Find hotels in Clayton, St. Louis from NT$2,225
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Discover 1,783 Clayton hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch

21C Museum Hotel St Louis
21C Museum Hotel St Louis

River City Casino & Hotel
River City Casino & Hotel

Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay

Residence Inn By Marriott St. Louis Clayton
Residence Inn By Marriott St. Louis Clayton

AC Hotel St. Louis Clayton
AC Hotel St. Louis Clayton
Where to stay in Clayton

Downtown St. Louis
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
Creve Coeur
Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

Downtown West
If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Soulard
Brewery tours, a farmers market, global restaurants, blues bars and a Mardi Gras parade make this one of the city’s liveliest neighborhoods.
Top Clayton Hotel Reviews

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
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Hotels in top St. Louis neighborhoods
- Hotels in Downtown St. Louis
- Hotels in Clayton
- Hotels in Central West End
- Hotels in Creve Coeur
- Hotels in Downtown West
- Hotels in Soulard
- Hotels in St. Charles Historic District
- Hotels in The Hill
- Hotels in Ladue
- Hotels in University City
- Hotels in Midtown
- Hotels in Dogtown
- Hotels in The Grove
- Hotels in Tower Grove South
- Hotels in Shaw
- Hotels in Lafayette Square
- Hotels in The Gate
- Hotels in Benton Park
- Hotels in Southwest Garden
- Hotels in Tower Grove East
Hotels near popular St. Louis Attractions
- Hotels near Chapel of St. Timothy And St. Titus
- Hotels near Busch Stadium
- Hotels near St. Louis Union Station
- Hotels near Gateway Arch
- Hotels near Washington University in St. Louis
- Hotels near St. Louis Zoo
- Hotels near Enterprise Center
- Hotels near Dome at America’s Center
- Hotels near City Museum
- Hotels near Forest Park
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Hotels Close to Nearby Airports
Clayton Hotels by Star Rating
Explore more hotels
- Renaissance St. Louis Airport Hotel
- Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
- Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
- Pear Tree Inn St. Louis Airport
- Pear Tree Inn St. Louis Near Union Station
- Marriott St. Louis Grand
- Best Western St. Louis-Kirkwood Route 66
- 21C Museum Hotel St Louis
- Drury Inn & Suites St. Louis Union Station
- Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
- Home2 Suites by Hilton St. Louis Downtown
- La Quinta Inn & Suites by Wyndham St. Louis Westport