Find hotels in Illinois Medical District, Chicago

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Our top choices for Illinois Medical District hotels

Hampton Inn & Suites Chicago Medical District UIC

Hampton Inn & Suites Chicago Medical District UIC
2.5 star property
Illinois Medical District
9.6 out of 10, Exceptional, (378)
"Beautiful rooms, great breakfast and amazing customer service! "
United States
Keana
The price is NT$2,786
NT$3,271 total
includes taxes & fees
Dec 29 - Dec 30
Hampton Inn & Suites Chicago Medical District UIC

Hyatt House Chicago Medical/University District

Hyatt House Chicago Medical/University District
3.5 star property
Illinois Medical District
9.0 out of 10, Wonderful, (1272)
"Clean room, nice staff, great location "
United States
Kati
The price is NT$2,935
NT$3,446 total
includes taxes & fees
Dec 29 - Dec 30
Hyatt House Chicago Medical/University District

Hyatt Place Chicago Medical/University District

Hyatt Place Chicago Medical/University District
3.0 star property
Illinois Medical District
9.0 out of 10, Wonderful, (1428)
"We have stayed here many times. The staff are very pleasant and accommodating and the rooms are perfect.we also enjoyed a good drink and snack in the hotel bar."
United States
Margaret
The price is NT$2,777
NT$3,260 total
includes taxes & fees
Dec 29 - Dec 30
Hyatt Place Chicago Medical/University District

Freehand Chicago

Freehand Chicago
4.0 star property
River North, 4.7 km from Illinois Medical District
8.0 out of 10, Very Good, (2655)
"It's an excellent place."
United States
Jose
The price is NT$1,846
NT$2,723 total
includes taxes & fees
Jan 4 - 2026/1/5
Freehand Chicago

Aloft Chicago Mag Mile

Aloft Chicago Mag Mile
3.0 star property
Streeterville, 5.2 km from Illinois Medical District
8.6 out of 10, Excellent, (2975)
"Great place to stay"
United States
Elisha
The price is NT$2,714
NT$3,186 total
includes taxes & fees
Jan 6 - 2026/1/7
Aloft Chicago Mag Mile

Club Quarters Hotel Wacker at Michigan, Chicago

Club Quarters Hotel Wacker at Michigan, Chicago
4.0 star property
The Loop, 4.6 km from Illinois Medical District
8.8 out of 10, Excellent, (2006)
"Great stay"
United States
Kramer
The price is NT$2,625
NT$3,081 total
includes taxes & fees
Dec 23 - Dec 24
Club Quarters Hotel Wacker at Michigan, Chicago

Sable at Navy Pier Chicago, Curio Collection by Hilton

Sable at Navy Pier Chicago, Curio Collection by Hilton
4.0 star property
Streeterville, 6.4 km from Illinois Medical District
9.4 out of 10, Exceptional, (2284)
"Great staff and restaurants!!"
United States
Abigale
The price is NT$2,698
NT$4,242 total
includes taxes & fees
Jan 20 - 2026/1/21
Sable at Navy Pier Chicago, Curio Collection by Hilton

Hyatt Centric Chicago Magnificent Mile

Hyatt Centric Chicago Magnificent Mile
4.0 star property
Streeterville, 5.1 km from Illinois Medical District
9.0 out of 10, Wonderful, (1059)
"Perfect location to surrounding area and activities, friendly staff, clean rooms, amazing gym, and delicious food."
United States
Hannah
The price is NT$3,093
NT$4,557 total
includes taxes & fees
Jan 2 - 2026/1/3
Hyatt Centric Chicago Magnificent Mile

Warwick Allerton - Chicago

Warwick Allerton - Chicago
4.0 star property
Magnificent Mile, 5.1 km from Illinois Medical District
8.4 out of 10, Very Good, (3018)
"Enjoyed this hotel stay. "
United States
Kimberly
The price is NT$2,020
NT$3,298 total
includes taxes & fees
Dec 28 - Dec 29
Warwick Allerton - Chicago

Hilton Chicago

Hilton Chicago
4.0 star property
The Loop, 4.2 km from Illinois Medical District
8.4 out of 10, Very Good, (2413)
"The room was clean and the staff was outstanding. "
United States
Albert
The price is NT$3,597
NT$5,149 total
includes taxes & fees
Dec 29 - Dec 30
Hilton Chicago

Congress Plaza Hotel

Congress Plaza Hotel
3.5 star property
The Loop, 4.2 km from Illinois Medical District
8.0 out of 10, Very Good, (9690)
"Wonderful stay!"
United States
Zach
The price is NT$6,505
NT$7,636 total
includes taxes & fees
Dec 31 - 2026/1/1
Congress Plaza Hotel

L7 Chicago by LOTTE

L7 Chicago by LOTTE
4.5 star property
Theatre District, 4.5 km from Illinois Medical District
9.6 out of 10, Exceptional, (3422)
"Enjoyed my stay"
United States
Karen
The price is NT$3,664
NT$4,302 total
includes taxes & fees
Dec 25 - Dec 26
L7 Chicago by LOTTE

Embassy Suites by Hilton Chicago Downtown Magnificent Mile

Embassy Suites by Hilton Chicago Downtown Magnificent Mile
4.0 star property
Streeterville, 5.2 km from Illinois Medical District
8.2 out of 10, Very Good, (2757)
"Excellent place to stay "
United States
Teniesha
The price is NT$2,472
NT$3,828 total
includes taxes & fees
Jan 11 - 2026/1/12
Embassy Suites by Hilton Chicago Downtown Magnificent Mile

