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Oct 23 - Oct 25
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Oct 30 - Nov 1

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Our top choices for Siesta Isle hotels

A row of turquoise Adirondack chairs with umbrellas, a wooden deck, and a marina in the background.

1. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
Siesta Isle
9.0 out of 10, Wonderful, (1,003 reviews)
"I like this hotel we have been twice"
United States
Giovanna
The price is NT$2,770
NT$3,089 total
includes taxes & fees
Oct 19 - Oct 20
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
A large, clear swimming pool with multiple lounge areas and palm trees.

2. Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers
4.0 star property
2.6 km from Siesta Isle
9.0 out of 10, Wonderful, (2,676 reviews)
"Very nice place to stay in for the weekend"
United States
Jose
The price is NT$5,803
NT$8,096 total
includes taxes & fees
Oct 19 - Oct 20
Margaritaville Beach Resort Fort Myers
A swimming pool with a rock arch structure, a multi-story building with balconies, and palm trees in the background.

3. Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
1.8 km from Siesta Isle
9.4 out of 10, Exceptional, (1,480 reviews)
"It's nice place to stay"
United States
Mario
The price is NT$6,969
NT$9,903 total
includes taxes & fees
Nov 15 - Nov 16
Pink Shell Beach Resort and Marina
A modern dining area with wooden flooring, white chairs, and large windows offering a view of the beach.

4. Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
2.2 km from Siesta Isle
9.4 out of 10, Exceptional, (1,004 reviews)
"The location was amazing. Right on the beach and close to restaurants."
United States
Radiana
The price is NT$7,019
NT$7,827 total
includes taxes & fees
Nov 1 - Nov 2
Best Western Plus Beach Resort
An outdoor patio with tables and chairs, umbrellas, and a pool in the background.

5. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
2.7 km from Siesta Isle
9.2 out of 10, Wonderful, (1,001 reviews)
"Very clean and comfortable hotel! Great breakfast too!"
United States
Gigette
The price is NT$3,111
NT$3,468 total
includes taxes & fees
Oct 21 - Oct 22
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
A spacious lobby with a high ceiling, a seating area with a sofa and chairs, a small round table, and a decorative wall with artwork.

6. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
2.6 km from Siesta Isle
8.8 out of 10, Excellent, (1,002 reviews)
"One of the best properties I’ve stayed in and the staff were excellent."
United States
Christina
The price is NT$2,896
NT$3,229 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

7. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
2.7 km from Siesta Isle
8.8 out of 10, Excellent, (1,001 reviews)
"The hotel was in a great location, very clean and had great breakfast options."
United States
jennifer
The price is NT$3,046
NT$3,396 total
includes taxes & fees
Oct 19 - Oct 20
Residence Inn by Marriott Fort Myers Sanibel
A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

8. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
2.3 km from Siesta Isle
8.2 out of 10, Very good, (1,389 reviews)
"The staff was very helpful during my stay."
United States
Samantha
The price is NT$2,333
NT$2,601 total
includes taxes & fees
Oct 26 - Oct 27
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a stone archway.

9. The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites
3.0 star property
2.4 km from Siesta Isle
8.6 out of 10, Excellent, (1,821 reviews)
"excellent place to stay"
United States
Shayne
The price is NT$3,396
NT$4,434 total
includes taxes & fees
Nov 10 - Nov 11
The Lighthouse Resort Inn & Suites
A wooden deck with outdoor seating, a thatched-roof structure, and string lights.

10. Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
1.1 km from Siesta Isle
8.6 out of 10, Excellent, (1,000 reviews)
"Great place to stay, especially on a fishing trip!"
United States
Mitchel
The price is NT$3,028
NT$3,376 total
includes taxes & fees
Oct 19 - Oct 20
Latitude 26 Waterfront Resort & Marina
Living area

11. Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
2.7 km from Siesta Isle
8.8 out of 10, Excellent, (2,127 reviews)
"Great place to stay!!"
United States
ROBERT
The price is NT$4,637
NT$5,892 total
includes taxes & fees
Oct 21 - Oct 22
Lani Kai Beachfront Resort
A beach view from a balcony with a pool, palm trees, and a building with a balcony.

12. Edison Beach House

Edison Beach House
3.5 star property
2.3 km from Siesta Isle
9.4 out of 10, Exceptional, (1,943 reviews)
"Great stay."
United States
Angie
The price is NT$4,899
NT$6,727 total
includes taxes & fees
Oct 19 - Oct 20
Edison Beach House
A marina with boats docked, surrounded by palm trees and a building with a red-tiled roof.

13. Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina
3.0 star property
2.1 km from Siesta Isle
9.4 out of 10, Exceptional, (1,001 reviews)
"I love Matanza. It's in a great location, walking distance to everything. I enjoyed sitting on the canal/bay and seeing all the wildlife, especially Manatee! We stayed in the 2 bedroom and it was perfect!"
United States
Tammy
The price is NT$5,282
NT$6,699 total
includes taxes & fees
Oct 19 - Oct 20
Matanzas Inn Bayside Resort and Marina
A beachfront hotel with a pool, beach, and ocean view.

14. DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
2.9 km from Siesta Isle
9.2 out of 10, Wonderful, (1,315 reviews)
"Would be willing to stay there again."
United States
Angela
The price is NT$6,488
NT$8,498 total
includes taxes & fees
Nov 18 - Nov 19
DiamondHead Beach Resort
A balcony with tables set for dining, overlooking a beach with palm trees and the ocean.

