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Find hotels in Medical Center Area, Boston

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Dec 19 - Dec 20
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Dec 20 - Dec 21
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Dec 19 - Dec 21
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Dec 26 - Dec 28

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Our top choices for Medical Center Area hotels

Exterior detail
The Inn at Longwood Medical

The Inn at Longwood Medical

The Inn at Longwood Medical
3.5 star property
Medical Center Area
8.4 out of 10, Very Good, (1004)
"Nice hotel in a good location. "
United States
Chrisann
The price is NT$6,407
NT$8,379 total
includes taxes & fees
Jan 1 - 2026/1/2
The Inn at Longwood Medical
Daily continental breakfast for a fee
enVision Hotel Boston Everett

enVision Hotel Boston Everett

enVision Hotel Boston Everett
2.0 star property
8.4 km from Medical Center Area
8.6 out of 10, Excellent, (1002)
"Staff was friendly and it was nice to have places to eat at"
United States
Marcelo
The price is NT$3,110
NT$3,474 total
includes taxes & fees
Dec 21 - Dec 22
enVision Hotel Boston Everett
Reception
Hotel 1868

Hotel 1868

Hotel 1868
3.5 star property
5.7 km from Medical Center Area
9.4 out of 10, Exceptional, (1000)
"Great stay overall "
United States
Elisabet
The price is NT$3,598
NT$4,171 total
includes taxes & fees
Jan 4 - 2026/1/5
Hotel 1868
Desk, laptop workspace, blackout drapes, iron/ironing board
Sonesta Simply Suites Boston Burlington

Sonesta Simply Suites Boston Burlington

Sonesta Simply Suites Boston Burlington
2.0 star property
19 km from Medical Center Area
9.0 out of 10, Wonderful, (140)
" Check in and out staff very nice. Great room for the price "
United States
Victoria
The price is NT$2,996
NT$3,347 total
includes taxes & fees
Dec 27 - Dec 28
Sonesta Simply Suites Boston Burlington
View from property
Nantasket Beach Resort

Nantasket Beach Resort

Nantasket Beach Resort
3.0 star property
21.1 km from Medical Center Area
8.6 out of 10, Excellent, (1000)
"Staff was delightful and rooms were cute! "
United States
Robert
The price is NT$3,758
NT$4,860 total
includes taxes & fees
Dec 22 - Dec 23
Nantasket Beach Resort
Lobby sitting area
Midtown Hotel

Midtown Hotel

Midtown Hotel
2.0 star property
Prudential - St. Botolph, 1.7 km from Medical Center Area
7.4 out of 10, Good, (1006)
"A pleasant hotel, well-located, with friendly service and clean rooms."
United States
Renato Reis
The price is NT$3,266
NT$3,803 total
includes taxes & fees
Dec 21 - Dec 22
Midtown Hotel
Cocktail bar
Canopy By Hilton Boston Downtown

Canopy By Hilton Boston Downtown

Canopy By Hilton Boston Downtown
4.0 star property
Government Center, 4.7 km from Medical Center Area
9.6 out of 10, Exceptional, (1000)
"Great hotel!"
United States
Jonathan
The price is NT$4,012
NT$5,957 total
includes taxes & fees
Dec 29 - Dec 30
Canopy By Hilton Boston Downtown
Restaurant
Porter Square Hotel

Porter Square Hotel

Porter Square Hotel
3.0 star property
5.8 km from Medical Center Area
9.2 out of 10, Wonderful, (1002)
"Room is perfect and girls at the front desk are super sweet & helpful!"
Canada
Leah
The price is NT$3,836
NT$4,448 total
includes taxes & fees
Dec 29 - Dec 30
Porter Square Hotel
2 bars/lounges
Concord's Colonial Inn

Concord's Colonial Inn

Concord's Colonial Inn
3.0 star property
24.4 km from Medical Center Area
8.6 out of 10, Excellent, (1001)
"We loved historic inn, and its location in Concord "
United States
Kevin
The price is NT$3,690
NT$4,122 total
includes taxes & fees
Dec 21 - Dec 22
Concord's Colonial Inn
Bar (on property)
Pennyweight Hotel Boston, Curio Collection by Hilton

