Our top choices for Northeast Missouri hotels

Club Suite, 1 King Bed, Hot Tub | Private spa tub

Pinemark Inn & Suites

St. Clair

Alicia

NT$4,742 total

includes taxes & fees

Apr 5 - Apr 6

Depot Inn and Suites

La Plata

Marlin

NT$3,110 total

includes taxes & fees

Mar 29 - Mar 30

Super 8 by Wyndham Washington

Washington

Brenda

NT$3,002 total

includes taxes & fees

Mar 26 - Mar 27

Sleep Inn & Suites Hannibal West

Hannibal

Elizabeth

NT$4,046 total

includes taxes & fees

Apr 12 - Apr 13

Best Western Plus Washington Hotel

Washington

Shane

NT$4,677 total

includes taxes & fees

Mar 22 - Mar 23

Desk, iron/ironing board, WiFi, bed sheets

Best Western On The River

Hannibal

Steven

NT$3,694 total

includes taxes & fees

Mar 22 - Mar 23

Quality Inn & Suites Hannibal West

Hannibal

Wendy

NT$2,816 total

includes taxes & fees

Mar 26 - Mar 27

Heritage Hotel Quincy

Quincy

Miguel

NT$2,544 total

includes taxes & fees

Mar 20 - Mar 21

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Wentzville

Jason

NT$5,123 total

includes taxes & fees

Mar 22 - Mar 23

Comfort Suites St Charles - St Louis

St. Charles

Elizabeth

NT$3,391 total

includes taxes & fees

Mar 29 - Mar 30

Super 8 by Wyndham Kirksville-University Area

Kirksville

Brenda

NT$2,254 total

includes taxes & fees

Apr 2 - Apr 3

Stoney Creek Inn Quincy

Quincy

Heather

Super 8 by Wyndham Union

Union

Frances

NT$2,818 total

includes taxes & fees

Apr 5 - Apr 6

Country Inn & Suites by Radisson, St. Charles Historic District

St. Charles Historic District

Jean

NT$4,785 total

includes taxes & fees

Apr 19 - Apr 20

Hampton Inn St. Louis Wentzville

Wentzville

Rachel

NT$4,345 total

includes taxes & fees

Apr 5 - Apr 6

Drury Inn & Suites St. Louis St. Peters

St. Peters

Roxanne

NT$4,027 total

includes taxes & fees

Mar 29 - Mar 30

Quality Inn Kirksville

Kirksville

Don

NT$2,289 total

includes taxes & fees

Apr 1 - Apr 2

Ameristar Casino Resort and Spa

St. Charles

Mary

NT$7,530 total

includes taxes & fees

Mar 23 - Mar 24

Holiday Inn Express & Suites St Peters by IHG

St. Peters

Margaret

NT$4,258 total

includes taxes & fees

Mar 29 - Mar 30

Comfort Inn Near Six Flags St. Louis

Pacific

Jean

NT$3,452 total

includes taxes & fees

Apr 6 - Apr 7

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Vacation Rentals in Northeast Missouri

Cabin

Cannon Dam Cabins

Perry

"management great, cabins very comfortable and roomy, good location"

Apartment

Walk to Carondelet Park: Quiet Couple's Getaway

Carondelet

"We had a nice stay, close to things we wanted to do"

Cottage

Walk to Tower Grove Park: St Louis Getaway

Tower Grove South

"Great house, perfect location, comfortable amenities. "

Cottage

Hillside Cabin on 43 Acres w/ Private Lake & View!

Defiance

"We had a wonderful stay. The property is beautiful and well maintained, and the cabin is cute, comfortable, and well equipped. Nick is a very courteous host. We couldn’t have hoped for a better Thanksgiving getaway!"

Apartment

Lovely Couples Escape on Mississippi River!

St. Charles

"Amazing place to stay, quiet and relaxing would definitely stay there again"

Apartment

Charming Berger Apt on 42-acre Farm w/ Pool Access

Berger

Apartment

'the Ruebling House' Historic Defiance Apartment!

Defiance

"This was are first family Vacation and are stay was amazing nice and clean with plenty of space. I would definitely recommend to a friend."

Cottage

'hidden Paradise' on 5 Acres w/ Hot Tub & Deck!

Florissant

"Beautiful well kept secret in a very peaceful setting: we had a large family Thanksgiving week in this beautiful place. There was more than enough rooms for four families to come together and still have enough room for dining visitors. It is beyond well equipped and you should contact the owner before you bring unnecessary items. Great hot tub. Spacious and well equipped baths and showers with all personal supplies and plush towels. Beds were all amazing. There is a great playroom...

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Stay near popular Central United States attractions

Busch Stadium

4.6/5 (2,624 reviews)

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed theater scene or attend a baseball game.

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Enterprise Center

4.3/5 (835 reviews)

Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's great live music or attend a baseball game.

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Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Union Station to Enterprise Center—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri

Grant\'s Farm which includes heritage architecture

Top Northeast Missouri Hotel Reviews

River City Casino & Hotel

10/10 Excellent

"Great front desk assistance and nice facility with some non-smoking areas!"

Clayton Plaza Hotel & Extended Stay

6/10 Okay

"Nice location and friendly staff, beautiful lobby. Our room had drywall missing on some corners, and the shower was kind of gross. Bathroom had some cool features like a vanity mirror with a ring light and you could control the water temperature to the degree using a touchscreen (???) but I didn’t feel comfortable because of how obviously dirty it was."

Hilton St. Louis Airport

4/10 Poor

"The conference rooms had terrible temperature control, we were either sweating or freezing. The beds were too soft, & the pillows were terrible it was hard to sleep. The shower that I took at the property was nothing but cold water for the entire 20 minutes. I would not recommend this hotel to anyone. The only good thing was the staff. Friendly, outgoing and helpful at every turn "

Pear Tree Inn St. Louis Near Union Station

10/10 Excellent

"I've stayed at a lot of hotels and very few had fresh towels in the pool no matter what time we were there. This hotel had towels at all hours which was a blessing as our kids wanted to swim at the start, Middle and end of the day. The afternoon popcorn and evening drinks were a pleasant surprise too. Great hotel in downtown St Louis! "

Drury Inn & Suites St. Louis Union Station

8/10 Good

"The location of the hotel is a great location for attending events at the Enterprise Center. The foods offered for the evening and the breakfast foods were good. We liked the room; it was a good size. The thing that we did not like was the hotel is older and the charging options aren't as good. We were in room 303 and neither plug-in on the lamp in between the beds did not work at all."