15. The Bay Inn at Lani Kai

The Bay Inn at Lani Kai
3.0 star property
2.7 km from Siesta Isle
8.0 out of 10, Very good, (530 reviews)
"Clean room, helpful staff, very close to the beach."
United States
Andrea
The price is NT$3,231
NT$4,325 total
includes taxes & fees
Oct 20 - Oct 21
The Bay Inn at Lani Kai
A hotel room with a large bed, two bedside tables with lamps, a nightstand, and a window with curtains.

16. Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG
3.0 star property
4.9 km from Siesta Isle
7.6 out of 10, Good, (1,000 reviews)
"I was satisfied with the price for a short stay."
United States
James
The price is NT$2,171
NT$2,421 total
includes taxes & fees
Oct 20 - Oct 21
Candlewood Suites Fort Myers Sanibel Gateway by IHG
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

17. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
9.7 km from Siesta Isle
9.4 out of 10, Exceptional, (1,712 reviews)
"Quiet and clean hotel, very friendly staff, good breakfast!!"
United States
MARYTE
The price is NT$3,273
NT$3,649 total
includes taxes & fees
Oct 28 - Oct 29
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
A beach with a variety of seashells and pebbles.

18. Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
10.1 km from Siesta Isle
9.2 out of 10, Wonderful, (2,371 reviews)
"Great place in a great location, very much recommended"
United States
Eldad
The price is NT$5,800
NT$7,370 total
includes taxes & fees
Oct 19 - Oct 20
Sanibel Island Beach Resort
A hotel room with a bed, a TV on a dresser, a window with curtains, and a small table.

19. Drury Inn & Suites Fort Myers Airport FGCU

Drury Inn & Suites Fort Myers Airport FGCU
4.0 star property
16.5 km from Siesta Isle
9.6 out of 10, Exceptional, (1,001 reviews)
"Great place to stay! Very courteous staff! Wife and I will stay there again."
United States
Mark
The price is NT$3,726
NT$4,154 total
includes taxes & fees
Oct 22 - Oct 23
Drury Inn & Suites Fort Myers Airport FGCU
An indoor swimming pool with clear water, a lifeguard station, and a seating area with chairs.

20. Comfort Inn & Suites Fort Myers Airport

Comfort Inn & Suites Fort Myers Airport
2.5 star property
18.1 km from Siesta Isle
8.6 out of 10, Excellent, (1,162 reviews)
"The breakfast was amazing"
United States
Erika
The price is NT$2,391
NT$2,666 total
includes taxes & fees
Oct 25 - Oct 26
Comfort Inn & Suites Fort Myers Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Hotels recommended for families in Siesta Isle

A row of turquoise Adirondack chairs with umbrellas, a wooden deck, and a marina in the background.

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
Siesta Isle
9.0 out of 10, Wonderful, (1,003)
The price is NT$2,770
NT$3,089 total
includes taxes & fees
Oct 19 - Oct 20
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Where to stay in Siesta Isle

Find the best Siesta Isle areas and neighborhoods for the activities you enjoy most.
A sunset over a calm sea with trees framing the view.

Mid Island

While visiting Mid Island, you might make a stop by sights like Estero Boulevard Beach and Sterling Ave Beach.

A pier extending into the water with two gazebos at the end, under a sunset sky.

South Island

While visiting South Island, you might make a stop by sights like Santini Marina Shopping Plaza and Castle Beach.

A coastal town with a marina, residential buildings, and a clear view of the ocean.

TP Hill's

When in TP Hill's, you can plan a visit to Key West Express and Estero Boulevard Beach, some noteworthy sights in the nearby area.

A beach at sunset with a pink and purple sky, people walking, and a lifeguard tower in the distance.
Photo by Abby Chase
Open Photo by Abby Chase

Downtown Fort Myers Beach

If you're spending some time in Downtown Fort Myers Beach, Lynn Hall Memorial Park and Estero Boulevard Beach are top sights worth seeing.

A coastal town with a beach, buildings, and a road.

Winklers

While Winklers might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Key West Express and Estero Boulevard Beach.

Top Siesta Isle Hotel Reviews

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

10/10 Excellent
"We had a short weekend stay and Lani Kai was a perfect location for our getaway. We had a king beach view room that was perfect! This hotel has a laidback feel. If you are looking for fancy, this would not be your fit. We definitely recommend this hotel."
Christine 3-night trip
Posted 1 hour ago
Lani Kai Beachfront Resort

Frequently asked questions

What is Siesta Isle like?
Travelers will be sure to find plenty to entertain them in Fort Myers Beach's Siesta Isle neighborhood. Consider a visit to San Carlos Bay - Bunche Beach Preserve as part of your Siesta Isle travel plans.
Where is the best place to stay in Siesta Isle?
Based on our traveler data, Latitude 26 Waterfront Boutique Resort - Fort Myers Beach is one of the top choices for your stay in Siesta Isle. This hotel offers a marina and free breakfast.
How many hotels will I find in Siesta Isle?
If you're searching for places to stay in Fort Myers Beach, Expedia has something to meet your needs with 27 Siesta Isle hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Siesta Isle, will I receive a refund?
Yes, you'll find most room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a non-refundable reservation, you might still have the option to cancel and be given a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to view the top deals on offer in Siesta Isle.
Where can I learn more about changing or cancelling my trip to Siesta Isle?
To access more information about picking new dates or cancelling your trip to Siesta Isle, head over to our customer service page.
What are the top things to see and do in Siesta Isle?
San Carlos Bay - Bunche Beach Preserve is an attraction you might want to check out while you're in Siesta Isle. Key West Express and Bunche Beach are also worth a visit when you're out sightseeing in Fort Myers Beach.

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