Southeast Missouri, MO
Travel Guide
Visit Southeast Missouri
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
The price is NT$3,371 per night from May 7 to May 8
NT$3,371
NT$3,803 total
May 7 - May 8
includes taxes & fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,009 reviews)
Comfortable beds, great breakfast. One of the best hotel breakfasts we have had. Friendly staff, very convenient location. Would definitely stay again.
Reviewed on 2026/4/13
The Riverview
777 Main St Cape Girardeau MO
The price is NT$4,208 per night from Apr 20 to Apr 21
NT$4,208
NT$4,746 total
Apr 20 - Apr 21
includes taxes & fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Century Casino & Hotel Cape ...
9.4/10 Exceptional! (547 reviews)
Bedbugs
Reviewed on 2026/4/12
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
The price is NT$3,244 per night from Apr 27 to Apr 28
NT$3,244
NT$3,729 total
Apr 27 - Apr 28
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,004 reviews)
Helpful and friendly staff. Room and hotel was clean. A great stay!
Reviewed on 2026/4/10
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
9.8/10 Exceptional! (59 reviews)
Cozy and most of all very accomodating staff. The best stay.. there is no one like it. (No exaggeration)
Reviewed on 2026/4/10
Johnson's Shut-ins State Park
148 Taum Sauk Trail Middle Brook MO
Stay at this cabin in Middle Brook. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Johnson's Shut-ins State Park and Taum Sauk ...
10/10 Exceptional! (2 reviews)
The cabin was beautiful with everything you could ever need! My one note would be the handicap shower pressure was abysmal but everything else was great
Reviewed on 2026/4/13
Lake Wappapello
8005 Missouri 172 Williamsville MO
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located ...
10/10 Exceptional! (2 reviews)
Pet friendly. Family-friendly
Reviewed on 2026/4/12
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check Southeast Missouri hotel availability
Popular places to visit
Elephant Rocks State Park
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Southeast Missouri State University
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Current River State Park
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Lake Wappapello
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Big Spring
Enjoy an outing to Big Spring during your stay in Van Buren. Wander the forest and riverfront while you're in the area.
Hawn State Park
You can take time to visit Hawn State Park during your travels to Ste Genevieve. Discover the area's coffeehouses or seek out the golf courses.
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- Adults Only Resorts & in Southeast Missouri
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- Black Hotels
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- 3 Star Hotels in Doe Run
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- Flights from Park Hills
- Flights to Fredericktown
- Flights from Friedheim
- Flights to Southeast Missouri
- Flights from Jasper (APT) to Poplar Bluff (POF)
- Flights from New Offenburg
- Flights from Branson (BKG) to Poplar Bluff (POF)
- Flights from Minneapolis (MSP) to Poplar Bluff (POF)
- Flights from Ada (ADT) to Poplar Bluff (POF)
- Flights from St. Louis (SUS) to Poplar Bluff (POF)
- Flights from Los Angeles (LAX) to Poplar Bluff (POF)
- Flights from Fredericktown
- Flights from Black
- Flights from Belleview
- Flights to Ironton
- Flights from Mountain Home (WMH) to Poplar Bluff (POF)
- Flights from Murray (CEY) to Poplar Bluff (POF)
- Flights from Southeast Missouri
- Crown Valley Winery
- Visit Ironton
- Visit Tiff
- Visit Flat River
- Visit Ellington
- Twin Oaks Vineyard & Winery
- Visit Annapolis
- Visit Belleview
- Weingarten Vineyard
- Visit Dutchtown
- Visit Eminence
- Visit Doniphan
- Visit Winona
- Visit Farmington
- Visit Zalma
- Visit Bloomsdale
- Visit Jackson
- Visit Cadet
- Walnut Hollow Lake
- Visit Cherryville
- National Shrine of Our Lady of the Miraculous Medal
- Visit Desloge
- Visit Lesterville
- Visit Friedheim
- Johnson's Shut-ins State Park
- Taum Sauk Mountain State Park
- Visit Middle Brook
- Visit Marble Hill
- Visit Qulin