The Whitehall Hotel, BW Premier Collection

The Whitehall Hotel, BW Premier Collection
3.5 star property
Streeterville, 5.3 km from Illinois Medical District
8.2 out of 10, Very Good, (3816)
"Clean room, good location, friendly staff"
United States
Zacharias
The price is NT$2,416
NT$2,836 total
includes taxes & fees
Jan 5 - 2026/1/6
The Whitehall Hotel, BW Premier Collection

DoubleTree by Hilton Chicago - Magnificent Mile

DoubleTree by Hilton Chicago - Magnificent Mile
4.0 star property
Streeterville, 5.2 km from Illinois Medical District
8.8 out of 10, Excellent, (2204)
"Very friendly staff, clean rooms, the location is amazing and near of everything "
United States
Sarwat
The price is NT$2,821
NT$3,312 total
includes taxes & fees
Jan 4 - 2026/1/5
DoubleTree by Hilton Chicago - Magnificent Mile

River Hotel

River Hotel
4.0 star property
The Loop, 4.6 km from Illinois Medical District
8.8 out of 10, Excellent, (4861)
"Great location, comfortable room, and nice staff."
United States
Claudia
The price is NT$2,625
NT$3,081 total
includes taxes & fees
Dec 23 - Dec 24
River Hotel

Hyatt Regency Chicago

Hyatt Regency Chicago
4.0 star property
The Loop, 4.8 km from Illinois Medical District
9.4 out of 10, Exceptional, (3411)
"The Hotel was amazing great location "
United States
Donnisha
The price is NT$4,387
NT$6,076 total
includes taxes & fees
Jan 5 - 2026/1/6
Hyatt Regency Chicago

LondonHouse Chicago, Curio Collection by Hilton

LondonHouse Chicago, Curio Collection by Hilton
4.5 star property
The Loop, 4.6 km from Illinois Medical District
9.4 out of 10, Exceptional, (3468)
"Great hotel! "
United States
Kianna
The price is NT$4,115
NT$4,831 total
includes taxes & fees
Jan 4 - 2026/1/5
LondonHouse Chicago, Curio Collection by Hilton

Cambria Hotel Chicago Loop - Theatre District

Cambria Hotel Chicago Loop - Theatre District
4.0 star property
Theatre District, 4.2 km from Illinois Medical District
8.8 out of 10, Excellent, (1466)
"The staff was super friendly at check-in and the bartender was very nice!"
United States
Jennifer
The price is NT$2,775
NT$3,257 total
includes taxes & fees
Jan 4 - 2026/1/5
Cambria Hotel Chicago Loop - Theatre District

Eurostars Magnificent Mile

Eurostars Magnificent Mile
4.0 star property
River North, 4.8 km from Illinois Medical District
9.0 out of 10, Wonderful, (3171)
"Amazing stay very clean and beautiful views "
United States
Deigo
The price is NT$2,954
NT$3,468 total
includes taxes & fees
Jan 22 - 2026/1/23
Eurostars Magnificent Mile
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Illinois Medical District

Find the best Illinois Medical District areas and neighborhoods for the activities you enjoy most.

Downtown Chicago

The heart of the Midwest’s glittering metropolis has many offerings, from shopping and dining to parks, museums and exciting contemporary public art.

Magnificent Mile

Upscale shopping district with luxury department stores, boutiques, and acclaimed restaurants, featuring landmarks like the Wrigley Building and Chicago Water Tower. The Magnificent Mile is easily accessible by public transit and seasonal trolley service.

The Loop

Chicago's central business district boasts numerous global businesses, retail establishments, and theaters. Explore the Loop Retail Historic District, Chicago Landmark Historic Michigan Boulevard District, and visit iconic attractions like the Art Institute of Chicago.

River North

Artistic spirit thrives here, with art galleries and a design district featuring luxury interior furnishings. Explore Kingsbury Park, enjoy vibrant nightlife on Hubbard Street, and visit the iconic Contemporaine Building.

Theatre District

While you're in Theatre District, take in top sights like Michigan Avenue or State Street, and hop on the metro to see more the city at Washington Station or Monroe Station (Blue Line).

Top Illinois Medical District Hotel Reviews

Frequently asked questions

What's it like in Illinois Medical District?
Guests are sure to enjoy their time checking out all that Chicago's Illinois Medical District neighborhood has to offer.
Where is the best place to stay in Illinois Medical District?
Based on Expedia customer reviews, Hampton Inn & Suites Chicago Medical District UIC is the highest ranked property in Illinois Medical District. This hotel is a short 15-minute walk from United Center, and it offers free breakfast and an indoor pool. Other top choices in the neighborhood include Hyatt House Chicago Medical/University District and Hyatt Place Chicago Medical/University District.
How many hotels are there in the Illinois Medical District area?
If you're searching for places to stay in Chicago, choose from one of Expedia's 11 hotels and other accommodations in Illinois Medical District.
If I need to cancel my hotel reservation in Illinois Medical District, will I receive a refund?
Yes! Most hotel reservations are refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best options available in Illinois Medical District.
Where can I learn more about changing or cancelling my trip to Illinois Medical District?
To access more information about changing or cancelling your trip to Illinois Medical District, head over to our customer service page.
What can I see and do in this Chicago neighborhood?
Don't miss favorite places to visit in the surrounding area, such as Michigan Avenue, United Center, and Soldier Field. Michael Jordan Statue and National Museum of Mexican Art are also worth a visit when you're out sightseeing in Chicago.
How can I get around Illinois Medical District and the greater Chicago area?
Ready to get out and explore the city? Polk Station (Pink Line) is the closest metro station.

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