Southeast Missouri Vacations

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Find the Best Southeast Missouri Vacation Packages

Southeast Missouri Hotel Deals

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
The price is NT$1,658 per night from Sep 2 to Sep 3
NT$1,658
NT$1,888 total
Sep 2 - Sep 3
includes taxes & fees
8/10 Very Good! (1,004 reviews)
"I actually stay there a couple times a month. I do it for the pool most all their staff is very friendly jay is especially/. I would recommend it to anyone."

Reviewed on 2025/8/17

Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview

The Riverview

2 out of 5
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is NT$3,159 per night from Aug 20 to Aug 21
NT$3,159
NT$3,563 total
Aug 20 - Aug 21
includes taxes & fees
9.2/10 Wonderful! (392 reviews)
"I loved the rooms. They were spacious, clean and the bed was wonderful. However, the lobby smelled of smoke. The rooms did not, but the lobby definitely did."

Reviewed on 2025/8/18

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is NT$2,699 per night from Aug 31 to Sep 1
NT$2,699
NT$3,045 total
Aug 31 - Sep 1
includes taxes & fees
9.4/10 Exceptional! (1,004 reviews)
"Just a short stay while a family member had surgery. I was comfortable and it was quiet. The free breakfast was very nice."

Reviewed on 2025/8/15

Drury Plaza Hotel Cape Girardeau Conference Center
See all 585 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Southeast Missouri

Echo Bluff is Missouri's newest State Park.

Echo Bluff State Park

You can take time to visit Echo Bluff State Park during your travels to Salem. While you're in the area, stroll along the riverfront.

Echo Bluff State Park

Isle Casino Cape Girardeau

Why not roll the dice with a visit to Isle Casino Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

Isle Casino Cape Girardeau

National Shrine of Our Lady of the Miraculous Medal

Find out about the history of Perryville when you take a trip to National Shrine of Our Lady of the Miraculous Medal. Take in the festivals while you're in the area.

National Shrine of Our Lady of the Miraculous Medal

Frequently asked questions

How much does a Southeast Missouri vacation package cost?
Cross off another part of the world with our Southeast Missouri vacation packages, which start from just . Select the flights and hotels that match your travel plans. Then, add on one or two tours or experiences for an unforgettable adventure.
How do I get a cheap travel package to Southeast Missouri?
Browse and book everything in the one place with our Southeast Missouri vacation packages. You'll find deals on flights, hotels, tours and more that'll keep your pocket happy and your adventurous spirit alive. And, with more than 550 partner airlines and 1,000,000 hotels around the world to select from, you'll have endless opportunities to mix and match your own way.
What are the top hotels in Southeast Missouri?
When it comes to properties in Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West are a couple of favorites. If you're considering heading to Ste Genevieve, City Place St. Louis Downtown and The Branson Hillside Hotel are waiting to welcome you.
How far in advance should I book my Southeast Missouri vacation?
It's tricky picking the perfect time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to a year in advance. If you can't book ahead, don't worry. Cheap prices appear from time to time within a few weeks of departure dates.
What does an Expedia Southeast Missouri travel package include?
From hotels and flights to car rentals, Expedia can help you craft a Southeast Missouri package that fits you. Vacationing for a week or two? Look into a rental car, hotel and flight bundle. If you're taking a quick break, a hotel and airfare deal may suit you better. Experiences can also be added once you've made your booking. Our packages make it a breeze to plan and save.
What should I know before booking a Southeast Missouri travel package?
When you book your flights, hotels and car rentals together, you'll pick up terrific discounts. Whether you're planning a beach escape in a villa or prefer to stay in a comfortable hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Southeast Missouri Expedia vacation package?
You can, and with over 550 airlines to pick from around the world, you're spoiled for choice. Have a look through the available options and see which airline best suits your budget and needs.
If I'm not able to travel, can I cancel my Southeast Missouri vacation package?
Because we understand life is full of surprises, the answer is yes. To learn more, head to our Customer Service Portal. But generally speaking, if you've booked your Southeast Missouri vacation package in the last 24 hours, you may be able to cancel or change it for no charge. Your hotel, airline or car rental company may charge a fee if your booking is older than that.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.