Find All South Carolina Midlands Hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Find All South Carolina Midlands Hotels
We have found 3135 South Carolina Midlands Hotels
- Fairfield Inn & Suites by Marriott Santee
- TownePlace Suites Columbia West/Lexington
- SpringHill Suites by Marriott Orangeburg
- Home2 Suites by Hilton Columbia Downtown
- Comfort Inn Fort Mill Amusement Park at Carowinds Blvd
- Courtyard by Marriott Ballantyne
- Clarion Inn Columbia Airport
- Woodspring Suites Sumter Near Shaw Afb
- Comfort Suites Florence I-95
- Home2 Suites by Hilton Fort Mill, SC
- Comfort Suites Rock Hill Manchester Meadows Area
- Comfort Inn & Suites Santee
- Homewood Suites By Hilton Columbia Downtown
- Home2 Suites by Hilton Rock Hill
- Hawthorn Extended Stay By Wyndham Columbia / Ft. Jackson
- Sleep Inn Fort Mill near Carowinds Blvd
- Sleep Inn & Suites
- Quality Inn & Suites Lexington
- Courtyard by Marriott Columbia Cayce
- SpringHill Suites by Marriott Florence
- Hilton Garden Inn Columbia Downtown, SC
- Fairfield Inn & Suites by Marriott Columbia Downtown
- Hyatt Place Sumter / Downtown
- Hampton Inn & Suites Lexington Columbia
- Red Roof Inn Dillon, SC
- Hilton Garden Inn Rock Hill
- Fairfield Inn by Marriott Hartsville
- Holiday Inn & Suites Columbia NE - Ft Jackson Area by IHG
- Aloft Florence
- Holiday Inn Rock Hill by IHG
- Baymont by Wyndham Columbia Northwest
- Home2 Suites by Hilton Columbia Harbison
- TRU BY Hilton North Augusta
- Quality Inn West Columbia - Cayce
- Holiday Inn Express & Suites Latta by IHG
- Courtyard by Marriott Charlotte Fort Mill, SC
- Hampton Inn Columbia-I-26 Airport
- Spark by Hilton Rock Hill
- Best Western Executive Inn
- Tru By Hilton Fort Mill, SC
- Extended Stay America Suites Rock Hill
- Best Western Plus Santee Inn
- Lexington Expo Hotel by IHG
- Sleep Inn Near Ft Jackson
- Tru by Hilton Sumter
- Hampton Inn & Suites Orangeburg
- Staybridge Suites Columbia by IHG
- Comfort Inn & Suites Orangeburg
- Courtyard by Marriott Florence
- Residence Inn Columbia West/Lexington
- Super 8 by Wyndham Columbia SC / Ft. Jackson
- Delta Hotels by Marriott Columbia Northeast
- Howard Johnson by Wyndham Rock Hill
- Super 8 by Wyndham Harbison/Parkridge Hospital
- Fairfield Inn by Marriott Orangeburg
- Holiday Inn Express & Suites Newberry by IHG
- Comfort Inn Columbia West
- Holiday Inn Santee by IHG
- Clarion Inn & Suites Florence - Darlington
- Quality Inn & Suites Ft. Jackson Maingate
- Fairfield Inn & Suites by Marriott Florence I-20
- Days Inn by Wyndham Dillon
- Courtyard by Marriott Rock Hill
- Springhill Suites by Marriott Cheraw
- Holiday Inn Express Hotel & Suites Camden-I20 (Hwy 521) by IHG
- Travelodge by Wyndham Orangeburg
- Carriage House Inn
- Comfort Inn Blythewood - North Columbia
- Hampton Inn Manning
- Hotel Florence, Tapestry Collection by Hilton
- Clarion Inn & Suites Aiken South
- Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area
- Hampton Inn & Suites Fort Mill
- Holiday Inn Express & Suites Aiken by IHG
- Baymont by Wyndham Orangeburg North
- Best Western Inn
- Fairfield Inn & Suites by Marriott Aiken
- Homewood Suites by Hilton Florence
- WoodSpring Suites Fort Mill
- Super 8 by Wyndham Lancaster
- Red Roof Inn Florence - Civic Center
- Hampton Inn Newberry-Opera House
- Spark by Hilton Florence North I-95, SC
- Fairfield by Marriott Inn & Suites Columbia Harbison
- Holiday Inn Express Hotel & Suites Blythewood by IHG
- Super 8 by Wyndham, Orangeburg
- Gallus Stadium Park Inn, an Ascend Collection Hotel
- Super 8 by Wyndham Florence
- avid Hotel Fort Mill - Carowinds Blvd by IHG
- Red Roof Inn Rock Hill
- Holiday Inn Express Sumter by IHG
- Quality Inn & Suites
- Hampton Inn Columbia I-20-Clemson Road
- Motel 6 Rock Hill, SC
- Sleep Inn Florence North
- Homewood Suites by Hilton Columbia
- Colony Inn
- Quality Inn at the Park
- Affordable Suites Florence
Let Expedia take you to the best Hotels in South Carolina Midlands. You'll find the largest selection of hotel deals, discount prices, and cheap hotel rates on reservations anywhere in the world. Expedia, the leader in world travel, gives you customer reviews, maps, and the best selection of hotels near landmarks and attractions.