Find Resorts & Hotels with Spas in Texas Medical Center, TX

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Nov 7 - Nov 8
Tomorrow
Nov 8 - Nov 9
Next weekend
Nov 13 - Nov 15
In two weeks
Nov 20 - Nov 22

Our top choices for Texas Medical Center hotels with a spa

A lobby with a marble floor, a reception desk, a seating area with sofas, a fountain, and a staircase.

1. Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center
9.0 out of 10, Wonderful, (3,819 reviews)
  • cleanliness
    Luxurious full-service spa retreat with rooftop pool views and designer rooms for a rejuvenating Houston escape.
The price is NT$4,822
NT$5,660 total
includes taxes & fees
Nov 22 - Nov 23
Blossom Hotel Houston, Curio Collection by Hilton
A spacious living area with a dining table, chairs, and a chandelier.

2. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,007 reviews)
  • cleanliness
    Escape to a spa sanctuary with hydromassage showers and heavenly massages at this chic Museum District aparthotel with poolside relaxation.
The price is NT$6,338
NT$8,973 total
includes taxes & fees
Nov 22 - Nov 23
Hotel Zaza Houston Museum District
A large indoor swimming pool with multiple lounge areas and a city view.

3. Hilton Americas-Houston

Hilton Americas-Houston
4.0 star property
Downtown Houston
9.4 out of 10, Exceptional, (1,891 reviews)
  • cleanliness
    Rejuvenate at this Houston hotel with 4 luxurious spa treatment rooms, sauna, and indoor pool with city views.
The price is NT$5,091
NT$6,023 total
includes taxes & fees
Nov 22 - Nov 23
Hilton Americas-Houston
A modern lobby with a blue carpet, seating area, and large windows.

4. Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,511 reviews)
The price is NT$3,252
NT$3,805 total
includes taxes & fees
Nov 8 - Nov 9
Wyndham Houston at Reliant Park & Medical Center
A reception area with a marble floor, a wooden reception desk, and a large floral arrangement above the desk.

5. JW Marriott Houston Downtown

JW Marriott Houston Downtown
5.0 star property
Downtown Houston
9.0 out of 10, Wonderful, (1,000 reviews)
  • cleanliness
    Downtown escape at this luxury hotel offers a full-service spa with 4 treatment rooms and a health club for ultimate rejuvenation.
The price is NT$8,070
NT$9,672 total
includes taxes & fees
Nov 21 - Nov 22
JW Marriott Houston Downtown
A modern living room with a sofa, green armchairs, a coffee table, and a bookshelf.

6. The Laura Hotel, Houston Downtown, Autograph Collection

The Laura Hotel, Houston Downtown, Autograph Collection
4.5 star property
Downtown Houston
9.2 out of 10, Wonderful, (1,281 reviews)
  • cleanliness
    Rejuvenate at this downtown Houston hotel's full-service spa offering deep-tissue and hot stone massages amid luxurious surroundings.
The price is NT$5,552
NT$7,533 total
includes taxes & fees
Nov 22 - Nov 23
The Laura Hotel, Houston Downtown, Autograph Collection
A modern hotel room with a sofa, a small table, and a lamp.

7. Marriott Marquis Houston

Marriott Marquis Houston
4.0 star property
Downtown Houston
9.0 out of 10, Wonderful, (1,343 reviews)
  • cleanliness
    Surrender to pure bliss at this contemporary Houston retreat with 7 treatment rooms and 2 sparkling pools, just steps from Discovery Green.
The price is NT$8,837
NT$11,425 total
includes taxes & fees
Nov 22 - Nov 23
Marriott Marquis Houston
A modern building entrance with a black car parked in front.

8. Four Seasons Hotel Houston

Four Seasons Hotel Houston
5.0 star property
Downtown Houston
9.2 out of 10, Wonderful, (1,000 reviews)
  • cleanliness
    Revitalizing spa retreat with Ayurvedic treatments and poolside cabanas awaits at this luxury Houston hotel.
The price is NT$19,268
NT$22,707 total
includes taxes & fees
Nov 23 - Nov 24
Four Seasons Hotel Houston
A reception area with a modern design, featuring a reception desk, a green sign with the name "MOKARA," and a patterned wall.

9. Omni Houston Hotel

Omni Houston Hotel
4.0 star property
Greater Uptown
9.2 out of 10, Wonderful, (1,017 reviews)
  • cleanliness
    Indulge in blissful rejuvenation at this upscale Houston retreat with 7 treatment rooms and outdoor pools nestled among greenery.
The price is NT$5,493
NT$6,523 total
includes taxes & fees
Nov 21 - Nov 22
Omni Houston Hotel
A modern lobby with a central reception desk, a staircase, and a mezzanine level with a railing.

10. Thompson Houston, by Hyatt

Thompson Houston, by Hyatt
4.0 star property
Fourth Ward
9.4 out of 10, Exceptional, (353 reviews)
  • cleanliness
    Experience relaxing spa therapies and luxurious wellness treatments at this art deco hotel near a nature reserve.
The price is NT$7,953
NT$10,708 total
includes taxes & fees
Nov 29 - Nov 30
Thompson Houston, by Hyatt
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Texas Medical Center

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A hotel lobby with a grand chandelier, a reception desk, and a carpet with the hotel's name.
Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
9.0
Wonderful
3,819 reviews
View
A modern lobby with a blue carpet, seating area, and large windows.
Wyndham Houston at Reliant Park & Medical Center
3.5 star property
7.2
Good
1,511 reviews
View
A spacious living area with a dining table, chairs, and a chandelier.
Hotel Zaza Houston Museum District
4.5 star property
9.2
Wonderful
1,007 reviews
View
A large indoor swimming pool with multiple lounge areas and a city view.
Hilton Americas-Houston
4.0 star property
9.4
Exceptional
1,891 reviews
View
A modern hotel with a large pool, surrounded by well-maintained lawns and trees.
Omni Houston Hotel
4.0 star property
9.2
Wonderful
1,017 reviews
View

Top Texas Medical Center Hotel Reviews

A lobby with a marble floor, a reception desk, a seating area with sofas, a fountain, and a staircase.
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
Texas Medical Center

10/10 Excellent

Nice hotel with friendly staff, but the area around the hotel is somewhat shady.
United States
Andrew
Reviewed June 24, 2025
Blossom Hotel Houston, Curio Collection by Hilton

Frequently Asked Questions

Looking to vacation at a spa hotel in Texas Medical Center?

Forget the stress of everyday life and book yourself a lush spa hotel. Check out the museums and restaurants in Texas Medical Center—your day trip starts here. Be sure to enjoy the shopping during your stay. Spa hotels are a great way to break away from your daily routine and add a layer of luxury to your vacation.

What is the best spa hotel in Texas Medical Center?

Blossom Hotel Houston, Curio Collection by Hilton is a top spa hotel featuring a rooftop terrace, a 24-hour fitness center, an outdoor pool, and a restaurant. Spend an afternoon at the spa where you’ll find facials, Swedish massages, and deep-tissue massages.

How many spa hotels are there in Texas Medical Center?

Among Expedia's 177 accommodation options in Texas Medical Center, there is 1 spa hotel.

What's there to see and do in Texas Medical Center?

Enjoy all that Texas Medical Center has to offer when you visit Houston Zoo, Daikin Park, and Reliant Stadium. If you have extra time while you're in the area, you might want to stop by Toyota Center and Houston Natural Science Museum.

What is a Texas Medical Center spa hotel?

Spa hotels in Texas Medical Center have full on-site spas offering services like couples massages and a selection of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are ideal if you are looking for some R&R during your vacation.

Explore a world of travel with Expedia