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Find Resorts & Hotels with Spas in Uptown, IL

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Check availability on Uptown Resorts & Hotels with Spas

Tonight
Dec 28 - Dec 29
Tomorrow
Dec 29 - Dec 30
Next weekend
Jan 2 - Jan 4
In two weeks
Jan 9 - Jan 11

Our top choices for Uptown hotels with a spa

Massages
21C Museum Hotel St Louis

21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (1514)
"Hotel was comfortable, clean and unique. All staff was wonderful "
United States
Sharon
The price is NT$4,498
NT$5,417 total
includes taxes & fees
Jan 4 - 2026/1/5
21C Museum Hotel St Louis
Couples treatment rooms, hot tub, body treatments, aromatherapy
Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1001)
"Everything exceeded my expectations from the welcoming staff to the luxuriously appointed room, to the 4 feet deep bathtub in which to soak my cares away--it was a total dream come true. I would come back in a heartbeat at this home away from home. "
United States
Lynne
The price is NT$13,045
NT$15,254 total
includes taxes & fees
Jan 1 - 2026/1/2
Four Seasons Hotel St Louis
Body treatments, aromatherapy, hot stone massages, deep-tissue massages
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (554)
"The stay was ok even though nothing was explained to be. The hours of restaurant, where the gym is located about the bar in the room nothing. "
United States
Shemelle
The price is NT$15,686
NT$18,311 total
includes taxes & fees
Dec 30 - Dec 31
The Ritz-Carlton, St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Uptown Hotel Reviews

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

10/10 Excellent
"Everything was great."
Doreen 1-night trip
Posted 13 hours ago
Hyatt Regency St. Louis at The Arch

Frequently asked questions

Looking for a spa hotel in Uptown?
Treat yourself to some pampering and book a hotel with a spa. Hotels with spas are the perfect way to break away from your routine and add a layer of luxury to your weekend away.
What's there to see and do in Uptown?
When you're in Uptown, enjoy exploring the sights and attractions here including World's Largest Catsup Bottle, Busch Stadium, and St. Louis Union Station. If you have a little extra time during your trip, you might want to check out Gateway Conference Center and Cahokia Mounds State Historic Site.
What is a Uptown spa hotel?
Spa hotels in Uptown have on-site spas and offer services including therapies and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.

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