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Find Business Hotels in Southwest Illinois, IL

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Check availability on Southwest Illinois Business Hotels

Tonight
Dec 30 - Dec 31
Tomorrow
Dec 31 - Jan 1
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Our top choices for Southwest Illinois business-friendly hotels

Lobby
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1602)
"Clean nice people great place to stay"
United States
John
The price is NT$2,952
NT$3,339 total
includes taxes & fees
Jan 4 - 2026/1/5
Drury Plaza Hotel Mt. Vernon
Exterior
Drury Inn & Suites Marion

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1011)
"Very nice hotel! Friendly staff and great amenities. We will definitely stay again during our travels. "
United States
Renee
The price is NT$2,041
NT$2,449 total
includes taxes & fees
Jan 8 - 2026/1/9
Drury Inn & Suites Marion
Free daily buffet breakfast
Holiday Inn Express & Suites Mount Vernon by IHG

Holiday Inn Express & Suites Mount Vernon by IHG

Holiday Inn Express & Suites Mount Vernon by IHG
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1005)
"Clean room, kind staff. Breakfast was good. "
United States
Kathryn
The price is NT$3,109
NT$3,513 total
includes taxes & fees
Jan 4 - 2026/1/5
Holiday Inn Express & Suites Mount Vernon by IHG
Terrace/patio
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1007)
"It's great for travelers!"
United States
Kerry
The price is NT$3,413
NT$3,850 total
includes taxes & fees
Dec 31 - 2026/1/1
Comfort Suites Mount Vernon
Room, 1 Queen Bed, Accessible, Non Smoking | Desk, blackout drapes, iron/ironing board, free cribs/infant beds
Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL
2.5 star property
Mount Vernon
7.8 out of 10, Good, (1004)
"reception was great, room clean, and the price was right."
United States
tom
The price is NT$1,978
NT$2,259 total
includes taxes & fees
Jan 13 - 2026/1/14
Super 8 by Wyndham Mt. Vernon IL
Lobby
SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (914)
"Great place to stay."
United States
Stephen
The price is NT$2,261
NT$2,509 total
includes taxes & fees
Jan 6 - 2026/1/7
SureStay Hotel by Best Western Whittington Rend Lake
Reception
Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites
2.5 star property
Centralia
9.6 out of 10, Exceptional, (608)
"Very beautiful place to stay "
United States
Valerie
The price is NT$3,787
NT$4,241 total
includes taxes & fees
Jan 11 - 2026/1/12
Best Western Plus Centralia Hotel & Suites
Exterior
Holiday Inn Carbondale-Conference Center by IHG

Holiday Inn Carbondale-Conference Center by IHG

Holiday Inn Carbondale-Conference Center by IHG
3.0 star property
Carbondale
8.8 out of 10, Excellent, (647)
"nice stay! "
United States
James
The price is NT$3,580
NT$4,116 total
includes taxes & fees
Jan 28 - 2026/1/29
Holiday Inn Carbondale-Conference Center by IHG
Seasonal outdoor pool, pool umbrellas, sun loungers
Quality Inn & Suites Vandalia near I-70 and Hwy 51

Quality Inn & Suites Vandalia near I-70 and Hwy 51

Quality Inn & Suites Vandalia near I-70 and Hwy 51
2.5 star property
Vandalia
8.4 out of 10, Very Good, (1003)
"Awesome place to stay. Clean room, comfortable bed, amenities were accommodating, plenty of restaurants near by to choose from, and near the highway."
United States
Evelyn
The price is NT$2,073
NT$2,259 total
includes taxes & fees
Jan 4 - 2026/1/5
Quality Inn & Suites Vandalia near I-70 and Hwy 51
Lobby sitting area
Baymont by Wyndham Marion

