A crowded beach with people sunbathing and swimming.

Find Resorts & Hotels with Spas in Southwest Florida, FL

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Southwest Florida Resorts & Hotels with Spas

This weekend
Next weekend

Our top choices for Southwest Florida hotels with a spa

1. Comfort Suites Fort Myers East I-75

Comfort Suites Fort Myers East I-75
2.5 star property
Fort Myers
9.6 out of 10, Exceptional, (598 reviews)
"Very good hotel"
United States
Eloan
The price is NT$2,833
NT$3,159 total
includes taxes & fees
Nov 22 - Nov 23
Comfort Suites Fort Myers East I-75

2. MainStay Suites Fort Myers East I-75

MainStay Suites Fort Myers East I-75
2.5 star property
Fort Myers
9.6 out of 10, Exceptional, (419 reviews)
"Awesome place to stay"
United States
Marcellus
The price is NT$4,156
NT$4,634 total
includes taxes & fees
Nov 23 - Nov 24
MainStay Suites Fort Myers East I-75

3. Comfort Inn Fort Myers Northeast

Comfort Inn Fort Myers Northeast
2.5 star property
Fort Myers
7.8 out of 10, Good, (774 reviews)
"Quiet and peaceful, restaurants close by,"
United States
Scott
The price is NT$2,347
NT$2,617 total
includes taxes & fees
Nov 22 - Nov 23
Comfort Inn Fort Myers Northeast

4. Veras Inn & Suites

Veras Inn & Suites
2.5 star property
Fort Myers
7.8 out of 10, Good, (8 reviews)
The price is NT$2,611
NT$2,911 total
includes taxes & fees
Nov 3 - Nov 4
Veras Inn & Suites

5. Extended Stay America Select Suites - Fort Myers - Northeast

Extended Stay America Select Suites - Fort Myers - Northeast
2.5 star property
Fort Myers
5.6 out of 10, (1,000 reviews)
"Clean rooms and friendly staff"
United States
Janis
The price is NT$1,727
NT$1,926 total
includes taxes & fees
Nov 4 - Nov 5
Extended Stay America Select Suites - Fort Myers - Northeast

6. Holiday Inn Express & Suites Fort Myers Airport by IHG

Holiday Inn Express & Suites Fort Myers Airport by IHG
2.5 star property
Daniels Corridor
9.4 out of 10, Exceptional, (1,211 reviews)
"Clean room and very friendly staff. Close and convenient super easy shuttle."
United States
Amy
The price is NT$3,521
NT$3,925 total
includes taxes & fees
Nov 13 - Nov 14
Holiday Inn Express & Suites Fort Myers Airport by IHG

7. Fairfield Inn & Suites by Marriott Cape Coral/North Fort Myers

Fairfield Inn & Suites by Marriott Cape Coral/North Fort Myers
3.0 star property
Hancock
9.4 out of 10, Exceptional, (914 reviews)
"The hotel was very clean and breakfast had a lot of variety"
United States
Mauricio
The price is NT$3,574
NT$3,985 total
includes taxes & fees
Nov 22 - Nov 23
Fairfield Inn & Suites by Marriott Cape Coral/North Fort Myers

8. Drury Inn & Suites Fort Myers Airport FGCU

Drury Inn & Suites Fort Myers Airport FGCU
4.0 star property
Miromar Lakes
9.6 out of 10, Exceptional, (1,004 reviews)
"clean nice location breakfast nice"
United States
Giselia Dos Santos
The price is NT$3,879
NT$4,325 total
includes taxes & fees
Dec 1 - Dec 2
Drury Inn & Suites Fort Myers Airport FGCU

9. Hampton Inn & Suites Fort Myers - Colonial Blvd

Hampton Inn & Suites Fort Myers - Colonial Blvd
2.5 star property
Fort Myers
9.4 out of 10, Exceptional, (1,002 reviews)
"Very nice place recommend it highly"
United States
Luis
The price is NT$3,297
NT$3,676 total
includes taxes & fees
Nov 22 - Nov 23
Hampton Inn & Suites Fort Myers - Colonial Blvd

10. Home2 Suites by Hilton Fort Myers Colonial Blvd

Home2 Suites by Hilton Fort Myers Colonial Blvd
3.0 star property
Fort Myers
9.4 out of 10, Exceptional, (846 reviews)
"Clean hotel friendly staff and nice breakfast."
United States
Julio
The price is NT$3,962
NT$4,418 total
includes taxes & fees
Nov 22 - Nov 23
Home2 Suites by Hilton Fort Myers Colonial Blvd

11. Homewood Suites by Hilton - Fort Myers

Homewood Suites by Hilton - Fort Myers
3.0 star property
Villas
9.2 out of 10, Wonderful, (1,003 reviews)
"Awesome location, facility and staff. I plan to stay there every time I visit Fort Meyers."
United States
Anne
The price is NT$3,574
NT$3,985 total
includes taxes & fees
Nov 8 - Nov 9
Homewood Suites by Hilton - Fort Myers

12. Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops
4.0 star property
Villas
9.0 out of 10, Wonderful, (1,198 reviews)
"Clean, affordable, good location for what we needed, restaurants in walking distance."
United States
James
The price is NT$3,574
NT$3,985 total
includes taxes & fees
Nov 22 - Nov 23
Doubletree by Hilton Fort Myers at Bell Tower Shops

13. StudioRes by Marriott Fort Myers Airport

StudioRes by Marriott Fort Myers Airport
3.0 star property
Fort Myers
9.4 out of 10, Exceptional, (181 reviews)
"Location was great."
United States
Joseph
The price is NT$2,743
NT$3,059 total
includes taxes & fees
Nov 9 - Nov 10
StudioRes by Marriott Fort Myers Airport

14. Towneplace Suites By Marriott Fort Myers Southeast

Towneplace Suites By Marriott Fort Myers Southeast
3.0 star property
Fort Myers
9.4 out of 10, Exceptional, (114 reviews)
"Great place!"
United States
Frantzy
The price is NT$4,075
NT$4,543 total
includes taxes & fees
Nov 24 - Nov 25
Towneplace Suites By Marriott Fort Myers Southeast

15. Extended Stay America Premier Suites - Fort Myers - Airport

Extended Stay America Premier Suites - Fort Myers - Airport
2.5 star property
Daniels Corridor
9.0 out of 10, Wonderful, (1,169 reviews)
"Very Good hotel , lot of parking spot , clean rooms . Recommended!"
Canada
Isaura
The price is NT$2,083
NT$2,322 total
includes taxes & fees
Nov 8 - Nov 9
Extended Stay America Premier Suites - Fort Myers - Airport

16. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
Caloosahatchee
9.4 out of 10, Exceptional, (1,739 reviews)
"Excellent hotel if you want to stay there for a few days"
United States
Gabriel
The price is NT$3,260
NT$3,635 total
includes taxes & fees
Nov 10 - Nov 11
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

17. Hampton Inn Fort Myers Downtown

Hampton Inn Fort Myers Downtown
3.0 star property
Fort Myers River District
9.2 out of 10, Wonderful, (1,071 reviews)
"Clean rooms and modern. Friendly staff"
United States
Donald
The price is NT$3,630
NT$4,047 total
includes taxes & fees
Nov 22 - Nov 23
Hampton Inn Fort Myers Downtown

18. Matlacha on Shoreview

Matlacha on Shoreview
2.0 star property
Cape Coral
9.6 out of 10, Exceptional, (304 reviews)
"The place was perfect for what we needed for this trip."
United States
Francisco
The price is NT$1,956
NT$4,362 total
includes taxes & fees
Nov 5 - Nov 6
Matlacha on Shoreview

19. Hampton Inn Fort Myers-Airport & I-75

Hampton Inn Fort Myers-Airport & I-75
3.5 star property
Daniels Corridor
9.0 out of 10, Wonderful, (1,007 reviews)
"We had a great stay"
Belgium
marleen
The price is NT$2,854
NT$3,182 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn Fort Myers-Airport & I-75

20. Home2 Suites by Hilton Fort Myers Airport

Home2 Suites by Hilton Fort Myers Airport
3.0 star property
Fort Myers
9.2 out of 10, Wonderful, (533 reviews)
"Comfortable and Clean convenient to the airport. Great place!"
United States
Donna
The price is NT$3,983
NT$4,441 total
includes taxes & fees
Nov 15 - Nov 16
Home2 Suites by Hilton Fort Myers Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Choose what matters most at spa hotels in Southwest Florida

Spa hotels with pools in Southwest Florida

Spa hotels with free breakfast in Southwest Florida

Spa hotels with hot tubs in Southwest Florida

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Southwest Florida

Top Southwest Florida attractions for a relaxing vacation

Travelers seeking spa hotels in Southwest Florida will find a paradise of rejuvenating experiences. Begin your journey in Naples, where pristine beaches meet luxurious resorts, offering indulgent spa treatments featuring local ingredients like coconut and citrus. Explore the stunning Naples Botanical Garden, a perfect spot for a serene stroll amid vibrant floral displays, followed by a blissful massage at one of the nearby wellness retreats. In Fort Myers, the Calusa Nature Center and Planetarium invites you to unwind in nature, with tranquil trails perfect for reflection before returning to your hotel for a soothing evening soak. For those venturing to Sanibel Island, the shell-strewn beaches provide a backdrop for relaxation, while local spas offer unique treatments that incorporate the island’s natural beauty. The area around Estero Bay is another gem, where eco-tours can be paired with spa days, allowing for a perfect blend of adventure and pampering. With a plethora of upscale hotels featuring world-class spas, Southwest Florida ensures that your stay is not just about relaxation but an immersive experience in a region that celebrates both nature and luxury.

Top Southwest Florida Hotel Reviews

Explore a world of travel with Expedia