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Top Luxury Central Missouri Hotels

Ramada by Wyndham Columbia

901 Conley Rd Columbia MO

2 hours drive from Lake of the Ozarks

Ramada by Wyndham Columbia awaits for a deluxe vacation. Popular amenities include an outdoor pool and a fitness center.

7.6/10 Good! (1,003 reviews)

Staff was ok but the room itself was horrible. There were bugs and it smelled the wall in the shower was crumbling. Wouldn’t suggest.

Reviewed on 2026/5/14

voco The Tiger Hotel Columbia, MO by IHG

23 S 8th St Columbia MO

2 hours drive from Lake of the Ozarks

Pamper yourself with a luxury stay at voco The Tiger Hotel Columbia, MO by IHG, where you can enjoy amenities like 24-hour room service, pillowtop beds, and ...

9/10 Wonderful! (1,003 reviews)

Beautiful hotel. Very spacious room, clean. Amazing bath/shower. Easy to walk to campus.

Reviewed on 2026/5/14

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr. Lake Ozark MO

20 min drive from Lake of the Ozarks

Pamper yourself with a luxe vacation at Lodge Of Four Seasons Golf Resort, Marina & Spa. Popular amenities include a spa, a golf course, and 5 bars.

7.4/10 Good! (1,121 reviews)

Classic ozark property. Beautiful view. Will definitely stay there again!

Reviewed on 2026/5/17

See all 5,098 properties in Central Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.