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Find Business Hotels in Southwest Illinois, IL

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Check availability on Southwest Illinois Business Hotels

Our top choices for Southwest Illinois business-friendly hotels

Free daily continental breakfast
Wingate by Wyndham St. Louis Airport

Wingate by Wyndham St. Louis Airport

Wingate by Wyndham St. Louis Airport
2.5 star property
St. Ann
9.2 out of 10, Wonderful, (1503)
"The room was very clean and the staff was very helpful."
United States
John
The price is NT$3,400
NT$4,003 total
includes taxes & fees
Dec 22 - Dec 23
Wingate by Wyndham St. Louis Airport
Lobby
SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (904)
"Great place to stay."
United States
Stephen
The price is NT$2,141
NT$2,376 total
includes taxes & fees
Dec 31 - 2026/1/1
SureStay Hotel by Best Western Whittington Rend Lake
Room, 1 Queen Bed, Accessible, Non Smoking | Desk, blackout drapes, iron/ironing board, free cribs/infant beds
Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL
2.5 star property
Mount Vernon
7.8 out of 10, Good, (1006)
"reception was great, room clean, and the price was right."
United States
tom
The price is NT$2,100
NT$2,394 total
includes taxes & fees
Jan 4 - 2026/1/5
Super 8 by Wyndham Mt. Vernon IL
Exterior
Best Western Marion Hotel

Best Western Marion Hotel

Best Western Marion Hotel
2.5 star property
Marion
8.2 out of 10, Very Good, (1006)
"Front staff (Cari) was so friendly and helpful during our stay. Our room was clean and the bed was comfortable."
United States
Wendy
The price is NT$2,221
NT$2,665 total
includes taxes & fees
Jan 18 - 2026/1/19
Best Western Marion Hotel
Exterior
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
2.5 star property
Murphysboro
9.4 out of 10, Exceptional, (512)
"great property, great breakfast, friendly and knowledgable staff."
United States
Ronald
The price is NT$3,185
NT$3,535 total
includes taxes & fees
Dec 20 - Dec 21
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Exterior
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
3.5 star property
Clayton
8.8 out of 10, Excellent, (3031)
"Clean room, good breakfast and good location "
United States
Martin
The price is NT$2,836
NT$3,310 total
includes taxes & fees
Dec 21 - Dec 22
Clayton Plaza Hotel & Extended Stay
Lobby
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1001)
"Rooms have been painted great breakfast close to interstate and restaurants"
United States
Stephen
The price is NT$3,433
NT$3,873 total
includes taxes & fees
Dec 23 - Dec 24
Comfort Suites Mount Vernon
Deluxe Studio Suite, 1 King Bed, Non Smoking | Pillowtop beds, in-room safe, desk, laptop workspace
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon
2.0 star property
O'Fallon
7.2 out of 10, Good, (1000)
"Staff were very friendly. It was clean & quiet. I will definitely stop again on my next trip. "
United States
Julian
The price is NT$1,339
NT$1,539 total
includes taxes & fees
Dec 28 - Dec 29
Super 8 by Wyndham O'Fallon
5 restaurants, breakfast, lunch, dinner served; American cuisine
River City Casino & Hotel

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
St. Louis
9.0 out of 10, Wonderful, (1449)
"Awesome place to stay!!"
United States
Kaitlyn
The price is NT$3,118
NT$4,087 total
includes taxes & fees
Dec 22 - Dec 23
River City Casino & Hotel
Lobby
Ramada by Wyndham Vandalia

Ramada by Wyndham Vandalia

Ramada by Wyndham Vandalia
2.0 star property
Vandalia
7.8 out of 10, Good, (809)
"Staffing was awesome and helpful. "
United States
Warren
The price is NT$2,010
NT$2,191 total
includes taxes & fees
Dec 21 - Dec 22
Ramada by Wyndham Vandalia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southwest Illinois Hotel Reviews

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

10/10 Excellent
"Drury provides the most value of any motel I have stayed in. Will stay at this one again."
Chuck 1-night trip
Posted 3 days ago
Drury Plaza Hotel Mt. Vernon

Frequently asked questions

How much do business-friendly hotels in Southwest Illinois cost?
You'll pay between NT$1,539 and NT$4,087 per night for business-friendly hotels in Southwest Illinois. Top deals on stays that cater to work-related travelers are only a click away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southwest Illinois?
There are multiple business-friendly hotels in Southwest Illinois with a total average guest review rating of 8.5, so you're sure to discover the perfect place. On your way to O'Fallon? Drury Inn & Suites St. Louis O'Fallon, IL is a top pick with corporate travelers. This 3-stars option has amenities like a swimming pool and WiFi. Hampton Inn O'Fallon also scores top marks from business guests. Take advantage of a swimming pool and an electric car charging station at this 2.5-stars escape in O'Fallon.
How many business-friendly hotels are there in Southwest Illinois?
Southwest Illinois has 105 business-friendly hotels to choose from. Whether you're attending a conference or meeting or simply working remotely, these properties are equipped with the amenities you need to keep you comfortable and productive.
What are the best cheap business-friendly hotels in Southwest Illinois?
When you need to make and close deals on the go in Southwest Illinois, Expedia will help you find the perfect business-friendly hotel. Hampton Inn O'Fallon is a popular budget option in O'Fallon. An electric car charging station and a swimming pool are among its many amenities. In search of low-cost stays in Marion? Comfort Inn & Suites Marion I-57 is recommended by many corporate guests. It comes with conveniences that make it easy to both work and relax, including pool sun loungers and a swimming pool. Business-friendly hotels in Southwest Illinois start at just NT$1,539 a night. Like to sightsee around Southwest Illinois without the high admission prices? Take a break from your work commitments to visit awesome free attractions like St. Clair Bowl in O'Fallon. Marion also has many things to do that don't cost a penny, including Williamson County Historical Museum. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Southwest Illinois that are also business friendly?
If you're traveling for business in Southwest Illinois and bringing family along with you, Expedia will help you locate a cozy and convenient stay. Drury Inn & Suites St. Louis O'Fallon, IL in O'Fallon is the perfect option for those combining work and pleasure. This 3-stars property comes with all the necessary amenities, like complimentary breakfast and a laundry service. Drury Inn & Suites St. Louis Fairview Heights is another terrific choice in O'Fallon. Get the best of both worlds — combine corporate travel and quality time with your family at this 3-stars property. Complimentary breakfast and WiFi are among the conveniences you'll find here. Once you've gotten work out of the way, get out and see O'Fallon with the kids. Popular family-friendly attractions include The Edge and St. Clair Bowl.
Why book your business-friendly hotel in Southwest Illinois with Expedia?
At Expedia, our top task is to help you land the ideal stay at the right price. From upmarket, corporate-friendly properties to affordable motels filled with all the amenities you need, you'll have your next work trip arranged in a few simple clicks.
How can I find cheap business-friendly hotels in Southwest Illinois?
When work takes you to Southwest Illinois, our "business friendly" filter will help you find a suitable hotel. From fast WiFi to meeting rooms and workspaces, they come with the amenities you need for a comfortable and productive stay. Another tip? Narrow your search by your budget and preferred star rating to see the cheapest accommodations.
What is there to do in Southwest Illinois near my business-friendly hotel?
Wherever your travels take you in Southwest Illinois, there's plenty to keep you busy. Staying a few days in O'Fallon? The Edge is a top attraction to include on your itinerary.

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