Find Resorts & Hotels with Spas in Otay Ranch, CA

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Our top choices for Otay Ranch hotels with a spa

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay
8.4 out of 10, Very Good, (1587)
"Totally Recommend! Rooms are really clean and comfortable, the staff are great as well. "
United States
Fernando
The price is NT$4,055
NT$6,324 total
includes taxes & fees
Jan 3 - 2026/1/4
Hyatt Regency Mission Bay Spa and Marina

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
El Cajon
9.2 out of 10, Wonderful, (1655)
"Very nice getaway for the family "
United States
Richard
Sycuan Casino Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay
8.4 out of 10, Very Good, (1318)
"Room was super clean and updated, location up against the bay was perfect. We really enjoyed our stay and want to come back soon!"
United States
Haley
The price is NT$4,309
NT$6,613 total
includes taxes & fees
Jan 4 - 2026/1/5
San Diego Mission Bay Resort

Loews Coronado Bay Resort

Loews Coronado Bay Resort
4.0 star property
Silver Strand
8.8 out of 10, Excellent, (1065)
"Clean room, gorgeous grounds, very friendly staff "
United States
Taryn
The price is NT$6,249
NT$8,470 total
includes taxes & fees
Jan 4 - 2026/1/5
Loews Coronado Bay Resort

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
Point Loma
8.8 out of 10, Excellent, (1559)
"Staff was great, easy check in and great location"
United States
Alysa
The price is NT$3,722
NT$4,278 total
includes taxes & fees
Jan 12 - 2026/1/13
Best Western Plus Island Palms Hotel & Marina

Viejas Casino & Willows Hotel

Viejas Casino & Willows Hotel
4.0 star property
Alpine
9.2 out of 10, Wonderful, (1004)
"Clean room, friendly staff."
United States
SERGIO
The price is NT$3,873
NT$4,828 total
includes taxes & fees
Jan 5 - 2026/1/6
Viejas Casino & Willows Hotel

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1904)
"Enjoyed my stay"
United States
Brandon
The price is NT$3,825
NT$5,975 total
includes taxes & fees
Jan 4 - 2026/1/5
Hilton San Diego Bayfront

Paradise Point Resort & Spa

Paradise Point Resort & Spa
4.0 star property
Mission Bay
8.6 out of 10, Excellent, (2361)
"A very unexpected surprise place for vacation! We truly enjoyed the resort, it reminds us of Hawaii! Just a great place and we highly recommend it!"
United States
Ralitza
The price is NT$4,062
NT$6,331 total
includes taxes & fees
Jan 18 - 2026/1/19
Paradise Point Resort & Spa

Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
4.0 star property
Mission Valley
9.2 out of 10, Wonderful, (2946)
"Great boutique hotel!!"
United States
Maksim
Legacy Resort Hotel & Spa

Coronado Island Marriott Resort & Spa

Coronado Island Marriott Resort & Spa
4.0 star property
Bayside
8.4 out of 10, Very Good, (1003)
"Great location. Very friendly staff and clean facilities. Plenty to do within walking distance "
United States
Elizabeth
The price is NT$7,734
NT$10,374 total
includes taxes & fees
Jan 30 - 2026/1/31
Coronado Island Marriott Resort & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Otay Ranch

Top Otay Ranch attractions for a relaxing vacation

In Otay Ranch, travelers seeking a spa hotel experience can enjoy a blend of relaxation and adventure. Start your day with a serene stroll through the Otay Ranch Town Center, where you can explore upscale shops and grab a gourmet coffee before indulging in a spa treatment. For a family-friendly outing, head to the nearby Aquatica San Diego, where thrilling water rides and lazy rivers provide an exhilarating escape, perfect for unwinding after a day of pampering. Nature enthusiasts can visit the scenic Otay Valley Regional Park, offering picturesque trails ideal for hiking or biking, followed by a rejuvenating afternoon at a local spa. Art lovers can appreciate the vibrant murals and local galleries in the area, adding a cultural touch to your stay. When it comes to accommodations, hotels in Otay Ranch feature luxurious amenities, from spacious suites to on-site spas offering personalized treatments designed to pamper both body and mind. Imagine relaxing in a hot stone massage after a day of exploring, all while enjoying attentive service that makes you feel valued and cared for. With great dining options nearby, you can easily savor delicious meals before retreating back to your tranquil hotel sanctuary.

Top Otay Ranch Hotel Reviews

Frequently asked questions

Looking to vacation at a spa hotel in Otay Ranch?
Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Spa hotels are a great way to break out of your daily routine and add a layer of luxury to your holiday.
What's there to see and do in Otay Ranch?
Take in some sights and attractions while you're in Otay Ranch by visiting Otay Ranch Town Center, San Diego Zoo, and San Ysidro Border Crossing. If you have extra time while you're in the area, you might want to stop by Petco Park and Port of San Diego.
What is a Otay Ranch spa hotel?
Spa hotels in Otay Ranch feature full on-site spas offering services like therapies and a choice of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.

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