
Days Inn & Suites by Wyndham Downtown/University of Houston

Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook

Omni Houston Hotel
Omni Houston Hotel

Hyatt Regency Houston/Galleria
Hyatt Regency Houston/Galleria

Houston Marriott West Loop by The Galleria
Houston Marriott West Loop by The Galleria
Where to stay in Uptown

Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.

Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Main Street Square Station.
Top Uptown Hotel Reviews

Club Quarters Hotel Downtown, Houston
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top Houston neighborhoods
- Hotels in Downtown Houston
- Hotels in The Galleria
- Hotels in Texas Medical Center
- Hotels in Montrose
- Hotels in Houston Central Business District
- Hotels in Houston Heights
- Hotels in Washington Ave./ Memorial Park
- Hotels in Northside
- Hotels in Southeast Houston
- Hotels in Midtown
- Hotels in South Central Houston
- Hotels in Westchase
- Hotels in Atascocita
- Hotels in Northeast Houston
- Hotels in Houston Museum District
- Hotels in Greater Uptown
- Hotels in Clear Lake
- Hotels in North Houston
- Hotels in Nassau Bay
- Hotels in Memorial
Hotels near popular Houston Attractions
- Hotels near The Galleria
- Hotels near Gerald D. Hines Waterwall Park
- Hotels near Williams Tower
- Hotels near Uptown Park
- Hotels near Ice at the Galleria
- Hotels near NRG Stadium
- Hotels near MD Anderson Cancer Center
- Hotels near George R. Brown Convention Center
- Hotels near Daikin Park
- Hotels near Toyota Center
More Hotel Options in Uptown
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- Hotels with smoking rooms in Uptown
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More Accommodation Types in Uptown
Uptown Hotels by Star Rating
Explore more hotels
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