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Our top choices for Santa Ana hotels

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (69 reviews)
"Excellent staff, close to metro and embassies. A good location, good room for a great price. I would stay again. "
United Kingdom
Mark
The price is NT$905
NT$995 total
includes taxes & fees
Apr 19 - Apr 20
Hostal La Cigarra

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (189 reviews)
"The wifi is strong enough to use for work. "
United States
Matthew
The price is NT$800
NT$880 total
includes taxes & fees
Apr 25 - Apr 26
Hotel República

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (88 reviews)
"The staff was absolutely phenomenal! So kind and accommodating even when certain events were out of their control they were still so wonderful!"
United States
Nicole
The price is NT$3,002
NT$4,250 total
includes taxes & fees
Apr 20 - Apr 21
Casco View Apartments

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15 reviews)
"Very clean and safe property"
United States
Javier Alberto Lindauer
The price is NT$2,041
NT$3,114 total
includes taxes & fees
Apr 19 - Apr 20
La Manzana by Wynwood House

ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.0 out of 10, (11 reviews)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
The price is NT$1,163
NT$1,280 total
includes taxes & fees
May 19 - May 20
ART CASCO The Hotel

Hotel Riazor

Hotel Riazor
3.0 star property
Santa Ana
3.8 out of 10, (11 reviews)
"Rough neighborhood "
Canada
Del
The price is NT$853
NT$938 total
includes taxes & fees
May 19 - May 20
Hotel Riazor

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
19.8 km from Santa Ana
8.4 out of 10, Very Good, (1,851 reviews)
"Property was good, would stay there again. "
United States
Juan
The price is NT$4,267
NT$4,693 total
includes taxes & fees
May 2 - May 3
Riande Aeropuerto Hotel & Casino

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
4.0 star property
21.1 km from Santa Ana
8.6 out of 10, Excellent, (2,493 reviews)
"Very convenient next to Airport, My check in process was fast , room was ready upon my Arrival"
United States
Susana
The price is NT$3,854
NT$4,448 total
includes taxes & fees
May 12 - May 13
Crowne Plaza Panama Airport by IHG

Hotel Costa Inn

Hotel Costa Inn
3.0 star property
Calidonia, 2.1 km from Santa Ana
7.0 out of 10, Good, (577 reviews)
"The room was clean; staff was helpful"
United States
Roxanne
The price is NT$900
NT$990 total
includes taxes & fees
Apr 19 - Apr 20
Hotel Costa Inn

ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport
2.0 star property
20.5 km from Santa Ana
8.8 out of 10, Excellent, (103 reviews)
"Nice people & room was nice"
United States
KAREN
The price is NT$3,791
NT$4,921 total
includes taxes & fees
Apr 19 - Apr 20
ORHO HOTEL BOUTIQUE PANAMA Airport

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz, 12.7 km from Santa Ana
9.6 out of 10, Exceptional, (688 reviews)
"Visited with friends and had a great stay! The rooms were very clean and comfortable, the staff was very kind, and the buffet breakfast was amazing. Pool was awesome. Highly recommend. "
United States
Leisha
The price is NT$8,507
NT$9,358 total
includes taxes & fees
May 8 - May 9
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Panama House Bed & Breakfast

Panama House Bed & Breakfast
2.5 star property
Bella Vista, 4.6 km from Santa Ana
9.0 out of 10, Wonderful, (199 reviews)
"Amenities, staff, cleanliness, price all excellent!"
United States
Christopher
The price is NT$1,088
NT$1,196 total
includes taxes & fees
Apr 19 - Apr 20
Panama House Bed & Breakfast

Dovle Residences by HMS-Preferred Member

Dovle Residences by HMS-Preferred Member
2.5 star property
San Francisco, 7.1 km from Santa Ana
7.0 out of 10, Good, (8 reviews)
"Inadequate heating in the pool , poor customer service. No hot water in the shower. It was a terrible experience but it’s a nice place, hopefully with better management can offer outstanding services "
United States
Herbert
The price is NT$4,065
NT$4,472 total
includes taxes & fees
May 10 - May 11
Dovle Residences by HMS-Preferred Member

