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Our top choices for Santa Ana hotels

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.4 out of 10, Good, (56 reviews)
"Excelente "
Mexico
David
The price is NT$802
NT$882 total
includes taxes & fees
Jan 16 - Jan 17
Hostal La Cigarra

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (62 reviews)
"We live this property and stay here whenever we are in town."
United States
chris
Casco View Apartments

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (182 reviews)
"Fantastic customer service"
United States
OLGA
Hotel República

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15 reviews)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is NT$1,935
NT$2,998 total
includes taxes & fees
Feb 8 - Feb 9
La Manzana by Wynwood House

Panama House Bed & Breakfast

Panama House Bed & Breakfast
2.5 star property
Bella Vista, 4.6 km from Santa Ana
9.0 out of 10, Wonderful, (188 reviews)
"It was a great stay in a great neighborhood with many food and beverage options, fantastic hosts and an interesting mix of people "
Canada
Brad
The price is NT$1,306
NT$1,437 total
includes taxes & fees
Jan 21 - Jan 22
Panama House Bed & Breakfast

Hotel Montreal

Hotel Montreal
3.5 star property
Bella Vista, 2.7 km from Santa Ana
6.0 out of 10, (401 reviews)
"The hotel was as I expected. Nothing fancy but clean, comfortable, with easy access from the city. There was parking always available. The restaurant, bar, and the pool were open. The people who worked there had the best predisposition to help and make our time in the hotel great. "
United States
Maria Eugenia Fourcade
Hotel Montreal

Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina
3.0 star property
El Cangrejo, 3.8 km from Santa Ana
7.4 out of 10, Good, (277 reviews)
"Good room - clean and quiet, Hotel location is on a commercial street with many restaurants and bars nearby and within walking distance to a metro station. "
Canada
P
The price is NT$2,284
NT$2,513 total
includes taxes & fees
Jan 18 - Jan 19
Ramada Panama Centro Via Argentina

Crowne Plaza Panama by IHG

Crowne Plaza Panama by IHG
4.0 star property
Bella Vista, 3.2 km from Santa Ana
8.2 out of 10, Very Good, (215 reviews)
"Staff were amazing . Great breakfast and convenient area close to the train station "
United States
Darius
The price is NT$2,782
NT$3,060 total
includes taxes & fees
Feb 1 - Feb 2
Crowne Plaza Panama by IHG

Toscana Inn

Toscana Inn
3.5 star property
El Cangrejo, 3.7 km from Santa Ana
9.0 out of 10, Wonderful, (728 reviews)
"Very comfortable, clean, located in El Cangrejo, a lively area. Breakfast was good and saved us time for our coming trip."
United States
Alberto
Toscana Inn

Hotel y Casino Central Park Panama

Hotel y Casino Central Park Panama
3.0 star property
Bethania, 5.6 km from Santa Ana
7.6 out of 10, Good, (430 reviews)
"Great service, clean, great location "
United States
EDGAR
The price is NT$2,049
NT$2,253 total
includes taxes & fees
Jan 16 - Jan 17
Hotel y Casino Central Park Panama

Hilton Garden Inn Panama City Downtown, Panama

Hilton Garden Inn Panama City Downtown, Panama
3.5 star property
El Cangrejo, 3.4 km from Santa Ana
8.6 out of 10, Excellent, (1,000 reviews)
"Room was great!"
United States
Rayad
The price is NT$2,722
NT$2,994 total
includes taxes & fees
Jan 21 - Jan 22
Hilton Garden Inn Panama City Downtown, Panama

MARINN PLACE Financial District

MARINN PLACE Financial District
3.5 star property
Campo Alegre, 3.3 km from Santa Ana
9.2 out of 10, Wonderful, (301 reviews)
"Second stay, very nice"
Canada
Xiaozhi
MARINN PLACE Financial District

Hotel Acapulco

Hotel Acapulco
3.0 star property
Calidonia, 1.3 km from Santa Ana
7.8 out of 10, Good, (130 reviews)
"Excelente"
United States
Alejandro
The price is NT$949
NT$1,044 total
includes taxes & fees
Jan 17 - Jan 18
Hotel Acapulco

Tantalo Hotel

Tantalo Hotel
3.5 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (277 reviews)
"Staff was amazing!! Room was great as well!! "
United States
John
Tantalo Hotel

Gran Evenia Panama

Gran Evenia Panama
4.5 star property
El Cangrejo, 3.8 km from Santa Ana
9.2 out of 10, Wonderful, (204 reviews)
"The property was conveniently located near shops, restaurants and casinos. The food at breakfast was good. Although the pancakes could be better. "
United States
Nicole
Gran Evenia Panama

Hotel Vía España

Hotel Vía España
3.0 star property
Calidonia, 2.4 km from Santa Ana
6.2 out of 10, (173 reviews)
"The hotel is very deteriorated, they must replaces all linens, towels, update all bathrooms. The elevator was constantly out of service, we stayed there because we were must of the time out at a convention, but the place needs a lot of repairing."
United States
Jacob
Hotel Vía España

Hampton by Hilton Panama

Hampton by Hilton Panama
3.0 star property
El Cangrejo, 3.8 km from Santa Ana
7.8 out of 10, Good, (1,000 reviews)
"It was really quiet to have a peaceful rest. "
United States
Ana
The price is NT$2,333
NT$2,566 total
includes taxes & fees
Jan 24 - Jan 25
Hampton by Hilton Panama

Holiday Inn Panama Canal by IHG

Holiday Inn Panama Canal by IHG
3.5 star property
6 km from Santa Ana
8.6 out of 10, Excellent, (447 reviews)
"The staff was so cordial and nice "
United States
Sonny
The price is NT$3,383
NT$3,721 total
includes taxes & fees
Feb 2 - Feb 3
Holiday Inn Panama Canal by IHG

Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites
3.5 star property
El Cangrejo, 3.4 km from Santa Ana
8.8 out of 10, Excellent, (494 reviews)
"Clean room good staff and great breakfast "
United States
Gaudencio Y Mireya
Torres de Alba Hotel & Suites

Hotel Pension Corona

Hotel Pension Corona
2.5 star property
Calidonia, 1.8 km from Santa Ana
7.8 out of 10, Good, (114 reviews)
"Great spot for the price "
United States
frank
Hotel Pension Corona
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Crown Casino. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Felipe

If you're spending some time in San Felipe, Interoceanic Canal Museum and National Theater are top sights worth seeing.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighborhood that travelers like for its seafood restaurants, shopping, and parks. Are you looking for Santa Ana travel tips? Be sure to check out Cinta Costera and Avenida Balboa while you're in the neighborhood.
Where is the best hotel for a stay in Santa Ana?
Based on Expedia customer reviews, Hotel República is the highest ranked property in Santa Ana. This hotel is a short 4-minute walk from Avenida Balboa, and it offers a rooftop terrace and free WiFi. Another top choice in the area is Hostal La Cigarra.
How many hotels can I expect to find in Santa Ana?
Expedia has 111 hotels and other accommodations in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! Most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Add dates, click "Search", then use the "fully refundable" filter to get top deals in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about picking new dates or cancelling your trip to Santa Ana, head over to our customer service page.
What is there to do in this Panama City neighborhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighborhood. Albrook Shopping Mall, Amador Theater, and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.