Find Luxury Hotels in Downtown South San Francisco, CA

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Check availability on Downtown South San Francisco Luxury Hotels

Top Downtown South San Francisco Hotel Reviews

Hotel Nikko San Francisco

Hotel Nikko San Francisco

10/10 Excellent
"Great rooms"
Amy 1-night trip
Posted 1 day ago
Hotel Nikko San Francisco

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Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Downtown South San Francisco?
Use Expedia to arrange your flight to San Francisco Intl. Airport (SFO) airport or Oakland Intl. Airport (OAK) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to get what you want to make your stay relaxing and comfortable. If you want an upscale hotel with fine dining, a spa, or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that Downtown South San Francisco offers.
What's there to see and do in Downtown South San Francisco?
Experience Downtown South San Francisco with a stop at San Francisco Bay, Oracle Park, and Pier 39. If you have extra time while you're in the area, you might want to stop by SFO Museum and Artichoke Joe's Casino.