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Top Luxury Central Missouri Hotels

Ramada by Wyndham Columbia

901 Conley Rd, Columbia, MO

2 hours drive from Lake of the Ozarks

Ramada by Wyndham Columbia awaits for a deluxe vacation. Popular amenities include an outdoor pool and a fitness center.

7.4/10 Good! (1,009 reviews)

The room was nice specially the bathroom but it did need a bit upkeep to a few spots on walls. Freezer needs to thaw out ice buildup.

Reviewed on 2025/10/27

voco, The Tiger Hotel, Columbia, MO by IHG

23 S 8th St, Columbia, MO

2 hours drive from Lake of the Ozarks

Pamper yourself with a luxury stay at voco, The Tiger Hotel, Columbia, MO by IHG, where you can enjoy amenities like 24-hour room service, pillowtop beds, and ...

8.8/10 Excellent! (1,000 reviews)

Beautiful

Reviewed on 2025/10/18

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr., Lake Ozark, MO

20 min drive from Lake of the Ozarks

Pamper yourself with a luxe vacation at Lodge Of Four Seasons Golf Resort, Marina & Spa. Popular amenities include a spa, a golf course, and 5 bars.

7.2/10 Good! (1,047 reviews)

Nice place. Good parking and convenient location to restaurants.

Reviewed on 2025/10/30

See all 4,635 properties in Central Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.