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Find Luxury Hotels in Uptown, IL

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Check availability on Uptown Luxury Hotels

Tonight
Dec 27 - Dec 28
Tomorrow
Dec 28 - Dec 29
Next weekend
Jan 2 - Jan 4
In two weeks
Jan 9 - Jan 11

Our top choices for Uptown luxury hotels

Breakfast, lunch and dinner served
Live by Loews - St.Louis

Live by Loews - St.Louis

Live by Loews - St.Louis
4.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1103)
"Clean room, great restaurant and bar down stairs "
United States
Ambria
The price is NT$4,684
NT$5,570 total
includes taxes & fees
Dec 29 - Dec 30
Live by Loews - St.Louis
Exterior
Moonrise Hotel

Moonrise Hotel

Moonrise Hotel
4.0 star property
Delmar Loop
9.0 out of 10, Wonderful, (1916)
"Great place"
United States
Edward
The price is NT$3,710
NT$4,412 total
includes taxes & fees
Dec 29 - Dec 30
Moonrise Hotel
Lobby
St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton
4.0 star property
Downtown West
8.6 out of 10, Excellent, (1002)
"The hotel itself was just beautiful and grand! Beautifully decorated for the holidays and the amenities and attractions surrounding Union station were perfect for our family of 4! Our room was spacious and clean and we loved our stay! "
United States
Kelly
The price is NT$4,923
NT$5,855 total
includes taxes & fees
Jan 4 - 2026/1/5
St. Louis Union Station Hotel, Curio Collection by Hilton
Rooftop bar
Hotel Saint Louis, Autograph Collection

Hotel Saint Louis, Autograph Collection

Hotel Saint Louis, Autograph Collection
4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (470)
"Great hotel. "
United States
Abby
The price is NT$4,872
NT$5,795 total
includes taxes & fees
Jan 2 - 2026/1/3
Hotel Saint Louis, Autograph Collection
Interior
21C Museum Hotel St Louis

21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (1510)
"Hotel was comfortable, clean and unique. All staff was wonderful "
United States
Sharon
The price is NT$4,498
NT$5,417 total
includes taxes & fees
Jan 4 - 2026/1/5
21C Museum Hotel St Louis
Lobby
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch
4.0 star property
Downtown St. Louis
8.4 out of 10, Very Good, (4031)
"Staff was supper nice and it all went so smooth."
United States
Brayden
The price is NT$3,112
NT$3,670 total
includes taxes & fees
Dec 30 - Dec 31
Hyatt Regency St. Louis at The Arch
3 bars/lounges, rooftop bar
Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark
4.0 star property
Downtown St. Louis
7.6 out of 10, Good, (1072)
"Clean room, this hotel is great for young people, night activity, 360 rooftop bar always crowded but pretty."
United States
Joan
The price is NT$4,614
NT$5,487 total
includes taxes & fees
Jan 3 - 2026/1/4
Hilton St. Louis at the Ballpark
Rooftop bar
Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1001)
"Everything exceeded my expectations from the welcoming staff to the luxuriously appointed room, to the 4 feet deep bathtub in which to soak my cares away--it was a total dream come true. I would come back in a heartbeat at this home away from home. "
United States
Lynne
The price is NT$13,045
NT$15,254 total
includes taxes & fees
Jan 1 - 2026/1/2
Four Seasons Hotel St Louis
Lounge
The Westin St. Louis

The Westin St. Louis

The Westin St. Louis
4.5 star property
Downtown St. Louis
8.6 out of 10, Excellent, (1003)
"Great location "
United States
Gregory
The price is NT$3,981
NT$4,655 total
includes taxes & fees
Jan 3 - 2026/1/4
The Westin St. Louis
Seasonal outdoor pool
The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis
4.5 star property
Central West End
9.0 out of 10, Wonderful, (1002)
"Always, a great time and place to stay."
United States
Lubna
The price is NT$4,747
NT$6,524 total
includes taxes & fees
Jan 18 - 2026/1/19
The Royal Sonesta Chase Park Plaza St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Uptown Hotel Reviews

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

10/10 Excellent
"Yes. The staff was nice and very helpful."
Adrienne 2-night trip
Posted 2 days ago
Clayton Plaza Hotel & Extended Stay

Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to Uptown?
Expedia can help you arrange a flight to St. Louis Lambert Intl. Airport (STL) airport, and then you can select from various places to stay that will deliver the luxury you'd like to find. Amenities are an important consideration when you plan a trip, so we make it easy to get what you want to make your stay relaxing and comfortable. If you want a posh hotel with fine dining, a spa, or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that Uptown offers. Uptown has some interesting things to see and do including World's Largest Catsup Bottle and Kruta Bakery, so you might want to take in the local sights during your visit.
What's there to see and do in Uptown?
Enjoy Uptown and visit World's Largest Catsup Bottle, Busch Stadium, and St. Louis Union Station. If you have a bit of extra time while you're in the area, you might want to check out Gateway Conference Center and Cahokia Mounds State Historic Site.

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