Pennyweight Hotel Boston, Curio Collection by Hilton

Pennyweight Hotel Boston, Curio Collection by Hilton
4.0 star property
West End, 4.5 km from Medical Center Area
8.2 out of 10, Very Good, (1082)
"Room was great and check in was quick"
United States
Cheryl
The price is NT$4,111
NT$5,889 total
includes taxes & fees
Dec 27 - Dec 28
Pennyweight Hotel Boston, Curio Collection by Hilton
Front of property
Newbury Guest House

Newbury Guest House

Newbury Guest House
3.0 star property
2.1 km from Medical Center Area
9.4 out of 10, Exceptional, (1000)
"Beautiful property, excellent staff!"
United States
Candace
The price is NT$4,072
NT$4,680 total
includes taxes & fees
Jan 11 - 2026/1/12
Newbury Guest House
Desk, iron/ironing board, free cribs/infant beds, rollaway beds
Courtyard by Marriott Boston-Cambridge

Courtyard by Marriott Boston-Cambridge

Courtyard by Marriott Boston-Cambridge
3.5 star property
2.5 km from Medical Center Area
8.8 out of 10, Excellent, (1007)
"Great place if you are travelling for"
United States
Karim
The price is NT$2,562
NT$3,981 total
includes taxes & fees
Jan 4 - 2026/1/5
Courtyard by Marriott Boston-Cambridge
Reception
Harvard Square Hotel

Harvard Square Hotel

Harvard Square Hotel
3.0 star property
4.1 km from Medical Center Area
8.4 out of 10, Very Good, (653)
"Convenient, nice staff, clean. "
United States
Sarita
Harvard Square Hotel
Interior
Staypineapple, A Delightful Hotel, South End

Staypineapple, A Delightful Hotel, South End

Staypineapple, A Delightful Hotel, South End
3.0 star property
2.8 km from Medical Center Area
9.0 out of 10, Wonderful, (1001)
"Great stay"
United States
John
The price is NT$2,526
NT$3,858 total
includes taxes & fees
Jan 5 - 2026/1/6
Staypineapple, A Delightful Hotel, South End
Terrace/patio
AC Hotel by Marriott Boston Downtown

AC Hotel by Marriott Boston Downtown

AC Hotel by Marriott Boston Downtown
3.5 star property
3.5 km from Medical Center Area
8.8 out of 10, Excellent, (1003)
"Spotless, beautiful modern furniture, great mattress "
United States
Afroditi
The price is NT$3,595
NT$5,105 total
includes taxes & fees
Dec 27 - Dec 28
AC Hotel by Marriott Boston Downtown
Lobby
Residence Inn by Marriott Boston Downtown / South End

Residence Inn by Marriott Boston Downtown / South End

Residence Inn by Marriott Boston Downtown / South End
3.0 star property
1.9 km from Medical Center Area
8.6 out of 10, Excellent, (1001)
"Super clean and spacious room. Really lovely "
United States
Jia
The price is NT$4,112
NT$4,789 total
includes taxes & fees
Dec 23 - Dec 24
Residence Inn by Marriott Boston Downtown / South End
Lobby
Hampton Inn Boston Bedford Burlington

Hampton Inn Boston Bedford Burlington

Hampton Inn Boston Bedford Burlington
2.5 star property
22.1 km from Medical Center Area
9.2 out of 10, Wonderful, (1001)
"great breakfast, helpful staff, beds a little soft for me, but my dad loved them- super convenient, will stay again!"
United States
denise
The price is NT$3,078
NT$3,438 total
includes taxes & fees
Dec 26 - Dec 27
Hampton Inn Boston Bedford Burlington
Suite, Multiple Beds (John Adams Presidential Suite) | Frette Italian sheets, premium bedding, pillowtop beds, minibar
Boston Harbor Hotel

Boston Harbor Hotel

Boston Harbor Hotel
5.0 star property
4.8 km from Medical Center Area
9.8 out of 10, Exceptional, (1003)
"Love this hotel. "
United States
Alisha
The price is NT$13,710
NT$15,983 total
includes taxes & fees
Jan 18 - 2026/1/19
Boston Harbor Hotel
Indoor pool
Sheraton Boston Needham Hotel

