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Our top choices for Northeast Missouri hotels

A bedroom with a four-poster bed, a bedside table with a lamp, a desk with a telephone, and a bathroom with a bathtub and a hanging plant.

1. Depot Inn and Suites

La Plata

JERROD

NT$3,425 total

includes taxes & fees

Nov 8 - Nov 9

A modern dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and a patterned wall decoration.

2. Holiday Inn Express & Suites Kirksville - University Area by IHG

Kirksville

Jimmy

NT$4,101 total

includes taxes & fees

Nov 30 - Dec 1

A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.

3. Sleep Inn & Suites Hannibal West

Hannibal

ELAINE

NT$3,857 total

includes taxes & fees

Nov 25 - Nov 26

A bathroom with a large bathtub, a chair, and a small shelf with plants.

4. Pinemark Inn & Suites

St. Clair

Michael

NT$4,797 total

includes taxes & fees

Nov 3 - Nov 4

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

5. Best Western On The River

Hannibal

Rob

NT$3,797 total

includes taxes & fees

Nov 9 - Nov 10

A Comfort Inn hotel with a modern design, featuring a covered entrance and a clear sky in the background.

6. Comfort Inn Sullivan

Sullivan

Sammy

NT$4,046 total

includes taxes & fees

Nov 22 - Nov 23

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

7. Best Western Plus Washington Hotel

Washington

Carl

NT$4,973 total

includes taxes & fees

Nov 3 - Nov 4

A hotel reception desk with a modern design, a sign indicating it's a Hilton Honors location, and a variety of snacks and beverages on shelves.

8. Hampton Inn By Hilton Warrenton I-70

Warrenton

Tammy

NT$5,433 total

includes taxes & fees

Nov 8 - Nov 9

A hotel room with a large bed, two bedside lamps, a nightstand with a phone, a mirror, and a bathtub.

9. Oak Hill Inn & Suites

Canton

Regina

NT$3,491 total

includes taxes & fees

Dec 1 - Dec 2

A hotel room with two beds, a nightstand with a lamp, and a window with blinds.

10. Super 8 by Wyndham Kirksville-University Area

Kirksville

Maria Modesta

NT$2,380 total

includes taxes & fees

Nov 22 - Nov 23

A hotel room with a bed, desk, chair, and a bathroom with a bathtub.

11. Quality Inn & Suites Hannibal West

Hannibal

Gayle

NT$2,823 total

includes taxes & fees

Nov 29 - Nov 30

A hotel room with a bed, a lamp, a mirror, and a door.

12. Town & Country Inn and Suites

Quincy

Tracy

A reception area with a counter, a trash bin, and a seating area with chairs.

13. Travelier Motel

Macon

Dovey

NT$2,524 total

includes taxes & fees

Nov 3 - Nov 4

A hotel room with two beds, a desk, a chair, and a large window.

14. Super 8 by Wyndham Washington

Washington

Kenneth

NT$2,973 total

includes taxes & fees

Nov 16 - Nov 17

A lobby with a reception desk, blue sofas, a coffee table, and a plant display.

15. Drury Inn & Suites St. Louis Arnold

Arnold

Kristine

NT$4,748 total

includes taxes & fees

Nov 8 - Nov 9

A spacious lobby with a high ceiling, a reception desk, seating areas, and a staircase leading to an upper level.

16. Holiday Inn Express & Suites St Peters by IHG

St. Peters

Roxanne

NT$4,623 total

includes taxes & fees

Nov 8 - Nov 9

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

17. Hyatt Place St. Louis/Chesterfield

Chesterfield

Debbie

NT$5,256 total

includes taxes & fees

Nov 3 - Nov 4

A hotel room with a bed, a nightstand, a lamp, a neon sign, and a door with a number.

18. Shamrock Court Motel

Sullivan

MaryLynn

NT$6,209 total

includes taxes & fees

Nov 3 - Nov 4

An indoor swimming pool with clear glass walls, blue lounge chairs, and a lifeguard stand.

19. Hampton Inn By Hilton St Louis Airport

Woodson Terrace

Judith

NT$4,475 total

includes taxes & fees

Nov 19 - Nov 20

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

20. The Wildwood Hotel

Wildwood

Lori

NT$3,114 total

includes taxes & fees

Nov 16 - Nov 17

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Compare top hotels in Northeast Missouri