Baymont by Wyndham Marion

Baymont by Wyndham Marion
2.5 star property
Marion
8.4 out of 10, Very Good, (1082)
"This place was nice for the money and our 1 night stay. "
United States
Charles
The price is NT$2,387
NT$2,864 total
includes taxes & fees
Jan 18 - 2026/1/19
Baymont by Wyndham Marion
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southwest Illinois Hotel Reviews

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

10/10 Excellent
"This comfort inn is great. We always stay here. Clean updated rooms. Eco friendly with individually wrapped bar soap exception. Great breakfast. Friendly staff. Close to highway for easy on/off for trip ease."
Georgia 1-night trip
Posted 4 hours ago
Comfort Suites Mount Vernon

Frequently asked questions

How much do business-friendly hotels in Southwest Illinois cost?
You'll pay between NT$2,259 and NT$4,241 per night for business-friendly hotels in Southwest Illinois. Top deals on stays that cater to work-related travelers are only a click away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southwest Illinois?
There are multiple business-friendly hotels in Southwest Illinois with a total average guest review rating of 8.7, so you're sure to discover the perfect place. On your way to O'Fallon? Drury Inn & Suites St. Louis O'Fallon, IL is a top pick with corporate travelers. This 3-stars option has amenities like a swimming pool and WiFi. Hampton Inn O'Fallon also scores top marks from business guests. Take advantage of a swimming pool and an electric car charging station at this 2.5-stars escape in O'Fallon.
How many business-friendly hotels are there in Southwest Illinois?
Southwest Illinois has 105 business-friendly hotels to choose from. Whether you're attending a conference or meeting or simply working remotely, these properties are equipped with the amenities you need to keep you comfortable and productive.
What are the best cheap business-friendly hotels in Southwest Illinois?
When you need to make and close deals on the go in Southwest Illinois, Expedia will help you find the perfect business-friendly hotel. Hampton Inn O'Fallon is a popular budget option in O'Fallon. An electric car charging station and a swimming pool are among its many amenities. In search of low-cost stays in Marion? Comfort Inn & Suites Marion I-57 is recommended by many corporate guests. It comes with conveniences that make it easy to both work and relax, including pool sun loungers and a swimming pool. Business-friendly hotels in Southwest Illinois start at just NT$2,259 a night. Like to sightsee around Southwest Illinois without the high admission prices? Take a break from your work commitments to visit awesome free attractions like St. Clair Bowl in O'Fallon. Marion also has many things to do that don't cost a penny, including Williamson County Historical Museum. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Southwest Illinois that are also business friendly?
If you're traveling for business in Southwest Illinois and bringing family along with you, Expedia will help you locate a cozy and convenient stay. Drury Inn & Suites St. Louis O'Fallon, IL in O'Fallon is the perfect option for those combining work and pleasure. This 3-stars property comes with all the necessary amenities, like complimentary breakfast and a laundry service. Drury Inn & Suites St. Louis Fairview Heights is another terrific choice in O'Fallon. Get the best of both worlds — combine corporate travel and quality time with your family at this 3-stars property. Complimentary breakfast and WiFi are among the conveniences you'll find here. Once you've gotten work out of the way, get out and see O'Fallon with the kids. Popular family-friendly attractions include The Edge and St. Clair Bowl.
Why book your business-friendly hotel in Southwest Illinois with Expedia?
At Expedia, our top task is to help you land the ideal stay at the right price. From upmarket, corporate-friendly properties to affordable motels filled with all the amenities you need, you'll have your next work trip arranged in a few simple clicks.
How can I find cheap business-friendly hotels in Southwest Illinois?
When work takes you to Southwest Illinois, our "business friendly" filter will help you find a suitable hotel. From fast WiFi to meeting rooms and workspaces, they come with the amenities you need for a comfortable and productive stay. Another tip? Narrow your search by your budget and preferred star rating to see the cheapest accommodations.
What is there to do in Southwest Illinois near my business-friendly hotel?
Wherever your travels take you in Southwest Illinois, there's plenty to keep you busy. Staying a few days in O'Fallon? The Edge is a top attraction to include on your itinerary.

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