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Top Luxury Central Missouri Hotels

Ramada by Wyndham Columbia

901 Conley Rd Columbia MO

2 hours drive from Lake of the Ozarks

Ramada by Wyndham Columbia awaits for a deluxe vacation. Popular amenities include an outdoor pool and a fitness center.

7.6/10 Good! (1,006 reviews)

"One of the bulbs in the bathroom wasn't working, the sink slowly drain, wall at headboard, bed by the window, needs serious patching work, musty smell. Breakfast was ok."

Reviewed on 2026/5/18

voco The Tiger Hotel Columbia, MO by IHG

23 S 8th St Columbia MO

2 hours drive from Lake of the Ozarks

Pamper yourself with a luxury stay at voco The Tiger Hotel Columbia, MO by IHG, where you can enjoy amenities like 24-hour room service, pillowtop beds, and ...

9/10 Wonderful! (1,005 reviews)

"The location can’t be beat but the fees on fees on fees are ridiculous for mid-MO. And free parking is not free if valet has to be involved whenever we need our car."

Reviewed on 2026/5/18

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr. Lake Ozark MO

20 min drive from Lake of the Ozarks

Pamper yourself with a luxe vacation at Lodge Of Four Seasons Golf Resort, Marina & Spa. Popular amenities include a spa, a golf course, and 5 bars.

7.4/10 Good! (1,122 reviews)

"Classic ozark property. Beautiful view. Will definitely stay there again!"

Reviewed on 2026/5/17

See all 5,098 properties in Central Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.