Depot Inn and Suites 3.5 star property La Plata View	Holiday Inn Express & Suites Kirksville - University Area by IHG 2.5 star property Kirksville View	Sleep Inn & Suites Hannibal West 2.5 star property Hannibal View	Pinemark Inn & Suites 2.0 star property St. Clair View	Best Western On The River 2.5 star property Hannibal View
9.8 Exceptional 744 reviews	9.2 Wonderful 582 reviews	9.6 Exceptional 1,001 reviews	9.6 Exceptional 1,004 reviews	8.8 Excellent 1,008 reviews
The price is NT$3,161 NT$3,425 total includes taxes & fees Nov 8 - Nov 9	The price is NT$3,618 NT$4,101 total includes taxes & fees Nov 30 - Dec 1	The price is NT$3,315 NT$3,857 total includes taxes & fees Nov 25 - Nov 26	The price is NT$4,382 NT$4,797 total includes taxes & fees Nov 3 - Nov 4	The price is NT$3,292 NT$3,797 total includes taxes & fees Nov 9 - Nov 10
Yes, Breakfast included Yes, Pool No Spa Yes, Pet friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa No Pet friendly No WiFi included Yes, Parking

Vacation Rentals in Northeast Missouri

Cottage

A covered porch with a white door, two folding chairs, and a concrete walkway.

Peaceful Missouri Cabin Rental on 55 Acres!

Canton

"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "

Cabin

A park with a pond, picnic tables, and a gazebo.

Cannon Dam Cabins

Perry

"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"

Aparthotel

A compact living space with a sofa, a TV, a kitchen area with a fridge, microwave, and coffee maker, and a dining table.

The Mercantile on the Katy Trail

Hermann

"We loved this place- very unique! Clean and great communication from hosts."

Treehouse

A wooden bridge leading to a two-story house with multiple windows and a covered porch.

The Cottage

Hermann

"Our host mentioned he does not receive messages from Expedia postings. So if you are not receiving check-in information, you might want to find another way to contact them. The property is lovely. The Treehouse was perfect for my granddaughter and me."

Apartment

A modern hotel lobby with a marble reception desk, a TV mounted on the wall, and a seating area with chairs and a sofa.

Landing Furnished Apartments - Central West End

Central West End

"Parking was behind a large mechanical gate which did not always work. Could sometimes be noisy outside in the evening due to college clientele. Had to park on the street most of the time because of gate issues."

Vacation Home

A two-story building with a balcony, outdoor seating area, and string lights.

StayAtlas Retreat w/ Pool, Gym, Games, BBQ

Mount Pleasant

"The property was such a fun surprise- the neighborhood was a little sketchy, but it was great on the inside and the backyard... Great experience, fun complimentary toiletries, etc"

Cottage

A patio with a fire pit, outdoor furniture, and a wooden deck.

Downtown Hermann Vacation Home Near Wineries!

Hermann

"This is a very cute little house on the end of a quiet street. It's within easy walking distance of all the shops, restaurants, wineries, distilleries, and bars between 1st Street and 5th Street. If you don't mind a longer, hillier walk you could also go further south to City Park or to Stone Hill winery. But there's also easy transportation on the Trolley or local ride services. We were happy to find there were more beds than pictured (3 queen size downstairs between 2 bedrooms, and 2 queens...

Cottage

Updated Missouri Cabin Rental on Large Farm

Canton

"The cabin rental was a great stay. Had some connection problems with the t.v. couldn't get past the check out date. The wifi was easy to hook up. The cabin was clean and smelled fresh. Did have some problems with ants on the countertop. Great place to stay, enjoyed our visit."

Apartment

A deck with outdoor furniture, a grill, and a view of a golf course and lake.

Charming Berger Apt on 42-acre Farm w/ Pool Access

Berger

Apartment

A covered outdoor patio with wooden flooring, metal chairs, tables, and ceiling fans.

Studio Stay w/ Deck in Missouri Wine Country

New Haven

"It is a clean efficiency with modern amenities but with a touch of country flair! Sara is the property manager and is absolutely wonderful! Based on their availability, I would absolutely stay there again!!!!! Even if I can't stay there, I am definitely going to get some of thar great ice cream and home cooking at the restaurant in the same building!"

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Stay near popular Northeast Missouri attractions

The Saint Louis Zoo sign with vines on the wall.

St. Louis Zoo

9.2/10 (4,367 reviews)

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

See properties

Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri

A large eye sculpture in a park surrounded by trees.

Top Northeast Missouri Hotel Reviews

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

10/10 Excellent

"Very nice hotel on St. Louis! We got there late at night so didn’t get to use many of their amenities but the rooftop bar was really nice!"

21C Museum Hotel St Louis

10/10 Excellent

"My boyfriend & I stayed here for our anniversary since we usually spend them at home, and this was the best hotel for a staycation! From the hotel, to even restaurant staff, everyone was so pleasant. We had a Luxury King Suite and it was absolutely beautiful. We decided this hotel will become a place we start to return to for future anniversaries and I couldn’t be more excited! While we went out for Halloween and only stayed for 1 night, we never got to actually take a moment to enjoy some the of the main hotel amenities but still had the best time and we have already recommended it to others!"