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Find Family Hotels in Southeast Missouri, MO
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Our top choices for Southeast Missouri family-friendly hotels
9.4 out of 10, Exceptional, (1000)
"Great place. Friendly staff clean"
Jeff
The price is NT$2,824
NT$3,247 total
includes taxes & fees
Jan 6 - 2026/1/7
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1001)
"This Drury is our preferred place to stay when visiting family in Cape Girardeau. The hotel Staff is always warm and small town friendly! The hotel is nice and the breakfast buffet is outstanding!! "
Michael
The price is NT$2,824
NT$3,185 total
includes taxes & fees
Jan 8 - 2026/1/9
Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (547)
"lean, updated rooms, friendly staff and great breakfast."
Linda
The price is NT$2,856
NT$3,269 total
includes taxes & fees
Jan 25 - 2026/1/26
9.2 out of 10, Wonderful, (972)
"Nice room helpful staff. "
Deborah
The price is NT$3,297
NT$3,725 total
includes taxes & fees
Jan 10 - 2026/1/11
9.0 out of 10, Wonderful, (456)
"Very clean and super friendly staff!"
Katherine
The price is NT$3,220
NT$3,646 total
includes taxes & fees
Jan 11 - 2026/1/12
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (145)
"Lovely staff clean hotel comfortable beds "
Kastriot
The price is NT$2,762
NT$3,115 total
includes taxes & fees
Jan 8 - 2026/1/9
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)Sikeston
8.4 out of 10, Very Good, (725)
"Clean room and easy access to room"
Anne
The price is NT$1,741
NT$1,985 total
includes taxes & fees
Jan 29 - 2026/1/30
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical CenterCape Girardeau
9.0 out of 10, Wonderful, (1003)
"Nice place for a stay at a reasonable price."
Arthur
The price is NT$2,196
NT$2,478 total
includes taxes & fees
Jan 7 - 2026/1/8
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southeast Missouri Hotel Reviews
Motel 6 Poplar Bluff, MO
10/10 Excellent
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