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (5,306 reviews)
"Great place to stay, great staff, I had a good time in the hotel itself "
United States
Walana
The price is NT$4,581
NT$5,039 total
includes taxes & fees
May 5 - May 6
Hotel Riu Plaza Panama

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este, 10.2 km from Santa Ana
9.4 out of 10, Exceptional, (268 reviews)
"The stay was wonderful and seamless they are very friendly and efficient as always"
United States
Clifford
The price is NT$3,786
NT$4,165 total
includes taxes & fees
Apr 23 - Apr 24
Arcadia Condo Suites

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
14.7 km from Santa Ana
9.0 out of 10, Wonderful, (1,005 reviews)
"Staff and facilities excellent. "
United States
August H.
The price is NT$3,196
NT$3,515 total
includes taxes & fees
May 12 - May 13
Courtyard by Marriott Panama Metromall

Hotel Pension Corona

Hotel Pension Corona
2.5 star property
Calidonia, 1.8 km from Santa Ana
7.8 out of 10, Good, (118 reviews)
"Great spot for the price "
United States
frank
The price is NT$621
NT$682 total
includes taxes & fees
Apr 19 - Apr 20
Hotel Pension Corona

Residencial & Hotel Palazzo

Residencial & Hotel Palazzo
3.0 star property
Calidonia, 1.4 km from Santa Ana
7.4 out of 10, Good, (132 reviews)
"One of the staff members were always there for me, his name is Willy. Willy helped me park my rental car, helped me find food and brought it to my room, helped me carry my luggage and he made me feel like home. He even helped me find a taxi cab at night when I didn't want to drive. My bed sheets were always cleaned when I returned to my room at night, I also had cleaned towels and I liked the location, right in the heart of Panama. Good AC and hot water. "
United States
Robert
The price is NT$1,084
NT$1,193 total
includes taxes & fees
May 18 - May 19
Residencial & Hotel Palazzo

Canova

Canova
3.0 star property
Calidonia, 1.4 km from Santa Ana
8.2 out of 10, Very Good, (156 reviews)
"Plenty of shops nearby , decent area. The staff was pretty nice . "
United States
Lazaria
The price is NT$912
NT$1,003 total
includes taxes & fees
May 17 - May 18
Canova

Hotel Marparaiso

Hotel Marparaiso
3.0 star property
Calidonia, 1.7 km from Santa Ana
7.8 out of 10, Good, (173 reviews)
"I love the hotel and ever thing about it ,location transport, safe around the hotle ."
United States
Andres
The price is NT$1,149
NT$1,264 total
includes taxes & fees
Apr 19 - Apr 20
Hotel Marparaiso
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas, sun loungers
Casco View Apartments
3.5 star property
9.0
Wonderful
88 reviews
View
Bar (on property)
Hostal La Cigarra
2.0 star property
7.6
Good
69 reviews
View
Apartment (20) | Iron/ironing board, free WiFi, bed sheets
La Manzana by Wynwood House
3.0 star property
7.2
Good
15 reviews
View
Double Room | View from room
Hotel República
2.0 star property
6.6
189 reviews
View
Front of property
ART CASCO The Hotel
2.0 star property
6.0
11 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

San Felipe

If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighborhood that travelers like for its seafood restaurants, shopping, and parks. Are you looking for Santa Ana travel tips? Be sure to check out Avenida Balboa and El Machetazo Santa Ana while you're in the neighborhood.
Where is the best hotel for a stay in Santa Ana?
Based on our traveler data, Casco View Apartments is one of the top choices for your stay in Santa Ana. This condo is a short 8-minute walk from Avenida Balboa, and it offers an outdoor pool and in-room kitchens.
How many hotels can I expect to find in Santa Ana?
Expedia has 93 hotels and other accommodations in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! Most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Add dates, click "Search", then use the "fully refundable" filter to get top deals in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about picking new dates or cancelling your trip to Santa Ana, head over to our customer service page.
What is there to do in this Panama City neighborhood?
If you're looking forward to a day of shopping in Santa Ana, consider El Machetazo Santa Ana or Avenida Balboa, and pick out the perfect souvenir. When you're sightseeing in Panama City, Albrook Shopping Mall and Avenida Central are also worth a stop.