Sheraton Boston Needham Hotel

Sheraton Boston Needham Hotel
3.5 star property
10.3 km from Medical Center Area
8.8 out of 10, Excellent, (1525)
"Great experience amazing food"
United States
David
The price is NT$3,722
NT$4,157 total
includes taxes & fees
Jan 5 - 2026/1/6
Sheraton Boston Needham Hotel
BBQ/picnic area
HYATT house Boston/Waltham

HYATT house Boston/Waltham

HYATT house Boston/Waltham
3.0 star property
14.1 km from Medical Center Area
8.8 out of 10, Excellent, (1072)
"The Staff was great, the room was clean and comfortable and the breakfast was good! "
United States
Meridith
The price is NT$3,186
NT$3,558 total
includes taxes & fees
Jan 16 - 2026/1/17
HYATT house Boston/Waltham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Medical Center Area

Find the best Medical Center Area areas and neighborhoods for the activities you enjoy most.
Downtown Boston which includes night scenes and a city as well as a small group of people

Downtown Boston

Densely packed with highrise buildings, this area boasts landmarks like Custom House Tower and is close to Quincy Market, Faneuil Hall, and the Old State House. Find headquarters of major banks, hotels, and investment firms here.

Seaport District which includes a city, a river or creek and a high rise building

Seaport District

Experience a transformed industrial area with office towers, innovation labs, and 78 restaurants. Visit the Institute of Contemporary Art and easily access Downtown Boston via the Evelyn Moakley Bridge.

Back Bay featuring a city, heritage architecture and street scenes

Back Bay

Victorian brownstone homes and cultural institutions like the Boston Public Library define this area. Shop at Newbury Street, Prudential Center, and Copley Place, or explore sights like Trinity Church and the John Hancock Tower.

Beacon Hill which includes landscape views

Beacon Hill

Historic Federal-style rowhouses, gaslit streets, and brick sidewalks create a charming atmosphere. Explore the Boston African American National Historic Site, shop on Charles Street, and easily access MBTA stations.

Boston Harbor which includes performance art, music and a bay or harbor

North End

Indulge in Italian cuisine at numerous restaurants and bakeries, explore historic sites like Old North Church and Paul Revere House, and enjoy performances at NEMPAC and Improv Asylum Theater. Easily accessible via MBTA lines, buses, and ferries.

Top Medical Center Area Hotel Reviews

citizenM Boston North Station

citizenM Boston North Station

10/10 Excellent
"Clean rooms great staff amazing location. Bartenders were very friendly and helpful "
Shalik 1-night trip
Posted 23 hours ago
citizenM Boston North Station

Frequently asked questions

What's it like in Medical Center Area?
Guests are sure to enjoy their time checking out all that Boston's Medical Center Area neighborhood has to offer. Be sure to check out Isabella Stewart Gardner Museum and Warren Anatomical Museum as part of your Medical Center Area travel plans.
What's a favorite hotel to stay in Medical Center Area?
Based on Expedia customer reviews, The Inn at Longwood Medical is the highest ranked property in Medical Center Area. This hotel is a short 1-minute walk from Children's Hospital Boston, and it offers a restaurant and a fitness center.
How many hotels are there in Medical Center Area?
When you want to kick up your feet after a day of exploring the sights in Boston, you can choose from 17 Expedia hotels and other accommodations in Medical Center Area.
If I need to cancel my hotel reservation in Medical Center Area, will I receive a refund?
Yes, most hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to get the best deals available in Medical Center Area.
Where can I learn more about changing or cancelling my trip to Medical Center Area?
For more information about updating your trip to Medical Center Area or cancelling it, go to https://www.expedia.com/service/.
What can I see and do in this Boston neighborhood?
Sights like Isabella Stewart Gardner Museum and Warren Anatomical Museum can be part of your cultural tour of Medical Center Area. When you're sightseeing in Boston, Fenway Park and Copley Square are also worth a stop.
How can I get around Medical Center Area and the greater Boston area?
If you want to see more of the city, Longwood Medical Area Station is the closest metro stop. Others nearby include Brigham Circle Station and Museum of Fine Arts Station.

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